Abstract:
AIMS:It has been proposed that competitive sport increases the risk of ventricular tachyarrhythmias (VTA) and death in patients with arrhythmogenic right-ventricular cardiomyopathy (ARVC). However, it is unknown whether this only applies to competitive sport or if recreational sports activity also increases the risk of VTA/death. METHODS AND RESULTS:Probands diagnosed with ARVC according to the 2010 task force criteria for ARVC (n = 108) were included in the current analysis. At the time of enrolment, study participants were questioned about exercise level prior to and after ARVC diagnosis, within three categories of sports participation: competitive (n = 41), recreational (n = 48), and inactive (n = 19). Competitive sport was associated with a significantly higher risk of VTA/death when compared with both recreational sport [HR = 1.99 (1.21-3.28), P = 0.007] and inactive patients [HR = 2.05 (1.07-3.91), P = 0.030]. No increased risk of VTA/death was associated with recreational sport when compared with patients who were inactive [HR = 1.03 (0.54-1.97), P = 0.930]. Symptoms developed at an earlier age in patients who participated in competitive sport (30 ± 12 years), when compared with patients who participated in recreational sport (38 ± 17 years) (P = 0.015) and inactive patients (41 ± 11 years) (P = 0.002). No difference in age at first symptom was seen between patients who participated in recreational sport and inactive patients (P = 0.651). CONCLUSION:Competitive sport was associated with a two-fold increased risk of VTA/death, and earlier presentation of symptoms, when compared with inactive patients, and to patients who participated in recreational sport. When compared with inactive patients, recreational sport was not associated with earlier onset of symptoms or increased risk of VTA/death. ClinicalTrials.gov Identifier: NCT00024505.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Ruwald AC,Marcus F,Estes NA 3rd,Link M,McNitt S,Polonsky B,Calkins H,Towbin JA,Moss AJ,Zareba Wdoi
10.1093/eurheartj/ehv110subject
Has Abstractpub_date
2015-07-14 00:00:00pages
1735-43issue
27eissn
0195-668Xissn
1522-9645pii
ehv110journal_volume
36pub_type
临床试验,杂志文章abstract:UNLABELLED:To study the ablation effects induced by excimer laser coronary angioplasty (ELCA), we examined 41 segments of nine isolated coronary arteries. An electronic intracoronary ultrasound device (ICUS: 20 MHz, 3.5F, Endosonics) was positioned coaxially within the vessel. Angioplasty was performed using a 1.7 mm E...
journal_title:European heart journal
pub_type: 杂志文章
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pub_type: 杂志文章,meta分析,评审
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:1995-11-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:1991-04-01 00:00:00
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更新日期:2002-08-01 00:00:00
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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doi:
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更新日期:2011-03-01 00:00:00
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