A single dose of erythropoietin in ST-elevation myocardial infarction.

Abstract:

AIMS:Cardioprotective effects of erythropoietin (EPO) have been shown in experimental and smaller clinical studies. We performed a prospective, multicentre, randomized trial to assess the effects of a single high dose of EPO after primary coronary intervention (PCI) for an ST-elevation myocardial infarction (STEMI). Methods and results Patients with a successful PCI for a first STEMI were randomized to receive either standard medical care alone, or in combination with a single bolus with 60,000 IU i.v. of epoetin alfa within 3 h after PCI. Primary endpoint was left ventricular ejection fraction (LVEF) after 6 weeks, assessed by planar radionuclide ventriculography. Pre-specified secondary endpoints included enzymatic infarct size and major adverse cardiovascular events. A total of 529 patients were enrolled (EPO n = 263, control n = 266). At baseline (before EPO administration), groups were well-matched for all relevant characteristics. After a mean of 6.5 (± 2.0) weeks, LVEF was 0.53 (± 0.10) in the EPO group and 0.52 (± 0.11) in the control group (P = 0.41). Median area under the curve (inter-quartile range) after 72 h for creatinine kinase was 50 136 (28 212-76 664)U/L per 72 h in the EPO group and 53 510 (33 973-90 486)U/L per 72 h in the control group (P = 0.058). More major adverse cardiac events occurred in the control than in the EPO group (19 vs. 8; P = 0.032). Conclusion A single high dose of EPO after a successful PCI for a STEMI did not improve LVEF after 6 weeks. However, the use of EPO was related to less major adverse cardiovascular events and a favourable clinical safety profile. CLINICAL TRIAL REGISTRATION INFORMATION:NCT00449488; http://www.clinicaltrials.gov/ct2/show/NCT00449488?term=voors&rank=2.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Voors AA,Belonje AM,Zijlstra F,Hillege HL,Anker SD,Slart RH,Tio RA,van 't Hof A,Jukema JW,Peels HO,Henriques JP,Ten Berg JM,Vos J,van Gilst WH,van Veldhuisen DJ,HEBE III Investigators.

doi

10.1093/eurheartj/ehq304

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

2593-600

issue

21

eissn

0195-668X

issn

1522-9645

pii

ehq304

journal_volume

31

pub_type

杂志文章,多中心研究,随机对照试验
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    更新日期:2001-02-01 00:00:00

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    更新日期:2018-08-07 00:00:00

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    更新日期:2011-10-01 00:00:00

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    更新日期:2012-08-01 00:00:00

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    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

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    pub_type: 杂志文章

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    authors: Perdoncin E,Seth M,Dixon S,Cannon L,Khandelwal A,Riba A,David S,Wohns D,Gurm H

    更新日期:2016-06-21 00:00:00

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    更新日期:1987-06-01 00:00:00

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    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:

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    更新日期:1993-11-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2010-08-01 00:00:00

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    pub_type: 杂志文章,评审

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    更新日期:1995-12-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehq439

    authors: Stewart S,Carrington M,Pretorius S,Methusi P,Sliwa K

    更新日期:2011-02-01 00:00:00

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    pub_type: 临床试验,杂志文章

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    更新日期:2013-07-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060056

    authors: Legrand V,Mancini GB,Le Free MT,Vogel RA

    更新日期:1992-01-01 00:00:00

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    pub_type: 杂志文章,多中心研究

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    更新日期:2010-01-01 00:00:00

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    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehp109

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    更新日期:2009-06-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1093/eurheartj/14.2.150

    authors: Thomas SH,Crowther A

    更新日期:1993-02-01 00:00:00

  • Is pulsed Doppler echocardiography an adequate method to evaluate left ventricular function during filling in hypertensive patients?

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    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/11.suppl_g.79

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    更新日期:1990-11-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehr076

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    更新日期:2011-05-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1053/euhj.2000.2245

    authors: Tesson F,Sylvius N,Pilotto A,Dubosq-Bidot L,Peuchmaurd M,Bouchier C,Benaiche A,Mangin L,Charron P,Gavazzi A,Tavazzi L,Arbustini E,Komajda M

    更新日期:2000-11-01 00:00:00

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    更新日期:2013-04-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:2003-12-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a015008

    authors: Rogg H,de Gasparo M,Graedel E,Stulz P,Burkart F,Eberhard M,Erne P

    更新日期:1996-07-01 00:00:00

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    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:

    authors: Warner TD

    更新日期:1993-11-01 00:00:00

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    pub_type: 杂志文章

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    authors: Parati G,Pomidossi G,Grassi G,Gavazzi C,Ramirez A,Gregorini L,Mancia G

    更新日期:1983-07-01 00:00:00