A single dose of erythropoietin in ST-elevation myocardial infarction.


AIMS:Cardioprotective effects of erythropoietin (EPO) have been shown in experimental and smaller clinical studies. We performed a prospective, multicentre, randomized trial to assess the effects of a single high dose of EPO after primary coronary intervention (PCI) for an ST-elevation myocardial infarction (STEMI). Methods and results Patients with a successful PCI for a first STEMI were randomized to receive either standard medical care alone, or in combination with a single bolus with 60,000 IU i.v. of epoetin alfa within 3 h after PCI. Primary endpoint was left ventricular ejection fraction (LVEF) after 6 weeks, assessed by planar radionuclide ventriculography. Pre-specified secondary endpoints included enzymatic infarct size and major adverse cardiovascular events. A total of 529 patients were enrolled (EPO n = 263, control n = 266). At baseline (before EPO administration), groups were well-matched for all relevant characteristics. After a mean of 6.5 (± 2.0) weeks, LVEF was 0.53 (± 0.10) in the EPO group and 0.52 (± 0.11) in the control group (P = 0.41). Median area under the curve (inter-quartile range) after 72 h for creatinine kinase was 50 136 (28 212-76 664)U/L per 72 h in the EPO group and 53 510 (33 973-90 486)U/L per 72 h in the control group (P = 0.058). More major adverse cardiac events occurred in the control than in the EPO group (19 vs. 8; P = 0.032). Conclusion A single high dose of EPO after a successful PCI for a STEMI did not improve LVEF after 6 weeks. However, the use of EPO was related to less major adverse cardiovascular events and a favourable clinical safety profile. CLINICAL TRIAL REGISTRATION INFORMATION:NCT00449488; http://www.clinicaltrials.gov/ct2/show/NCT00449488?term=voors&rank=2.


Eur Heart J


European heart journal


Voors AA,Belonje AM,Zijlstra F,Hillege HL,Anker SD,Slart RH,Tio RA,van 't Hof A,Jukema JW,Peels HO,Henriques JP,Ten Berg JM,Vos J,van Gilst WH,van Veldhuisen DJ,HEBE III Investigators.




Has Abstract


2010-11-01 00:00:00














  • Causes of late mortality with dual antiplatelet therapy after coronary stents.

    abstract:AIMS:In the dual antiplatelet therapy (DAPT) study, continued thienopyridine beyond 12 months after drug-eluting stent placement was associated with increased mortality compared with placebo. We sought to evaluate factors related to mortality in randomized patients receiving either drug-eluting or bare metal stents in ...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Mauri L,Elmariah S,Yeh RW,Cutlip DE,Steg PG,Windecker S,Wiviott SD,Cohen DJ,Massaro JM,D'Agostino RB Sr,Braunwald E,Kereiakes DJ,DAPT Study Investigators.

    更新日期:2016-01-21 00:00:00

  • Sex differences in survival after myocardial infarction in Sweden; data from the Swedish National Acute Myocardial Infarction Register.

    abstract:AIMS:Women, particularly younger women, hospitalized with acute myocardial infarction have been found to have poorer prognosis than men. A large proportion of deaths due to myocardial infarction, however, occur in the pre-hospital phase. We set out to analyse age-specific sex differences in survival after myocardial in...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Rosengren A,Spetz CL,Köster M,Hammar N,Alfredsson L,Rosén M

    更新日期:2001-02-01 00:00:00

  • Exercise unmasks distinct pathophysiologic features in heart failure with preserved ejection fraction and pulmonary vascular disease.

    abstract:Aims:Pulmonary hypertension (PH) and pulmonary vascular disease (PVD) are common and associated with adverse outcomes in heart failure with preserved ejection fraction (HFpEF). Little is known about the impact of PVD on the pathophysiology of exercise intolerance. Methods and results:Heart failure with preserved eject...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Gorter TM,Obokata M,Reddy YNV,Melenovsky V,Borlaug BA

    更新日期:2018-08-07 00:00:00

  • Biventricular pacing is superior to right ventricular pacing in bradycardia patients with preserved systolic function: 2-year results of the PACE trial.

    abstract:AIMS:The Pacing to Avoid Cardiac Enlargement (PACE) trial is a prospective, double-blinded, randomized, multicentre study that reported the superiority of biventricular (BiV) pacing to right ventricular apical (RVA) pacing in the prevention of left ventricular (LV) adverse remodelling and deterioration of systolic func...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Chan JY,Fang F,Zhang Q,Fung JW,Razali O,Azlan H,Lam KH,Chan HC,Yu CM

    更新日期:2011-10-01 00:00:00

  • Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study.

    abstract:AIMS:Anecdotal observations suggest that sub-clinical electrophysiological manifestations of arrhythmogenic right ventricular cardiomyopathy (ARVC) develop before detectable structural changes ensue on cardiac imaging. To test this hypothesis, we investigated a murine model with conditional cardiac genetic deletion of ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Gomes J,Finlay M,Ahmed AK,Ciaccio EJ,Asimaki A,Saffitz JE,Quarta G,Nobles M,Syrris P,Chaubey S,McKenna WJ,Tinker A,Lambiase PD

    更新日期:2012-08-01 00:00:00

  • Tissue plasminogen activator and other risk factors as predictors of cardiovascular events in patients with severe angina pectoris.

    abstract::The value of measurements of the fibrinolytic factors, tissue plasminogen activator and plasminogen activator inhibitor, for predicting death and non-fatal cardiovascular events was studied in 213 consecutive patients with angiographically documented coronary artery disease. In the course of 4-year follow-up, 47 patie...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Jansson JH,Nilsson TK,Olofsson BO

    更新日期:1991-02-01 00:00:00

  • Vericiguat in patients with worsening chronic heart failure and preserved ejection fraction: results of the SOluble guanylate Cyclase stimulatoR in heArT failurE patientS with PRESERVED EF (SOCRATES-PRESERVED) study.

    abstract:Aims:To determine tolerability and the optimal dose regimen of the soluble guanylate cyclase stimulator vericiguat in patients with chronic heart failure and preserved ejection fraction (HFpEF). Methods and results:SOCRATES-PRESERVED was a prospective, randomized, placebo-controlled double-blind, Phase 2b dose-finding...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Pieske B,Maggioni AP,Lam CSP,Pieske-Kraigher E,Filippatos G,Butler J,Ponikowski P,Shah SJ,Solomon SD,Scalise AV,Mueller K,Roessig L,Gheorghiade M

    更新日期:2017-04-14 00:00:00

  • The comparative efficacy of bivalirudin is markedly attenuated by use of radial access: insights from Blue Cross Blue Shield of Michigan Cardiovascular Consortium.

    abstract:AIM:The purpose of our study was to evaluate the relative impact of bivalirudin on bleeding outcomes associated with trans-radial interventions (TRI) in real world practice. METHODS AND RESULTS:Data for patients undergoing percutaneous coronary intervention (PCI) between January 2010 and March 2014 at the 47 hospitals...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Perdoncin E,Seth M,Dixon S,Cannon L,Khandelwal A,Riba A,David S,Wohns D,Gurm H

    更新日期:2016-06-21 00:00:00

  • Coronary angioplasty for treatment of unstable angina with transient marked ST-segment elevation.

    abstract::The immediate and short-term results of coronary angioplasty were analysed in 16 patients who presented with chest pain at rest associated with transient marked ST-segment elevation (greater than or equal to 0.5 mV). The number of in hospital ischaemic attacks was on average 2.8 (range 1-8). All patients had at least ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: de Feyter PJ,Serruys PW,van den Brand M,Soward A

    更新日期:1987-06-01 00:00:00

  • Myocardial ischaemia in the hypertensive patient--the role of coronary microcirculation abnormalities.

    abstract::Clinicians have long suspected that hypertrophied hearts have an inadequate coronary circulation. This clinical suspicion resulted from the observation that a large proportion of patients with left ventricular hypertrophy who have normal coronary arteriograms complain of angina and have ischaemia-like ST segment depre...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Kaski JC

    更新日期:1993-11-01 00:00:00

  • The diagnostic accuracy of 256-row computed tomographic angiography compared with invasive coronary angiography in patients with suspected coronary artery disease.

    abstract:AIMS:To assess the diagnostic accuracy of 256-row computed tomographic angiography (CTA) in patients with suspected coronary artery disease (CAD). Non-invasive imaging of the coronary artery by CTA has increasingly been used in recent years. The accuracy of 256-row CTA has not yet been studied. We sought to assess the ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Chao SP,Law WY,Kuo CJ,Hung HF,Cheng JJ,Lo HM,Shyu KG

    更新日期:2010-08-01 00:00:00

  • The 60 minutes myocardial infarction project. Treatment and clinical outcome of patients with acute myocardial infarction in Germany.

    abstract:AIMS:To describe patient characteristics, pre-hospital delay, treatment, complications and outcome in patients with acute myocardial infarction admitted to hospitals in Germany. METHODS AND RESULTS:The study was of prospective observational multicentre design. Those involved were consecutive patients with acute Q-wave...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究


    authors: Rustige J,Schiele R,Burczyk U,Koch A,Gottwik M,Neuhaus KL,Tebbe U,Uebis R,Senges J

    更新日期:1997-09-01 00:00:00

  • Aldosterone and heart failure.

    abstract::In untreated congestive heart failure, aldosterone plasma concentrations are elevated in proportion to the severity of the disease and are further increased by the use of diuretic treatment. Angiotensin II, plasma potassium concentration, and corticotropin are the major stimulators of aldosterone synthesis. During ang...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Zannad F

    更新日期:1995-12-01 00:00:00

  • Standing at the crossroads between new and historically prevalent heart disease: effects of migration and socio-economic factors in the Heart of Soweto cohort study.

    abstract:AIMS:Migration, urbanization, and change in socio-economic factors have potentially profound effects on heart disease in low-to-middle income countries. METHODS AND RESULTS:Chris Hani Baragwanath Hospital in Soweto, South Africa, provides health care to >1 million Africans. We systematically captured data from all de ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Stewart S,Carrington M,Pretorius S,Methusi P,Sliwa K

    更新日期:2011-02-01 00:00:00

  • Progression of aortic valve stenosis is associated with bone remodelling and secondary hyperparathyroidism in elderly patients--the COFRASA study.

    abstract:AIMS:There is currently no medical therapy that can prevent the progression of aortic valve stenosis (AS). Recent data highlight a possible relationship between bone metabolism and AS progression but prospective data are lacking. METHODS AND RESULTS:Serum levels of calcium, phosphorus, creatinine, 25-OH vitamin D, int...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章


    authors: Hekimian G,Boutten A,Flamant M,Duval X,Dehoux M,Benessiano J,Huart V,Dupré T,Berjeb N,Tubach F,Iung B,Vahanian A,Messika-Zeitoun D

    更新日期:2013-07-01 00:00:00

  • Clinical value of digital radiographic coronary quantification: comparison with visual assessment and coronary flow reserve.

    abstract::The value of quantitative assessment of coronary artery dimensions at the site of the most critical coronary stenosis was assessed by comparison with the correspondent reactive hyperaemia as measured by digital subtraction angiography and with the functional results. Thirty-two coronary lesions were analysed and flow ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Legrand V,Mancini GB,Le Free MT,Vogel RA

    更新日期:1992-01-01 00:00:00

  • Do systemic risk factors impact invasive findings from virtual histology? Insights from the international virtual histology registry.

    abstract:AIMS:Cardiovascular risk factors such as elevated serum lipid levels are important in the development of coronary atherosclerosis. Radiofrequency (RF) analysis of intravascular ultrasound [IVUS, Virtual histology (VH)] offers a unique tool to study the composition of coronary atherosclerotic plaque in vivo. We used dat...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究


    authors: Philipp S,Böse D,Wijns W,Marso SP,Schwartz RS,König A,Lerman A,Garcia-Garcia HM,Serruys PW,Erbel R

    更新日期:2010-01-01 00:00:00

  • Pulse pressure and risk of cardiovascular outcomes in patients with hypertension and coronary artery disease: an INternational VErapamil SR-trandolapril STudy (INVEST) analysis.

    abstract:AIM:The purpose of this study was to assess the relationship between pulse pressure (PP) and cardiovascular outcomes in a large, elderly, coronary artery disease (CAD) population with hypertension, and compare the predictive power of PP with other blood pressure measures. METHODS AND RESULTS:In INternational VErapamil...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验


    authors: Bangalore S,Messerli FH,Franklin SS,Mancia G,Champion A,Pepine CJ

    更新日期:2009-06-01 00:00:00

  • Impedance cardiography during exercise in patients with coronary heart disease.

    abstract::Impedance cardiography may be a simple way of assessing left ventricular performance during exercise. Measurements were therefore made during exercise testing in 102 consecutive male patients with suspected coronary disease prior to cardiac catheterization. These were subsequently divided into four groups: group A, no...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Thomas SH,Crowther A

    更新日期:1993-02-01 00:00:00

  • Is pulsed Doppler echocardiography an adequate method to evaluate left ventricular function during filling in hypertensive patients?

    abstract::Pulsed Doppler tracings of the mitral inflow are often proposed to describe left ventricular function during filling in hypertensive patients. The tracings are determined by the complex interaction of left atrial pressure and left ventricular relaxation, diastolic compliance and contractility of the left atrium. They ...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Diebold B,Cohen A,Zelinsky R,Raffoul H,Foucher A,Guermonprez JL,Peronneau P

    更新日期:1990-11-01 00:00:00

  • Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6).

    abstract:AIMS:Short QT syndrome (SQTS) is a genetically determined ion-channel disorder, which may cause malignant tachyarrhythmias and sudden cardiac death. Thus far, mutations in five different genes encoding potassium and calcium channel subunits have been reported. We present, for the first time, a novel loss-of-function mu...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Templin C,Ghadri JR,Rougier JS,Baumer A,Kaplan V,Albesa M,Sticht H,Rauch A,Puleo C,Hu D,Barajas-Martinez H,Antzelevitch C,Lüscher TF,Abriel H,Duru F

    更新日期:2011-05-01 00:00:00

  • Epidemiology of desmin and cardiac actin gene mutations in a european population of dilated cardiomyopathy.

    abstract:AIMS:Although dilated cardiomyopathy is the most frequent form of cardiomyopathy, its aetiology is still poorly understood. In about 20-30% of cases the disease is familial with a large predominance of autosomal dominant transmission. Ten different chromosomal loci have been described for autosomal dominant forms of di...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Tesson F,Sylvius N,Pilotto A,Dubosq-Bidot L,Peuchmaurd M,Bouchier C,Benaiche A,Mangin L,Charron P,Gavazzi A,Tavazzi L,Arbustini E,Komajda M

    更新日期:2000-11-01 00:00:00

  • Genes for blood pressure: an opportunity to understand hypertension.

    abstract::Hypertension (HTN) is quantitatively the major cardiovascular risk factor and responsible for ∼50% of cardiovascular morbidity and mortality. Blood pressure (BP) is also a classical complex genetic trait with heritability estimates of 30-50%. Although much is known about BP regulation, the intrinsic origin of essentia...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Ehret GB,Caulfield MJ

    更新日期:2013-04-01 00:00:00

  • Surgery of prosthetic valve thrombosis.

    abstract::From January 1978 to August 1983, 41 prosthetic valve thromboses in 34 patients were operated upon in our service. They comprised 15 aortic, 25 mitral and one tricuspid valve thromboses. Seven patients had massive thrombus with dysfunction of the prosthesis; others had small and disseminated thrombi on their prosthesi...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Pavie A,Bors V,Baud F,Gandjbakhch I,Cabrol C

    更新日期:1984-10-01 00:00:00

  • Exercise echocardiography performed early and late after percutaneous transluminal coronary angioplasty for prediction of restenosis.

    abstract::The purpose of this prospective study was to examine the incidence of exercise-induced ischaemia before and after angioplasty as well as 4 months later by exercise echocardiography, to evaluate the prognostic value of exercise echocardiography performed after angioplasty as regards the development of restenosis and to...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Hoffmann R,Lethen H,Flachskampf FA,Hanrath P

    更新日期:1995-12-01 00:00:00

  • A practical risk score for early prediction of neurological outcome after out-of-hospital cardiac arrest: MIRACLE2.

    abstract:AIMS:The purpose of this study was to develop a practical risk score to predict poor neurological outcome after out-of-hospital cardiac arrest (OOHCA) for use on arrival to a Heart Attack Centre. METHODS AND RESULTS:From May 2012 to December 2017, 1055 patients had OOHCA in our region, of whom 373 patients were includ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Pareek N,Kordis P,Beckley-Hoelscher N,Pimenta D,Kocjancic ST,Jazbec A,Nevett J,Fothergill R,Kalra S,Lockie T,Shah AM,Byrne J,Noc M,MacCarthy P

    更新日期:2020-12-14 00:00:00

  • Effects of growth hormone on circulating cytokine network, and left ventricular contractile performance and geometry in patients with idiopathic dilated cardiomyopathy.

    abstract:BACKGROUND:Recent experimental and clinical data indicate that abnormal central and peripheral immune reactions contribute to the progression of chronic heart failure, and that immunomodulation may be an important therapeutic approach in this syndrome. Aims We sought to study the effects of growth hormone (GH) administ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Adamopoulos S,Parissis JT,Paraskevaidis I,Karatzas D,Livanis E,Georgiadis M,Karavolias G,Mitropoulos D,Degiannis D,Kremastinos DT

    更新日期:2003-12-01 00:00:00

  • Angiotensin II-receptor subtypes in human atria and evidence for alterations in patients with cardiac dysfunction.

    abstract::Angiotensin II (AII) has been implicated as an important factor in the pathophysiology of heart diseases. Following the recent identification of two subtypes of the AII receptor in cardiac tissue of animals, we investigated the possible occurrence of these, or similar, subtypes in human atrial tissue. In right-atrial ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Rogg H,de Gasparo M,Graedel E,Stulz P,Burkart F,Eberhard M,Erne P

    更新日期:1996-07-01 00:00:00

  • Characterization of endothelin synthetic pathways and receptor subtypes: physiological and pathophysiological implications.

    abstract::The endothelins are a family of three widely expressed 21 amino acid peptides. Apart from the ability to constrict vascular smooth muscle, they have numerous other potent effects, from enhancing mitogenesis to influencing nervous function. The pathway of their production involves the initial synthesis of a predominant...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Warner TD

    更新日期:1993-11-01 00:00:00

  • Mechanisms of antihypertensive action of beta-adrenergic blocking drugs: evidence against potentiation of baroreflexes.

    abstract::A possibility that can be advanced to explain the antihypertensive effect of beta-blocking drugs is that they act through the baroreflex control of the cardiovascular system. In 38 essential hypertensive patients we measured 1) The lengthening and shortening in R-R interval caused by stimulation or deactivation of art...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Parati G,Pomidossi G,Grassi G,Gavazzi C,Ramirez A,Gregorini L,Mancia G

    更新日期:1983-07-01 00:00:00