Abstract:
:The non-invasive quantification of mitral and aortic regurgitation using the left-to-right stroke count ratio (SCR) calculated with gated equilibrium radionuclide ventriculography (RNV), is affected by the overlap of atria and ventricles and the consequent difficult definition of the ventricular regions of interest (ROI). Various solutions of the problem have been proposed. In this study we evaluated the results obtained with a technique based on visual inspection of the RNV images (variable ROI method--VRI) and those of two approaches which utilize functional images (stroke volume image method--SVI--and Fourier amplitude ratio--FAR), by comparing them with the invasive quantification of valvular regurgitation according to Sandler et al. (stroke volume ratio--SVR). Forty patients (15 controls and 25 valvular patients) were studied. In the control group the range of the SVR was 0.81 +/- 1.11 (mean +/- 1 SD = 1.01 +/- 0.08). The SCR was 0.83-L28 (1.03 +/- 0.15) with VRI, 1.10-1.15 (1.30 +/- 0.14) with SVI and 1.11-1.58 (1.35 +/- 0.17) with FAR. The correlations between SVR and SCR were r = 0.47 (P less than 0.05), r = 0.62 (P less than 0.001) and r = 0.55 (P less than 0.01) respectively with VRI, SVI and FAR. The SCR of valvular patients fell in the range of controls in 11/25 using VRI, 6/25 using SVI and in 4/25 using FAR. This overlap was present in 2/25 with the invasive quantification. Irrespective of the method used, a reliable assessment of the valvular regurgitation was not possible in two patients with severely depressed left ventricular function. We conclude that the use of techniques based on functional images clearly improves the effectiveness of the non-invasive quantification of valvular regurgitation with the SCR even if this cannot be regarded as a substitute for invasive quantification and has a limited reliability in particular groups of patients.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Sciagrà R,Voth E,Tebbe U,Schicha H,Neuhaus KLdoi
10.1093/oxfordjournals.eurheartj.a062176subject
Has Abstractpub_date
1987-10-01 00:00:00pages
1109-18issue
10eissn
0195-668Xissn
1522-9645journal_volume
8pub_type
杂志文章abstract::The efficacies and safety of nicorandil, 20 mg b.d., and diltiazem, 60 mg t.d., in the treatment of stable angina pectoris were compared in a double-blind randomized parallel group study involving 123 patients. The duration of the study was 3 months. Exercise tolerance tests were performed by the patients when on plac...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1093/eurheartj/14.suppl_b.30
更新日期:1993-07-01 00:00:00
abstract::The present study was designed to examine the effects of a new organic nitrate, teopranitol, in acute myocardial ischaemia. Adult cats were subjected to 5 h of myocardial ischaemia by permanent ligation of the left anterior descending coronary artery (LAD). Teopranitol (10 mg kg-1 X h) or physiological saline (vehicle...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a062083
更新日期:1986-05-01 00:00:00
abstract::There is lack of consistent correlation between left ventricular function at rest, haemodynamic measurements at rest, symptomatic status and exercise tolerance. Haemodynamic data appear comparable in patients whose exercise tolerance is limited clinically by fatigue and by breathlessness. Selected patients with left v...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/9.suppl_f.63
更新日期:1988-04-01 00:00:00
abstract:AIMS:We examined the left lateral ridge (LLR) between the orifices of the left pulmonary veins and the left atrial appendage for a better understanding of its structural composition relevant to ablations for atrial fibrillation (AF). METHODS AND RESULTS:The LLR and its surrounding areas were studied in 40 heart specim...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehm606
更新日期:2008-02-01 00:00:00
abstract:Aims:Optimal blood pressure for prevention of cardiovascular (CV) events in patients with Type 2 diabetes mellitus (T2DM) remains uncertain and there is concern for increased risk with low diastolic blood pressure (DBP). This study analysed the association between blood pressure and CV outcomes in high-risk patients wi...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehx809
更新日期:2018-06-21 00:00:00
abstract:AIMS:The long QT syndrome is mainly defined by QT interval prolongation (QTc > 0.44s). However, data obtained in genotyped patients showed that resting QTc measurement alone may be inaccurate for ascertaining the phenotype. The aim of this study was to evaluate the diagnostic performance of QT interval rate-dependence ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1053/euhj.1997.0730
更新日期:1998-01-01 00:00:00
abstract::To assess if cold-induced vasoconstriction may persist during exercise and contribute to the development of myocardial ischaemia, we studied 11 patients with exertional angina and angiographically proven coronary artery disease, in all cases involving the proximal portion of the left anterior descending artery. Great ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061847
更新日期:1985-03-01 00:00:00
abstract:AIMS:This prospective, randomized, controlled, multicentre study aimed to evaluate efficacy and safety of exercise training in patients with pulmonary arterial (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). METHODS AND RESULTS:For the first time a specialized PAH/CTEPH rehabilitation programme was im...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehaa696
更新日期:2020-11-24 00:00:00
abstract:BACKGROUND:In the acute phase of myocardial infarction (acute MI) marked endothelial damage occurs within the first 24h following thrombolysis with streptokinase. We investigated whether this is associated with a change in levels of vascular endothelial growth factor (VEGF, possibly marking angiogenesis) in the first 2...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1053/euhj.2002.3312
更新日期:2002-10-01 00:00:00
abstract:Aims:Fractional flow reserve (FFR) has proven to its prognostic and therapeutic value. However, the additive prognostic value of coronary flow reserve (CFR) remains unclear. This study sought to investigate the clinical utility of combined FFR and CFR measurements to predict outcomes. Methods and results:Using the pro...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1093/eurheartj/ehx139
更新日期:2017-07-01 00:00:00
abstract::Hypokalaemia commonly occurs in acute myocardial infarction (AMI) and may be caused by elevated serum levels of adrenaline, allegedly by beta 2-adrenergic mediated influx of potassium (K) into cells. We investigated the effect on serum K of intravenous acebutolol (a relatively beta 1-selective agent) in 50 patients wi...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a062036
更新日期:1986-02-01 00:00:00
abstract::Cardiac troponins (cTns) I and T have long been the most successful cardiac-specific circulating biomarkers in cardiovascular (CV) medicine, having changed dramatically the diagnosis of acute myocardial infarction, while being independent predictors of outcome in several cardiac conditions and non-cardiac conditions. ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehaa083
更新日期:2020-11-01 00:00:00
abstract:AIMS:To quantify the prevalence of coronary artery calcification (CAC) in relation to cardiovascular risk factors in marathon runners, and to study its role for myocardial damage and coronary events. METHODS AND RESULTS:In 108 apparently healthy male marathon runners aged >or=50 years, with >or=5 marathon competitions...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehn163
更新日期:2008-08-01 00:00:00
abstract::Re-entry was demonstrated as a self-perpetuating mechanism as early as 1906. It may lead to single-cycle electrocardiographic phenomena as well as reciprocating tachycardias. Factors favouring re-entry are as follows. Unidirectional or temporary local block of conduction, a mechanism always involved in initiation of r...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/5.suppl_b.19
更新日期:1984-09-01 00:00:00
abstract:AIMS:To investigate the association between neutrophil count, outcomes, and benefit of clopidogrel therapy in ST-elevation myocardial infarction (STEMI). METHODS AND RESULTS:Baseline neutrophil count was measured in 2865 patients in CLARITY-TIMI 28, a randomized trial of clopidogrel vs. placebo in STEMI patients under...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/eurheartj/ehn112
更新日期:2008-04-01 00:00:00
abstract:AIMS:Raised blood pressure (BP) is the biggest contributor to mortality and disease burden worldwide and fewer than half of those with hypertension are aware of it. May Measurement Month (MMM) is a global campaign set up in 2017, to raise awareness of high BP and as a pragmatic solution to a lack of formal screening wo...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehz300
更新日期:2019-07-01 00:00:00
abstract:AIMS:We analysed the contemporary incidence, outcomes, and predictors of heart failure (HF) and/or left ventricular systolic dysfunction (LVSD) before discharge in patients with acute myocardial infarction (MI). The baseline presence of HF or LVSD, or its development during hospitalisation, increases short- and long-te...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ehj.2004.08.006
更新日期:2004-11-01 00:00:00
abstract::Sudden cardiac death (SCD) accounts for approximately one-third of all deaths among patients with non-ischaemic cardiomyopathy (NICM). Implantable cardioverter-defibrillator (ICD) therapy has been the primary intervention for managing individuals at high risk for SCD. However, individual ICD trials in the NICM populat...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/ehy344
更新日期:2018-08-14 00:00:00
abstract:AIMS:Whether the association between fibrinogen and cardiovascular events reflects an association with advanced atherosclerosis in general, or rupture-prone plaques in particular, is unclear. We examined whether fibrinogen predicts incidence of ischaemic stroke, advanced atherosclerosis (measured as carotid artery sten...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1016/s0195-668x(02)00467-0
更新日期:2003-03-01 00:00:00
abstract::Morphological changes in human myocardium associated with pressure overload-induced left ventricular hypertrophy were studied in 22 normal and 21 hypertrophic hearts obtained at autopsy. Samples were obtained from the left lateral ventricular wall, half way between the apex and the base. Myocyte dimensions, polyploidi...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a059928
更新日期:1991-04-01 00:00:00
abstract::Clinical management of refractory heart failure remains challenging, with a high rate of rehospitalizations despite advances in medical and device therapy. Care can be provided in person, via telehomecare (by telephone), or telemonitoring, which involves wireless technology for remote follow-up. Telemonitoring wireles...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/ehr005
更新日期:2011-06-01 00:00:00
abstract:Aims:Pulmonary hypertension (PH) and pulmonary vascular disease (PVD) are common and associated with adverse outcomes in heart failure with preserved ejection fraction (HFpEF). Little is known about the impact of PVD on the pathophysiology of exercise intolerance. Methods and results:Heart failure with preserved eject...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehy331
更新日期:2018-08-07 00:00:00
abstract::Recently, bisoprolol has been investigated regarding its effects on exercise tolerance and the duration of action in patients with coronary heart disease (CHD) following single oral administration. It appears, however, that the extent of effects of 5 mg bisoprolol is not fully established yet. Therefore, the effects o...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/eurheartj/8.suppl_m.31
更新日期:1987-12-01 00:00:00
abstract::Hypercholesterolaemia is an important risk factor for cardiovascular disease. Both total and LDL cholesterol levels are three-fold higher at the end of the first year of life and about four-fold higher in adulthood compared with the neonatal period. In the USA, only 25% of infants are exclusively breastfed and simple ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehaa868
更新日期:2020-12-16 00:00:00
abstract:AIM:To compare patients treated for heart failure in relation to the management in general practices versus hospital admission. METHODS AND RESULTS:Twelve randomly selected general practices (GP) were screened for patients receiving ACE-inhibitor, digoxin, or loop diuretic treatment. The first 500 volunteers of 959 po...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ehj.2004.06.033
更新日期:2004-10-01 00:00:00
abstract:AIMS:Long-term randomized comparisons of percutaneous coronary intervention (PCI) to coronary artery bypass grafting (CABG) in left main coronary (LM) disease and/or three-vessel disease (3VD) patients have been limited. This analysis compares 3-year outcomes in LM and/or 3VD patients treated with CABG or PCI with TAXU...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/eurheartj/ehr213
更新日期:2011-09-01 00:00:00
abstract:Aims:There are limited data on the clinical implications of total physiologic atherosclerotic burden assessed by invasive physiologic studies in patients with coronary artery disease. We investigated the prognostic implications of total physiologic atherosclerotic burden assessed by total sum of fractional flow reserve...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehx458
更新日期:2018-03-14 00:00:00
abstract::Left ventricular performance at rest and during supine symptom-limited exercise was determined by radionuclide ventriculography (RNV) in 65 subjects of the age of 65 years or older. Eleven subjects had no evidence of coronary artery disease (CAD) by history or submaximal stress ECG. In this control group left ventricu...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/5.suppl_e.55
更新日期:1984-11-01 00:00:00
abstract:AIMS:To assess the long-term benefit-risk ratio of drug-eluting (DES) vs. bare-metal stents (BMS) relative to stent size. METHODS AND RESULTS:All 826 consecutive BASKET (BAsel Stent Kosten-Effektivitäts Trial) patients randomized 2:1 to DES vs. BMS were followed after 3 years. Data were analysed separately for patient...
journal_title:European heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1093/eurheartj/ehn516
更新日期:2009-01-01 00:00:00
abstract::Late potentials detected by the signal-averaged ECG (SAECG) identify post-infarction patients at risk from sustained ventricular tachycardia (VT) and sudden death. Hypertrophic cardiomyopathy (HCM) is also associated with increased risk of sudden death. In adults, episodes of non-sustained VT on ambulatory ECG monitor...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/14.7.941
更新日期:1993-07-01 00:00:00