Abstract:
Aims:Despite the well-defined association of high-sensitivity hsCRP with cardiovascular outcomes in apparently healthy adults and those with acquired heart disease, the relevance of this inflammatory marker in adults with congenital heart disease (ACHD) remains unclear. We aimed to examine the clinical correlates and prognostic value of high-sensitivity C-reactive protein levels in ACHD. Methods and results:We conducted a prospective cohort study of (n = 707) outpatient ACHD (age 39 ± 14 years, 49% women), enrolled mainly at a referral centre, who had serum hsCRP measured in conjunction with a clinical assessment between 2012 and 2016. We analysed clinical correlates of hsCRP and its association with adverse events including the primary combined outcome of all-cause mortality or non-elective cardiovascular hospitalization. Higher hsCRP was strongly associated with measures of functional status including New York Heart Association class and peak V̇O2, and with comorbidities such as atrial arrhythmia. During average follow-up of 815 ± 536 days, 114 patients (16%) experienced the primary outcome, including 29 deaths. Having elevated hsCRP, in the highest (≥2.98 mg/L) compared with the lower three quartiles, conferred increased risk for the primary outcome [30.5% vs. 11.3%, adjusted hazard ratio (HR) = 2.00, 95% confidence interval (CI) 1.35-2.97; P = 0.0006] and all-cause mortality (11.9% vs. 1.5%, adjusted HR = 4.23, 95% CI 1.87-9.59; P = 0.0006). Elevated hsCRP was associated with adverse outcomes across ACHD subgroups and other patient characteristics. Conclusion:Adults with congenital heart disease with elevated hsCRP have not only worse functional status and exercise capacity, but also greater risk for death or non-elective cardiovascular hospitalization. Further study is warranted to characterize the role of inflammation in the pathophysiology of ACHD.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Opotowsky AR,Valente AM,Alshawabkeh L,Cheng S,Bradley A,Rimm EB,Landzberg MJdoi
10.1093/eurheartj/ehy362subject
Has Abstractpub_date
2018-09-07 00:00:00pages
3253-3261issue
34eissn
0195-668Xissn
1522-9645pii
5053120journal_volume
39pub_type
杂志文章abstract:AIMS:To analyse whether the proportion of patients with lone atrial fibrillation engaged in chronic sport practice was higher than that observed in the general population. METHODS AND RESULTS:The records of 1160 patients, seen at the arrhythmia outpatient clinic, were reviewed. A total of 70 patients (6%) suffered lon...
journal_title:European heart journal
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doi:10.1053/euhj.2001.2802
更新日期:2002-03-01 00:00:00
abstract:AIMS:Cardiomyopathies are a heterogeneous group of disorders associated with premature death due to ventricular arrhythmia or heart failure. The purpose of this study was to examine the characteristics of patients enrolled in the pilot phase of the EURObservational Research Programme (EORP) cardiomyopathy registry. ME...
journal_title:European heart journal
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journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/ehi841
更新日期:2006-07-01 00:00:00
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journal_title:European heart journal
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pub_type: 杂志文章
doi:10.1093/eurheartj/14.1.96
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doi:10.1093/oxfordjournals.eurheartj.a062440
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abstract::When selecting coronary stenoses for interventional treatment, assessment of reversible ischaemia is paramount from a symptomatic as well as prognostic point of view. Fractional flow reserve (FFR) is now considered the gold standard for invasive assessment of ischaemia. By measuring FFR in the catheterization laborato...
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a062359
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journal_title:European heart journal
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doi:10.1093/oxfordjournals.eurheartj.a060618
更新日期:1994-07-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1093/eurheartj/ehi446
更新日期:2006-02-01 00:00:00
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journal_title:European heart journal
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doi:10.1093/oxfordjournals.eurheartj.a061847
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pub_type: 杂志文章,meta分析
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doi:10.1093/oxfordjournals.eurheartj.a060567
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a060928
更新日期:1995-03-01 00:00:00
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pub_type: 新闻
doi:
更新日期:2015-06-01 00:00:00
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doi:10.1093/oxfordjournals.eurheartj.a059437
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/14.1.40
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pub_type: 临床试验,杂志文章,多中心研究
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehv757
更新日期:2016-10-01 00:00:00