Functional significance of angiotensin receptors in human myocardium. Significant differences between atrial and ventricular myocardium.

Abstract:

:We studied the effects of angiotensin (Ang) I and II in a variety of isolated human cardiac tissues contracting under physiological conditions (37 degrees C, 60 beats.min-1). Ang I and II consistently increased the peak developed force of human atrial muscles by 30-40%, an effect that was completely blocked by 10(-6) M saralasine, but not by the combination of prazosin and propranolol. However, neither Ang I or II had significant inotropic effects in right and left ventricular human preparations. We were also able to demonstrate that the positive inotropic effect of Ang II in human right atrial tissue is mediated by the AT1 receptor subtype but not the AT2 receptor subtype.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Holubarsch C,Schmidt-Schweda S,Knorr A,Duis J,Pieske B,Ruf T,Fasol R,Hasenfuss G,Just H

doi

10.1093/eurheartj/15.suppl_d.88

subject

Has Abstract

pub_date

1994-12-01 00:00:00

pages

88-91

eissn

0195-668X

issn

1522-9645

journal_volume

15 Suppl D

pub_type

杂志文章
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