Drug- and disease-induced changes of human cardiac beta 1- and beta 2-adrenoceptors.

Abstract:

:Cardiac beta-adrenoceptor density and subtype distribution has been determined in different kinds of heart failure. A decrease in cardiac beta-adrenoceptor function appears to be a general phenomenon in all kinds of heart failure. However, cardiac beta 1- and beta 2-adrenoceptors seem to be differentially affected in different kinds of heart failure: while in end-stage idiopathic dilated cardiomyopathy the diminished cardiac beta-adrenoceptor function is due to a selective loss in beta 1-adrenoceptors, in mitral valve disease, tetralogy of Fallot and end-stage ischaemic cardiomyopathy it is characterized by a concomitant reduction in beta 1- and beta 2-adrenoceptors. Chronic treatment of heart failure patients with beta-adrenoceptor antagonists leads to an up-regulation of cardiac beta-adrenoceptors, but in a subtype-selective fashion: beta 1-selective antagonists increase only cardiac beta 1-adrenoceptors, whereas non-selective antagonists increase both beta 1- and beta 2-adrenoceptors. Such a (subtype-selective) 'recovery' of cardiac beta-adrenoceptors may be one reason for the beneficial effects of low-dose beta-adrenoceptor antagonist treatment in patients with severe heart failure.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Brodde OE,Zerkowski HR,Borst HG,Maier W,Michel MC

doi

10.1093/eurheartj/10.suppl_b.38

subject

Has Abstract

pub_date

1989-06-01 00:00:00

pages

38-44

eissn

0195-668X

issn

1522-9645

journal_volume

10 Suppl B

pub_type

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