Supplementation with vitamins C and E suppresses leukocyte oxygen free radical production in patients with myocardial infarction.

Abstract:

:Clinical studies suggest that neutrophil activation during acute myocardial infarction (MI) aggravates tissue injury. Activated neutrophils are an important source of oxygen free radicals (OFR), the injurious effects of which are counteracted by endogenous antioxidants. We have previously shown in healthy subjects that supplementation with antioxidant vitamins C and E suppresses OFR production by isolated neutrophils assayed by chemiluminescence (CL). The present study, performed in patients with acute MI aimed (1) to investigate the effect of vitamin C and E supplementation upon neutrophil OFR production and serum lipid peroxides, (2) to evaluate serum levels of vitamins C and E in the course of MI. Forty-five patients with acute MI were randomized to receive either conventional treatment only (control, n=22). All measurements were performed on the 1st and 14th day. Neutrophil OFR production assayed by CL decreased significantly in VIT patients (Wilcoxon test for paired data P<0.01, Chi square test P<0.01). In the control group, changes in OFR production were not significant. Serum lipid peroxides (measured as TBARS) increased in controls (P<0.05), but remained stable in VIT patients. Mean (+/-SE) serum ascorbic acid and tocopherol on the 1st day were 0.43 +/- 0.18% and 3.25 +/- 1.32 microM.M(-1) cholesterol, respectively, in all patients. On the 14th day in non-supplemented patients mean tocopherol was unchanged, whereas ascorbic acid increased significantly (0.63 +/- 0.24 mg%, P<0.01) suggesting that a low basal level was associated at least in part with the acute phase of the disease. An expected increase in serum vitamin levels occurred in VIT patients. In conclusion, supplementation with vitamins C and E suppresses neutrophil OFR production and lowers the marker of lipid peroxidation in patients with MI.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Herbaczyńska-Cedro K,K+osiewicz-Wasek B,Cedro K,Wasek W,Panczenko-Kresowska B,Wartanowicz M

doi

10.1093/oxfordjournals.eurheartj.a061045

subject

Has Abstract

pub_date

1995-08-01 00:00:00

pages

1044-9

issue

8

eissn

0195-668X

issn

1522-9645

journal_volume

16

pub_type

临床试验,杂志文章,随机对照试验
  • Extracellular matrix deposition in hypertensive hearts antifibrotic effects of ramipril.

    abstract::Hypertension induced in rats by suprarenal banding has a blood pressure elevating effect that is accompanied by the occurrence of cardiac hypertrophy and fibrosis. This phenomenon is already present at 2 weeks after banding and persists up to 1.5 years. The increase in cardiac weight is mostly due to the development o...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/16.suppl_c.33

    authors: Nagasawa K,Zimmermann R,Münkel B,Linz W,Schölkens B,Schaper J

    更新日期:1995-05-01 00:00:00

  • Non-invasive measurement of cardiac output by a carbon dioxide rebreathing method at rest and during exercise.

    abstract::Cardiac output was measured in 11 patients undergoing routine cardiac catheterization using a carbon dioxide rebreathing technique and compared with cardiac output measured by direct Fick and thermodilution. The carbon dioxide rebreathing technique gave consistently lower values for cardiac output than the other two m...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060504

    authors: Nugent AM,McParland J,McEneaney DJ,Steele I,Campbell NP,Stanford CF,Nicholls DP

    更新日期:1994-03-01 00:00:00

  • Delivery of care for adult patients with congenital heart disease in Europe: results from the Euro Heart Survey.

    abstract:AIMS:The increasing number of adults with congenital heart disease (CHD) has prompted the development of recommendations for the management of these patients and for the organization of their healthcare. The aim of this report is to describe the delivery of care in Europe for adults with congenital cardiac anomalies. ...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehi858

    authors: Moons P,Engelfriet P,Kaemmerer H,Meijboom FJ,Oechslin E,Mulder BJ,Expert Committee of Euro Heart Survey on Adult Congenital Heart Disease.

    更新日期:2006-06-01 00:00:00

  • Characterization of endothelin synthetic pathways and receptor subtypes: physiological and pathophysiological implications.

    abstract::The endothelins are a family of three widely expressed 21 amino acid peptides. Apart from the ability to constrict vascular smooth muscle, they have numerous other potent effects, from enhancing mitogenesis to influencing nervous function. The pathway of their production involves the initial synthesis of a predominant...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:

    authors: Warner TD

    更新日期:1993-11-01 00:00:00

  • Functional significance of angiotensin receptors in human myocardium. Significant differences between atrial and ventricular myocardium.

    abstract::We studied the effects of angiotensin (Ang) I and II in a variety of isolated human cardiac tissues contracting under physiological conditions (37 degrees C, 60 beats.min-1). Ang I and II consistently increased the peak developed force of human atrial muscles by 30-40%, an effect that was completely blocked by 10(-6) ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/15.suppl_d.88

    authors: Holubarsch C,Schmidt-Schweda S,Knorr A,Duis J,Pieske B,Ruf T,Fasol R,Hasenfuss G,Just H

    更新日期:1994-12-01 00:00:00

  • Accelerating impact of diabetes mellitus on mortality in the years following an acute myocardial infarction. TRACE Study Group. Trandolapril Cardiac Evaluation.

    abstract:AIMS:The development of risk associated with diabetes mellitus during long-term follow-up after a myocardial infarction has not been studied in detail. We have studied time-related changes of risk of death during 10 years of follow-up in a cohort of patients not treated with thrombolytic therapy (the Glostrup cohort) a...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1999.1530

    authors: Melchior T,Kober L,Madsen CR,Seibaek M,Jensen GV,Hildebrandt P,Torp-Pedersen C

    更新日期:1999-07-01 00:00:00

  • Management of atrial fibrillation in patients with heart failure.

    abstract::Atrial fibrillation (AF) and chronic heart failure (CHF) are two major and even growing cardiovascular conditions that often coexist. However, few data are available to guide treatment of AF in patients with CHF. This review summarizes current literature concerning the following topics: (i) prognostic relevance of AF ...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehm341

    authors: Neuberger HR,Mewis C,van Veldhuisen DJ,Schotten U,van Gelder IC,Allessie MA,Böhm M

    更新日期:2007-11-01 00:00:00

  • Continuation of antiarrhythmic drugs, or arrhythmia surgery after multiple drug failures. A randomized trial in the treatment of postinfarction ventricular tachycardia.

    abstract:BACKGROUND:In patients with postinfarction sustained ventricular tachycardia showing one or more antiarrhythmic drug failures, the question is how long to proceed with new drug trials before deciding to perform map-guided arrhythmia surgery. Although the techniques of this surgery developed rapidly in the early 1980s, ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a014910

    authors: van Hemel NM,Kingma JH,Defauw JJ,Hoogteijling-van Dusseldorp E,Kelder JC,Beukema WP,Vermeulen FE

    更新日期:1996-04-01 00:00:00

  • Cardiac resynchronization therapy non-responder to responder conversion rate in the more response to cardiac resynchronization therapy with MultiPoint Pacing (MORE-CRT MPP) study: results from Phase I.

    abstract:AIMS:To assess the impact of MultiPoint™ Pacing (MPP)-programmed according to the physician's discretion-in non-responders to standard biventricular pacing after 6 months. METHODS AND RESULTS:The study enrolled 1921 patients receiving a quadripolar cardiac resynchronization therapy (CRT) system capable of MPP™ therapy...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehz109

    authors: Leclercq C,Burri H,Curnis A,Delnoy PP,Rinaldi CA,Sperzel J,Lee K,Calò L,Vicentini A,Concha JF,Thibault B

    更新日期:2019-09-14 00:00:00

  • Effect of uniformly prolonged, and increased basic dispersion of repolarization on premature dispersion on ventricular surface in dogs: role of action potential duration and activation time differences.

    abstract::Strong experimental evidence links ventricular fibrillation to an increased temporal dispersion of the recovery of excitability. The effect of an overall prolongation of repolarization and an increased basic dispersion of repolarization on premature dispersion was studied on ventricular surface in 10 dogs. Our observa...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/6.suppl_d.15

    authors: Amlie JP,Kuo CS,Munakata K,Reddy PS,Surawicz B

    更新日期:1985-11-01 00:00:00

  • Acute effects of angiotensin-converting enzyme inhibition on coronary vasomotion in hypertensive patients.

    abstract::Coronary vasodilator responses to pharmacological (acetylcholine) and physiological (cold pressor test and flow dependent dilation) stimuli are impaired in hypertensive patients. The ability of angiotensin-converting enzyme inhibitors to restore normal coronary responses in hypertension and the potential mechanisms in...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:

    authors: Nitenberg A,Antony I

    更新日期:1998-09-01 00:00:00

  • Prevention of reentrant tachycardia by single beat or repetitive stimulation.

    abstract::Eleven patients with an atrioventricular accessory pathway were studied by programmed electrical stimulation to determine if reentrant tachycardia could be prevented by delivery of either a single atrial extrastimulus, applied at a critical time after the tachycardia-initiating stimulus (or stimuli), or a train of sti...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061756

    authors: Kuck KH,Kunze KP,Schlüter M,Bleifeld W

    更新日期:1985-01-01 00:00:00

  • Ischaemic threshold and haemodynamic changes during angina at rest in patients with unstable angina.

    abstract::To examine whether increases in heart rate might be a common trigger of angina at rest, changes in heart rate, blood pressure and rate-pressure product during pain were compared with the ischaemic threshold (heart rate with ST segment shift > = 1 mm), determined by atrial pacing, in 272 patients with unstable angina. ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/14.9.1170

    authors: Figueras J,Lidón RM,Serés L

    更新日期:1993-09-01 00:00:00

  • Impact of diabetes mellitus on long-term survival in patients with congestive heart failure.

    abstract:AIMS:To test the hypothesis that diabetic status may be used as a prognostic indicator in heart failure (HF) patients. METHODS AND RESULTS:We studied 1246 consecutive patients with left ventricular dysfunction. All patients had a cardiopulmonary exercise test and an echocardiogram. Cardiac catheterisation was systemat...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ehj.2004.01.010

    authors: De Groote P,Lamblin N,Mouquet F,Plichon D,McFadden E,Van Belle E,Bauters C

    更新日期:2004-04-01 00:00:00

  • Predictors of major bleeding in acute coronary syndromes: the Global Registry of Acute Coronary Events (GRACE).

    abstract:AIMS:There have been no large observational studies attempting to identify predictors of major bleeding in patients with acute coronary syndromes (ACS), particularly from a multinational perspective. The objective of our study was thus to develop a prediction rule for the identification of patients with ACS at higher r...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1016/s0195-668x(03)00485-8

    authors: Moscucci M,Fox KA,Cannon CP,Klein W,López-Sendón J,Montalescot G,White K,Goldberg RJ

    更新日期:2003-10-01 00:00:00

  • A comparison of single-lead atrial pacing with dual-chamber pacing in sick sinus syndrome.

    abstract:AIMS:In patients with sick sinus syndrome, bradycardia can be treated with a single-lead pacemaker or a dual-chamber pacemaker. Previous trials have revealed that pacing modes preserving atrio-ventricular synchrony are superior to single-lead ventricular pacing, but it remains unclear if there is any difference between...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehr022

    authors: Nielsen JC,Thomsen PE,Højberg S,Møller M,Vesterlund T,Dalsgaard D,Mortensen LS,Nielsen T,Asklund M,Friis EV,Christensen PD,Simonsen EH,Eriksen UH,Jensen GV,Svendsen JH,Toff WD,Healey JS,Andersen HR,DANPACE Investigato

    更新日期:2011-03-01 00:00:00

  • Reduced blood pressure-lowering effect of catheter-based renal denervation in patients with isolated systolic hypertension: data from SYMPLICITY HTN-3 and the Global SYMPLICITY Registry.

    abstract:Aims:Catheter-based renal artery denervation (RDN) has been shown to lower blood pressure (BP) in certain patients with uncontrolled hypertension. Isolated systolic hypertension (ISH) (systolic BP [SBP] ≥140 mmHg and diastolic BP <90 mmHg), characterized by increased vascular stiffness, is the predominant hypertensive ...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehw325

    authors: Mahfoud F,Bakris G,Bhatt DL,Esler M,Ewen S,Fahy M,Kandzari D,Kario K,Mancia G,Weber M,Böhm M

    更新日期:2017-01-07 00:00:00

  • Impact of restenosis 10 years after coronary angioplasty.

    abstract:AIMS:The aim of the study was to compare the 10-year follow-up results of patients with or without restenosis following single-vessel percutaneous transluminal coronary angioplasty (PTCA). METHODS AND RESULTS:A total of 313 patients with successful PTCA (> or = 20% reduction in luminal diameter narrowing without acute...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1997.0863

    authors: Espinola-Klein C,Rupprecht HJ,Erbel R,Nafe B,Brennecke R,Meyer J

    更新日期:1998-07-01 00:00:00

  • Left ventricular function as an end-point of thrombolytic therapy.

    abstract::For clinical prognosis, LV function is best described in terms of ejection fraction (EF) or end-systolic volume (ESV). Because deterioration of LV function is the most important adverse prognostic factor for patients after recovery from myocardial infarction, any agent which improves function should improve long-term ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/eurheartj/11.suppl_f.5

    authors: Norris RM,White HD

    更新日期:1990-08-01 00:00:00

  • Efficacy and safety of aspirin for primary prevention of cardiovascular events: a meta-analysis and trial sequential analysis of randomized controlled trials.

    abstract:AIMS:The role of aspirin in the primary prevention setting is continuously evolving. Recent randomized trials have challenged the role of aspirin in the primary prevention setting. METHODS AND RESULTS:Electronic databases were searched for randomized trials that compared aspirin vs. placebo (or control) in subjects wi...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析

    doi:10.1093/eurheartj/ehy813

    authors: Mahmoud AN,Gad MM,Elgendy AY,Elgendy IY,Bavry AA

    更新日期:2019-02-14 00:00:00

  • Cardiovascular critical event pathways for the progression of heart failure; a report from the ATLAS study.

    abstract:AIMS:To determine the sequence of critical cardiovascular events in the progression of heart failure, and whether aetiology or high-dose vs low-dose lisinopril affected these pathways. METHODS AND RESULTS:This was a post-hoc investigation of the ATLAS database, which comprised 3164 patients with chronic heart failure,...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2000.2570

    authors: Cleland JG,Thygesen K,Uretsky BF,Armstrong P,Horowitz JD,Massie B,Packer M,Poole-Wilson PA,Rydén L,ATLAS investigators.

    更新日期:2001-09-01 00:00:00

  • Community intervention to control plasma lipids.

    abstract::A necessary part of the strategy of modification of hypercholesterolaemia to prevent coronary heart disease (CHD) is the detection and treatment, by diet or by drugs, of high risk individuals. There are several drawbacks to this approach: (1) the cost of screening to find individuals at risk and of monitoring by physi...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/8.suppl_e.71

    authors: Marmot MG

    更新日期:1987-08-01 00:00:00

  • Nitric oxide for inhalation in ST-elevation myocardial infarction (NOMI): a multicentre, double-blind, randomized controlled trial.

    abstract:Aims:Inhalation of nitric oxide (iNO) during myocardial ischaemia and after reperfusion confers cardioprotection in preclinical studies via enhanced cyclic guanosine monophosphate (cGMP) signalling. We tested whether iNO reduces reperfusion injury in patients with ST-elevation myocardial infarction (STEMI; NCT01398384)...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehy232

    authors: Janssens SP,Bogaert J,Zalewski J,Toth A,Adriaenssens T,Belmans A,Bennett J,Claus P,Desmet W,Dubois C,Goetschalckx K,Sinnaeve P,Vandenberghe K,Vermeersch P,Lux A,Szelid Z,Durak M,Lech P,Zmudka K,Pokreisz P,Vranckx

    更新日期:2018-08-01 00:00:00

  • N-methylethanolamine attenuates cardiac fibrosis and improves diastolic function: inhibition of phospholipase D as a possible mechanism.

    abstract:AIM:Ventricular fibrosis is promoted by many effectors that chronically activate phospholipase D (PLD), and induces cardiac dysfunction and heart failure in cardiovascular diseases. Since ethanolamine is a product of PLD, we hypothesised that an administration of an analogue of ethanolamine, N-methylethanolamine (MEA),...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ehj.2004.05.003

    authors: Yamamoto K,Takahashi Y,Mano T,Sakata Y,Nishikawa N,Yoshida J,Oishi Y,Hori M,Miwa T,Inoue S,Masuyama T

    更新日期:2004-07-01 00:00:00

  • The long-term impact of the angiotensin-converting enzyme inhibitor trandolapril on mortality and hospital admissions in patients with left ventricular dysfunction after a myocardial infarction: follow-up to 12 years.

    abstract:AIMS:To investigate the long-term benefits of treatment with angiotensin-converting enzyme (ACE)-inhibitors in patients with myocardial infarction (MI) and left ventricular dysfunction (LVD). METHODS AND RESULTS:In the trandolapril cardiac evaluation (TRACE) study, 1749 patients with LVD (ejection fraction< or =35%) w...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehi021

    authors: Buch P,Rasmussen S,Abildstrom SZ,Køber L,Carlsen J,Torp-Pedersen C,TRACE investigators.

    更新日期:2005-01-01 00:00:00

  • The immediate effect of nitroglycerin on total body blood volume distribution in patients with congestive heart failure: a non-invasive study.

    abstract::The effect of sublingually administered nitroglycerin (0.5 mg) on distribution of blood volume in 16 patients with congestive heart failure (NYHA class II and III), randomly assigned to placebo (N = 8) or nitroglycerin (N = 8) was studied 20 minutes after in vivo labelling of red blood cells with 99m-Tc pertechnetate....

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a062177

    authors: Schneider AJ,Teule GJ,Groeneveld AB,Nauta J,Luth WJ,Thijs LG

    更新日期:1987-10-01 00:00:00

  • How critical is frame selection in quantitative coronary angiographic studies?

    abstract::To analyse quantitatively a coronary arterial segment from a cineangiogram, an end-diastolic or neighbouring frame is usually selected. However, different cardiologists may select other (although usually neighbouring) frames, even when the same selection criteria are followed. It is also possible that the frames are s...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/10.suppl_f.54

    authors: Reiber JH,van Eldik-Helleman P,Kooijman CJ,Tijssen JG,Serruys PW

    更新日期:1989-11-01 00:00:00

  • Prognostic value of left ventricular volume response during dobutamine stress echocardiography.

    abstract:AIMS:An abnormal left ventricular volume response during dobutamine echocardiography identified patients with severe coronary artery disease. The aim of the study was to assess the prognostic value of left ventricular volume changes during dobutamine stress echocardiography in 136 patients. METHODS AND RESULTS:Endpoin...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a015139

    authors: Coletta C,Galati A,Ricci R,Sestili A,Guagnozzi G,Re F,Ceci V

    更新日期:1997-10-01 00:00:00

  • Hypertrophic remodelling in cardiac regulatory myosin light chain (MYL2) founder mutation carriers.

    abstract:AIMS:Phenotypic heterogeneity and incomplete penetrance are common in patients with hypertrophic cardiomyopathy (HCM). We aim to improve the understanding in genotype-phenotype correlations in HCM, particularly the contribution of an MYL2 founder mutation and risk factors to left ventricular hypertrophic remodelling. ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehv522

    authors: Claes GR,van Tienen FH,Lindsey P,Krapels IP,Helderman-van den Enden AT,Hoos MB,Barrois YE,Janssen JW,Paulussen AD,Sels JW,Kuijpers SH,van Tintelen JP,van den Berg MP,Heesen WF,Garcia-Pavia P,Perrot A,Christiaans I,Salem

    更新日期:2016-06-14 00:00:00

  • Impact of early vs. late microvascular obstruction assessed by magnetic resonance imaging on long-term outcome after ST-elevation myocardial infarction: a comparison with traditional prognostic markers.

    abstract:AIMS:Early and late microvascular obstruction (MO) assessed by magnetic resonance imaging (MRI) are prognostic markers for combined clinical endpoints after ST-elevation myocardial infarction (STEMI). However, there are only limited data for hard endpoints and no consensus exists which of the two best predicts clinical...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehq247

    authors: de Waha S,Desch S,Eitel I,Fuernau G,Zachrau J,Leuschner A,Gutberlet M,Schuler G,Thiele H

    更新日期:2010-11-01 00:00:00