Development of nitrate tolerance and usefulness of pulse therapy in a patient with vasospastic angina.

Abstract:

:In a 58-year-old man with vasospastic angina, we investigated the relationship between the antianginal effects of isosorbide dinitrate (ISDN) and plasma ISDN concentration. Despite adequate plasma ISDN levels, sustained therapy using ISDN tapes and oral ISDN (transcutaneously 160 mg and orally 100 mg ISDN day-1) failed to exhibit antianginal effects. However, pulse therapy using sublingual short-acting ISDN prevented anginal episodes, although the plasma ISDN levels were less than those of sustained therapy. Nitrate tolerance of the antianginal effects was avoided by creating an abrupt plasma ISDN concentration gradient using sublingual ISDN.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Hoshio A,Shirota K,Sawada Y,Doi T,Miyakoda H,Kotake H,Mashiba H

doi

10.1093/oxfordjournals.eurheartj.a060270

subject

Has Abstract

pub_date

1992-06-01 00:00:00

pages

853-5

issue

6

eissn

0195-668X

issn

1522-9645

journal_volume

13

pub_type

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