Abstract:
AIMS:Trans-fatty acids (TFAs) are generated by the food industry and also occur naturally in trace amounts in dairy products. For the latter, beneficial health effects have been claimed, while there are numerous reports about TFA of industrial origin being hazardous to human health. Therefore, we aimed to investigate the association of TFA with mortality in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. METHODS AND RESULTS:The fatty acid composition of erythrocyte membranes was analysed using the HS-Omega-3 Index(®) methodology in 3259 participants of the LURIC study at baseline. During a median of 10.0 years of follow-up, a total of 975 (29.9%) study participants died, 614 (18.8%) from cardiovascular causes including 254 (7.8%) sudden cardiac deaths (SCDs). Association of TFA with clinical outcome was investigated with Cox proportional hazards regression. Total TFAs were inversely associated with mortality due to cardiovascular causes or SCD. This was mainly driven by the naturally occurring TFA C16:1n-7t (trans-palmitoleic acid). The reduced risk of SCD associated with C16:1n-7t persisted after multivariate adjustment with a hazard ratio of 0.63 (0.46-0.86) for the third tertile compared with the first tertile. There was no association of any TFA subgroup with an increased risk of adverse outcomes. CONCLUSIONS:In contrast to previous findings, the low concentrations of total TFAs found in LURIC were inversely associated with adverse cardiac outcomes. While the naturally occurring TFA C16:1n-7t was associated with reduced risk, no increased risk was found for industrially produced TFAs.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Kleber ME,Delgado GE,Lorkowski S,März W,von Schacky Cdoi
10.1093/eurheartj/ehv446subject
Has Abstractpub_date
2016-04-01 00:00:00pages
1072-8issue
13eissn
0195-668Xissn
1522-9645pii
ehv446journal_volume
37pub_type
杂志文章abstract:AIMS:In animal models of obesity and diabetes mellitus, myocardial TG accumulation is associated with decreased myocardial function. In the physiologically ageing heart, myocardial triglyceride (TG) accumulation may also occur due to reduced myocardial fatty acid oxidation. The role of myocardial TG in the ageing human...
journal_title:European heart journal
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doi:10.1093/eurheartj/ehn207
更新日期:2008-06-01 00:00:00
abstract::Arbutamine (Gensia, Inc., San Diego, CA) is a newly-developed sympathomimetic agent specifically designed for cardiovascular stress testing. It has been successfully used for the detection of coronary artery disease in conjunction with electrocardiography, echocardiographic and radionuclide techniques. Arbutamine incr...
journal_title:European heart journal
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journal_title:European heart journal
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doi:10.1093/eurheartj/11.suppl_e.122
更新日期:1990-08-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-01-01 00:00:00
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更新日期:2012-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/eurheartj/ehu039
更新日期:2014-06-14 00:00:00
abstract::It is now recognised after many years of speculation regarding the role of mammalian atria in the direct regulation of intravascular volume, that atrial myocites produce a peptide hormone that results in natriuresis and diuresis, under the condition of atrial distention. This atrial natriuretic factor (ANF) is secrete...
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pub_type: 杂志文章
doi:10.1093/eurheartj/9.suppl_h.29
更新日期:1988-06-01 00:00:00
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doi:10.1093/eurheartj/ehl086
更新日期:2006-09-01 00:00:00
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doi:10.1093/oxfordjournals.eurheartj.a060309
更新日期:1992-08-01 00:00:00
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doi:10.1093/eurheartj/ehn124
更新日期:2008-05-01 00:00:00
abstract::The non-invasive quantification of mitral and aortic regurgitation using the left-to-right stroke count ratio (SCR) calculated with gated equilibrium radionuclide ventriculography (RNV), is affected by the overlap of atria and ventricles and the consequent difficult definition of the ventricular regions of interest (R...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a062176
更新日期:1987-10-01 00:00:00
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pub_type: 临床试验,杂志文章
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abstract::The effects of oral sotalol were compared with the findings obtained in the baseline study of a group of 26 consecutive patients with sustained monomorphic ventricular tachycardia or ventricular fibrillation and inducible ventricular tachycardia. The mean age was 62 years and the mean ejection fraction 33%. The number...
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a059469
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2010-11-01 00:00:00
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journal_title:European heart journal
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更新日期:2008-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-11-21 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/16.suppl_b.103
更新日期:1995-04-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2011-10-01 00:00:00