Late potentials in arrhythmogenic right ventricular dysplasia. Prevalence, diagnostic and prognostic values.

Abstract:

:A time-domain signal-averaged ECG was performed in 52 patients with arrhythmogenic right ventricular dysplasia (ARVD) proven by angiography, in 45 control subjects with normal hearts, and in 132 patients with various types of ventricular arrhythmias and no evidence of cardiac disease during routine cardiac examination. Based on the results of control subjects, patients with at least 2/3 abnormal parameters (QRS > or = 113 ms, LAS > or = 38 ms, RMS 40 < or = 16 microV) were considered as having late potentials (LP). Prevalence of LP was 75% (39/52) in patients with ARVD, 19% (25/132) in patients with apparently idiopathic ventricular arrhythmias, and 4% (4/45) in controls (P < 0.01). In ARVD, no relationship was found between LP and age, type of ventricular arrhythmia (sustained or not), or extent of the disease on angiography. A significant correlation was found between the values of two parameters (QRS and LAS length) and the delay between the first ventricular arrhythmia and the examination (r = 0.39 and 0.42 respectively, P < 0.01). Further examinations (echo and/or angiography) revealed underlying heart disease in 26/132 patients with apparently normal hearts, including 13 with ARVD. LP were present in 21/26 patients (81%) with diseased heart vs 4/106 (4%) in those with normal hearts after complete examination, giving a sensitivity of 86%, and a specificity of 96% for detecting underlying heart disease. During a follow-up of 3.1 +/- 1.2 years after signal-averaged ECG, only one patient died from heart failure.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Eur Heart J

journal_title

European heart journal

authors

Leclercq JF,Coumel P

doi

10.1093/eurheartj/14.suppl_e.80

subject

Has Abstract

pub_date

1993-09-01 00:00:00

pages

80-3

eissn

0195-668X

issn

1522-9645

journal_volume

14 Suppl E

pub_type

杂志文章
  • Angiographically evident thrombus following fibrinolytic therapy is associated with impaired myocardial perfusion in STEMI: a CLARITY-TIMI 28 substudy.

    abstract:AIMS:The presence of residual thrombus following fibrinolytic therapy for ST-segment elevation myocardial infarction (STEMI) may predispose to greater embolization and microvascular dysfunction. METHODS AND RESULTS:We hypothesized that even in the presence of a patent epicardial artery, residual thrombus would be asso...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehl149

    authors: Kirtane AJ,Vafai JJ,Murphy SA,Aroesty JM,Sabatine MS,Cannon CP,Gibson CM,TIMI Study Group.

    更新日期:2006-09-01 00:00:00

  • Comparison of coronary bypass surgery with drug-eluting stenting for the treatment of left main and/or three-vessel disease: 3-year follow-up of the SYNTAX trial.

    abstract:AIMS:Long-term randomized comparisons of percutaneous coronary intervention (PCI) to coronary artery bypass grafting (CABG) in left main coronary (LM) disease and/or three-vessel disease (3VD) patients have been limited. This analysis compares 3-year outcomes in LM and/or 3VD patients treated with CABG or PCI with TAXU...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehr213

    authors: Kappetein AP,Feldman TE,Mack MJ,Morice MC,Holmes DR,Ståhle E,Dawkins KD,Mohr FW,Serruys PW,Colombo A

    更新日期:2011-09-01 00:00:00

  • Marathon run: cardiovascular adaptation and cardiovascular risk.

    abstract::The first marathon run as an athletic event took place in the context of the Olympic Games in 1896 in Athens, Greece. Today, participation in a 'marathon run' has become a global phenomenon attracting young professional athletes as well as millions of mainly middle-aged amateur athletes worldwide each year. One of the...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/eht502

    authors: Predel HG

    更新日期:2014-11-21 00:00:00

  • Non-invasive assessment of cardiac physiology by tissue Doppler echocardiography. A comparison with invasive haemodynamics.

    abstract:BACKGROUND:Tissue Doppler echocardiography reveals characteristic patterns of myocardial velocities within systole and diastole which are not well understood. AIM:The purpose of this study was to determine the relationship of myocardial velocity patterns, as assessed by tissue Doppler echocardiography, to the contract...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a015236

    authors: Zamorano J,Wallbridge DR,Ge J,Drozd J,Nesser J,Erbel R

    更新日期:1997-02-01 00:00:00

  • Altered limbic and autonomic processing supports brain-heart axis in Takotsubo syndrome.

    abstract:AIMS:Takotsubo syndrome (TTS) is characterized by acute left ventricular dysfunction often triggered by emotional or physical stress. Severe activation of the sympathetic nervous system with catecholamine release caused by a dysfunctional limbic system has been proposed as a potential mechanism. We hypothesize that bra...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehz068

    authors: Templin C,Hänggi J,Klein C,Topka MS,Hiestand T,Levinson RA,Jurisic S,Lüscher TF,Ghadri JR,Jäncke L

    更新日期:2019-04-14 00:00:00

  • Effect of fish oil on ventricular tachyarrhythmia in three studies in patients with implantable cardioverter defibrillators.

    abstract:AIMS:To determine the effects of omega-3 polyunsaturated fatty acids (omega-3 PUFAs) from fish on the incidence of recurrent ventricular arrhythmia in implantable cardioverter defibrillator (ICD) patients by combining results from published trials. METHODS AND RESULTS:We searched in the Medline, EMBASE, and Cochrane d...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/eurheartj/ehp003

    authors: Brouwer IA,Raitt MH,Dullemeijer C,Kraemer DF,Zock PL,Morris C,Katan MB,Connor WE,Camm JA,Schouten EG,McAnulty J

    更新日期:2009-04-01 00:00:00

  • Early revascularization is associated with improved survival in elderly patients with acute myocardial infarction complicated by cardiogenic shock: a report from the SHOCK Trial Registry.

    abstract:AIMS:The SHould we emergently revascularize Occluded Coronaries in cardiogenic shocK (SHOCK) Trial showed no benefit of early revascularization in patients aged >/=75 years with acute myocardial infarction and cardiogenic shock. We examined the effect of age on treatment and outcomes of patients with cardiogenic shock ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/s0195-668x(02)00844-8

    authors: Dzavik V,Sleeper LA,Cocke TP,Moscucci M,Saucedo J,Hosat S,Jiang X,Slater J,LeJemtel T,Hochman JS,SHOCK Investigators.

    更新日期:2003-05-01 00:00:00

  • Haemodynamic effects of high doses of insulin during acute left ventricular failure in dogs.

    abstract::Haemodynamic effects of pharmacological doses of insulin during acute ischaemic heart failure were studied in 8 dogs. Severe depression of left ventricular function was induced by the injection of 50 micron plastic microspheres into the left main coronary artery. This was demonstrated by a significant increase in left...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061885

    authors: Reikerås O,Gunnes P,Sørlie D,Ekroth R,Jorde R,Mjøs OD

    更新日期:1985-05-01 00:00:00

  • Strict blood glucose control with insulin during intensive care after cardiac surgery: impact on 4-years survival, dependency on medical care, and quality-of-life.

    abstract:AIMS:To document the impact of intensive insulin therapy during intensive care on long-term (4 years) outcome of high-risk cardiac surgery patients. METHODS AND RESULTS:In this pre-planned sub-analysis and follow-up study of a large, randomized controlled trial on the effects of intensive insulin therapy during critic...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehi855

    authors: Ingels C,Debaveye Y,Milants I,Buelens E,Peeraer A,Devriendt Y,Vanhoutte T,Van Damme A,Schetz M,Wouters PJ,Van den Berghe G

    更新日期:2006-11-01 00:00:00

  • How many patients with heart failure are eligible for cardiac resynchronization? Insights from two prospective cohorts.

    abstract:AIMS:To determine what proportion of patients with heart failure are eligible for cardiac resynchronization therapy (CRT). METHODS AND RESULTS:Eligibility criteria from the trials establishing the efficacy of CRT were applied to two prospective cohorts: the first enrolled patients with newly diagnosed heart failure di...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehi446

    authors: McAlister FA,Tu JV,Newman A,Lee DS,Kimber S,Cujec B,Armstrong PW

    更新日期:2006-02-01 00:00:00

  • Optimal timing of invasive angiography in stable non-ST-elevation myocardial infarction: the Leipzig Immediate versus early and late PercutaneouS coronary Intervention triAl in NSTEMI (LIPSIA-NSTEMI Trial).

    abstract:AIMS:The optimal timing of intervention in non-ST-elevation myocardial infarction (NSTEMI) remains uncertain. The aim of this multicentre trial was to assess whether an immediate invasive approach is superior to an early invasive or a selective invasive approach with respect to reduction of large infarction. METHODS A...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehr418

    authors: Thiele H,Rach J,Klein N,Pfeiffer D,Hartmann A,Hambrecht R,Sick P,Eitel I,Desch S,Schuler G,LIPSIA-NSTEMI Trial Group.

    更新日期:2012-08-01 00:00:00

  • Effect of acupuncture in patients with angina pectoris.

    abstract::Twenty-one patients with stable effort angina pectoris were randomized in a crossover study to 4 weeks traditional Chinese acupuncture or placebo tablet treatment. The patients had at least five anginal attacks per week in spite of intensive treatment. Acupuncture was given three times per week at main points Neiguan ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a059865

    authors: Richter A,Herlitz J,Hjalmarson A

    更新日期:1991-02-01 00:00:00

  • Thrombolytic therapy in Europe: current status.

    abstract::Thrombolytic therapy is a practical, effective approach to the management of acute myocardial infarction that is widely used in Europe today. Early European trials demonstrated a clear reduction in mortality in patients who received thrombolytic therapy compared with those given conventional treatment. The findings of...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/17.suppl_e.21

    authors: Vahanian A

    更新日期:1996-09-01 00:00:00

  • Potent inhibition of thrombin with a monoclonal antibody against tissue factor (Sunol-cH36): results of the PROXIMATE-TIMI 27 trial.

    abstract:AIMS:Exposure of tissue factor (TF) is a critical proximal step in the pathogenesis of acute coronary syndromes. Sunol-cH36, a chimaeric monoclonal antibody to TF, blocks binding of factor X to the TF:VIIa complex. This report describes the first completed trial of Sunol-cH36 in humans. METHODS AND RESULTS:We assessed...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1093/eurheartj/ehi094

    authors: Morrow DA,Murphy SA,McCabe CH,Mackman N,Wong HC,Antman EM

    更新日期:2005-04-01 00:00:00

  • Relationship between admission serum sodium concentration and clinical outcomes in patients hospitalized for heart failure: an analysis from the OPTIMIZE-HF registry.

    abstract:AIMS:Hyponatraemia has been shown to be an independent predictor of mortality in selected patients with heart failure enrolled in clinical trials. The predictive value of hyponatraemia has not been evaluated in unselected patients hospitalized with heart failure. METHODS AND RESULTS:OPTIMIZE-HF is a registry and perfo...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehl542

    authors: Gheorghiade M,Abraham WT,Albert NM,Gattis Stough W,Greenberg BH,O'Connor CM,She L,Yancy CW,Young J,Fonarow GC,OPTIMIZE-HF Investigators and Coordinators.

    更新日期:2007-04-01 00:00:00

  • One-year clinical outcomes of protected and unprotected left main coronary artery stenting.

    abstract:AIMS:To evaluate outcomes for left main coronary artery (LMCA) stenting and compare results between protected (left coronary grafted) and unprotected LMCA stenting in the current bare-metal stent era. METHODS:We reviewed outcomes among 142 consecutive patients who underwent protected or unprotected LMCA stenting since...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1016/s0195-668x(03)00314-2

    authors: Kelley MP,Klugherz BD,Hashemi SM,Meneveau NF,Johnston JM,Matthai WH Jr,Banka VS,Herrmann HC,Hirshfeld JW Jr,Kimmel SE,Kolansky DM,Horwitz PA,Schiele F,Bassand JP,Wilensky RL

    更新日期:2003-09-01 00:00:00

  • A novel risk prediction score in atrial fibrillation for a net clinical outcome from the ENGAGE AF-TIMI 48 randomized clinical trial.

    abstract:Aims:The choice between initiating a non-vitamin K antagonist oral anticoagulant (NOAC) and a vitamin K antagonist (VKA) in patients with atrial fibrillation (AF) may be challenging. To assist in this decision, we developed a risk score to identify patients for whom a therapeutic benefit of NOACs over VKA is predicted....

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehw565

    authors: Fanola CL,Giugliano RP,Ruff CT,Trevisan M,Nordio F,Mercuri MF,Antman EM,Braunwald E

    更新日期:2017-03-21 00:00:00

  • A single dose of erythropoietin in ST-elevation myocardial infarction.

    abstract:AIMS:Cardioprotective effects of erythropoietin (EPO) have been shown in experimental and smaller clinical studies. We performed a prospective, multicentre, randomized trial to assess the effects of a single high dose of EPO after primary coronary intervention (PCI) for an ST-elevation myocardial infarction (STEMI). Me...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehq304

    authors: Voors AA,Belonje AM,Zijlstra F,Hillege HL,Anker SD,Slart RH,Tio RA,van 't Hof A,Jukema JW,Peels HO,Henriques JP,Ten Berg JM,Vos J,van Gilst WH,van Veldhuisen DJ,HEBE III Investigators.

    更新日期:2010-11-01 00:00:00

  • Regional myocardial deformation in children with hypertrophic cardiomyopathy: morphological and clinical correlations.

    abstract:AIMS:Hypertrophic cardiomyopathy (HCM) is a disease with marked regional differences in wall thickness. However, the relation between myocardial function and wall thickness has not been well studied. Ultrasonic strain rate (SR) imaging makes it possible to study the regional myocardial deformation. We investigated whet...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehm444

    authors: Ganame J,Mertens L,Eidem BW,Claus P,D'hooge J,Havemann LM,McMahon CJ,Elayda MA,Vaughn WK,Towbin JA,Ayres NA,Pignatelli RH

    更新日期:2007-12-01 00:00:00

  • Physical activity levels, ownership of goods promoting sedentary behaviour and risk of myocardial infarction: results of the INTERHEART study.

    abstract:AIMS:To evaluate the association between occupational and leisure-time physical activity (PA), ownership of goods promoting sedentary behaviour, and the risk of myocardial infarction (MI) in different socio-economic populations of the world. Studies in developed countries have found low PA as a risk factor for cardiova...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehr432

    authors: Held C,Iqbal R,Lear SA,Rosengren A,Islam S,Mathew J,Yusuf S

    更新日期:2012-02-01 00:00:00

  • Experimental electrophysiology and arrhythmogenicity. Anisotropy and ventricular tachycardia.

    abstract::In a 2-D model of anisotropy, created by freezing the intramural and endocardial layers of a Langendorf perfused rabbit heart, sustained ventricular tachycardia (VT) with a cycle length of 130 ms and an excitable gap of 30 ms could be initiated by rapid pacing. High resolution mapping (256 points) of the thin survivin...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/10.suppl_e.2

    authors: Allessie MA,Schalij MJ,Kirchhof CJ,Boersma L,Huybers M,Hollen J

    更新日期:1989-09-01 00:00:00

  • Atrial fibrillation and cardiac fibrosis.

    abstract::The understanding of atrial fibrillation (AF) evolved from a sole rhythm disturbance towards the complex concept of a cardiomyopathy based on arrhythmia substrates. There is evidence that atrial fibrosis can be visualized using late gadolinium enhancement cardiac magnetic resonance imaging and that it is a powerful pr...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehz786

    authors: Sohns C,Marrouche NF

    更新日期:2020-03-07 00:00:00

  • Pharmacokinetics of organic nitrates in man: an overview.

    abstract::The pharmacokinetics of glyceryl trinitrate are still not completely understood. The substance disappears rapidly from plasma largely by extrahepatic mechanisms. It is converted in glyceryl dinitrates and glyceryl mononitrates. After transdermal application of a controlled delivery system, plasma concentrations of gly...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/9.suppl_a.33

    authors: Bogaert MG

    更新日期:1988-01-01 00:00:00

  • Troponin I and cardiovascular risk prediction in the general population: the BiomarCaRE consortium.

    abstract:AIMS:Our aims were to evaluate the distribution of troponin I concentrations in population cohorts across Europe, to characterize the association with cardiovascular outcomes, to determine the predictive value beyond the variables used in the ESC SCORE, to test a potentially clinically relevant cut-off value, and to ev...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehw172

    authors: Blankenberg S,Salomaa V,Makarova N,Ojeda F,Wild P,Lackner KJ,Jørgensen T,Thorand B,Peters A,Nauck M,Petersmann A,Vartiainen E,Veronesi G,Brambilla P,Costanzo S,Iacoviello L,Linden G,Yarnell J,Patterson CC,Everett BM

    更新日期:2016-08-07 00:00:00

  • Combined non-invasive functional and anatomical diagnostic work-up in clinical practice: the magnetic resonance and computed tomography in suspected coronary artery disease (MARCC) study.

    abstract:AIMS:The combined use of cardiac computed tomography (CT) coronary angiography (CTCA) and myocardial perfusion imaging allows the non-invasive evaluation of coronary morphology and function. Cardiovascular magnetic resonance (CMR) imaging has several advantages: it can simultaneously assess myocardial perfusion, ventri...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/eht077

    authors: Groothuis JG,Beek AM,Brinckman SL,Meijerink MR,van den Oever ML,Hofman MB,van Kuijk C,van Rossum AC

    更新日期:2013-07-01 00:00:00

  • Platelet glycoprotein IIb/IIIa receptor inhibition as adjunctive treatment during saphenous vein graft stenting: differential effects after randomization to occlusion or filter-based embolic protection.

    abstract:AIMS:Although embolic protection devices reduce complications during saphenous vein graft (SVG) stenting, adverse events still occur in approximately 10% of patients. IIb/IIIa antagonists have not been proven effective during SVG intervention. We hypothesized that adjunctive use of these agents might enhance the effica...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehi736

    authors: Jonas M,Stone GW,Mehran R,Hermiller J,Feldman R,Herrmann HC,Cox DA,Kuntz RE,Popma JJ,Rogers C,FilterWire EX Randomized Evalulation (FIRE) Investigators.

    更新日期:2006-04-01 00:00:00

  • Obesity and weight loss are inversely related to mortality and cardiovascular outcome in prediabetes and type 2 diabetes: data from the ORIGIN trial.

    abstract:AIMS:The association of body weight and weight change with mortality and cardiovascular (CV) outcome in patients with diabetes mellitus (DM) is not clearly established. We assessed the relationship between weight, weight change, and outcomes in patients with established CV risk factors and type 2 DM or pre-diabetes. M...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehaa293

    authors: Doehner W,Gerstein HC,Ried J,Jung H,Asbrand C,Hess S,Anker SD

    更新日期:2020-07-21 00:00:00

  • Plasma concentrations of platelet-specific proteins in young female acute myocardial infarction survivors and their age-matched female controls.

    abstract::The steady state plasma concentrations of the two platelet-specific proteins beta-thromboglobulin (BTG) and platelet factor 4 (PF4) were determined in two groups of females: 36 acute myocardial infarction (AMI) survivors, and 38 age-matched control subjects. For the AMI patients the mean BTG and PF4 values were 57 +/-...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061465

    authors: Kutti J,Johansson S,Eriksson KA,Sigvaldason A,Vedin A,Wadenvik H,Wilhelmsson C

    更新日期:1983-05-01 00:00:00

  • Biological signals of cardiac hypertrophy.

    abstract::Chronic increases in haemodynamic load modify the expression of cardiac genes, leading to a new phenotype better adapted to the new functional demand. Several mechanisms such as the global activation of genes, the modulation of single genes and/or differential expression of multigene families may account for these mod...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/11.suppl_g.1

    authors: Samuel JL,Dubus I,Contard F,Schwartz K,Rappaport L

    更新日期:1990-11-01 00:00:00

  • Standardized exercise training is feasible, safe, and effective in pulmonary arterial and chronic thromboembolic pulmonary hypertension: results from a large European multicentre randomized controlled trial.

    abstract:AIMS:This prospective, randomized, controlled, multicentre study aimed to evaluate efficacy and safety of exercise training in patients with pulmonary arterial (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). METHODS AND RESULTS:For the first time a specialized PAH/CTEPH rehabilitation programme was im...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehaa696

    authors: Grünig E,MacKenzie A,Peacock AJ,Eichstaedt CA,Benjamin N,Nechwatal R,Ulrich S,Saxer S,Bussotti M,Sommaruga M,Ghio S,Gumbiene L,Palevičiūtė E,Jurevičienė E,Cittadini A,Stanziola AA,Marra AM,Kovacs G,Olschewski H,Barb

    更新日期:2020-11-24 00:00:00