Is a systolic blood pressure target


AIMS:Major guidelines recommend lowering systolic blood pressure (SBP) to <140 mmHg in all hypertensives, but evidence is missing whether this is beneficial in (i) uncomplicated hypertensives, (ii) grade 1 hypertensives, and (iii) elderly hypertensives. Providing this missing evidence is important to justify efforts and costs of aggressive therapy in all hypertensives. METHODS AND RESULTS:Felodipine Event Reduction (FEVER) was a double-blind, randomized trial on 9711 Chinese hypertensives, in whom cardiovascular outcomes were significantly reduced by more intense therapy (low-dose hydrochlorothiazide and low-dose felodipine) achieving a mean of 138 mmHg SBP compared with less-intense therapy (low-dose hydrochlorothiazide and placebo) achieving a mean of 142 mmHg. FEVER included older and younger patients, and patients with and without diabetes or cardiovascular disease. In the analyses here reported, Cox regression models assessed outcome differences between more and less-intense treatments in groups of patients with different baseline characteristics. Significant reductions in stroke were found in uncomplicated hypertensives (-39%, P = 0.002), in hypertensives with randomization SBP <153 mmHg (-29%, P = 0.03), and in elderly hypertensives (-44%, P < 0.001), when their SBP was lowered by more intense treatment. Significant reductions (between -29 and -47%, P = 0.02 to <0.001) were also found in all cardiovascular events and all deaths. Achieving mean SBP values <140 mmHg by adding a small dose of a generic drug prevented 2.1 (uncomplicated hypertensives) and 5.2 (elderly) cardiovascular events every 100 patients treated for 3.3 years. CONCLUSIONS:These analyses provide strong support, missing so far, to guidelines recommending goal SBP <140 mmHg in uncomplicated hypertensives, individuals with moderately elevated BP and elderly hypertensives.


Eur Heart J


European heart journal


Zhang Y,Zhang X,Liu L,Zanchetti A,FEVER Study Group.




Has Abstract


2011-06-01 00:00:00














  • Combination reperfusion therapy with abciximab and reduced dose reteplase: results from TIMI 14. The Thrombolysis in Myocardial Infarction (TIMI) 14 Investigators.

    abstract::Aims Abciximab has previously been shown to enhance thrombolysis and improve myocardial perfusion when combined with reduced doses of alteplase. The purpose of the reteplase phase of TIMI 14 was to evaluate the effects of abciximab when used in combination with a reduced dose of reteplase for ST-elevation myocardial i...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Antman EM,Gibson CM,de Lemos JA,Giugliano RP,McCabe CH,Coussement P,Menown I,Nienaber CA,Rehders TC,Frey MJ,Van der Wieken R,Andresen D,Scherer J,Anderson K,Van de Werf F,Braunwald E

    更新日期:2000-12-01 00:00:00

  • Treatment and outcomes of patients with evolving myocardial infarction: experiences from the SYNERGY trial.

    abstract:AIMS:Patients with myocardial infarction (MI) presenting immediately after symptom onset may be treated less aggressively due to their non-elevated troponin status. We compared the initial treatment and clinical outcomes of patients presenting with evolving MI (EMI) with those presenting with MI. METHODS AND RESULTS:T...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Miller CD,Banerjee A,Mahaffey KW,Kontos MC,Fermann G,Pollack CV Jr,Antman E,Aylward P,Goodman SG,Santos R,Ferguson JJ,Califf RM,Hoekstra JW

    更新日期:2007-05-01 00:00:00

  • Clonal haematopoiesis in patients with degenerative aortic valve stenosis undergoing transcatheter aortic valve implantation.

    abstract:AIMS:Clonal haematopoiesis of indeterminate potential (CHIP), defined as the presence of an expanded somatic blood cell clone without other haematological abnormalities, was recently shown to increase with age and is associated with coronary artery disease and calcification. The most commonly mutated CHIP genes, DNMT3A...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Mas-Peiro S,Hoffmann J,Fichtlscherer S,Dorsheimer L,Rieger MA,Dimmeler S,Vasa-Nicotera M,Zeiher AM

    更新日期:2020-02-21 00:00:00

  • Two types of left ventricular wall motion abnormalities with distinct clinical features in patients with hypertrophic cardiomyopathy.

    abstract::During the long-term follow-up of patients with hypertrophic cardiomyopathy (HCM), some patients develop left ventricular (LV) wall motion abnormalities in the absence of fixed coronary artery disease. The purpose of this study is to clarify which clinical features in patients with HCM seem to influence gradual develo...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Ishiwata S,Nishiyama S,Nakanishi S,Seki A

    更新日期:1993-12-01 00:00:00

  • Haemodynamic effects of enalaprilat and preload in acute severe heart failure complicating myocardial infarction.

    abstract::In this study, the acute haemodynamic effects of angiotensin converting enzyme (ACE) inhibition with intravenous enalaprilat alone or in combination with preload restoration were determined in patients with severe heart failure complicating acute myocardial infarction. Ten patients with raised pulmonary arterial wedge...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Tohmo H,Karanko M,Korpilahti K

    更新日期:1994-04-01 00:00:00

  • Angiographic assessment of human coronary artery endothelial function by measurement of endothelium-dependent vasodilation.

    abstract::In isolated atherosclerotic human coronary arteries endothelium-dependent vascular relaxation is abolished with acetylcholine whereas another EDRF-dependent vasodilator, substance P, still produces significant relaxation. To study further these in vitro findings, graded doses of acetylcholine and substance P, which pr...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Bossaller C,Hehlert-Friedrich C,Jost S,Rafflenbeul W,Lichtlen P

    更新日期:1989-11-01 00:00:00

  • Congenital valvular aortic stenosis in adults.

    abstract::Based on a study of 20 patients operated on between the ages of 21 and 38 for congenital valvular aortic stenosis, the distinguishing features of congenital aortic valvular stenosis in adults are reviewed: valvular calcification (75%), valvular dome rarely present (10%), usually moderate cardiac disability (70%), dimi...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Guerin F,Richaud M,Duboc D,Toussaint M,Leurent B,Corone P,Vernant P,Spaulding C

    更新日期:1988-04-01 00:00:00

  • Strategies to attenuate micro-vascular obstruction during P-PCI: the randomized reperfusion facilitated by local adjunctive therapy in ST-elevation myocardial infarction trial.

    abstract:BACKGROUND:Microvascular obstruction (MVO) following primary percutaneous coronary intervention (PPCI) treatment of ST-segment elevation myocardial infarction (STEMI) contributes to infarct expansion, left ventricular (LV) remodelling, and worse clinical outcomes. The REFLO-STEMI trial tested whether intra-coronary (IC...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验


    authors: Nazir SA,McCann GP,Greenwood JP,Kunadian V,Khan JN,Mahmoud IZ,Blackman DJ,Been M,Abrams KR,Shipley L,Wilcox R,Adgey AA,Gershlick AH

    更新日期:2016-06-21 00:00:00

  • Role of blood pressure response to provocative tests in the prediction of hypertension in adolescents.

    abstract::To assess the value of exercise stress testing and of mental stress as predictors of hypertension, we studied 130 normotensive males 14-18 years of age. Sixty-five had at least one hypertensive parent (SHT), while 65 had normotensive parents (SNT). Systolic (SBP) and diastolic (DBP) blood pressure, rate-pressure produ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Radice M,Alli C,Avanzini F,Di Tullio M,Mariotti G,Taioli E,Zussino A,Folli G

    更新日期:1985-06-01 00:00:00

  • The neurohormonal basis of pulmonary hypertension in heart failure with preserved ejection fraction.

    abstract:AIMS:Pulmonary hypertension (PH) represents an important phenotype among the broader spectrum of patients with heart failure with preserved ejection fraction (HFpEF), but its mechanistic basis remains unclear. We hypothesized that activation of endothelin and adrenomedullin, two counterregulatory pathways important in ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章


    authors: Obokata M,Kane GC,Reddy YNV,Melenovsky V,Olson TP,Jarolim P,Borlaug BA

    更新日期:2019-12-01 00:00:00

  • One-year clinical outcomes of protected and unprotected left main coronary artery stenting.

    abstract:AIMS:To evaluate outcomes for left main coronary artery (LMCA) stenting and compare results between protected (left coronary grafted) and unprotected LMCA stenting in the current bare-metal stent era. METHODS:We reviewed outcomes among 142 consecutive patients who underwent protected or unprotected LMCA stenting since...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Kelley MP,Klugherz BD,Hashemi SM,Meneveau NF,Johnston JM,Matthai WH Jr,Banka VS,Herrmann HC,Hirshfeld JW Jr,Kimmel SE,Kolansky DM,Horwitz PA,Schiele F,Bassand JP,Wilensky RL

    更新日期:2003-09-01 00:00:00

  • Why did persons invited to train in cardiopulmonary resuscitation not do so?

    abstract::All citizens (N = 22066) aged 16 to 65 of a medium-sized Belgian town were personally invited to CPR training sessions held in their neighbourhood. 1152 responded by attending a training session. Those who did not so respond were surveyed (random sample N = 600) for reasons of their not coming. The sample fitted well ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Lejeune PO,Delooz HH

    更新日期:1987-03-01 00:00:00

  • In-hospital mortality of habitual cigarette smokers after acute myocardial infarction; the "smoker's paradox" in a countrywide study.

    abstract:AIMS:Habitual cigarette smokers, paradoxically, present improved short-term prognosis after acute myocardial infarction, a phenomenon often termed "smoker's paradox". We sought to examine cigarette smokers' post-infarction survival advantage in a countrywide survey of unselected, consecutive patients presenting with ac...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Andrikopoulos GK,Richter DJ,Dilaveris PE,Pipilis A,Zaharoulis A,Gialafos JE,Toutouzas PK,Chimonas ET

    更新日期:2001-05-01 00:00:00

  • Effect of fentanyl on cardiac automaticity and conduction: direct or mediated action?

    abstract::The effects of fentanyl at a dose of 100 on cardiac automaticity, refractoriness and conduction have been studied in a model of heterotopic heart transplantation which combines a denervated heart (donor) and a non-denervated heart (recipient) in each of 20 dogs employed. Once the surgical procedure had...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Alvarez L,Escudero C,Carmona JA,Silva L,Castillo-Olivares JL

    更新日期:1992-09-01 00:00:00

  • Alinidine as a model of the mode of action of specific bradycardic agents on SA node activity.

    abstract::Three different bradycardic agents, alinidine, AQ-A39 and UL-FS49 increase the intrinsic cycle length of the isolated SA node preparation of the rabbit. This increase is mainly caused by a decrease in rate of diastolic depolarization. One of these agents, alinidine, was used to study the underlying ionic mechanism of ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: van Ginneken AC,Bouman LN,Jongsma HJ,Duivenvoorden JJ,Opthof T,Giles WR

    更新日期:1987-12-01 00:00:00

  • Lipoproteins of human peripheral lymph.

    abstract::The concentration of cholesterol in peripheral lymph is roughly one tenth of that in the blood plasma of the same subject. In lymph, there is virtually no very low density lipoprotein (VLDL), probably due to low permeability of the vascular endothelium for particles of this size. More than 95% of apo B-containing lipo...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Reichl D

    更新日期:1990-08-01 00:00:00

  • Comparison of the effects of two doses of bisoprolol on exercise tolerance in exercise-induced stable angina pectoris.

    abstract::Recently, bisoprolol has been investigated regarding its effects on exercise tolerance and the duration of action in patients with coronary heart disease (CHD) following single oral administration. It appears, however, that the extent of effects of 5 mg bisoprolol is not fully established yet. Therefore, the effects o...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: de Muinck E,Wagner G,vd Ven LL,Lie KI

    更新日期:1987-12-01 00:00:00

  • Prevention of restenosis by a novel drug-eluting stent system with a dose-adjustable, polymer-free, on-site stent coating.

    abstract:AIMS:Drug-eluting stents (DES) represent a major advance in interventional cardiology. Along with the success shown, current DES also present limitations related to the presence of polymer-coating, fixed drug, and dose used. With the ISAR (Individualized Drug-Eluting Stent System to Abrogate Restenosis) project, a DES ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章


    authors: Hausleiter J,Kastrati A,Wessely R,Dibra A,Mehilli J,Schratzenstaller T,Graf I,Renke-Gluszko M,Behnisch B,Dirschinger J,Wintermantel E,Schömig A,investigators of the individualizable durg-eluting Stent System to Abrogate Restenosi

    更新日期:2005-08-01 00:00:00

  • Everolimus-eluting bioresorbable vascular scaffolds for treatment of patients presenting with ST-segment elevation myocardial infarction: BVS STEMI first study.

    abstract:AIMS:We evaluated the feasibility and the acute performance of the everolimus-eluting bioresorbable vascular scaffolds (BVS) for the treatment of patients presenting with ST-segment elevation myocardial infarction (STEMI). METHODS AND RESULTS:The present investigation is a prospective, single-arm, single-centre study,...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Diletti R,Karanasos A,Muramatsu T,Nakatani S,Van Mieghem NM,Onuma Y,Nauta ST,Ishibashi Y,Lenzen MJ,Ligthart J,Schultz C,Regar E,de Jaegere PP,Serruys PW,Zijlstra F,van Geuns RJ

    更新日期:2014-03-01 00:00:00

  • From traditional pharmacological towards nucleic acid-based therapies for cardiovascular diseases.

    abstract::Nucleic acid-based therapeutics are currently developed at large scale for prevention and management of cardiovascular diseases (CVDs), since: (i) genetic studies have highlighted novel therapeutic targets suggested to be causal for CVD; (ii) there is a substantial recent progress in delivery, efficacy, and safety of ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Landmesser U,Poller W,Tsimikas S,Most P,Paneni F,Lüscher TF

    更新日期:2020-10-21 00:00:00

  • Ineligibility for predischarge exercise testing after myocardial infarction in the elderly: implications for prognosis.

    abstract::This study describes the clinical profile and prognosis of elderly patients not eligible for predischarge exercise testing. The database consisted of 133 patients 55-64 years of age, and 111 patients older than 64 years of age who survived an acute myocardial infarction. Follow-up was one year. In the younger age grou...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Deckers JW,Fioretti P,Brower RW,Simoons ML,Baardman T,Hugenholtz PG

    更新日期:1984-11-01 00:00:00

  • Advanced heart failure: feasibility study of long-term continuous axial flow pump support.

    abstract:AIMS:A lack of donor hearts has stimulated interest in using blood pumps to treat severe heart failure. We tested the hypothesis that a new continuous flow circulatory assist device could be employed safely to relieve symptoms of heart failure and evaluated the potential to prolong life. METHODS AND RESULTS:An intraca...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究


    authors: Siegenthaler MP,Westaby S,Frazier OH,Martin J,Banning A,Robson D,Pepper J,Poole-Wilson P,Beyersdorf F

    更新日期:2005-05-01 00:00:00

  • Early detection of pulmonary vascular disease in pulmonary arterial hypertension: time to move forward.

    abstract::Pulmonary arterial hypertension (PAH) can be a rapidly progressive disorder and is associated with high rate of mortality, despite medical intervention. With the availability of effective therapy, early disease detection is an important strategic objective to improve treatment outcomes. Resting echocardiography is cur...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Lau EM,Manes A,Celermajer DS,Galiè N

    更新日期:2011-10-01 00:00:00

  • Drug plasma levels and coronary vasodilation after isosorbide dinitrate chewing capsules.

    abstract::Five, ten and fifteen min after sublingual administration of 10mg isosorbide dinitrate (ISDN) in chewing capsules, in 10 patients with coronary artery disease, ISDN plasma levels were correlated with the dilation of epicardial coronary arteries as well as with changes in aortic blood pressure and heart rate. Due to th...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Jost S,Rafflenbeul W,Knop I,Bossaller C,Gulba D,Hecker H,Lippolt P,Lichtlen PR

    更新日期:1989-11-01 00:00:00

  • Randomized trial of paclitaxel- and sirolimus-eluting stents in small coronary vessels.

    abstract:AIMS:Sirolimus- and paclitaxel-eluting stents effectively reduce restenosis in small coronary vessels. The relative efficacy of these drug-eluting stents in this high-risk subset is not known. METHODS AND RESULTS:A total of 360 patients undergoing percutaneous coronary intervention for de novo lesions in native corona...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Mehilli J,Dibra A,Kastrati A,Pache J,Dirschinger J,Schömig A,Intracoronary Drug-Eluting Stenting to Abrogate Restenosis in Small Arteries (ISAR-SMART 3) Study Investigators.

    更新日期:2006-02-01 00:00:00

  • Comparison between the effect of L-propionylcarnitine, L-acetylcarnitine and nitroglycerin in chronic peripheral arterial disease: a haemodynamic double blind echo-Doppler study.

    abstract::The haemodynamic effects on the peripheral vascular bed of L-acetylcarnitine, L-propionylcarnitine, and nitroglycerin were tested by echo-Doppler in a double blind cross-over study. Eleven male patients suffering from peripheral arterial obliterative disease (PAOD) in the second stage of Fontaine's classification, and...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sabbá C,Berardi E,Antonica G,Ferraioli G,Buonamico P,Godi L,Brevetti G,Albano O

    更新日期:1994-10-01 00:00:00

  • Dobutamine stress--Doppler echocardiography before and after coronary angioplasty.

    abstract::To determine if dobutamine-induced myocardial ischaemia causes abnormalities in Doppler parameters of left ventricular ejection and filling and to assess early effects of successful coronary angioplasty (PTCA) on these parameters, dobutamine stress echocardiography and Doppler studies were performed once in 11 normal ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: el-Said ES,Fioretti PM,Roelandt JR,McNeill AJ,Rijsterborgh H,Forster T,Di Mario C,Linker DT

    更新日期:1993-08-01 00:00:00

  • Changes of fluid-dynamic parameters in peripheral stenoses with transcutaneous interventions.

    abstract:UNLABELLED:Peripheral vessels provide a useful in vivo haemodynamic model allowing evaluation of local intravascular fluid dynamics. Velocity measurements using a 0.018 inch Doppler-tipped angioplasty guidewire, quantitative angiography and laboratory data were gathered from 45 patients with a total of 48 percutaneous ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Wellnhofer E,Biamino G,Sauer HU,Trebeljahr A,Stalke J,Ragg C,Oswald H,Gotze S,Fleck E,Felix R

    更新日期:1995-10-01 00:00:00

  • From guidelines to clinical practice: the impact of hospital and geographical characteristics on temporal trends in the management of acute coronary syndromes. The Global Registry of Acute Coronary Events (GRACE).

    abstract:AIMS:The extent to which hospital and geographic characteristics influence the time course of uptake of evidence from key clinical trials and practice guidelines is unknown. The gap between evidence and practice is well recognized but the factors influencing this disjunction, and the extent to which such factors are mo...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究


    authors: Fox KA,Goodman SG,Anderson FA Jr,Granger CB,Moscucci M,Flather MD,Spencer F,Budaj A,Dabbous OH,Gore JM,GRACE Investigators.

    更新日期:2003-08-01 00:00:00

  • Long-term prognostic value of residual pulmonary vascular obstruction at discharge in patients with intermediate- to high-risk pulmonary embolism.

    abstract:BACKGROUND:We evaluated prognostic value at 6 months of residual pulmonary vascular obstruction (RPVO) measured before discharge in patients with intermediate- or high-risk pulmonary embolism (PE). METHODS AND RESULTS:Prospective registry including 416 consecutive patients with intermediate- or high-risk PE who surviv...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Meneveau N,Ider O,Seronde MF,Chopard R,Davani S,Bernard Y,Schiele F

    更新日期:2013-03-01 00:00:00