A single dose of erythropoietin in ST-elevation myocardial infarction.

Abstract:

AIMS:Cardioprotective effects of erythropoietin (EPO) have been shown in experimental and smaller clinical studies. We performed a prospective, multicentre, randomized trial to assess the effects of a single high dose of EPO after primary coronary intervention (PCI) for an ST-elevation myocardial infarction (STEMI). Methods and results Patients with a successful PCI for a first STEMI were randomized to receive either standard medical care alone, or in combination with a single bolus with 60,000 IU i.v. of epoetin alfa within 3 h after PCI. Primary endpoint was left ventricular ejection fraction (LVEF) after 6 weeks, assessed by planar radionuclide ventriculography. Pre-specified secondary endpoints included enzymatic infarct size and major adverse cardiovascular events. A total of 529 patients were enrolled (EPO n = 263, control n = 266). At baseline (before EPO administration), groups were well-matched for all relevant characteristics. After a mean of 6.5 (± 2.0) weeks, LVEF was 0.53 (± 0.10) in the EPO group and 0.52 (± 0.11) in the control group (P = 0.41). Median area under the curve (inter-quartile range) after 72 h for creatinine kinase was 50 136 (28 212-76 664)U/L per 72 h in the EPO group and 53 510 (33 973-90 486)U/L per 72 h in the control group (P = 0.058). More major adverse cardiac events occurred in the control than in the EPO group (19 vs. 8; P = 0.032). Conclusion A single high dose of EPO after a successful PCI for a STEMI did not improve LVEF after 6 weeks. However, the use of EPO was related to less major adverse cardiovascular events and a favourable clinical safety profile. CLINICAL TRIAL REGISTRATION INFORMATION:NCT00449488; http://www.clinicaltrials.gov/ct2/show/NCT00449488?term=voors&rank=2.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Voors AA,Belonje AM,Zijlstra F,Hillege HL,Anker SD,Slart RH,Tio RA,van 't Hof A,Jukema JW,Peels HO,Henriques JP,Ten Berg JM,Vos J,van Gilst WH,van Veldhuisen DJ,HEBE III Investigators.

doi

10.1093/eurheartj/ehq304

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

2593-600

issue

21

eissn

0195-668X

issn

1522-9645

pii

ehq304

journal_volume

31

pub_type

杂志文章,多中心研究,随机对照试验
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    更新日期:1988-12-01 00:00:00

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    更新日期:2007-09-01 00:00:00

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    更新日期:2001-09-01 00:00:00

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    authors: Kaltenbach M

    更新日期:1987-09-01 00:00:00

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    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:1985-01-01 00:00:00

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    更新日期:2007-09-01 00:00:00

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    doi:10.1093/oxfordjournals.eurheartj.a060841

    authors: Hoffmann R,Lethen H,Flachskampf FA,Hanrath P

    更新日期:1995-12-01 00:00:00

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    pub_type: 杂志文章

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    authors: Ross SB,Jones K,Blanch B,Puranik R,McGeechan K,Barratt A,Semsarian C

    更新日期:2020-04-07 00:00:00

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    pub_type: 杂志文章

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    更新日期:1991-08-01 00:00:00

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    pub_type: 杂志文章,评审

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    pub_type: 杂志文章

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    更新日期:2011-03-01 00:00:00

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    pub_type: 杂志文章,多中心研究,随机对照试验

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    更新日期:2011-09-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:1993-02-01 00:00:00

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    更新日期:2006-02-01 00:00:00

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    doi:10.1093/oxfordjournals.eurheartj.a060150

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    doi:

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    pub_type: 临床试验,杂志文章,随机对照试验

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    authors: Bovy P,Juchmes J,Fossion A

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    pub_type: 杂志文章,meta分析

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