Right coronary artery flow impairment in patients with pulmonary hypertension.

abstract：AIMS:We describe a new strategic stepwise mapping approach for fast and accurate identification and ablation of ectopic atrial foci using an electroanatomic mapping system. METHODS AND RESULTS:Mapping procedures started with the acquisition of four points at the superior/septal part of the tricuspid annulus. According...

journal_title：European heart journal

authors： Wetzel U,Hindricks G,Schirdewahn P,Dorszewski A,Fleck A,Heinke F,Kottkamp H

更新日期：2002-09-01 00:00:00

abstract：AIMS:We investigated the prevalence of prior myocardial infarction (MI) and incidence of ischaemic cardiovascular (CV) events among atrial fibrillation (AF) patients. METHODS AND RESULTS:In ROCKET AF, 14 264 patients with nonvalvular AF were randomized to rivaroxaban or warfarin. The key efficacy outcome for these ana...

journal_title：European heart journal

authors： Mahaffey KW,Stevens SR,White HD,Nessel CC,Goodman SG,Piccini JP,Patel MR,Becker RC,Halperin JL,Hacke W,Singer DE,Hankey GJ,Califf RM,Fox KA,Breithardt G,ROCKET AF Investigators.

更新日期：2014-01-01 00:00:00

abstract：AIMS:Homozygous familial hypercholesterolaemia (HoFH) is a rare life-threatening condition characterized by markedly elevated circulating levels of low-density lipoprotein cholesterol (LDL-C) and accelerated, premature atherosclerotic cardiovascular disease (ACVD). Given recent insights into the heterogeneity of geneti...

journal_title：European heart journal

authors： Cuchel M,Bruckert E,Ginsberg HN,Raal FJ,Santos RD,Hegele RA,Kuivenhoven JA,Nordestgaard BG,Descamps OS,Steinhagen-Thiessen E,Tybjærg-Hansen A,Watts GF,Averna M,Boileau C,Borén J,Catapano AL,Defesche JC,Hovingh GK,Hump

更新日期：2014-08-21 00:00:00

abstract：AIMS:Older people increasingly constitute a large proportion of the acute coronary syndrome (ACS) population. We examined the relationship of age with receipt of more intensive management and secondary prevention medicine. Then, the comparative association of intensive management (reperfusion/angiography) over a conser...

journal_title：European heart journal

authors： Zaman MJ,Stirling S,Shepstone L,Ryding A,Flather M,Bachmann M,Myint PK

更新日期：2014-06-14 00:00:00

abstract：AIMS:Thrombin plays a key role in the clinical syndrome of unstable angina. We investigated the safety and efficacy of five dose levels of efegatran sulphate, a direct thrombin inhibitor, compared to heparin in patients with unstable angina. METHODS:Four hundred and thirty-two patients with unstable angina were enroll...

journal_title：European heart journal

authors： Klootwijk P,Lenderink T,Meij S,Boersma H,Melkert R,Umans VA,Stibbe J,Müller EJ,Poortermans KJ,Deckers JW,Simoons ML

更新日期：1999-08-01 00:00:00

abstract：AIMS:To document the impact of intensive insulin therapy during intensive care on long-term (4 years) outcome of high-risk cardiac surgery patients. METHODS AND RESULTS:In this pre-planned sub-analysis and follow-up study of a large, randomized controlled trial on the effects of intensive insulin therapy during critic...

journal_title：European heart journal

authors： Ingels C,Debaveye Y,Milants I,Buelens E,Peeraer A,Devriendt Y,Vanhoutte T,Van Damme A,Schetz M,Wouters PJ,Van den Berghe G

更新日期：2006-11-01 00:00:00

abstract：:Although the number of individuals reaching 80 who are considered to be healthy is increasing, the very elderly are likely to have long-term conditions, to report symptoms and/or be taking at least one regular medication. The impact of antihypertensive treatment has to be taken into account in this context. The treatm...

journal_title：European heart journal

authors： Peters R,Beckett N,McCormack T,Fagard R,Fletcher A,Bulpitt C

更新日期：2014-07-01 00:00:00

abstract：AIMS:Statins are essential for the reduction of risk of coronary heart disease (CHD) in familial hypercholesterolemia (FH). One of many genes influenced by statin treatment is the ATP-binding cassette transporter A1 (ABCA1) gene, which plays an important role in metabolism of high-density lipoprotein (HDL). The present...

journal_title：European heart journal

authors： Versmissen J,Oosterveer DM,Yazdanpanah M,Mulder M,Dehghan A,Defesche JC,Kastelein JJ,Sijbrands EJ

更新日期：2011-02-01 00:00:00

abstract：:This study analyses the immediate outcome and the risk of recurrent restenosis in patients who, at the time of repeat coronary angioplasty for a first restenosis, had unstable (n = 50), 19%) or stable (n = 218, 81%) angina. Successful angioplasty was accomplished in 250 (93%) patients, 222 (89%) of whom had follow-up ...

journal_title：European heart journal

authors： Bauters C,Lablanche JM,McFadden EP,Leroy F,Bertrand ME

更新日期：1993-02-01 00:00:00

abstract：AIMS:There is no cure for pulmonary arterial hypertension, but current approved treatment options include prostanoids, endothelin-receptor antagonists, and phosphodiesterase type-5 inhibitors. The effect on survival of these compounds has not been appropriately assessed in individual trials because of small sample size...

journal_title：European heart journal

authors： Galiè N,Manes A,Negro L,Palazzini M,Bacchi-Reggiani ML,Branzi A

更新日期：2009-02-01 00:00:00

abstract：:The concept of coronary vascular reserve stems from the description of coronary autoregulation by Mosher in 1964. Schematically, the coronary blood flow at rest depends on the determinants of myocardial oxygen demand (heart rate, contractility and ventricular load). If maximal coronary vasodilation is produced, it res...

journal_title：European heart journal

authors： Nitenberg A,Antony I

更新日期：1995-08-01 00:00:00

abstract：AIMS:We examined the left lateral ridge (LLR) between the orifices of the left pulmonary veins and the left atrial appendage for a better understanding of its structural composition relevant to ablations for atrial fibrillation (AF). METHODS AND RESULTS:The LLR and its surrounding areas were studied in 40 heart specim...

journal_title：European heart journal

authors： Cabrera JA,Ho SY,Climent V,Sánchez-Quintana D

更新日期：2008-02-01 00:00:00

abstract：:Valvular heart disease is a significant, global cause of morbidity and mortality. In the ageing population of industrialized nations, degenerative aortic stenosis has become the most common native valve disorder. Although surgical aortic valve replacement is associated with excellent clinical outcomes, a large number ...

journal_title：European heart journal

authors： Schoenhagen P,Tuzcu EM,Kapadia SR,Desai MY,Svensson LG

更新日期：2009-09-01 00:00:00

abstract：AIMS:To investigate whether Atorvastatin (Ator) treatment improves the cardiac micro-environment that facilitates survival and differentiation of bone-marrow-derived mesenchymal stem cells (MSCs) implanted in the post-infarct myocardium. METHODS AND RESULTS:Myocardial infarction was created by coronary ligation and im...

journal_title：European heart journal

authors： Yang YJ,Qian HY,Huang J,Geng YJ,Gao RL,Dou KF,Yang GS,Li JJ,Shen R,He ZX,Lu MJ,Zhao SH

更新日期：2008-06-01 00:00:00

abstract：:The scientific assessment of diagnostic tests should not be based upon a small series of results published by the best academic institutions, but ought to require large scale, multicentre validation founded on grass roots institutions with real doctors, real patients and real problems. To this purpose, an internationa...

journal_title：European heart journal

authors： Picano E,Sicari R,Landi P,Raciti M,Pingitore A,Vassalle C,Mathias W Jr,Lowenstein J,Petix N,Gigli G

更新日期：1995-10-01 00:00:00

abstract：:The prognostic significance of angina pectoris and the effect of intervention with verapamil on the incidence of angina pectoris were studied in patients recovering from myocardial infarction and included in the Danish Verapamil Infarction Trial II. During the second week after admission patients were doubly-blindly r...

journal_title：European heart journal

authors： Jespersen CM,Hansen JF,Mortensen LS

更新日期：1994-02-01 00:00:00

abstract：:The alterations of the beta-adrenoceptor adenylyl cyclase are reviewed. In failing myocardium, the down-regulation of beta 1-adrenoceptors is accompanied by a decrease in steady state mRNA levels, as studied with quantitative polymerase chain reactions in dilated and ischaemic cardiomyopathy. The density of beta 2-adr...

journal_title：European heart journal

authors： Böhm M,Lohse MJ

更新日期：1994-12-01 00:00:00

abstract：:Thrombolytic treatment efficacy is greater when the delay between onset of pain and treatment is short. One way to shorten this delay is to give treatment at home, but one cannot recommend this technique if it has not been demonstrated first, that pre-hospital thrombolysis is feasible and safe, and second, that it is ...

journal_title：European heart journal

authors： Castaigne AD,Hervé C,Duval-Moulin AM,Gaillard M,Dubois-Randé JL,Lellouche D

更新日期：1990-08-01 00:00:00

abstract：AIMS:There is little evidence to inform routine practice in the use of coronary angiography and revascularization procedures after acute myocardial infarction. Large differences in the uptake of these procedures have been reported but representative data are scarce. Outcome studies have produced opposing conclusions co...

journal_title：European heart journal

authors： Woods KL,Ketley D,Agusti A,Hagn C,Kala R,Karatzas NB,Leizorowicz A,Reikvam A,Schilling J,Seabra-Gomes R,Vasiliauskas D,Wilhelmsen L

更新日期：1998-09-01 00:00:00

abstract：AIMS:Periconceptional folate supplementation prevents neural tube defects and possibly congenital heart defects (CHD) as well. The search for candidate genes involved in the folate metabolism includes the methylenetetrahydrofolate reductase (MTHFR) 677C > T polymorphism. We studied the association between MTHFR 677C > ...

journal_title：European heart journal

authors： van Beynum IM,Kapusta L,den Heijer M,Vermeulen SH,Kouwenberg M,Daniëls O,Blom HJ

更新日期：2006-04-01 00:00:00

abstract：:The effects of a single oral dose of nisoldipine, 10 mg, were investigated in two groups of patients. Firstly, the effects of nisoldipine on exercise left ventricular function were assessed in 20 patients with chronic stable angina and coronary disease. Secondly, the effects of nisoldipine on the left ventricular resp...

journal_title：European heart journal

authors： Dymond DS,Caplin JL,O'Keefe JC,Banim S

更新日期：1987-11-01 00:00:00

abstract：:Sudden cardiac death (SCD) accounts for approximately one-third of all deaths among patients with non-ischaemic cardiomyopathy (NICM). Implantable cardioverter-defibrillator (ICD) therapy has been the primary intervention for managing individuals at high risk for SCD. However, individual ICD trials in the NICM populat...

journal_title：European heart journal

authors： Pathak RK,Sanders P,Deo R

更新日期：2018-08-14 00:00:00

abstract：:One case of unruptured sinus of Valsalva aneurysm causing left coronary artery compression and lethal myocardial infarction in a 39-year old woman is described. In reviewing the literature, 15 previously published cases of sinus of Valsalva aneurysms disturbing coronary flow were found. It is concluded that the mechan...

journal_title：European heart journal

authors： Brandt J,Jögi P,Lührs C

更新日期：1985-12-01 00:00:00

abstract：AIMS:Collagen degradation in atherosclerotic plaques with thin fibrous caps renders them more prone to rupture. Fibroblast activation protein (FAP) plays a role in arthritis and tumour formation through its collagenase activity. However, the significance of FAP in thin-cap human fibroatheromata remains unknown. METHOD...

journal_title：European heart journal

authors： Brokopp CE,Schoenauer R,Richards P,Bauer S,Lohmann C,Emmert MY,Weber B,Winnik S,Aikawa E,Graves K,Genoni M,Vogt P,Lüscher TF,Renner C,Hoerstrup SP,Matter CM

更新日期：2011-11-01 00:00:00

abstract：AIMS:The management and outcomes of patients with functional moderate/severe mitral regurgitation and severe left ventricular (LV) systolic dysfunction are not well defined. We sought to determine the characteristics, management strategies, and outcomes of patients with moderate or severe mitral regurgitation (MR) and ...

journal_title：European heart journal

authors： Samad Z,Shaw LK,Phelan M,Ersboll M,Risum N,Al-Khalidi HR,Glower DD,Milano CA,Alexander JH,O'Connor CM,Wang A,Velazquez EJ

更新日期：2015-10-21 00:00:00

abstract：:The effects of fentanyl at a dose of 100 micrograms.kg-1 on cardiac automaticity, refractoriness and conduction have been studied in a model of heterotopic heart transplantation which combines a denervated heart (donor) and a non-denervated heart (recipient) in each of 20 dogs employed. Once the surgical procedure had...

journal_title：European heart journal

authors： Alvarez L,Escudero C,Carmona JA,Silva L,Castillo-Olivares JL

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:In the acute phase of myocardial infarction (acute MI) marked endothelial damage occurs within the first 24h following thrombolysis with streptokinase. We investigated whether this is associated with a change in levels of vascular endothelial growth factor (VEGF, possibly marking angiogenesis) in the first 2...

journal_title：European heart journal

authors： Chung NA,Lydakis C,Belgore F,Blann AD,Lip GY

更新日期：2002-10-01 00:00:00

abstract：Aim:Hypertrophic cardiomyopathy (HCM) exhibits genetic heterogeneity that is dominated by variation in eight sarcomeric genes. Genetic variation in a large number of non-sarcomeric genes has also been implicated in HCM but not formally assessed. Here we used very large case and control cohorts to determine the extent t...

journal_title：European heart journal

authors： Walsh R,Buchan R,Wilk A,John S,Felkin LE,Thomson KL,Chiaw TH,Loong CCW,Pua CJ,Raphael C,Prasad S,Barton PJ,Funke B,Watkins H,Ware JS,Cook SA

更新日期：2017-12-07 00:00:00

abstract：AIMS:Although regular physical activity has beneficial cardiovascular effects, exercise can trigger an acute cardiac event. We aimed to determine the incidence and prognosis of exercise-related out-of-hospital cardiac arrest (OHCA) in the general population. METHODS AND RESULTS:We prospectively collected all OHCAs in ...

journal_title：European heart journal

authors： Berdowski J,de Beus MF,Blom M,Bardai A,Bots ML,Doevendans PA,Grobbee DE,Tan HL,Tijssen JG,Koster RW,Mosterd A

更新日期：2013-12-01 00:00:00

abstract：Aims:To determine tolerability and the optimal dose regimen of the soluble guanylate cyclase stimulator vericiguat in patients with chronic heart failure and preserved ejection fraction (HFpEF). Methods and results:SOCRATES-PRESERVED was a prospective, randomized, placebo-controlled double-blind, Phase 2b dose-finding...

journal_title：European heart journal

authors： Pieske B,Maggioni AP,Lam CSP,Pieske-Kraigher E,Filippatos G,Butler J,Ponikowski P,Shah SJ,Solomon SD,Scalise AV,Mueller K,Roessig L,Gheorghiade M

更新日期：2017-04-14 00:00:00