Combination reperfusion therapy with abciximab and reduced dose reteplase: results from TIMI 14. The Thrombolysis in Myocardial Infarction (TIMI) 14 Investigators.

abstract：AIMS:The presence of residual thrombus following fibrinolytic therapy for ST-segment elevation myocardial infarction (STEMI) may predispose to greater embolization and microvascular dysfunction. METHODS AND RESULTS:We hypothesized that even in the presence of a patent epicardial artery, residual thrombus would be asso...

journal_title：European heart journal

authors： Kirtane AJ,Vafai JJ,Murphy SA,Aroesty JM,Sabatine MS,Cannon CP,Gibson CM,TIMI Study Group.

更新日期：2006-09-01 00:00:00

abstract：AIMS:To evaluate the effects of cardiac resynchronization therapy (CRT) on long-term survival of patients without baseline left ventricular (LV) mechanical dyssynchrony. METHODS AND RESULTS:A total of 290 heart failure patients (age 67 ± 10 years, 77% males) without significant baseline LV dyssynchrony (<60 ms as asse...

journal_title：European heart journal

authors： Auger D,Bleeker GB,Bertini M,Ewe SH,van Bommel RJ,Witkowski TG,Ng AC,van Erven L,Schalij MJ,Bax JJ,Delgado V

更新日期：2012-04-01 00:00:00

abstract：AIMS:Statins are essential for the reduction of risk of coronary heart disease (CHD) in familial hypercholesterolemia (FH). One of many genes influenced by statin treatment is the ATP-binding cassette transporter A1 (ABCA1) gene, which plays an important role in metabolism of high-density lipoprotein (HDL). The present...

journal_title：European heart journal

authors： Versmissen J,Oosterveer DM,Yazdanpanah M,Mulder M,Dehghan A,Defesche JC,Kastelein JJ,Sijbrands EJ

更新日期：2011-02-01 00:00:00

abstract：:The diagnosis and management of patients with renovascular disease and hypertension continue to elude healthcare providers. The advent of novel imaging and interventional techniques, and increased understanding of the pathways leading to irreversible renal injury and renovascular hypertension, have ushered in commenda...

journal_title：European heart journal

authors： Baumgartner I,Lerman LO

更新日期：2011-07-01 00:00:00

abstract：:Although indicated by several experimental studies, the presence of a renin-angiotensin system has not been demonstrated in the human heart. The influence of a local renin-angiotensin system on the coronary vessels may be difficult to establish after oral or intravenous administration of an angiotensin converting-enzy...

journal_title：European heart journal

authors： Foult JM,Tavolaro O,Antony I,Nitenberg A

更新日期：1989-11-01 00:00:00

abstract：:Nucleic acid-based therapeutics are currently developed at large scale for prevention and management of cardiovascular diseases (CVDs), since: (i) genetic studies have highlighted novel therapeutic targets suggested to be causal for CVD; (ii) there is a substantial recent progress in delivery, efficacy, and safety of ...

journal_title：European heart journal

authors： Landmesser U,Poller W,Tsimikas S,Most P,Paneni F,Lüscher TF

更新日期：2020-10-21 00:00:00

abstract：AIMS:in hypertrophic cardiomyopathy (HCM), the following five risk factors have a major role in the primary prevention of sudden death (SD): family history of SD (FHSD), syncope, massive wall thickness (MWTh) >30 mm, non-sustained ventricular tachycardia (nsVT) in Holter monitoring of electrocardiography, and abnormal ...

journal_title：European heart journal

authors： Dimitrow PP,Chojnowska L,Rudzinski T,Piotrowski W,Ziólkowska L,Wojtarowicz A,Wycisk A,Dabrowska-Kugacka A,Nowalany-Kozielska E,Sobkowicz B,Wróbel W,Aleszewicz-Baranowska J,Rynkiewicz A,Loboz-Grudzien K,Marchel M,Wysokinski

更新日期：2010-12-01 00:00:00

abstract：AIMS:Clonal haematopoiesis of indeterminate potential (CHIP), defined as the presence of an expanded somatic blood cell clone without other haematological abnormalities, was recently shown to increase with age and is associated with coronary artery disease and calcification. The most commonly mutated CHIP genes, DNMT3A...

journal_title：European heart journal

authors： Mas-Peiro S,Hoffmann J,Fichtlscherer S,Dorsheimer L,Rieger MA,Dimmeler S,Vasa-Nicotera M,Zeiher AM

更新日期：2020-02-21 00:00:00

abstract：:Previous evidence indicates that cells generate molecules that alter transcription in response to stress. Accordingly, we conducted preliminary experiments to characterize these molecules. Extracts were prepared from normal and experimental canine hearts in which a 100 mmHg gradient was created across the ascending ao...

journal_title：European heart journal

authors： Hammond GL,Lai YK,Markert CL

更新日期：1984-12-01 00:00:00

abstract：:The optimal length of clopidogrel therapy in patients with acute coronary syndromes or in those who have undergone percutaneous coronary intervention (PCI) remains controversial. We therefore sought to determine the risk of both perioperative and premature discontinuation of clopidogrel. PubMed and EMBASE databases we...

journal_title：European heart journal

authors： Gaglia MA Jr,Waksman R

更新日期：2011-10-01 00:00:00

abstract：:Between 1968 and 1984, 78 patients (mean age 43, range 14 to 65 years) underwent combined aortic, mitral and tricuspid surgery (22 triple valve replacements, 56 aortic valve replacements with tricuspid conservative surgery and mitral valve replacement (N = 48), or commissuroplasty (N = 8). Pre-operative consequences o...

journal_title：European heart journal

authors： Michel PL,Houdart E,Ghanem G,Badaoui G,Hage A,Acar J

更新日期：1987-05-01 00:00:00

abstract：AIMS:Inhibition of nitric oxide synthesis causes a decrease in the basal diameter of normal distal epicardial coronary arteries in normal subjects. The effects of inhibition of nitric oxide in atheromatous coronary arteries is unknown. This study assessed the effects of the inhibition of nitric oxide synthesis in epica...

journal_title：European heart journal

authors： Tousoulis D,Davies GJ,Tentolouris C,Crake T,Lefroy DC,Toutouzas P

更新日期：1997-04-01 00:00:00

abstract：AIMS:The aim of this study involves the early identification, among apparently healthy individuals, of those at high risk for sudden cardiac death. We tested the hypothesis that individuals who respond to mild mental stress in preparation for exercise test with the largest heart rate increases might be at highest risk....

journal_title：European heart journal

authors： Jouven X,Schwartz PJ,Escolano S,Straczek C,Tafflet M,Desnos M,Empana JP,Ducimetière P

更新日期：2009-07-01 00:00:00

abstract：AIMS:Elevated blood pressure (EBP) is the most prevalent and potentially modifiable risk factor for AF, yet little is known of its atrial effects. We aimed to characterize the atrial electrical and structural changes in a chronic ovine model of EBP after prenatal corticosteroid exposure. METHODS AND RESULTS:Twelve she...

journal_title：European heart journal

authors： Kistler PM,Sanders P,Dodic M,Spence SJ,Samuel CS,Zhao C,Charles JA,Edwards GA,Kalman JM

更新日期：2006-12-01 00:00:00

abstract：:Contradictory two-dimensional echocardiographic findings have been reported in relation to the role of prolapse of the mitral valve and lack of systolic leaflet coaptation in mitral regurgitation secondary to coronary heart disease. A prospective study of 22 patients with chronic coronary heart disease and mitral regu...

journal_title：European heart journal

authors： Ballester M,Tasca R,Marin L,Rees S,Rickards A,McDonald L

更新日期：1983-08-01 00:00:00

abstract：:The long-term efficacy of transdermal nitrate therapy, in particular the ability of a single patch to provide 24 h prophylaxis against angina, has been questioned. Two mechanisms have been suggested for this loss of effect: the development of pharmacological tolerance, and premature patch exhaustion. This study was de...

journal_title：European heart journal

authors： James MA,Papouchado M,Jones JV

更新日期：1991-12-01 00:00:00

abstract：AIMS:Increasing evidence supports a role for inflammation in promoting atrial fibrillation (AF) and statins have anti-inflammatory effects that may be relevant for the prevention of AF. However, studies of statin therapy and incident AF have yielded mixed results and not focused on individuals with an underlying pro-in...

journal_title：European heart journal

authors： Peña JM,MacFadyen J,Glynn RJ,Ridker PM

更新日期：2012-02-01 00:00:00

abstract：:After single chamber atrial pacemaker implantation, serial electrophysiologic studies were performed noninvasively at intervals of 3 months over a total period of 3 years in 24 patients with symptomatic sinus node dysfunction. All patients underwent invasive electrophysiologic studies before pacemaker implantation and...

journal_title：European heart journal

authors： van Mechelen R,Segers A,Hagemeijer F

更新日期：1984-08-01 00:00:00

abstract：:Oxygen supplementation is a standard treatment for all patients who present with acute coronary syndrome, regardless of oxygen saturation levels. Most of the data regarding the function of oxygen in myocardial infarction is based on a limited number of basic and clinical studies. We performed a systematic literature r...

journal_title：European heart journal

authors： Shuvy M,Atar D,Gabriel Steg P,Halvorsen S,Jolly S,Yusuf S,Lotan C

更新日期：2013-06-01 00:00:00

abstract：:Earlier studies have shown that return to work following PTCA is frequent; however PTCA is now performed in patients with more extensive coronary artery disease. The present study was designed to compare the vocational outcome of patients who underwent PTCA in 1980-1982 with that of patients who underwent the procedur...

journal_title：European heart journal

authors： Danchin N,Juilliere Y,Selton-Suty C,Vaillant G,Pernot C,Gilgenkrantz JM,Villemot JP,Mathieu P,Cherrier F

更新日期：1989-12-01 00:00:00

abstract：:At the moment, the most reliable method for diagnosing right ventricular dysplasia is considered to be angiography. Morphological alterations such as the presence of akinetic/dyskinetic areas, aneurysmatic dilatations and deep anteroapical fissuring, not necessarily associated with an increase in ventricular volume, a...

journal_title：European heart journal

authors： Chiddo A,Locuratolo N,Gaglione A,Bortone A,Troito G,Musci S,Grimaldi N,Rizzon P

更新日期：1989-09-01 00:00:00

abstract：:An elevation of the cardiopulmonary baroreflex control of the forearm vascular resistances due to an impairment of the arterial baroreflex has been postulated in borderline hypertension. The purpose of the study is to verify this hypothesis. The arterial baroreflex sensitivity, measured by the phenylephrine method is ...

journal_title：European heart journal

authors： Bovy P,Juchmes J,Fossion A

更新日期：1983-11-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) can be a rapidly progressive disorder and is associated with high rate of mortality, despite medical intervention. With the availability of effective therapy, early disease detection is an important strategic objective to improve treatment outcomes. Resting echocardiography is cur...

journal_title：European heart journal

authors： Lau EM,Manes A,Celermajer DS,Galiè N

更新日期：2011-10-01 00:00:00

abstract：AIMS:To evaluate the accuracy of echocardiography in conjunction with quantitative high-dose dipyridamole technetium-99m sestamibi tomography (SPECT) in detecting coronary allograft vasculopathy. METHODS AND RESULTS:Seventy-eight consecutive heart transplant recipients underwent echocardiography while at rest and high...

journal_title：European heart journal

authors： Ciliberto GR,Ruffini L,Mangiavacchi M,Parolini M,Sara R,Massa D,De Maria R,Gronda E,Vitali E,Parodi O

更新日期：2001-06-01 00:00:00

abstract：AIMS:We sought to define the mechanisms and correlates of leptin's vascular actions in humans with coronary artery disease. METHODS AND RESULTS:In 131 patients (age 65.7+/-0.7 years mean+/-SEM), ex vivo vascular reactivity to leptin (10(-13)-10(-7) M) was assessed in saphenous vein (SV) rings. Leptin led to SV relaxat...

journal_title：European heart journal

authors： Momin AU,Melikian N,Shah AM,Grieve DJ,Wheatcroft SB,John L,El Gamel A,Desai JB,Nelson T,Driver C,Sherwood RA,Kearney MT

更新日期：2006-10-01 00:00:00

abstract：AIMS:Quantitative analysis of rest-stress myocardial perfusion magnetic resonance imaging (MRI) can provide assessments of regional myocardial perfusion reserve (MPR). The purpose of this study was to compare regional MPR determined by myocardial perfusion MRI with coronary flow reserve (CFR) by intracoronary Doppler f...

journal_title：European heart journal

authors： Kurita T,Sakuma H,Onishi K,Ishida M,Kitagawa K,Yamanaka T,Tanigawa T,Kitamura T,Takeda K,Ito M

更新日期：2009-02-01 00:00:00

abstract：:In the blood-vessel wall, the endothelium plays a key functional role by generating several substances that modulate vascular smooth muscle tone, as well as growth, and platelet function. This review focuses on the role of the endothelial L-arginine/nitric oxide signal transduction pathway in the maintenance of vascul...

journal_title：European heart journal

authors： Cosentino F,Lüscher TF

更新日期：1995-11-01 00:00:00

abstract：:The effect of diuretic dose on the haemodynamic response to captopril was assessed in nine patients with chronic cardiac failure. Each patient was given an intravenous dose of captopril while maintained on (a) a low dose diuretic regime, and (b) a high dose diuretic regime. Activity of the renin angiotensin aldosteron...

journal_title：European heart journal

authors： Flapan AD,Davies E,Williams BC,Shaw TR,Edwards CR

更新日期：1992-07-01 00:00:00

abstract：Aims:The differential impact on ischaemic and bleeding events of the type of drug-eluting stent [durable polymer stents [DES] vs. biodegradable polymer stents vs. bioresorbable scaffolds (BRS)] and length of dual antiplatelet therapy (DAPT) remains to be defined. Methods and results:Randomized controlled trials compar...

journal_title：European heart journal

authors： D'Ascenzo F,Iannaccone M,Saint-Hilary G,Bertaina M,Schulz-Schüpke S,Wahn Lee C,Chieffo A,Helft G,Gili S,Barbero U,Biondi Zoccai G,Moretti C,Ugo F,D'Amico M,Garbo R,Stone G,Rettegno S,Omedè P,Conrotto F,Templin C,C

更新日期：2017-11-07 00:00:00

abstract：AIMS:Genome-wide association studies have previously identified INSIG2 as a candidate gene for plasma low-density lipoprotein cholesterol (LDL-c). However, we suspect a role for CCDC93 in the same locus because of its involvement in the recycling of the LDL-receptor (LDLR). METHODS AND RESULTS:Characterization of the ...

journal_title：European heart journal

authors： Rimbert A,Dalila N,Wolters JC,Huijkman N,Smit M,Kloosterhuis N,Riemsma M,van der Veen Y,Singla A,van Dijk F,Biobank-Based Integrative Omics Studies Consortium.,Frikke-Schmidt R,Burstein E,Tybjærg-Hansen A,van de Sluis B,Kui

更新日期：2020-03-01 00:00:00