The association between older age and receipt of care and outcomes in patients with acute coronary syndromes: a cohort study of the Myocardial Ischaemia National Audit Project (MINAP).

Abstract:

AIMS:Older people increasingly constitute a large proportion of the acute coronary syndrome (ACS) population. We examined the relationship of age with receipt of more intensive management and secondary prevention medicine. Then, the comparative association of intensive management (reperfusion/angiography) over a conservative strategy on time to death was investigated by age. METHODS AND RESULTS:Using data from 155 818 patients in the national registry for ACS in England and Wales [the Myocardial Ischaemia National Audit Project (MINAP)], we found that older patients were incrementally less likely to receive secondary prevention medicines and intensive management for both ST-elevation myocardial infarction (STEMI) and non-ST elevation myocardial infarction (NSTEMI). In STEMI patients ≥85 years, 55% received reperfusion compared with 84% in those aged 18 to <65 [odds ratio 0.22 (95% CI 0.21, 0.24)]. Not receiving intensive management was associated with worse survival [mean follow-up 2.29 years (SD 1.42)] in all age groups (adjusted for sex, cardiovascular risk factors, co-morbidities, healthcare factors, and case severity), but there was an incremental reduction in survival benefit from intensive management with increasing age. In STEMI patients aged 18-64, 65-74, 75-84, and ≥85, adjusted hazard ratios (HRs) for all-cause mortality comparing conservative treatment to intensive management were 1.98 (1.78, 2.19), 1.65 (1.51, 1.80), 1.62 (1.52, 1.72), and 1.36 (1.27, 1.47), respectively. In NSTEMI patients, the respective HRs were 4.37 (4.00, 4.78), 3.76 (3.54, 3.99), 2.79 (2.67, 2.91), and 1.90 (1.77, 2.04). CONCLUSION:We found an incremental reduction in the use of evidence-based therapies with increasing age using a national ACS registry cohort. While survival benefit from more intensive management reduced with older age, better survival was associated with intensive management at all ages highlighting the requirement to improve standard of care in older patients with ACS.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Zaman MJ,Stirling S,Shepstone L,Ryding A,Flather M,Bachmann M,Myint PK

doi

10.1093/eurheartj/ehu039

subject

Has Abstract

pub_date

2014-06-14 00:00:00

pages

1551-8

issue

23

eissn

0195-668X

issn

1522-9645

pii

ehu039

journal_volume

35

pub_type

杂志文章
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    doi:

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    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehr422

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    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

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    authors: Briguori C,Tobis J,Nishida T,Vaghetti M,Albiero R,Di Mario C,Colombo A

    更新日期:2002-02-01 00:00:00

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    更新日期:1994-03-01 00:00:00

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    pub_type: 杂志文章,多中心研究

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    pub_type: 共识发展会议,杂志文章,评审

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    pub_type: 杂志文章

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    更新日期:1993-02-01 00:00:00

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    pub_type: 杂志文章

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    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    更新日期:1995-11-01 00:00:00

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    doi:10.1093/oxfordjournals.eurheartj.a061811

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    doi:10.1093/eurheartj/ehp260

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    更新日期:2009-09-01 00:00:00

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    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/11.suppl_c.30

    authors: Pouleur H

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    journal_title:European heart journal

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    doi:10.1093/oxfordjournals.eurheartj.a060632

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    更新日期:1994-08-01 00:00:00