The codex of science: honesty, precision, and truth--and its violations.


:Science has made enormous achievements for our understanding of the world and for everyday life: we now know that we live on a spherical planet of the solar system, we understand the origin of the species, we can take a train, survive myocardial infarction, and fly to the moon. This has been made possible thanks to a persistent search for truth by great scientists and the scientific community at large. Our assumptions were often wrong, but the scientific process advanced by a productive interplay of conjectures and refutations. As in any profession, there is misconduct, i.e. sloppiness, plagiarism up to falsification, or even fabrication of data. Although eventually fraudulent science has and will be disproved, it is morally inappropriate, damages the reputation of research and journals in which its products are published, may endanger patients, and misuses grant money of federal and private institutions. Thus, as editors and readers, we should be aware of it based on its typical pattern, but we must avoid an atmosphere of distrust, as trust is the essence of scientific exchange and progress.


Eur Heart J


European heart journal


Lüscher TF




Has Abstract


2013-04-01 00:00:00














  • Why did persons invited to train in cardiopulmonary resuscitation not do so?

    abstract::All citizens (N = 22066) aged 16 to 65 of a medium-sized Belgian town were personally invited to CPR training sessions held in their neighbourhood. 1152 responded by attending a training session. Those who did not so respond were surveyed (random sample N = 600) for reasons of their not coming. The sample fitted well ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Lejeune PO,Delooz HH

    更新日期:1987-03-01 00:00:00

  • Influence of coronary vessel dominance on short- and long-term outcome in patients after ST-segment elevation myocardial infarction.

    abstract:AIMS:Prognostic importance of coronary vessel dominance in patients with ST-elevation myocardial infarction (STEMI) remains uncertain. The aim of this study was to assess influence of coronary vessel dominance on the short- and long-term outcome after STEMI. METHODS AND RESULTS:Coronary angiographic images of consecut...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Veltman CE,van der Hoeven BL,Hoogslag GE,Boden H,Kharbanda RK,de Graaf MA,Delgado V,van Zwet EW,Schalij MJ,Bax JJ,Scholte AJ

    更新日期:2015-05-01 00:00:00

  • Happy heart syndrome: role of positive emotional stress in takotsubo syndrome.

    abstract:AIMS:Takotsubo syndrome (TTS) is typically provoked by negative stressors such as grief, anger, or fear leading to the popular term 'broken heart syndrome'. However, the role of positive emotions triggering TTS remains unclear. The aim of the present study was to analyse the prevalence and characteristics of patients w...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Ghadri JR,Sarcon A,Diekmann J,Bataiosu DR,Cammann VL,Jurisic S,Napp LC,Jaguszewski M,Scherff F,Brugger P,Jäncke L,Seifert B,Bax JJ,Ruschitzka F,Lüscher TF,Templin C,InterTAK Co-investigators:.

    更新日期:2016-10-01 00:00:00

  • In-hospital mortality of habitual cigarette smokers after acute myocardial infarction; the "smoker's paradox" in a countrywide study.

    abstract:AIMS:Habitual cigarette smokers, paradoxically, present improved short-term prognosis after acute myocardial infarction, a phenomenon often termed "smoker's paradox". We sought to examine cigarette smokers' post-infarction survival advantage in a countrywide survey of unselected, consecutive patients presenting with ac...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Andrikopoulos GK,Richter DJ,Dilaveris PE,Pipilis A,Zaharoulis A,Gialafos JE,Toutouzas PK,Chimonas ET

    更新日期:2001-05-01 00:00:00

  • Effect of dexamethasone on Coxsackievirus B2-infected rat beating heart cells in culture.

    abstract::The effects of dexamethasone on cultured rat beating heart cells experimentally infected with coxsackievirus B2 were investigated at an early stage (1-3 days) post challenge. Changes in the release of the cardiac enzyme, aspartate amino-transferase (AST), beating %, cytopathic effect (CPE), virus titre, ultrastructure...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Yang YZ,Yuan WL,Guo Q,Gong ZX,Zhow TS,Shen JY,Chen HZ

    更新日期:1991-08-01 00:00:00

  • Value of oesophageal pacing in evaluation of atrial arrhythmias.

    abstract::The study of 'atrial vulnerability' is often clinically indicated but it requires the use of invasive intracardiac stimulation. The purpose of the study was to assess the use of oesophageal pacing in the evaluation of atrial tachyarrhythmias (ATA). Fifty-five patients with documented ATA (group I) and 60 without (grou...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Brembilla-Perrot B

    更新日期:1994-08-01 00:00:00

  • Exercise-induced right ventricular dysfunction is associated with ventricular arrhythmias in endurance athletes.

    abstract:AIMS:Intense exercise places disproportionate strain on the right ventricle (RV) which may promote pro-arrhythmic remodelling in some athletes. RV exercise imaging may enable early identification of athletes at risk of arrhythmias. METHODS AND RESULTS:Exercise imaging was performed in 17 athletes with RV ventricular a...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: La Gerche A,Claessen G,Dymarkowski S,Voigt JU,De Buck F,Vanhees L,Droogne W,Van Cleemput J,Claus P,Heidbuchel H

    更新日期:2015-08-07 00:00:00

  • Ventricular pre-excitation.

    abstract::Pilots and new applicants with asymptomatic 'safe' WPW syndrome should be allowed to fly but not as pilot in sole command. Professional pilots with tachyarrhythmia related to a pre-excitation syndrome should usually be disqualified . Personnel who have undergone successful surgical treatment by ablation of an accessor...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Ward D

    更新日期:1984-03-01 00:00:00

  • Evidence for obesity paradox in patients with acute coronary syndromes: a report from the Swedish Coronary Angiography and Angioplasty Registry.

    abstract:AIMS:The obesity paradox refers to the epidemiological evidence that obesity compared with normal weight is associated with counter-intuitive improved health in a variety of disease conditions. The aim of this study was to investigate the relationship between body mass index (BMI) and mortality in patients with acute c...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Angerås O,Albertsson P,Karason K,Råmunddal T,Matejka G,James S,Lagerqvist B,Rosengren A,Omerovic E

    更新日期:2013-02-01 00:00:00

  • Cardio-Oncology Services: rationale, organization, and implementation.

    abstract:AIMS:Anticancer therapies have extended the lives of millions of patients with malignancies, but for some this benefit is tempered by adverse cardiovascular (CV) effects. Cardiotoxicity may occur early or late after treatment initiation or termination. The extent of this cardiotoxicity is variable, depending on the typ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Lancellotti P,Suter TM,López-Fernández T,Galderisi M,Lyon AR,Van der Meer P,Cohen Solal A,Zamorano JL,Jerusalem G,Moonen M,Aboyans V,Bax JJ,Asteggiano R

    更新日期:2019-06-07 00:00:00

  • Peak oxygen uptake is not determined by cardiac noradrenaline spillover in heart failure.

    abstract:AIMS:We recently found that resting muscle sympathetic nerve activity is inversely related to peak oxygen uptake (VO(2) peak) in patients with heart failure, suggesting a peripheral neurogenic limit to exercise in heart failure. No such relationship was observed in healthy controls. To determine whether this observatio...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Notarius CF,Azevedo ER,Parker JD,Floras JS

    更新日期:2002-05-01 00:00:00

  • The effects of intraventricular gradients on left ventricular ejection dynamics.

    abstract::The generation of abnormal gradients between the apical cavity and the subaortic valvular region of the left ventricle in patients with hypertrophic cardiomyopathy (HCM) has traditionally been equated to a dynamic obstruction to left ventricular outflow. To examine this concept in more detail, left ventricular ejectio...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Murgo JP,Alter BR,Dorethy JF,Altobelli SA,Craig WE,McGranahan GM Jr

    更新日期:1983-11-01 00:00:00

  • Natriuretic peptide-guided heart failure management.

    abstract::The natriuretic peptides are important tools to establish diagnosis and prognosis in heart failure (HF). With application of therapies for HF, changes in both B-type natriuretic peptide (BNP) and its amino terminal cleavage fragment (NT-proBNP) parallel the benefits of the HF therapy applied. This dynamic nature of BN...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Troughton R,Michael Felker G,Januzzi JL Jr

    更新日期:2014-01-01 00:00:00

  • Optimal timing of invasive angiography in stable non-ST-elevation myocardial infarction: the Leipzig Immediate versus early and late PercutaneouS coronary Intervention triAl in NSTEMI (LIPSIA-NSTEMI Trial).

    abstract:AIMS:The optimal timing of intervention in non-ST-elevation myocardial infarction (NSTEMI) remains uncertain. The aim of this multicentre trial was to assess whether an immediate invasive approach is superior to an early invasive or a selective invasive approach with respect to reduction of large infarction. METHODS A...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Thiele H,Rach J,Klein N,Pfeiffer D,Hartmann A,Hambrecht R,Sick P,Eitel I,Desch S,Schuler G,LIPSIA-NSTEMI Trial Group.

    更新日期:2012-08-01 00:00:00

  • Myocardial catecholamine concentrations in dilated cardiomyopathy and heart failure of different origins.

    abstract::Myocardial catecholamine concentrations were determined in endomyocardial biopsies from patients with heart failure to assess if tissue catecholamine levels relate to the severity of myocardial damage or the aetiology of the underlying disease. Methodological studies revealed a good reproducibility of catecholamine de...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Regitz V,Leuchs B,Bossaller C,Sehested J,Rappolder M,Fleck E

    更新日期:1991-08-01 00:00:00

  • Clonal haematopoiesis in patients with degenerative aortic valve stenosis undergoing transcatheter aortic valve implantation.

    abstract:AIMS:Clonal haematopoiesis of indeterminate potential (CHIP), defined as the presence of an expanded somatic blood cell clone without other haematological abnormalities, was recently shown to increase with age and is associated with coronary artery disease and calcification. The most commonly mutated CHIP genes, DNMT3A...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Mas-Peiro S,Hoffmann J,Fichtlscherer S,Dorsheimer L,Rieger MA,Dimmeler S,Vasa-Nicotera M,Zeiher AM

    更新日期:2020-02-21 00:00:00

  • Performance of EuroSCORE in CABG and off-pump coronary artery bypass grafting: single institution experience and meta-analysis.

    abstract:AIMS:To assess EuroSCORE performance in predicting in-hospital mortality in on-pump coronary artery bypass grafting (CABG) and off-pump coronary artery bypass grafting (OPCAB). METHODS AND RESULTS:Additive and logistic EuroSCORE were computed for consecutive patients undergoing CABG (n = 3440, 75%) or OPCAB (n = 1140,...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析,评审


    authors: Parolari A,Pesce LL,Trezzi M,Loardi C,Kassem S,Brambillasca C,Miguel B,Tremoli E,Biglioli P,Alamanni F

    更新日期:2009-02-01 00:00:00

  • Effects of simvastatin only or in combination with continuous combined hormone replacement therapy on serum lipid levels in hypercholesterolaemic post-menopausal women.

    abstract:AIMS:To evaluate the effects of simvastatin only or combined with continuous hormone replacement therapy on the serum lipid profile in hypercholesterolaemic post-menopausal women. METHODS AND RESULTS:One hundred hypercholesterolaemic post-menopausal women were given either simvastatin 10 mg daily together with oestrog...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Fak AS,Erenus M,Tezcan H,Caymaz O,Atagündüz P,Oktay S,Oktay A

    更新日期:2000-02-01 00:00:00

  • Long-lasting sport practice and lone atrial fibrillation.

    abstract:AIMS:To analyse whether the proportion of patients with lone atrial fibrillation engaged in chronic sport practice was higher than that observed in the general population. METHODS AND RESULTS:The records of 1160 patients, seen at the arrhythmia outpatient clinic, were reviewed. A total of 70 patients (6%) suffered lon...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Mont L,Sambola A,Brugada J,Vacca M,Marrugat J,Elosua R,Paré C,Azqueta M,Sanz G

    更新日期:2002-03-01 00:00:00

  • Supplementation with vitamins C and E suppresses leukocyte oxygen free radical production in patients with myocardial infarction.

    abstract::Clinical studies suggest that neutrophil activation during acute myocardial infarction (MI) aggravates tissue injury. Activated neutrophils are an important source of oxygen free radicals (OFR), the injurious effects of which are counteracted by endogenous antioxidants. We have previously shown in healthy subjects tha...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Herbaczyńska-Cedro K,K+osiewicz-Wasek B,Cedro K,Wasek W,Panczenko-Kresowska B,Wartanowicz M

    更新日期:1995-08-01 00:00:00

  • The effect of cardiac catheterization upon management of advanced aortic and mitral valve disease.

    abstract::We assessed the incremental effect of cardiac catheterization upon the management of 93 adult patients with aortic and/or mitral valve disease, referred for surgical consideration. There were 52 patients with aortic valve disease, 29 with mitral valve disease and 12 with aortic and mitral valve disease. Prior to cardi...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Leitch JW,Mitchell AS,Harris PJ,Fletcher PJ,Bailey BP

    更新日期:1991-05-01 00:00:00

  • Eccentric atherosclerotic plaques with positive remodelling have a pericardial distribution: a permissive role of epicardial fat? A three-dimensional intravascular ultrasound study of left anterior descending artery lesions.

    abstract:AIMS:The transversal distribution of coronary atherosclerotic plaques (AP) (myocardial vs pericardial) affects vessel remodelling. The aim of this study was to define the impact of transversal lesion distribution on vessel remodelling in proximal and distal coronary segments using a 3D intravascular ultrasound (IVUS) r...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Prati F,Arbustini E,Labellarte A,Sommariva L,Pawlowski T,Manzoli A,Pagano A,Motolese M,Boccanelli A

    更新日期:2003-02-01 00:00:00

  • Diagnostic work-up in cardiomyopathies: bridging the gap between clinical phenotypes and final diagnosis. A position statement from the ESC Working Group on Myocardial and Pericardial Diseases.

    abstract::In 2008, The ESC Working Group on Myocardial and Pericardial Diseases proposed an updated classification of cardiomyopathies based on morphological and functional phenotypes and subcategories of familial/genetic and non-familial/non-genetic disease. In this position statement, we propose a framework for the clinical a...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Rapezzi C,Arbustini E,Caforio AL,Charron P,Gimeno-Blanes J,Heliö T,Linhart A,Mogensen J,Pinto Y,Ristic A,Seggewiss H,Sinagra G,Tavazzi L,Elliott PM

    更新日期:2013-05-01 00:00:00

  • Anticoagulant properties, clinical efficacy and safety of efegatran, a direct thrombin inhibitor, in patients with unstable angina.

    abstract:AIMS:Thrombin plays a key role in the clinical syndrome of unstable angina. We investigated the safety and efficacy of five dose levels of efegatran sulphate, a direct thrombin inhibitor, compared to heparin in patients with unstable angina. METHODS:Four hundred and thirty-two patients with unstable angina were enroll...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Klootwijk P,Lenderink T,Meij S,Boersma H,Melkert R,Umans VA,Stibbe J,Müller EJ,Poortermans KJ,Deckers JW,Simoons ML

    更新日期:1999-08-01 00:00:00

  • Long-term prognosis of patients with paroxysmal atrial fibrillation complicating acute myocardial infarction. SPRINT Study Group.

    abstract::The aim of the study was to assess the relationship between paroxysmal atrial fibrillation during acute myocardial infarction and the long-term prognosis of patients after acute myocardial infarction. The incidence of paroxysmal atrial fibrillation among 5803 consecutive hospitalized patients was 9.9% (557/5803). Inci...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Behar S,Zahavi Z,Goldbourt U,Reicher-Reiss H

    更新日期:1992-01-01 00:00:00

  • The imperative for metrics in training.

    abstract::A twenty-first century model for the training and assessment of cardiac interventionists’ skills, outlined by Prof. John Morgan FRCP FESC. ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Morgan JM,Burri H,Binner L,Mansour H,Retzlaff H,Roca M,Gallagher A

    更新日期:2011-01-01 00:00:00

  • Role of angiotensin converting enzyme inhibitors in patients with left ventricular dysfunction and congestive heart failure.

    abstract::We now have conclusive data that ACE inhibitors reduce mortality, morbidity, and symptoms in patients with low ejection fraction and/or heart failure. Therefore, ACE inhibitors should be routinely used in all such patients, as long as there are no clear contraindications. Routine use of ACE inhibitors will lead to pro...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析


    authors: McKelvie R,McConachie D,Yusuf S

    更新日期:1994-05-01 00:00:00

  • Randomized factorial trial of high-dose intravenous streptokinase, of oral aspirin and of intravenous heparin in acute myocardial infarction. ISIS (International Studies of Infarct Survival) pilot study.

    abstract::619 patients with suspected acute myocardial infarction (MI) were randomized to receive either a high-dose short-term intravenous infusion of streptokinase (1.5 MU over one hour) or placebo. Using a '2 X 2 X 2 factorial' design, patients were also randomized to receive either oral aspirin (325 mg on alternate days for...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验



    更新日期:1987-06-01 00:00:00

  • Left posterior hemiblock related to an interventricular septum tumour. First case in the literature.

    abstract::A 22-year-old man who engaged in intense and regular physical exercise complained of atypical chest pain. The only remarkable abnormality found in the routine clinical work-up was a left posterior hemiblock. The echocardiogram and the magnetic resonance imaging (MRI) study showed a tumour in the posterior and superior...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Cola H,Hoffman R,Borrega NG,Lazzari JO

    更新日期:1992-04-01 00:00:00

  • Coronary vasodilation induced by intracoronary enalaprilat: an argument for the role of a local renin-angiotensin system in patients with dilated cardiomyopathy.

    abstract::Although indicated by several experimental studies, the presence of a renin-angiotensin system has not been demonstrated in the human heart. The influence of a local renin-angiotensin system on the coronary vessels may be difficult to establish after oral or intravenous administration of an angiotensin converting-enzy...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Foult JM,Tavolaro O,Antony I,Nitenberg A

    更新日期:1989-11-01 00:00:00