Treating hypertension in the very elderly-benefits, risks, and future directions, a focus on the hypertension in the very elderly trial.

abstract：AIMS:Short-QT syndrome 1 (SQT1) is an inherited channelopathy with accelerated repolarization due to gain-of-function in HERG/IKr. Patients develop atrial fibrillation, ventricular tachycardia (VT), and sudden cardiac death with pronounced inter-individual variability in phenotype. We generated and characterized transg...

journal_title：European heart journal

authors： Odening KE,Bodi I,Franke G,Rieke R,Ryan de Medeiros A,Perez-Feliz S,Fürniss H,Mettke L,Michaelides K,Lang CN,Steinfurt J,Pantulu ND,Ziupa D,Menza M,Zehender M,Bugger H,Peyronnet R,Behrends JC,Doleschall Z,Zur Hausen

更新日期：2019-03-07 00:00:00

abstract：AIMS:Efficacy of aspirin in primary prevention of cardiovascular disease (CVD) may be influenced by a common allele in guanylate cyclase GUCY1A3, which has been shown to modify platelet function and increase CVD risk. METHODS AND RESULTS:We investigated whether homozygotes of the GUCY1A3 rs7692387 risk (G) allele bene...

journal_title：European heart journal

authors： Hall KT,Kessler T,Buring JE,Passow D,Sesso HD,Zee RYL,Ridker PM,Chasman DI,Schunkert H

更新日期：2019-11-01 00:00:00

abstract：AIMS:The impact on mortality outcomes of beta-blockers and calcium blockers in post-myocardial infarction (MI) has been suggested to be related to resting heart rate (HR) reduction. A meta-regression of randomized clinical trials was carried out to assess this relationship using weighted meta-regression of logarithm of...

journal_title：European heart journal

authors： Cucherat M

更新日期：2007-12-01 00:00:00

abstract：AIMS:The study aimed to compare the addition of felodipine to metoprolol, and of the replacement of metoprolol by felodipine, with continuation of metoprolol, in patients with angina pectoris despite optimal beta-blockade. METHODS AND RESULTS:The study was double-blind, parallel, randomized and controlled, and compris...

journal_title：European heart journal

authors： Dunselman P,Liem AH,Verdel G,Kragten H,Bosma A,Bernink P

更新日期：1997-11-01 00:00:00

abstract：:In a prospective serial study of 96 patients with acute myocardial infarction, two dimensional echocardiography identified left ventricular thrombus in 18 patients. The majority of thrombi (15) developed within the first 4 days after admission. In three patients thrombi were identified for the first time 4 months afte...

journal_title：European heart journal

authors： Visser CA,Kan G,Lie KI,Durrer D

更新日期：1983-05-01 00:00:00

abstract：AIMS:This study assessed the relationship between inflammatory mediators and indices of infarct size and left-ventricular (LV) remodelling following successful primary percutaneous coronary intervention (PCI) in patients with first time ST elevation myocardial infarction (MI). METHODS AND RESULTS:Forty-two patients ad...

journal_title：European heart journal

authors： Ørn S,Manhenke C,Ueland T,Damås JK,Mollnes TE,Edvardsen T,Aukrust P,Dickstein K

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Recent identification of mutations in the beta-myosin heavy chain gene (MYH7), a major responsible gene for HCM, has provided the opportunity to characterize genotype-phenotype correlation in HCM families. In this study we analysed the phenotypic expression of two beta-myosin heavy chain (beta MHC) mutations...

journal_title：European heart journal

authors： Marian AJ,Mares A Jr,Kelly DP,Yu QT,Abchee AB,Hill R,Roberts R

更新日期：1995-03-01 00:00:00

abstract：AIMS:Our objective was to create a simple prognostic risk score for patients with systolic heart failure and mild symptoms. We then assessed the efficacy of eplerenone across different categories of risk. METHODS AND RESULTS:The Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure trial (EMP...

journal_title：European heart journal

authors： Collier TJ,Pocock SJ,McMurray JJ,Zannad F,Krum H,van Veldhuisen DJ,Swedberg K,Shi H,Vincent J,Pitt B

更新日期：2013-09-01 00:00:00

abstract：AIMS:To evaluate the effectiveness and safety of bivalirudin as used in routine care. Bivalirudin has been studied as an alternative to heparin plus glycoprotein IIb/IIIa inhibitor (GPI) during percutaneous coronary intervention (PCI). Trials have indicated that bivalirudin is non-inferior to heparin with respect to de...

journal_title：European heart journal

authors： Rassen JA,Mittleman MA,Glynn RJ,Alan Brookhart M,Schneeweiss S

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Maximal hyperaemia is paramount in the diagnosis of patients with coronary artery disease. However in these patients, enhanced alpha-adrenergic microvascular vasoconstriction may preclude adenosine to induce maximal hyperaemia. AIM:To assess the presence and the clinical relevance of residual microvascular ...

journal_title：European heart journal

authors： Barbato E,Bartunek J,Aarnoudse W,Vanderheyden M,Staelens F,Wijns W,Heyndrickx GR,Pijls NH,De Bruyne B

更新日期：2004-11-01 00:00:00

abstract：:The duration of the reduction of mortality after coronary artery bypass grafting (CABG) is an important issue and this study was undertaken to evaluate time in relation to excess mortality among CABG patients compared with the general population. Survival was analysed in 4661 patients who had undergone their first iso...

journal_title：European heart journal

authors： Ståhle E,Bergström R,Holmberg L,Edlund B,Nyström SO,Sjögren I,Hansson HE

更新日期：1994-09-01 00:00:00

abstract：AIMS:To investigate whether the benefit of thrombolytic therapy was sustained beyond the first decade. We report the 10-14 year outcome of 533 patients who were randomized to treatment with intracoronary streptokinase or to conventional therapy during the years 1980-1985. METHODS AND RESULTS:Details of survival and ca...

journal_title：European heart journal

authors： Maas AC,van Domburg RT,Deckers JW,Vermeer F,Remme WJ,Kamp O,Manger Cats V,Simoons ML

更新日期：1999-06-01 00:00:00

abstract：AIMS:The role of aspirin in the primary prevention setting is continuously evolving. Recent randomized trials have challenged the role of aspirin in the primary prevention setting. METHODS AND RESULTS:Electronic databases were searched for randomized trials that compared aspirin vs. placebo (or control) in subjects wi...

journal_title：European heart journal

authors： Mahmoud AN,Gad MM,Elgendy AY,Elgendy IY,Bavry AA

更新日期：2019-02-14 00:00:00

abstract：Aims:To analyse reasons, timing and predictors of hospital readmissions after transcatheter aortic valve implantation (TAVI). Methods and results:Patients included in the Bern TAVI Registry between August 2007 and June 2014 were analysed. Fine and Gray competing risk regression was used to identify factors predictive ...

journal_title：European heart journal

authors： Franzone A,Pilgrim T,Arnold N,Heg D,Langhammer B,Piccolo R,Roost E,Praz F,Räber L,Valgimigli M,Wenaweser P,Jüni P,Carrel T,Windecker S,Stortecky S

更新日期：2017-07-21 00:00:00

abstract：:The reperfusion era has dramatically and irrevocably transformed the management of ST-segment elevation myocardial infarction (STEMI). For the patient treated with fibrinolysis as the initial reperfusion strategy, subsequent options which are the subject of some controversy and the focus of this review are (i) facilit...

journal_title：European heart journal

authors： Kiernan TJ,Ting HH,Gersh BJ

更新日期：2007-07-01 00:00:00

abstract：:Atrial fibrillation is a frequent cause of stroke; in the elderly, more than 20% of strokes are attributed to this common arrhythmia. Anticoagulation with warfarin reduces the risk of stroke by ∼60%; however, a large proportion of patients with atrial fibrillation do not receive this treatment because of relative/abso...

journal_title：European heart journal

authors： Landmesser U,Holmes DR Jr

更新日期：2012-03-01 00:00:00

abstract：Aims:We have shown that extracellular vesicles (EVs) secreted by embryonic stem cell-derived cardiovascular progenitor cells (Pg) recapitulate the therapeutic effects of their parent cells in a mouse model of chronic heart failure (CHF). Our objectives are to investigate whether EV released by more readily available ce...

journal_title：European heart journal

authors： El Harane N,Kervadec A,Bellamy V,Pidial L,Neametalla HJ,Perier MC,Lima Correa B,Thiébault L,Cagnard N,Duché A,Brunaud C,Lemitre M,Gauthier J,Bourdillon AT,Renault MP,Hovhannisyan Y,Paiva S,Colas AR,Agbulut O,Hagège

更新日期：2018-05-21 00:00:00

abstract：:Recent innovations have the potential to improve rhythm control therapy in patients with atrial fibrillation (AF). Controlled trials provide new evidence on the effectiveness and safety of rhythm control therapy, particularly in patients with AF and heart failure. This review summarizes evidence supporting the use of ...

journal_title：European heart journal

authors： Willems S,Meyer C,de Bono J,Brandes A,Eckardt L,Elvan A,van Gelder I,Goette A,Gulizia M,Haegeli L,Heidbuchel H,Haeusler KG,Kautzner J,Mont L,Ng GA,Szumowski L,Themistoclakis S,Wegscheider K,Kirchhof P

更新日期：2019-12-07 00:00:00

abstract：AIMS:Major guidelines recommend lowering systolic blood pressure (SBP) to <140 mmHg in all hypertensives, but evidence is missing whether this is beneficial in (i) uncomplicated hypertensives, (ii) grade 1 hypertensives, and (iii) elderly hypertensives. Providing this missing evidence is important to justify efforts an...

journal_title：European heart journal

authors： Zhang Y,Zhang X,Liu L,Zanchetti A,FEVER Study Group.

更新日期：2011-06-01 00:00:00

abstract：:The Belgian Heart Disease Prevention Project was a controlled, randomized multifactorial intervention trial in middle-aged men which lasted 6 years. Significant net differences between intervention and control groups were observed in change in risk profile, in total mortality and in CHD incidence. The net difference i...

journal_title：European heart journal

authors： De Backer G,Kornitzer M,Dramaix M,Kittel F,Thilly C,Graffar M,Vuylsteek K

更新日期：1988-03-01 00:00:00

abstract：:Chronic increases in haemodynamic load modify the expression of cardiac genes, leading to a new phenotype better adapted to the new functional demand. Several mechanisms such as the global activation of genes, the modulation of single genes and/or differential expression of multigene families may account for these mod...

journal_title：European heart journal

authors： Samuel JL,Dubus I,Contard F,Schwartz K,Rappaport L

更新日期：1990-11-01 00:00:00

abstract：:ST segment monitoring by Holter ECG was conducted in 80 consecutive patients 2-4 weeks before aortocoronary bypass surgery and three weeks and six months after surgery. Preoperatively, all patients were under maximal medical therapy. In 31 out of 80 patients medical therapy could be stopped and thus 24-h ST monitoring...

journal_title：European heart journal

authors： Droste C,Lemmen S,Nitsche R,Betz P,Birnbaum D,Roskamm H

更新日期：1988-12-01 00:00:00

abstract：:The effects of oral sotalol were compared with the findings obtained in the baseline study of a group of 26 consecutive patients with sustained monomorphic ventricular tachycardia or ventricular fibrillation and inducible ventricular tachycardia. The mean age was 62 years and the mean ejection fraction 33%. The number...

journal_title：European heart journal

authors： Jordaens LJ,Palmer A,Clement DL

更新日期：1989-03-01 00:00:00

abstract：:There is lack of consistent correlation between left ventricular function at rest, haemodynamic measurements at rest, symptomatic status and exercise tolerance. Haemodynamic data appear comparable in patients whose exercise tolerance is limited clinically by fatigue and by breathlessness. Selected patients with left v...

journal_title：European heart journal

authors： Wenger NK

更新日期：1988-04-01 00:00:00

abstract：AIMS:To determine the prevalence, incidence rate, lifetime risk and prognosis of heart failure. METHODS AND RESULTS:The Rotterdam Study is a prospective population-based cohort study in 7983 participants aged > or =55. Heart failure was defined according to criteria of the European Society of Cardiology. Prevalence wa...

journal_title：European heart journal

authors： Bleumink GS,Knetsch AM,Sturkenboom MC,Straus SM,Hofman A,Deckers JW,Witteman JC,Stricker BH

更新日期：2004-09-01 00:00:00

abstract：Aims:Despite the well-defined association of high-sensitivity hsCRP with cardiovascular outcomes in apparently healthy adults and those with acquired heart disease, the relevance of this inflammatory marker in adults with congenital heart disease (ACHD) remains unclear. We aimed to examine the clinical correlates and p...

journal_title：European heart journal

authors： Opotowsky AR,Valente AM,Alshawabkeh L,Cheng S,Bradley A,Rimm EB,Landzberg MJ

更新日期：2018-09-07 00:00:00

abstract：:The effects of the calcium antagonist, diltiazem (D), on left ventricular (LV) response to postextrasystolic potentiation (PESP) were investigated in 15 coronary artery disease patients. Several haemodynamic and LV function parameters, as well as regional wall kinetics, were analysed. During LV angiography, which was ...

journal_title：European heart journal

authors： Di Donato M,Maioli M,Marchionni N,Barletta GA,Fantini F

更新日期：1990-07-01 00:00:00

abstract：AIMS:Release of progenitor cells is observed during inflammatory conditions and contributes to neovascularization. We, therefore, sought to investigate the relationship of circulating progenitor cells and interleukin (IL)-8 in acute myocardial infarction (AMI). METHODS AND RESULTS:From patients with stable angina and ...

journal_title：European heart journal

authors： Schömig K,Busch G,Steppich B,Sepp D,Kaufmann J,Stein A,Schömig A,Ott I

更新日期：2006-05-01 00:00:00

abstract：:A time-domain signal-averaged ECG was performed in 52 patients with arrhythmogenic right ventricular dysplasia (ARVD) proven by angiography, in 45 control subjects with normal hearts, and in 132 patients with various types of ventricular arrhythmias and no evidence of cardiac disease during routine cardiac examination...

journal_title：European heart journal

authors： Leclercq JF,Coumel P

更新日期：1993-09-01 00:00:00

abstract：:The long-term efficacy of transdermal nitrate therapy, in particular the ability of a single patch to provide 24 h prophylaxis against angina, has been questioned. Two mechanisms have been suggested for this loss of effect: the development of pharmacological tolerance, and premature patch exhaustion. This study was de...

journal_title：European heart journal

authors： James MA,Papouchado M,Jones JV

更新日期：1991-12-01 00:00:00