The codex of science: honesty, precision, and truth--and its violations.

abstract：AIMS:Positron emission tomography (PET) myocardial perfusion imaging (MPI) can non-invasively measure myocardial blood flow reserve (MBFR). We aimed to examine whether MBFR identifies patients with a survival benefit after revascularization, helping to guide post-test management. METHODS AND RESULTS:We examined all-ca...

journal_title：European heart journal

authors： Patel KK,Spertus JA,Chan PS,Sperry BW,Al Badarin F,Kennedy KF,Thompson RC,Case JA,McGhie AI,Bateman TM

更新日期：2020-02-01 00:00:00

abstract：:Echocardiographic parameters of left ventricular (LV) function were compared with the electrocardiographic findings in 40 patients with chronic severe aortic regurgitation. Total 12-lead QRS amplitude was linearly correlated with LV mass and its 'relative reduction' (less than 250 mm) indicated LV hypertrophy. Patient...

journal_title：European heart journal

authors： Scognamiglio R,Fasoli G,Bruni A,Dalla-Volta S

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Anti-ischaemic therapy with nitrates and/or calcium channel blockers profoundly affects the results of pharmacological stress echocardiography with coronary vasodilators but the influence on catecholamine stress testing remains unsettled. AIMS:The present study aimed to assess the effects of non-beta-blocke...

journal_title：European heart journal

authors： Dodi C,Pingitore A,Sicari R,Bruno G,Cordovil A,Picano E

更新日期：1997-02-01 00:00:00

abstract：AIMS:Growth differentiation factor 11 and/or its homologue growth differentiation factor 8 (GDF11/8) reverses age-related cardiac hypertrophy and vascular ageing in mice. We investigated whether GDF11/8 associates with cardiovascular outcomes, left ventricular hypertrophy (LVH), or age in humans. METHODS AND RESULTS:W...

journal_title：European heart journal

authors： Olson KA,Beatty AL,Heidecker B,Regan MC,Brody EN,Foreman T,Kato S,Mehler RE,Singer BS,Hveem K,Dalen H,Sterling DG,Lawn RM,Schiller NB,Williams SA,Whooley MA,Ganz P

更新日期：2015-12-21 00:00:00

abstract：AIMS:No-reflow after a primary percutaneous coronary intervention (PCI) is associated with a high incidence of left ventricular (LV) failure and a poor prognosis. Endothelin-1 (ET-1) is a potent endothelium-derived vasoconstrictor peptide and an important modulator of neutrophil function. Elevated systemic ET-1 levels ...

journal_title：European heart journal

authors： Niccoli G,Lanza GA,Shaw S,Romagnoli E,Gioia D,Burzotta F,Trani C,Mazzari MA,Mongiardo R,De Vita M,Rebuzzi AG,Lüscher TF,Crea F

更新日期：2006-08-01 00:00:00

abstract：AIMS:This study investigates whether increased right ventricular (RV) pressure in pulmonary hypertension (PH) impairs right coronary artery (RCA) flow and RV perfusion. METHODS:In 25 subjects, five patients with idiopathic pulmonary arterial hypertension, nine patients with chronic thromboembolic pulmonary arterial hy...

journal_title：European heart journal

authors： van Wolferen SA,Marcus JT,Westerhof N,Spreeuwenberg MD,Marques KM,Bronzwaer JG,Henkens IR,Gan CT,Boonstra A,Postmus PE,Vonk-Noordegraaf A

更新日期：2008-01-01 00:00:00

abstract：AIMS:The impact on mortality outcomes of beta-blockers and calcium blockers in post-myocardial infarction (MI) has been suggested to be related to resting heart rate (HR) reduction. A meta-regression of randomized clinical trials was carried out to assess this relationship using weighted meta-regression of logarithm of...

journal_title：European heart journal

authors： Cucherat M

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Sixteen cases of sudden unexpected cardiac death, 15 males and one female, are known to have occurred among young Swedish orienteers from 1979 to 1992, of which seven cases occurred between 1989 and 1992. This is considered to be indicative of an increased death rate. RESULTS:Histopathological evaluation sh...

journal_title：European heart journal

authors： Wesslén L,Påhlson C,Lindquist O,Hjelm E,Gnarpe J,Larsson E,Baandrup U,Eriksson L,Fohlman J,Engstrand L,Linglöf T,Nyström-Rosander C,Gnarpe H,Magnius L,Rolf C,Friman G

更新日期：1996-06-01 00:00:00

abstract：AIMS:In the dual antiplatelet therapy (DAPT) study, continued thienopyridine beyond 12 months after drug-eluting stent placement was associated with increased mortality compared with placebo. We sought to evaluate factors related to mortality in randomized patients receiving either drug-eluting or bare metal stents in ...

journal_title：European heart journal

authors： Mauri L,Elmariah S,Yeh RW,Cutlip DE,Steg PG,Windecker S,Wiviott SD,Cohen DJ,Massaro JM,D'Agostino RB Sr,Braunwald E,Kereiakes DJ,DAPT Study Investigators.

更新日期：2016-01-21 00:00:00

abstract：BACKGROUND:There is much interest in reported associations between serum C-reactive protein and incident ischaemic heart disease. It is uncertain what this association represents. We aimed to assess the effect of confounding from a number of different sources in the Caerphilly Prospective Heart Disease Study and in par...

journal_title：European heart journal

authors： Mendall MA,Strachan DP,Butland BK,Ballam L,Morris J,Sweetnam PM,Elwood PC

更新日期：2000-10-01 00:00:00

abstract：:The left atrial appendage (LAA) is the main source of thromboembolism in patients with non-valvular atrial fibrillation (AF). As such, the LAA can be the target of specific occluding device therapies. Optimal management of patients with AF includes a comprehensive knowledge of the many aspects related to LAA structure...

journal_title：European heart journal

authors： Patti G,Pengo V,Marcucci R,Cirillo P,Renda G,Santilli F,Calabrò P,De Caterina AR,Cavallari I,Ricottini E,Parato VM,Zoppellaro G,Di Gioia G,Sedati P,Cicchitti V,Davì G,Golia E,Pariggiano I,Simeone P,Abbate R,Prisco

更新日期：2017-03-21 00:00:00

abstract：AIMS:The aim is to compare the coronary risk chart published by the European Task Force for Prevention of Coronary Heart Disease and produced using a Framingham risk function, with a risk function derived from an Italian population study. METHODS AND RESULTS:Coronary risk function in this study was the result of longi...

journal_title：European heart journal

authors： Menotti A,Puddu PE,Lanti M

更新日期：2000-03-01 00:00:00

abstract：AIMS:The management and outcomes of patients with functional moderate/severe mitral regurgitation and severe left ventricular (LV) systolic dysfunction are not well defined. We sought to determine the characteristics, management strategies, and outcomes of patients with moderate or severe mitral regurgitation (MR) and ...

journal_title：European heart journal

authors： Samad Z,Shaw LK,Phelan M,Ersboll M,Risum N,Al-Khalidi HR,Glower DD,Milano CA,Alexander JH,O'Connor CM,Wang A,Velazquez EJ

更新日期：2015-10-21 00:00:00

abstract：AIMS:The aim of this study involves the early identification, among apparently healthy individuals, of those at high risk for sudden cardiac death. We tested the hypothesis that individuals who respond to mild mental stress in preparation for exercise test with the largest heart rate increases might be at highest risk....

journal_title：European heart journal

authors： Jouven X,Schwartz PJ,Escolano S,Straczek C,Tafflet M,Desnos M,Empana JP,Ducimetière P

更新日期：2009-07-01 00:00:00

abstract：AIMS:There is no cure for pulmonary arterial hypertension, but current approved treatment options include prostanoids, endothelin-receptor antagonists, and phosphodiesterase type-5 inhibitors. The effect on survival of these compounds has not been appropriately assessed in individual trials because of small sample size...

journal_title：European heart journal

authors： Galiè N,Manes A,Negro L,Palazzini M,Bacchi-Reggiani ML,Branzi A

更新日期：2009-02-01 00:00:00

abstract：:The choice of oral anticoagulant (OAC) for patients with atrial fibrillation (AF) may be influenced by individual clinical features or by patterns of risk factors and comorbidities. We reviewed analyses of subgroups of patients from trials of vitamin K antagonists vs. non-vitamin K oral anticoagulants (NOACs) for stro...

journal_title：European heart journal

authors： Diener HC,Aisenberg J,Ansell J,Atar D,Breithardt G,Eikelboom J,Ezekowitz MD,Granger CB,Halperin JL,Hohnloser SH,Hylek EM,Kirchhof P,Lane DA,Verheugt FWA,Veltkamp R,Lip GYH

更新日期：2017-03-21 00:00:00

abstract：AIMS:Adverse left ventricular (LV) remodelling after myocardial infarction (MI) frequently leads to congestive heart failure (CHF). We have previously shown that myocardial beta-adrenoceptor density (beta-ARD) is reduced soon after acute MI and correlates with LV dilatation in the short term. The aim of the present stu...

journal_title：European heart journal

authors： Gaemperli O,Liga R,Spyrou N,Rosen SD,Foale R,Kooner JS,Rimoldi OE,Camici PG

更新日期：2010-07-01 00:00:00

abstract：AIMS:We examined the left lateral ridge (LLR) between the orifices of the left pulmonary veins and the left atrial appendage for a better understanding of its structural composition relevant to ablations for atrial fibrillation (AF). METHODS AND RESULTS:The LLR and its surrounding areas were studied in 40 heart specim...

journal_title：European heart journal

authors： Cabrera JA,Ho SY,Climent V,Sánchez-Quintana D

更新日期：2008-02-01 00:00:00

abstract：:Atrial fibrillation is often associated with atrial enlargement and stretch is known to cause electrophysiological alterations. Acute stretch may, depending on the moment at which it is applied, cause action potential shortening or induce both early and delayed afterdepolarizations which, when large enough, may initia...

journal_title：European heart journal

authors： Janse MJ

更新日期：1997-05-01 00:00:00

abstract：AIMS:The evidence base for fasting plasma glucose (FPG) in the non-diabetic range as a risk factor for cardiovascular disease (CVD) is inconclusive. We investigated this question in the West of Scotland Coronary Prevention Study (WOSCOPS). METHODS AND RESULTS:In WOSCOPS, we related FPG in 6447 men (mean age 55 years) ...

journal_title：European heart journal

authors： Preiss D,Welsh P,Murray HM,Shepherd J,Packard C,Macfarlane P,Cobbe S,Ford I,Sattar N

更新日期：2010-05-01 00:00:00

abstract：AIMS:Whether increased homocysteine is one mechanism linking obstructive sleep apnoea (OSA) to cardiovascular abnormalities is unclear. We hypothesised that plasma homocysteine would be higher in OSA patients than in control subjects, would increase further during sleep, and decrease after treatment with continuous pos...

journal_title：European heart journal

authors： Svatikova A,Wolk R,Magera MJ,Shamsuzzaman AS,Phillips BG,Somers VK

更新日期：2004-08-01 00:00:00

abstract：:The clinical value of QRST isointegral maps (I-maps) for the detection of myocardial infarction (MI) in the presence of left bundle branch block (LBBB) was investigated. We recorded I-maps during sinus rhythm and right ventricular (RV) pacing, which simulated LBBB, in 62 patients with MI (42 patients had at least one ...

journal_title：European heart journal

authors： Suzuki A,Hirai M,Hayashi H,Tomita Y,Ichihara Y,Adachi M,Oguchi S,Takatsu F

更新日期：1993-08-01 00:00:00

abstract：AIMS:Morphological characteristics of non-significant coronary plaques (NSCPs) that develop rapid progression have not been fully elucidated. The aim of this study was to clarify the morphological characteristics of NSCPs in patients with coronary artery disease (CAD) using intravascular optical coherence tomography (O...

journal_title：European heart journal

authors： Uemura S,Ishigami K,Soeda T,Okayama S,Sung JH,Nakagawa H,Somekawa S,Takeda Y,Kawata H,Horii M,Saito Y

更新日期：2012-01-01 00:00:00

abstract：AIMS:Adenosine stress computed tomography myocardial perfusion imaging (CTP) is an emerging non-invasive method for detecting myocardial ischaemia. Its value when compared with fractional flow reserve (FFR), a highly accurate index of ischaemia, is unknown. Our aim was to determine the diagnostic accuracy of CTP and it...

journal_title：European heart journal

authors： Ko BS,Cameron JD,Meredith IT,Leung M,Antonis PR,Nasis A,Crossett M,Hope SA,Lehman SJ,Troupis J,DeFrance T,Seneviratne SK

更新日期：2012-01-01 00:00:00

abstract：AIMS:Exposure of tissue factor (TF) is a critical proximal step in the pathogenesis of acute coronary syndromes. Sunol-cH36, a chimaeric monoclonal antibody to TF, blocks binding of factor X to the TF:VIIa complex. This report describes the first completed trial of Sunol-cH36 in humans. METHODS AND RESULTS:We assessed...

journal_title：European heart journal

authors： Morrow DA,Murphy SA,McCabe CH,Mackman N,Wong HC,Antman EM

更新日期：2005-04-01 00:00:00

abstract：:Thrombolytic therapy is a practical, effective approach to the management of acute myocardial infarction that is widely used in Europe today. Early European trials demonstrated a clear reduction in mortality in patients who received thrombolytic therapy compared with those given conventional treatment. The findings of...

journal_title：European heart journal

authors： Vahanian A

更新日期：1996-09-01 00:00:00

abstract：:Impaired relaxation of the ventricle has been described in hypertrophy and in ischemic heart disease. Some of these abnormalities are transient, but all occur at an early stage of the disease. The underlying mechanisms may vary depending on the etiology of the disease, and, except for ischemic heart disease, true myoc...

journal_title：European heart journal

authors： Brutsaert DL

更新日期：1983-01-01 00:00:00

abstract：AIMS:Early and late microvascular obstruction (MO) assessed by magnetic resonance imaging (MRI) are prognostic markers for combined clinical endpoints after ST-elevation myocardial infarction (STEMI). However, there are only limited data for hard endpoints and no consensus exists which of the two best predicts clinical...

journal_title：European heart journal

authors： de Waha S,Desch S,Eitel I,Fuernau G,Zachrau J,Leuschner A,Gutberlet M,Schuler G,Thiele H

更新日期：2010-11-01 00:00:00

abstract：AIMS:Here, we aimed to determine the therapeutic effect of longevity-associated variant (LAV)-BPIFB4 gene therapy on atherosclerosis. METHODS AND RESULTS:ApoE knockout mice (ApoE-/-) fed a high-fat diet were randomly allocated to receive LAV-BPIFB4, wild-type (WT)-BPIFB4, or empty vector via adeno-associated viral vec...

journal_title：European heart journal

authors： Puca AA,Carrizzo A,Spinelli C,Damato A,Ambrosio M,Villa F,Ferrario A,Maciag A,Fornai F,Lenzi P,Valenti V,di Nonno F,Accarino G,Madonna M,Forte M,Calì G,Baragetti A,Norata GD,Catapano AL,Cattaneo M,Izzo R,Trimarc

更新日期：2020-07-07 00:00:00

abstract：:We assessed the incremental effect of cardiac catheterization upon the management of 93 adult patients with aortic and/or mitral valve disease, referred for surgical consideration. There were 52 patients with aortic valve disease, 29 with mitral valve disease and 12 with aortic and mitral valve disease. Prior to cardi...

journal_title：European heart journal

authors： Leitch JW,Mitchell AS,Harris PJ,Fletcher PJ,Bailey BP

更新日期：1991-05-01 00:00:00