The codex of science: honesty, precision, and truth--and its violations.

Abstract:

:Science has made enormous achievements for our understanding of the world and for everyday life: we now know that we live on a spherical planet of the solar system, we understand the origin of the species, we can take a train, survive myocardial infarction, and fly to the moon. This has been made possible thanks to a persistent search for truth by great scientists and the scientific community at large. Our assumptions were often wrong, but the scientific process advanced by a productive interplay of conjectures and refutations. As in any profession, there is misconduct, i.e. sloppiness, plagiarism up to falsification, or even fabrication of data. Although eventually fraudulent science has and will be disproved, it is morally inappropriate, damages the reputation of research and journals in which its products are published, may endanger patients, and misuses grant money of federal and private institutions. Thus, as editors and readers, we should be aware of it based on its typical pattern, but we must avoid an atmosphere of distrust, as trust is the essence of scientific exchange and progress.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Lüscher TF

doi

10.1093/eurheartj/eht063

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

1018-23

issue

14

eissn

0195-668X

issn

1522-9645

pii

eht063

journal_volume

34

pub_type

历史文章,杂志文章
  • DNA testing for hypertrophic cardiomyopathy: a cost-effectiveness model.

    abstract::Aims To explore the cost-effectiveness of alternative methods of screening family members for hypertrophic cardiomyopathy (HCM), the most common monogenic cardiac disorder and the most frequent cause of sudden cardiac death (SCD) in young people. Methods and results Economic decision model comparing cascade screening ...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehq067

    authors: Wordsworth S,Leal J,Blair E,Legood R,Thomson K,Seller A,Taylor J,Watkins H

    更新日期:2010-04-01 00:00:00

  • A single dose of erythropoietin in ST-elevation myocardial infarction.

    abstract:AIMS:Cardioprotective effects of erythropoietin (EPO) have been shown in experimental and smaller clinical studies. We performed a prospective, multicentre, randomized trial to assess the effects of a single high dose of EPO after primary coronary intervention (PCI) for an ST-elevation myocardial infarction (STEMI). Me...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehq304

    authors: Voors AA,Belonje AM,Zijlstra F,Hillege HL,Anker SD,Slart RH,Tio RA,van 't Hof A,Jukema JW,Peels HO,Henriques JP,Ten Berg JM,Vos J,van Gilst WH,van Veldhuisen DJ,HEBE III Investigators.

    更新日期:2010-11-01 00:00:00

  • Sudden death from pulmonary thromboembolism: chronobiological aspects.

    abstract::The aim of this study was to determine whether sudden cardiac death from pulmonary embolism exhibits any chronobiological rhythm. Five hundred and seven consecutive subjects dying suddenly outside of hospital and brought into our Emergency Department from January 1983 to December 1989 were studied. The time and date o...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/oxfordjournals.eurheartj.a060232

    authors: Gallerani M,Manfredini R,Ricci L,Grandi E,Cappato R,Calò G,Pareschi PL,Fersini C

    更新日期:1992-05-01 00:00:00

  • Clinical course and prognosis of patients with typical and atypical hypertrophic obstructive and with hypertrophic non-obstructive cardiomyopathy.

    abstract::In a total of 339 patients with hypertrophic cardiomyopathies (typical HOCM, n = 224; atypical HOCM, n = 30; HNCM, n = 80) the clinical course, the Sokolow-Lyon index in the ECG and the prognosis as demonstrated by cumulative survival rates were analysed to get more differentiated information for the characterization ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/4.suppl_f.145

    authors: Loogen F,Kuhn H,Gietzen F,Lösse B,Schulte HD,Bircks W

    更新日期:1983-11-01 00:00:00

  • Personalising the decision for prolonged dual antiplatelet therapy: development, validation and potential impact of prognostic models for cardiovascular events and bleeding in myocardial infarction survivors.

    abstract:Aims:The aim of this study is to develop models to aid the decision to prolong dual antiplatelet therapy (DAPT) that requires balancing an individual patient's potential benefits and harms. Methods and results:Using population-based electronic health records (EHRs) (CALIBER, England, 2000-10), of patients evaluated 1 ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehw683

    authors: Pasea L,Chung SC,Pujades-Rodriguez M,Moayyeri A,Denaxas S,Fox KAA,Wallentin L,Pocock SJ,Timmis A,Banerjee A,Patel R,Hemingway H

    更新日期:2017-04-07 00:00:00

  • Non-invasive coronary angiography with high resolution multidetector-row computed tomography. Results in 102 patients.

    abstract:AIMS:A new generation of multidetector-row CT (MDCT) scanners allows complete coronary coverage using retrospective ECG gating and 1mm slices. The purpose of this study was to investigate the potential of high resolution MDCT angiography with retrospective gating for detection of coronary artery stenoses. METHODS AND ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2002.3264

    authors: Kopp AF,Schroeder S,Kuettner A,Baumbach A,Georg C,Kuzo R,Heuschmid M,Ohnesorge B,Karsch KR,Claussen CD

    更新日期:2002-11-01 00:00:00

  • Concentration of apolipoprotein B is comparable with the apolipoprotein B/apolipoprotein A-I ratio and better than routine clinical lipid measurements in predicting coronary heart disease mortality: findings from a multi-ethnic US population.

    abstract:AIMS:Prospective studies indicate that apolipoprotein measurements predict coronary heart disease (CHD) risk; however, evidence is conflicting, especially in the US. Our aim was to assess whether measurements of apolipoprotein B (apoB) and apolipoprotein A-I (apoA-I) can improve the ability to predict CHD death beyond ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehn347

    authors: Sierra-Johnson J,Fisher RM,Romero-Corral A,Somers VK,Lopez-Jimenez F,Ohrvik J,Walldius G,Hellenius ML,Hamsten A

    更新日期:2009-03-01 00:00:00

  • Renal responses to atrial natriuretic factor in patients with congestive heart failure.

    abstract::It is now recognised after many years of speculation regarding the role of mammalian atria in the direct regulation of intravascular volume, that atrial myocites produce a peptide hormone that results in natriuresis and diuresis, under the condition of atrial distention. This atrial natriuretic factor (ANF) is secrete...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/9.suppl_h.29

    authors: Cody RJ,Atlas SA,Laragh JH

    更新日期:1988-06-01 00:00:00

  • Nifedipine and alpha 1-adrenergic blockade in Raynaud's phenomenon.

    abstract::The efficacy of nifedipine and prazosin in the treatment of Raynaud's phenomenon was assessed in a prospective double-blind randomized cross-over trial in 15 patients. Each patient received one week of nifedipine 20 mg TID, one week of prazosin 1 mg TID, and 2 weeks of placebo. Nifedipine was shown to be effective in ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061923

    authors: Kahan A,Foult JM,Weber S,Amor B,Menkes CJ,Degeorges M

    更新日期:1985-08-01 00:00:00

  • Randomized trial of paclitaxel- and sirolimus-eluting stents in small coronary vessels.

    abstract:AIMS:Sirolimus- and paclitaxel-eluting stents effectively reduce restenosis in small coronary vessels. The relative efficacy of these drug-eluting stents in this high-risk subset is not known. METHODS AND RESULTS:A total of 360 patients undergoing percutaneous coronary intervention for de novo lesions in native corona...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehi721

    authors: Mehilli J,Dibra A,Kastrati A,Pache J,Dirschinger J,Schömig A,Intracoronary Drug-Eluting Stenting to Abrogate Restenosis in Small Arteries (ISAR-SMART 3) Study Investigators.

    更新日期:2006-02-01 00:00:00

  • Atorvastatin treatment improves survival and effects of implanted mesenchymal stem cells in post-infarct swine hearts.

    abstract:AIMS:To investigate whether Atorvastatin (Ator) treatment improves the cardiac micro-environment that facilitates survival and differentiation of bone-marrow-derived mesenchymal stem cells (MSCs) implanted in the post-infarct myocardium. METHODS AND RESULTS:Myocardial infarction was created by coronary ligation and im...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehn167

    authors: Yang YJ,Qian HY,Huang J,Geng YJ,Gao RL,Dou KF,Yang GS,Li JJ,Shen R,He ZX,Lu MJ,Zhao SH

    更新日期:2008-06-01 00:00:00

  • Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: 'establishing normal and reference values'.

    abstract:AIMS:Carotid-femoral pulse wave velocity (PWV), a direct measure of aortic stiffness, has become increasingly important for total cardiovascular (CV) risk estimation. Its application as a routine tool for clinical patient evaluation has been hampered by the absence of reference values. The aim of the present study is t...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehq165

    authors: Reference Values for Arterial Stiffness' Collaboration.

    更新日期:2010-10-01 00:00:00

  • Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes.

    abstract:AIMS:To examine the relations between genetic loci, plasma lipoprotein(a) [Lp(a)] levels, and cardiovascular disease (CVD) risk among diabetic patients and compare with the observations in the general population. METHODS AND RESULTS:In two prospective cohorts of patients with type 2 diabetes (n= 2308) from the Nurses'...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehr350

    authors: Qi Q,Workalemahu T,Zhang C,Hu FB,Qi L

    更新日期:2012-02-01 00:00:00

  • Acute and subacute stent occlusion; risk-reduction by ionic contrast media.

    abstract:AIMS:Current data concerning the influence of X-ray contrast media on the incidence of thrombotic complications in interventional cardiology are controversial. The effect of ionic contrast media on acute (< or =72 h) and subacute (< or =30 days) stent thrombosis has not been investigated. METHODS:Three thousand, nine ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1053/euhj.2000.2319

    authors: Scheller B,Hennen B,Pohl A,Schieffer H,Markwirth T

    更新日期:2001-03-01 00:00:00

  • Success and complication rates of coronary angioplasty in patients with and without previous myocardial infarction.

    abstract::The primary success rate and incidence of major complications have been retrospectively assessed in a consecutive series of 224 patients undergoing percutaneous transluminal coronary angioplasty (PTCA) in one centre. The patients have been divided into three groups; those with angina and no previous myocardial infarct...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:

    authors: Perry RA,Seth A,Singh A,Shiu MF

    更新日期:1988-01-01 00:00:00

  • Left ventricular thrombosis and arterial embolism after thrombolysis in acute anterior myocardial infarction: predictors and effects of adjunctive antithrombotic therapy.

    abstract::The prevalence of left ventricular (LV) thrombosis and incidence of arterial embolism after acute anterior myocardial infarction (AAMI) treated with streptokinase 1.5 x 10(6) IU intravenously was studied in 136 patients enrolled consecutively in five cardiological centres. Adjunctive antithrombotic therapy was adminis...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1093/eurheartj/14.11.1489

    authors: Kontny F,Dale J,Hegrenaes L,Lem P,Søberg T,Morstøl T

    更新日期:1993-11-01 00:00:00

  • How many patients with heart failure are eligible for cardiac resynchronization? Insights from two prospective cohorts.

    abstract:AIMS:To determine what proportion of patients with heart failure are eligible for cardiac resynchronization therapy (CRT). METHODS AND RESULTS:Eligibility criteria from the trials establishing the efficacy of CRT were applied to two prospective cohorts: the first enrolled patients with newly diagnosed heart failure di...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehi446

    authors: McAlister FA,Tu JV,Newman A,Lee DS,Kimber S,Cujec B,Armstrong PW

    更新日期:2006-02-01 00:00:00

  • Opposite central cardiovascular effects of various morphine-like drugs and opiate peptides in the rat.

    abstract::Opiate agonists were administered into the cisterna magna of normotensive urethane-anaesthetized artificially-ventilated rats. Increases in blood pressure and heart rate were produced by fentanyl (0.3-3.0 nmol). [D-ala]2-met-enkephalinamide (17 nmol), and beta-endorphin (2.9 nmol). On the contrary, ethylketocyclazocin...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/4.suppl_g.61

    authors: Laurent S,Schmitt H

    更新日期:1983-11-01 00:00:00

  • Once more unto the breach: endothelial permeability and atherogenesis.

    abstract:: ...

    journal_title:European heart journal

    pub_type: 评论,杂志文章

    doi:10.1093/eurheartj/ehz081

    authors: Libby P

    更新日期:2019-03-14 00:00:00

  • Improved monitoring of myocardial ischaemia during major vascular surgery using transoesophageal echocardiography.

    abstract::As regional wall motion abnormality (RWA) is the first sign of ischaemia, transoesophageal echocardiography was evaluated as a monitoring device in 51 patients undergoing abdominal aortic surgery. Wall motion of the entire left ventricular wall (nine segments) was semiquantitatively evaluated 15 min before and after a...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060309

    authors: Koolen JJ,Visser CA,Reichert SL,Jaarsma WJ,Kromhout JG,van Wezel HB,Dunning AJ

    更新日期:1992-08-01 00:00:00

  • Acute rise of circulating vascular endothelial growth factor-A in patients with coronary artery disease following cardiothoracic surgery.

    abstract:AIMS:Vascular endothelial growth factor-A (VEGF-A) is an angiogenic and vasoprotective molecule whose expression is modulated by hypoxia and inflammatory mediators. Here we have tested the hypothesis that plasma levels of VEGF-A are influenced by pre-existing coronary artery disease and by changes in circulating interl...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2001.3034

    authors: Cotton JM,Mathur A,Hong Y,Brown AS,Martin JF,Erusalimsky JD

    更新日期:2002-06-01 00:00:00

  • An overview of reverse cholesterol transport.

    abstract::Reverse cholesterol transport is a multi-step process resulting in the net movement of cholesterol from peripheral tissues back to the liver via the plasma compartment. Cellular cholesterol efflux is mediated by HDL, acting in conjunction with the cholesterol esterifying enzyme, lecithin: cholesterol acyltransferase. ...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:

    authors: Tall AR

    更新日期:1998-02-01 00:00:00

  • Bleeding and blood transfusion issues in patients with non-ST-segment elevation acute coronary syndromes.

    abstract::Antithrombotic therapy and invasive risk stratification in selected high-risk patients have improved outcomes from non-ST-segment elevation acute coronary syndromes (NSTE-ACS), but carry a risk of bleeding and blood transfusion. Although the true incidence of bleeding depends on the population studied (i.e. clinical t...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehm019

    authors: Rao SV,Eikelboom JA,Granger CB,Harrington RA,Califf RM,Bassand JP

    更新日期:2007-05-01 00:00:00

  • Effect of revascularizing viable myocardium on left ventricular diastolic function in patients with ischaemic cardiomyopathy.

    abstract:AIMS:In patients with ischaemic left ventricular (LV) dysfunction and viable myocardium, revascularization improves systolic function. Diastolic dysfunction is also present in such patients; however, whether revascularization improves diastolic function also is largely unknown. METHODS:Twenty-six patients with chronic...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehp125

    authors: Carluccio E,Biagioli P,Alunni G,Murrone A,Leonelli V,Pantano P,Vincenti G,Giombolini C,Ragni T,Reboldi G,Gentile F,Ambrosio G

    更新日期:2009-06-01 00:00:00

  • Electrophysiology of heterotopic heart transplant: experimental study in dogs.

    abstract::Electrophysiological properties were studied in a heterotopic heart transplant model developed in 44 dogs (Group I). Cycle length was 359.5 +/- 55.2 ms in the recipient heart and 500.9 +/- 77.9 ms in the donor heart (P less than 0.001). Sinoatrial conduction time was 38.6 +/- 13.6 ms in the recipient heart and 38.6 +/...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a059744

    authors: Alvarez L,Escudero C,Alzueta J,Silva L,Márquez-Montes J,Castillo-Olivares JL

    更新日期:1990-06-01 00:00:00

  • Inhibitory effect of acute and chronic administration of digitalis on the sick sinus node.

    abstract::We have determined the effects of the acute administration of intravenous (i.v.) digitalis administration (0.8 mg of digoxin in 5-10 min) on the electrophysiological variables of 12 normal subjects (group 1), 12 patients with asymptomatic sinus node bradycardia (group 2) and 34 patients with symptomatic sinus node dys...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062071

    authors: Bolognesi R,Benedini G,Ferrari R,Visioli O

    更新日期:1986-04-01 00:00:00

  • Sudden death in hypertrophic cardiomyopathy: old risk factors re-assessed in a new model of maximalized follow-up.

    abstract:AIMS:in hypertrophic cardiomyopathy (HCM), the following five risk factors have a major role in the primary prevention of sudden death (SD): family history of SD (FHSD), syncope, massive wall thickness (MWTh) >30 mm, non-sustained ventricular tachycardia (nsVT) in Holter monitoring of electrocardiography, and abnormal ...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehq308

    authors: Dimitrow PP,Chojnowska L,Rudzinski T,Piotrowski W,Ziólkowska L,Wojtarowicz A,Wycisk A,Dabrowska-Kugacka A,Nowalany-Kozielska E,Sobkowicz B,Wróbel W,Aleszewicz-Baranowska J,Rynkiewicz A,Loboz-Grudzien K,Marchel M,Wysokinski

    更新日期:2010-12-01 00:00:00

  • Beta-blockers in heart failure. Future directions.

    abstract::The rationale for beta-blockade in heart failure is now well established. Heart failure mortality, which is predicted by neurohormonal activation, remains high despite modern treatment including ACE inhibition, and additional neurohormonal blockade has further therapeutic potential. Previous clinical trial experience ...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/17.suppl_b.39

    authors: Sharpe N

    更新日期:1996-04-01 00:00:00

  • Intramyocardial injection of vascular endothelial growth factor-A165 plasmid followed by granulocyte-colony stimulating factor to induce angiogenesis in patients with severe chronic ischaemic heart disease.

    abstract:AIMS:To assess the safety and effects of combined treatment with vascular endothelial growth factor-A(165) plasmid (VEGF-A(165)) and granulocyte- colony stimulating factor (G-CSF) mobilization of bone marrow stem cells in patients with severe chronic ischaemic heart disease (IHD). METHODS AND RESULTS:Sixteen patients ...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehl117

    authors: Ripa RS,Wang Y,Jørgensen E,Johnsen HE,Hesse B,Kastrup J

    更新日期:2006-08-01 00:00:00

  • Exercise-related out-of-hospital cardiac arrest in the general population: incidence and prognosis.

    abstract:AIMS:Although regular physical activity has beneficial cardiovascular effects, exercise can trigger an acute cardiac event. We aimed to determine the incidence and prognosis of exercise-related out-of-hospital cardiac arrest (OHCA) in the general population. METHODS AND RESULTS:We prospectively collected all OHCAs in ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/eht401

    authors: Berdowski J,de Beus MF,Blom M,Bardai A,Bots ML,Doevendans PA,Grobbee DE,Tan HL,Tijssen JG,Koster RW,Mosterd A

    更新日期:2013-12-01 00:00:00