Absence of nitroglycerin-induced heparin resistance in healthy volunteers.

Abstract:

:A previously described nitroglycerin-induced heparin resistance could not be verified by in-vitro experiments or in a randomized, double-blind, crossover trial in healthy volunteers. A clinically relevant attenuation of the anticoagulant effect of a heparin bolus (40 U.kg-1) by a concomitant infusion of nitroglycerin (100 micrograms.min-1) was absent. Activated partial thromboplastin time was not significantly different under nitroglycerin infusion as compared to placebo after heparin injection. Concentrations and activities of antithrombin III and heparin cofactor II remained unchanged during nitroglycerin infusion. An interaction of these two frequently combined drugs in patients with active thromboembolic disease or after a prolonged concomitant intravenous administration cannot be ruled out. Since this is of clinical importance, further studies must clarify a possible nitroglycerin-induced heparin resistance.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Schoenenberger RA,Ménat L,Weiss P,Marbet GA,Ritz R

doi

10.1093/oxfordjournals.eurheartj.a060182

subject

Has Abstract

pub_date

1992-03-01 00:00:00

pages

411-4

issue

3

eissn

0195-668X

issn

1522-9645

journal_volume

13

pub_type

临床试验,杂志文章,随机对照试验
  • C-reactive protein: relation to total mortality, cardiovascular mortality and cardiovascular risk factors in men.

    abstract:BACKGROUND:There is much interest in reported associations between serum C-reactive protein and incident ischaemic heart disease. It is uncertain what this association represents. We aimed to assess the effect of confounding from a number of different sources in the Caerphilly Prospective Heart Disease Study and in par...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1999.1982

    authors: Mendall MA,Strachan DP,Butland BK,Ballam L,Morris J,Sweetnam PM,Elwood PC

    更新日期:2000-10-01 00:00:00

  • Infection and inflammation as risk factors for myocardial infarction.

    abstract::Recent studies have illustrated that in addition to the well known risk factors, such as lipoproteins, smoking, hypertension, there are others that cause atherosclerosis and myocardial infarction. Our knowledge of atherosclerotic lesions has increased. We now know that atherosclerotic changes are due to inflammatory c...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:

    authors: Nieminen MS,Mattila K,Valtonen V

    更新日期:1993-12-01 00:00:00

  • The Journal of Interventional Cardiology.

    abstract::In a small field with an abundance of journals, the Journal of Interventional Cardiology is carving out its niche with articles about technologies on the horizon. ...

    journal_title:European heart journal

    pub_type: 新闻

    doi:

    authors: Taylor J

    更新日期:2012-07-01 00:00:00

  • Comparative effects of beta-adrenergic blockade in systolic hypertension according to age.

    abstract::Hemodynamic variables were measured in 34 patients with isolated systolic hypertension before and after acute administration of propranolol. The patients were separated into two groups, those younger than and those older than 45 years of age, respectively. After drug administration, systolic pressure decreased signifi...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/4.suppl_g.51

    authors: Levenson J,Simon A,Maarek B,Totomoukouo J,Gitelman R,Bouthier J,Safar M

    更新日期:1983-11-01 00:00:00

  • Why use a nitrate in 1990?

    abstract::Nitrates are beneficial because they combine coronary and noncoronary effects. They have proven clinical efficacy, relieving symptoms and documented evidence of ischaemia. They can be given to patients by multiple routes and can be easily combined with other anti-ischaemic drugs including aspirin, heparin, calcium ant...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:

    authors: Conti CR

    更新日期:1991-05-01 00:00:00

  • Ventricular rate-adaptive pacing in the elderly.

    abstract::The role of ventricular rate-adaptive pacing (VVIR) in the elderly was investigated in 12 patients with a mean age of 85 +/- 2 years (range 75-95 years) with implanted activity-initiated VVIR pacemakers. Although four patients had significant extracardiac diseases, all were capable of independent walking and self care...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a060291

    authors: Lau CP,Wong CK,Tai YT,Fong PC,Li JP,Chung FL

    更新日期:1992-07-01 00:00:00

  • Big men and atrial fibrillation: effects of body size and weight gain on risk of atrial fibrillation in men.

    abstract:AIMS:Obesity is a recognized risk factor for atrial fibrillation (AF), partly because of the association between body mass index (BMI) and atrial volume. We aimed to determine whether other factors relating to body size were related to AF. METHODS AND RESULTS:Data were derived from a random population sample of 6903 m...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehp076

    authors: Rosengren A,Hauptman PJ,Lappas G,Olsson L,Wilhelmsen L,Swedberg K

    更新日期:2009-05-01 00:00:00

  • Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6).

    abstract:AIMS:Short QT syndrome (SQTS) is a genetically determined ion-channel disorder, which may cause malignant tachyarrhythmias and sudden cardiac death. Thus far, mutations in five different genes encoding potassium and calcium channel subunits have been reported. We present, for the first time, a novel loss-of-function mu...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehr076

    authors: Templin C,Ghadri JR,Rougier JS,Baumer A,Kaplan V,Albesa M,Sticht H,Rauch A,Puleo C,Hu D,Barajas-Martinez H,Antzelevitch C,Lüscher TF,Abriel H,Duru F

    更新日期:2011-05-01 00:00:00

  • Changes in sarcolemmal Ca entry and sarcoplasmic reticulum Ca content in ventricular myocytes from patients with end-stage heart failure following myocardial recovery after combined pharmacological and ventricular assist device therapy.

    abstract:AIMS:Support with left ventricular assist devices (LVAD) improves cardiac performance in patients with end-stage heart failure. In some cases this strategy, combined with pharmacological treatment, has led to a clinical improvement which remained after LVAD explant. This study defines changes in Ca handling at the cell...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1016/s0195-668x(03)00242-2

    authors: Terracciano CM,Harding SE,Adamson D,Koban M,Tansley P,Birks EJ,Barton PJ,Yacoub MH

    更新日期:2003-07-01 00:00:00

  • The effects of intraventricular gradients on left ventricular ejection dynamics.

    abstract::The generation of abnormal gradients between the apical cavity and the subaortic valvular region of the left ventricle in patients with hypertrophic cardiomyopathy (HCM) has traditionally been equated to a dynamic obstruction to left ventricular outflow. To examine this concept in more detail, left ventricular ejectio...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/4.suppl_f.23

    authors: Murgo JP,Alter BR,Dorethy JF,Altobelli SA,Craig WE,McGranahan GM Jr

    更新日期:1983-11-01 00:00:00

  • Left posterior hemiblock related to an interventricular septum tumour. First case in the literature.

    abstract::A 22-year-old man who engaged in intense and regular physical exercise complained of atypical chest pain. The only remarkable abnormality found in the routine clinical work-up was a left posterior hemiblock. The echocardiogram and the magnetic resonance imaging (MRI) study showed a tumour in the posterior and superior...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060217

    authors: Cola H,Hoffman R,Borrega NG,Lazzari JO

    更新日期:1992-04-01 00:00:00

  • Unprotected left main revascularization in patients with acute coronary syndromes.

    abstract:AIMS:In acute coronary syndromes (ACS), the optimal revascularization strategy for unprotected left main coronary disease (ULMCD) has been little studied. The objectives of the present study were to describe the practice of ULMCD revascularization in ACS patients and its evolution over an 8-year period, analyse the pro...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehp353

    authors: Montalescot G,Brieger D,Eagle KA,Anderson FA Jr,FitzGerald G,Lee MS,Steg PG,Avezum A,Goodman SG,Gore JM,GRACE Investigators.

    更新日期:2009-10-01 00:00:00

  • The relationship of autonomic function to age-related changes in left ventricular filling in normal subjects.

    abstract::Heart rate and age are independent variables associated with the pattern of normal left ventricular filling. Since heart rate variability also varies with age, the relationship between these and left ventricular filling in normal subjects was assessed. In 31 subjects (age range 21 to 71 years), power spectral analysis...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060800

    authors: Finkelhor RS,Karwa P,Kaufman ES,Bahler RC

    更新日期:1995-11-01 00:00:00

  • Left ventricular hypertrophy and geometry in a population sample of elderly males.

    abstract:BACKGROUND:Recent studies have shown that left ventricular geometric adaptation to hypertension is complex. The spectrum of geometric adaptations in a general population and its relationship to systolic and diastolic function has, however, not been investigated. OBJECTIVES AND METHODS:This echocardiographic and Dopple...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a014795

    authors: Andrén B,Lind L,Hedenstierna G,Lithell H

    更新日期:1996-12-01 00:00:00

  • Modulation of sympathetic control by ACE inhibitors.

    abstract::ACE inhibitors may influence the actual concentrations of the peptides angiotensin I, angiotensin II and bradykinin. Since all three peptides are able to modulate catecholamine release, a change in noradrenaline and adrenaline release should be expected when angiotensin I converting enzyme (kininase II) is inhibited. ...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:

    authors: Dominiak P

    更新日期:1993-11-01 00:00:00

  • Why does atrial fibrillation occur?

    abstract::Atrial fibrillation is often associated with atrial enlargement and stretch is known to cause electrophysiological alterations. Acute stretch may, depending on the moment at which it is applied, cause action potential shortening or induce both early and delayed afterdepolarizations which, when large enough, may initia...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/18.suppl_c.12

    authors: Janse MJ

    更新日期:1997-05-01 00:00:00

  • A frequent variant in the ABCA1 gene is associated with increased coronary heart disease risk and a better response to statin treatment in familial hypercholesterolemia patients.

    abstract:AIMS:Statins are essential for the reduction of risk of coronary heart disease (CHD) in familial hypercholesterolemia (FH). One of many genes influenced by statin treatment is the ATP-binding cassette transporter A1 (ABCA1) gene, which plays an important role in metabolism of high-density lipoprotein (HDL). The present...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehq208

    authors: Versmissen J,Oosterveer DM,Yazdanpanah M,Mulder M,Dehghan A,Defesche JC,Kastelein JJ,Sijbrands EJ

    更新日期:2011-02-01 00:00:00

  • Mitral valve repair for mitral insufficiency.

    abstract::Degenerative mitral valve disease has become the major cause of mitral regurgitation in North America; it is incumbent on surgeons to know repair techniques and to document their results. Fortunately, improvements in myocardial protection have been concurrent with the evolution of mitral valve repair in our country. T...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/12.suppl_b.30

    authors: Loop FD,Cosgrove DM,Stewart WJ

    更新日期:1991-07-01 00:00:00

  • Left atrial appendage closure: a percutaneous transcatheter approach for stroke prevention in atrial fibrillation.

    abstract::Atrial fibrillation is a frequent cause of stroke; in the elderly, more than 20% of strokes are attributed to this common arrhythmia. Anticoagulation with warfarin reduces the risk of stroke by ∼60%; however, a large proportion of patients with atrial fibrillation do not receive this treatment because of relative/abso...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehr393

    authors: Landmesser U,Holmes DR Jr

    更新日期:2012-03-01 00:00:00

  • Report of a European Society of Cardiology-European Association of Percutaneous Cardiovascular Interventions task force on the evaluation of coronary stents in Europe: executive summary.

    abstract::The evaluation for European Union market approval of coronary stents falls under the Medical Device Directive that was adopted in 1993. Specific requirements for the assessment of coronary stents are laid out in supplementary advisory documents. In response to a call by the European Commission to make recommendations ...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehv203

    authors: Byrne RA,Serruys PW,Baumbach A,Escaned J,Fajadet J,James S,Joner M,Oktay S,Jüni P,Kastrati A,Sianos G,Stefanini GG,Wijns W,Windecker S

    更新日期:2015-10-07 00:00:00

  • Radioiodinated beta-methyl phenyl fatty acids as potential tracers for myocardial imaging and metabolism.

    abstract::Since fatty acids provide the majority of myocardial energy requirements under basal conditions, an alteration in the global or regional utilization of these substrates may be an early indicator of myocardial disease. To determine areas of potential clinical utility of fatty acid imaging, we synthesized a radioiodinat...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/6.suppl_b.85

    authors: Livni E,Elmaleh DR,Barlai-Kovach MM,Goodman MM,Knapp FF Jr,Strauss HW

    更新日期:1985-08-01 00:00:00

  • Should we SHIFT our thinking about digoxin? Observations on ivabradine and heart rate reduction in heart failure.

    abstract:AIMS:The importance of heart rate in the pathophysiology of heart failure with reduced LVEF has recently attracted attention. In particular, the findings of the Systolic Heart failure treatment with the I(f) inhibitor ivabradine Trial (SHIFT) have put special emphasis on heart rate reduction with ivabradine for improve...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehs004

    authors: Castagno D,Petrie MC,Claggett B,McMurray J

    更新日期:2012-05-01 00:00:00

  • Silent ischaemia in asymptomatic 'healthy' individuals with coronary risk factors.

    abstract::On the occasion of a routine medical check-up 256 out of 1100 individuals with an accumulation of coronary risk factors were screened for silent myocardial ischaemia by exercise testing and Holter monitoring. Of these individuals 5.5% had a pathological exercise test, 7.4% had ischaemia-like events on the Holter ECG, ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/9.suppl_n.65

    authors: Osterspey A,Treis-Müller I,Günther H,Eggeling T,Siglow C,Gedicke V,Höpp H,Diewitz M,Osterhues H,Hilger HH

    更新日期:1988-12-01 00:00:00

  • 24-h ECG monitoring in patients with rheumatoid arthritis.

    abstract::Although the main cardiac complication in patients with rheumatoid arthritis is subclinical pericarditis, mononuclear cell infiltrations into myocardium may cause cardiac arrhythmias and conduction defects. In order to examine these problems we evaluated 70 patients (53 women and 17 men) aged 18-83 years (average 56.7...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061005

    authors: Tłustochowicz W,Piotrowicz R,Cwetsch A,Raczka A,Kramarz E,Nowak J

    更新日期:1995-06-01 00:00:00

  • Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society.

    abstract:AIMS:Homozygous familial hypercholesterolaemia (HoFH) is a rare life-threatening condition characterized by markedly elevated circulating levels of low-density lipoprotein cholesterol (LDL-C) and accelerated, premature atherosclerotic cardiovascular disease (ACVD). Given recent insights into the heterogeneity of geneti...

    journal_title:European heart journal

    pub_type: 共识发展会议,杂志文章

    doi:10.1093/eurheartj/ehu274

    authors: Cuchel M,Bruckert E,Ginsberg HN,Raal FJ,Santos RD,Hegele RA,Kuivenhoven JA,Nordestgaard BG,Descamps OS,Steinhagen-Thiessen E,Tybjærg-Hansen A,Watts GF,Averna M,Boileau C,Borén J,Catapano AL,Defesche JC,Hovingh GK,Hump

    更新日期:2014-08-21 00:00:00

  • Long-lasting sport practice and lone atrial fibrillation.

    abstract:AIMS:To analyse whether the proportion of patients with lone atrial fibrillation engaged in chronic sport practice was higher than that observed in the general population. METHODS AND RESULTS:The records of 1160 patients, seen at the arrhythmia outpatient clinic, were reviewed. A total of 70 patients (6%) suffered lon...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2001.2802

    authors: Mont L,Sambola A,Brugada J,Vacca M,Marrugat J,Elosua R,Paré C,Azqueta M,Sanz G

    更新日期:2002-03-01 00:00:00

  • Heart failure syndrome. Rationale for current drug treatment.

    abstract::In the initial phase of heart failure, cardiac output and pressure are maintained by increasing sympathetic drive and by cell hypertrophy. Elevated end-diastolic volume, a reduced ejection fraction and a higher filling pressure also occur. Only in more severe heart failure, when cardiac output cannot be maintained, do...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/16.suppl_f.2

    authors: Burkart F

    更新日期:1995-07-01 00:00:00

  • Sustained-release diltiazem versus metoprolol in stable angina pectoris.

    abstract::The efficacy of sustained-release diltiazem (diltiazem-SR) 120 mg b.i.d. was compared with metoprolol 100 mg b.i.d. in 12 patients with stable angina. Following a 1-week placebo period, patients received diltiazem-SR or metoprolol in two 3-week treatment periods, in a randomized double-blind crossover design. Total ex...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a059403

    authors: Posma JL,van Dijk RB,Lie KI

    更新日期:1989-10-01 00:00:00

  • High-sensitivity C-reactive protein: potential adjunct for risk stratification in patients with stable congestive heart failure.

    abstract:AIMS:To determine the potential adjunct of high-sensitivity (hs) C-reactive protein for risk stratification in patients with stable congestive heart failure (CHF). METHODS AND RESULTS:We studied 546 consecutive patients clinically stable with an ejection fraction <45% who were referred to our centre for evaluation of ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehi501

    authors: Lamblin N,Mouquet F,Hennache B,Dagorn J,Susen S,Bauters C,de Groote P

    更新日期:2005-11-01 00:00:00

  • The effect of statin therapy on heart failure events: a collaborative meta-analysis of unpublished data from major randomized trials.

    abstract:AIMS:The effect of statins on risk of heart failure (HF) hospitalization and HF death remains uncertain. We aimed to establish whether statins reduce major HF events. METHODS AND RESULTS:We searched Medline, EMBASE, and the Cochrane Central Register of Controlled Trials for randomized controlled endpoint statin trials...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/eurheartj/ehv072

    authors: Preiss D,Campbell RT,Murray HM,Ford I,Packard CJ,Sattar N,Rahimi K,Colhoun HM,Waters DD,LaRosa JC,Amarenco P,Pedersen TR,Tikkanen MJ,Koren MJ,Poulter NR,Sever PS,Ridker PM,MacFadyen JG,Solomon SD,Davis BR,Simpson

    更新日期:2015-06-21 00:00:00