Response of recurrent giant cell myocarditis in a transplanted heart to intensive immunosuppression.

Abstract:

:A 35-year-old man developed giant cell myocarditis resulting in severe congestive cardiac failure. He needed urgent orthotopic cardiac transplantation despite maximal doses of inotropes and augmentation with an intra-aortic balloon pump. The patient presented with rhythm disturbances and echocardiographically diminished ventricular function at subsequent follow-up. Biopsies then taken revealed recurrence of myocarditis in the transplanted heart. Investigations revealed no obvious cause for the myocardial granulomas nor any evidence of systemic granulomatous disease. The patient received, in addition to maintenance cyclosporin A and azathioprine, high doses of corticosteroids which resulted in complete resolution of the inflammatory process and no recurrence has been detected to date. This case shows that giant cell myocarditis can recur in the transplanted heart despite routine immunosuppression with azathioprine and cyclosporin A and that additional treatment with high dose corticosteroids is effective in causing regression of the inflammatory process.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Kong G,Madden B,Spyrou N,Pomerance A,Mitchell A,Yacoub M

doi

10.1093/oxfordjournals.eurheartj.a059938

subject

Has Abstract

pub_date

1991-04-01 00:00:00

pages

554-7

issue

4

eissn

0195-668X

issn

1522-9645

journal_volume

12

pub_type

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