The codex of science: honesty, precision, and truth--and its violations.

abstract：:The aim of this study was to evaluate the effect of nadolol in modifying the standard deviation of RR intervals (SDRR) and the coefficient of variance (CV) in 47 patients characterized by symptomatic, frequent (> 30 h-1) and reproducible premature ventricular contractions (PVCs). Sixteen patients had suffered a previo...

journal_title：European heart journal

authors： Pitzalis MV,Mastropasqua F,Massari F,Totaro P,Passantino A,Rizzon P

更新日期：1995-02-01 00:00:00

abstract：AIMS:The population with stable coronary artery disease (SCAD) is growing but validated models to guide their clinical management are lacking. We developed and validated prognostic models for all-cause mortality and non-fatal myocardial infarction (MI) or coronary death in SCAD. METHODS AND RESULTS:Models were develop...

journal_title：European heart journal

authors： Rapsomaniki E,Shah A,Perel P,Denaxas S,George J,Nicholas O,Udumyan R,Feder GS,Hingorani AD,Timmis A,Smeeth L,Hemingway H

更新日期：2014-04-01 00:00:00

abstract：AIM:Cardiosphere-derived cells (CDCs) produce regenerative effects in the post-infarct setting. However, it is unclear whether CDCs are beneficial in non-ischaemic dilated cardiomyopathy (DCM). We tested the effects of CDC transplantation in mice with cardiac-specific Gαq overexpression, which predictably develop progr...

journal_title：European heart journal

authors： Aminzadeh MA,Tseliou E,Sun B,Cheng K,Malliaras K,Makkar RR,Marbán E

更新日期：2015-03-21 00:00:00

abstract：AIMS:Evidence is accumulating that inflammation plays a role in the pathophysiology of heart failure. Lipoprotein-associated phospholipase A2 (Lp-PLA2) has pro-inflammatory properties. We investigated whether Lp-PLA2 activity is associated with heart failure. METHODS AND RESULTS:Lp-PLA2 activity was determined in a ra...

journal_title：European heart journal

authors： van Vark LC,Kardys I,Bleumink GS,Knetsch AM,Deckers JW,Hofman A,Stricker BH,Witteman JC

更新日期：2006-10-01 00:00:00

abstract：:Recently, bisoprolol has been investigated regarding its effects on exercise tolerance and the duration of action in patients with coronary heart disease (CHD) following single oral administration. It appears, however, that the extent of effects of 5 mg bisoprolol is not fully established yet. Therefore, the effects o...

journal_title：European heart journal

authors： de Muinck E,Wagner G,vd Ven LL,Lie KI

更新日期：1987-12-01 00:00:00

abstract：:The value of measurements of the fibrinolytic factors, tissue plasminogen activator and plasminogen activator inhibitor, for predicting death and non-fatal cardiovascular events was studied in 213 consecutive patients with angiographically documented coronary artery disease. In the course of 4-year follow-up, 47 patie...

journal_title：European heart journal

authors： Jansson JH,Nilsson TK,Olofsson BO

更新日期：1991-02-01 00:00:00

abstract：AIMS:The utilization and timing of revascularization in unstable coronary artery disease varies, which could have important consequences for patients and for treatment costs. The FRISC II invasive trial compared an early invasive strategy vs a non-invasive strategy with respect to the composite end-point of death and m...

journal_title：European heart journal

authors： Janzon M,Levin LA,Swahn E

更新日期：2002-01-01 00:00:00

abstract：AIMS:The study set out to assess the relative contributions of donor heart rate, respiration and recipient atrial contraction on the mean of pulsed wave transmitral Doppler flow indices in orthotopic heart transplant recipients. This would provide information on the theoretical usefulness of pacemaker synchronization o...

journal_title：European heart journal

authors： Mannaerts H,Balk A,Roelandt J

更新日期：1997-10-01 00:00:00

abstract：AIMS:We sought to define the mechanisms and correlates of leptin's vascular actions in humans with coronary artery disease. METHODS AND RESULTS:In 131 patients (age 65.7+/-0.7 years mean+/-SEM), ex vivo vascular reactivity to leptin (10(-13)-10(-7) M) was assessed in saphenous vein (SV) rings. Leptin led to SV relaxat...

journal_title：European heart journal

authors： Momin AU,Melikian N,Shah AM,Grieve DJ,Wheatcroft SB,John L,El Gamel A,Desai JB,Nelson T,Driver C,Sherwood RA,Kearney MT

更新日期：2006-10-01 00:00:00

abstract：:During urgent cardiac catheterization total occlusion of a severe left main coronary artery stenosis occurred, leading to profound cardiogenic shock. The patient survived, after prompt left main coronary angioplasty was performed, followed by emergency coronary bypass surgery. ...

journal_title：European heart journal

authors： Groves PH,Ikram S,Hayward MW,Hall RJ

更新日期：1989-12-01 00:00:00

abstract：AIMS:To assess the diagnostic accuracy of 256-row computed tomographic angiography (CTA) in patients with suspected coronary artery disease (CAD). Non-invasive imaging of the coronary artery by CTA has increasingly been used in recent years. The accuracy of 256-row CTA has not yet been studied. We sought to assess the ...

journal_title：European heart journal

authors： Chao SP,Law WY,Kuo CJ,Hung HF,Cheng JJ,Lo HM,Shyu KG

更新日期：2010-08-01 00:00:00

abstract：AIMS:Determination of the influence of therapy with bisoprolol and nifedipine on the heart rate variability of patients from the Total Ischemic Burden Bisoprolol Study and examination of the prognostic value. METHODS AND RESULTS:Four hundred and twenty-two patients with stable angina were included. The heart rate vari...

journal_title：European heart journal

authors： Weber F,Schneider H,von Arnim T,Urbaszek W

更新日期：1999-01-01 00:00:00

abstract：:The L-arginine pathway within endothelial cells in the blood vessel wall is the source of production of the endogenous nitrovasodilator, nitric oxide (NO). NO is released under basal conditions and in response to various stimuli such as shear stress and in response to platelet-derived products, coagulation factors and...

journal_title：European heart journal

authors： Lüscher TF

更新日期：1991-11-01 00:00:00

abstract：:Nucleic acid-based therapeutics are currently developed at large scale for prevention and management of cardiovascular diseases (CVDs), since: (i) genetic studies have highlighted novel therapeutic targets suggested to be causal for CVD; (ii) there is a substantial recent progress in delivery, efficacy, and safety of ...

journal_title：European heart journal

authors： Landmesser U,Poller W,Tsimikas S,Most P,Paneni F,Lüscher TF

更新日期：2020-10-21 00:00:00

abstract：:To evaluate the efficacy and safety of hirudin, a direct thrombin inhibitor, in patients with acute myocardial infarction, a dose-finding, angiography study was carried out. After a pilot phase in 10 patients treated with a bolus of 0.1 mg.kg-1 and a continuous infusion of 0.06 mg.kg-1.h-1 (dose group I), two doses of...

journal_title：European heart journal

authors： Molhoek GP,Laarman GJ,Lok DJ,Luz CM,Kingma JH,Van den Bos AA,Zijnen P,Bosma AH,Hertzberger DP,Takens LH

更新日期：1995-07-01 00:00:00

abstract：:The antibody prevalence data indicate that C. pneumoniae infections are common worldwide and more frequently occur in middle-aged and elderly males than in females. C. pneumoniae infections are first acquired in childhood in heavily populated areas, whereas in northern countries, first infections are generally at teen...

journal_title：European heart journal

authors： Leinonen M

更新日期：1993-12-01 00:00:00

abstract：AIMS:To document the impact of intensive insulin therapy during intensive care on long-term (4 years) outcome of high-risk cardiac surgery patients. METHODS AND RESULTS:In this pre-planned sub-analysis and follow-up study of a large, randomized controlled trial on the effects of intensive insulin therapy during critic...

journal_title：European heart journal

authors： Ingels C,Debaveye Y,Milants I,Buelens E,Peeraer A,Devriendt Y,Vanhoutte T,Van Damme A,Schetz M,Wouters PJ,Van den Berghe G

更新日期：2006-11-01 00:00:00

abstract：:A previously described nitroglycerin-induced heparin resistance could not be verified by in-vitro experiments or in a randomized, double-blind, crossover trial in healthy volunteers. A clinically relevant attenuation of the anticoagulant effect of a heparin bolus (40 U.kg-1) by a concomitant infusion of nitroglycerin ...

journal_title：European heart journal

authors： Schoenenberger RA,Ménat L,Weiss P,Marbet GA,Ritz R

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:Following hospitalization with a range of cardiovascular disorders, substantial variation has been noted in clinical outcome, both between and within countries. OBJECTIVES:To examine the variation, between hospitals, in the clinical outcomes of death and readmission following hospitalization with heart fail...

journal_title：European heart journal

authors： Stewart S,Demers C,Murdoch DR,McIntyre K,MacLeod ME,Kendrick S,Capewell S,McMurray JJ

更新日期：2002-04-01 00:00:00

abstract：:This study describes the clinical profile and prognosis of elderly patients not eligible for predischarge exercise testing. The database consisted of 133 patients 55-64 years of age, and 111 patients older than 64 years of age who survived an acute myocardial infarction. Follow-up was one year. In the younger age grou...

journal_title：European heart journal

authors： Deckers JW,Fioretti P,Brower RW,Simoons ML,Baardman T,Hugenholtz PG

更新日期：1984-11-01 00:00:00

abstract：:We studied the effects of a chronic increase in flow and of chronic hypertension on regional pulmonary blood volume and extravascular lung density (lung tissue and interstitial water per unit thoracic volume) in one group of patients with intracardiac, left-to-right shunt and in another group with Eisenmenger's syndro...

journal_title：European heart journal

authors： Wollmer P,Rozkovec A,Rhodes CG,Allan RM,Maseri A

更新日期：1984-11-01 00:00:00

abstract：AIMS:Transplant-associated coronary artery disease (TxCAD) is a major cause of post-transplant graft failure. The aim of this study was to investigate a possible role of mannose-binding lectin (MBL) deficiency and complement activation in TxCAD. METHODS AND RESULTS:In a prospective study of heart transplant recipients...

journal_title：European heart journal

authors： Fiane AE,Ueland T,Simonsen S,Scott H,Endresen K,Gullestad L,Geiran OR,Haraldsen G,Heggelund L,Andreassen AK,Wergeland R,Frøland S,Aukrust P,Mollnes TE

更新日期：2005-08-01 00:00:00

abstract：:This report describes the results of right ventricle endomyocardial biopsies from 26 subjects (mean age 27 +/- 10 years) with premature ventricular beats and normal cardiac anatomy and mechanical function. Light microscopy examination revealed normal myocardium in 10 subjects (38%), acute myocarditis in two (7%), bord...

journal_title：European heart journal

authors： Di Biase M,Chiddo A,Caruso G,Tritto M,Marchese A,Rizzon P

更新日期：1992-06-01 00:00:00

abstract：:Recently published epidemiological and genetic studies strongly suggest a causal relationship of elevated concentrations of lipoprotein (a) [Lp(a)] with cardiovascular disease (CVD), independent of low-density lipoproteins (LDLs), reduced high density lipoproteins (HDL), and other traditional CVD risk factors. The ath...

journal_title：European heart journal

authors： Kostner KM,März W,Kostner GM

更新日期：2013-11-01 00:00:00

abstract：:Spinal cord electrical stimulation is an alternative therapy for patients with chronic pain syndromes including angina. Although it has been shown to produce symptomatic relief and reduce ischaemia, doubts remain about its long-term safety. We report here for the first time the results of a follow-up study over a peri...

journal_title：European heart journal

authors： Sanderson JE,Ibrahim B,Waterhouse D,Palmer RB

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:The economic evaluation of the results of the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Artery (GUSTO) trial found that recombinant tissue plasminogen activator is more cost-effective than streptokinase for the treatment of acute myocardial infarction. AIM:We...

journal_title：European heart journal

authors： Lorenzoni R,Pagano D,Mazzotta G,Rosen SD,Fattore G,De Caterina R,Gensini G

更新日期：1998-10-01 00:00:00

abstract：AIMS:Sudden unexplained death syndrome occurs in previously healthy South-east Asian young adults without any structural cause of death. The common electrocardiographic (ECG) change in sudden unexplained death syndrome survivors is right bundle branch block and ST elevations in leads V(1) to V(3), which are similar to ...

journal_title：European heart journal

authors： Sangwatanaroj S,Prechawat S,Sunsaneewitayakul B,Sitthisook S,Tosukhowong P,Tungsanga K

更新日期：2001-12-01 00:00:00

abstract：:Recent studies have illustrated that in addition to the well known risk factors, such as lipoproteins, smoking, hypertension, there are others that cause atherosclerosis and myocardial infarction. Our knowledge of atherosclerotic lesions has increased. We now know that atherosclerotic changes are due to inflammatory c...

journal_title：European heart journal

authors： Nieminen MS,Mattila K,Valtonen V

更新日期：1993-12-01 00:00:00

abstract：:To evaluate gender-related differences in left ventricular (LV) structure and function in aortic stenosis, LV biplane cineangiography, micromanometry and endomyocardial biopsies were carried out in 56 patients with aortic stenosis and normal coronary arteries. Patients were divided into males (M: n = 35), and females ...

journal_title：European heart journal

authors： Villari B,Campbell SE,Schneider J,Vassalli G,Chiariello M,Hess OM

更新日期：1995-10-01 00:00:00

abstract：AIMS:To determine the potential adjunct of high-sensitivity (hs) C-reactive protein for risk stratification in patients with stable congestive heart failure (CHF). METHODS AND RESULTS:We studied 546 consecutive patients clinically stable with an ejection fraction <45% who were referred to our centre for evaluation of ...

journal_title：European heart journal

authors： Lamblin N,Mouquet F,Hennache B,Dagorn J,Susen S,Bauters C,de Groote P

更新日期：2005-11-01 00:00:00