Prevalence and mechanism of streptokinase-induced platelet stimulation. Effect of acetylsalicylic acid.

Abstract:

:It was recently shown that streptokinase may induce clot formation in vivo by immunoglobulin G mediated platelet stimulation. We evaluated the in vitro effect of streptokinase on platelet function in 103 subjects, of whom 52 were < or = 30 years and 51 were > or = 50 years old. Although streptokinase inhibited platelet aggregation in the majority of cases, in nine the threshold concentration of ADP required to induce irreversible aggregation decreased with streptokinase (1 million Units. l-1) by 30% or more. This observation was confirmed in five of the nine by repeated measurements indicating reproducible streptokinase-induced platelet stimulation. Among the five, two were < or = 30, and three were > or = 50 years old. In none of the five subjects did the radio allergo sorbent test detect type E immunoglobulins directed against streptokinase in the serum. In contrast, in four of the five subjects, streptokinase-induced platelet hyperaggregability was suppressed by addition of goat antibodies against human immunoglobulin G, or F(ab')2-fragments of such antibodies. Acetylsalicylic acid did not prevent streptokinase-induced platelet stimulation, but in three of five cases, led to an increase in the control threshold concentration for ADP, so that after the decrease induced by streptokinase the threshold concentration for ADP was in the same range as before acetylsalicylic acid and streptokinase administration. Thus, streptokinase led to an inhibition of platelet aggregation in the majority of subjects evaluated. In a minority of five out of 103, however, streptokinase reproducibly caused platelet stimulation, presumably mediated by immunoglobulin G.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Eur Heart J

journal_title

European heart journal

authors

Terres W,Krüger K,Bleifeld W

doi

10.1093/oxfordjournals.eurheartj.a060094

subject

Has Abstract

pub_date

1992-11-01 00:00:00

pages

1514-20

issue

11

eissn

0195-668X

issn

1522-9645

journal_volume

13

pub_type

杂志文章
  • Combination reperfusion therapy with abciximab and reduced dose reteplase: results from TIMI 14. The Thrombolysis in Myocardial Infarction (TIMI) 14 Investigators.

    abstract::Aims Abciximab has previously been shown to enhance thrombolysis and improve myocardial perfusion when combined with reduced doses of alteplase. The purpose of the reteplase phase of TIMI 14 was to evaluate the effects of abciximab when used in combination with a reduced dose of reteplase for ST-elevation myocardial i...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1053/euhj.2000.2243

    authors: Antman EM,Gibson CM,de Lemos JA,Giugliano RP,McCabe CH,Coussement P,Menown I,Nienaber CA,Rehders TC,Frey MJ,Van der Wieken R,Andresen D,Scherer J,Anderson K,Van de Werf F,Braunwald E

    更新日期:2000-12-01 00:00:00

  • Weight gain after smoking cessation does not modify its protective effect on myocardial infarction and stroke: evidence from a cohort study of men.

    abstract:Aims:This study aimed to investigate the association between smoking cessation, post-cessation body mass index (BMI) change and risk of myocardial infarction (MI) and stroke in men. Methods and results:A prospective cohort study using the National Health Insurance Service (NHIS) data set collected from 2002 to 2013 wa...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehx761

    authors: Kim K,Park SM,Lee K

    更新日期:2018-05-01 00:00:00

  • International Expert Consensus Document on Takotsubo Syndrome (Part II): Diagnostic Workup, Outcome, and Management.

    abstract::The clinical expert consensus statement on takotsubo syndrome (TTS) part II focuses on the diagnostic workup, outcome, and management. The recommendations are based on interpretation of the limited clinical trial data currently available and experience of international TTS experts. It summarizes the diagnostic approac...

    journal_title:European heart journal

    pub_type: 共识发展会议,杂志文章

    doi:10.1093/eurheartj/ehy077

    authors: Ghadri JR,Wittstein IS,Prasad A,Sharkey S,Dote K,Akashi YJ,Cammann VL,Crea F,Galiuto L,Desmet W,Yoshida T,Manfredini R,Eitel I,Kosuge M,Nef HM,Deshmukh A,Lerman A,Bossone E,Citro R,Ueyama T,Corrado D,Kurisu S,

    更新日期:2018-06-07 00:00:00

  • Valve replacement in octogenarians: increased early mortality but good long-term result.

    abstract::Between January 1983 and December 1990, 20 patients aged 80 years or older underwent valvular surgery. The patients' ages varied from 80 to 87 years (mean, 82 +/- 1.5 years). The indication for operation was aortic stenosis in 19 patients, and mitral insufficiency after previous mitral valve replacement with a biopros...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060205

    authors: Pasic M,Carrel T,Laske A,Bauer E,Turina J,Jenni R,von Segesser L,Turina M

    更新日期:1992-04-01 00:00:00

  • Myocardial hydatid cyst ruptured into the pericardium: cross-sectional echocardiographic study and surgical treatment.

    abstract::We describe a patient with a large intramyocardial hydatid cyst lying in the postero-lateral segment of the left ventricle near the atrioventricular groove level which ruptured into the pericardial sac, resulting in cardiac tamponade. Cross-sectional echocardiographic examination from a modified four-chamber apical vi...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/9.7.819

    authors: De Martini M,Nador F,Binda A,Arpesani A,Odero A,Lotto A

    更新日期:1988-07-01 00:00:00

  • Anomalous coronary arteries coursing between the aorta and pulmonary trunk: clinical indications for coronary artery bypass.

    abstract::Coronary arteries of anomalous origin with subsequent coursing between the aorta and pulmonary trunk can cause ischaemia, infarction or sudden death. However, reports of surgical correction are sparse due to the rarity of ante-mortem diagnosis. We report two cases in which symptoms were related to anomalous origin of ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/12.7.832

    authors: Thomas D,Salloum J,Montalescot G,Drobinski G,Artigou JY,Grosgogeat Y

    更新日期:1991-07-01 00:00:00

  • Clopidogrel pre-treatment in stable angina: for all patients > 6 h before elective coronary angiography or only for angiographically selected patients a few minutes before PCI? A randomized multicentre trial PRAGUE-8.

    abstract:AIMS:To compare two different clopidogrel regimens on the outcomes of patients undergoing elective coronary angiography (CAG)+/-ad hoc percutaneous coronary intervention (PCI). METHODS AND RESULTS:Open-trial randomized 1028 patients with stable angina to group A ('non-selective'-clopidogrel 600 mg > 6 h before CAG; n ...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehn169

    authors: Widimsky P,Motovská Z,Simek S,Kala P,Pudil R,Holm F,Petr R,Bílková D,Skalická H,Kuchynka P,Poloczek M,Miklík R,Maly M,Aschermann M,PRAGUE-8 Trial Investigators.

    更新日期:2008-06-01 00:00:00

  • Antibiotic treatment of streptococcal and enterococcal endocarditis: an overview.

    abstract::The management of streptococcal and enterococcal endocarditis has changed in recent years with the development of effective new regimens that are easier to administer, but resistance to commonly used antibiotics has appeared, especially among enterococci. Beta-lactam antibiotics either alone or in combination are suit...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/16.suppl_b.75

    authors: Francioli P

    更新日期:1995-04-01 00:00:00

  • Worldwide experience with a totally subcutaneous implantable defibrillator: early results from the EFFORTLESS S-ICD Registry.

    abstract:AIMS:The totally subcutaneous implantable-defibrillator (S-ICD) is a new alternative to the conventional transvenous ICD system to minimize intravascular lead complications. There are limited data describing the long-term performance of the S-ICD. This paper presents the first large international patient population col...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehu112

    authors: Lambiase PD,Barr C,Theuns DA,Knops R,Neuzil P,Johansen JB,Hood M,Pedersen S,Kääb S,Murgatroyd F,Reeve HL,Carter N,Boersma L,EFFORTLESS Investigators.

    更新日期:2014-07-01 00:00:00

  • Systemic inflammation in patients with heart failure.

    abstract:AIMS:We hypothesized that chronic heart failure as a model of systemic hypoxia may result in systemic inflammation. The signs of a systemic inflammatory response should disappear after successful mechanical circulatory support using biventricular assist device systems. METHODS AND RESULTS:Plasma levels of cytokines (I...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1997.0858

    authors: Hasper D,Hummel M,Kleber FX,Reindl I,Volk HD

    更新日期:1998-05-01 00:00:00

  • Prognostic models for stable coronary artery disease based on electronic health record cohort of 102 023 patients.

    abstract:AIMS:The population with stable coronary artery disease (SCAD) is growing but validated models to guide their clinical management are lacking. We developed and validated prognostic models for all-cause mortality and non-fatal myocardial infarction (MI) or coronary death in SCAD. METHODS AND RESULTS:Models were develop...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/eht533

    authors: Rapsomaniki E,Shah A,Perel P,Denaxas S,George J,Nicholas O,Udumyan R,Feder GS,Hingorani AD,Timmis A,Smeeth L,Hemingway H

    更新日期:2014-04-01 00:00:00

  • The impact of early standard therapy on dyspnoea in patients with acute heart failure: the URGENT-dyspnoea study.

    abstract:AIMS:The vast majority of acute heart failure (AHF) trials to date have targeted dyspnoea. However, they enrolled patients relatively late and did not standardize their methods of dyspnoea measurement. URGENT Dyspnoea was designed to determine changes in dyspnoea in response to initial, standard therapy in patients pre...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehp458

    authors: Mebazaa A,Pang PS,Tavares M,Collins SP,Storrow AB,Laribi S,Andre S,Mark Courtney D,Hasa J,Spinar J,Masip J,Frank Peacock W,Sliwa K,Gayat E,Filippatos G,Cleland JG,Gheorghiade M

    更新日期:2010-04-01 00:00:00

  • Indices of effectiveness of medical and surgical treatment in 40 cases of prosthetic valve endocarditis.

    abstract::Forty patients with prosthetic valve endocarditis (PVE) presenting during a 12-year period at a single hospital were studied. Twenty-six were male and 14 female and ages ranged from 19 to 67 years. During the first six post-operative months, most episodes were caused by staphylococci (38%) and Gram negative bacilli (2...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/5.suppl_c.133

    authors: Gayet JL,Etienne J,Malquarti V,Gruer LD,Didier B,Chuzel M,Champsaur G,Chassignolle J,Fleurette J,Delaye J

    更新日期:1984-10-01 00:00:00

  • Does exercise-induced myocardial ischaemia cause enhanced platelet activation and fibrin formation in patients with stable angina and severe coronary artery disease?

    abstract::In this study, betathromboglobulin (BTG) and fibrinopeptide A (FPA) in peripheral venous blood were measured in 20 patients with stable angina pectoris before and immediately after exercise-induced myocardial ischaemia; in 5 of the 20 patients stable angina was associated with typical peripheral artery disease. A tota...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/8.7.734

    authors: Gallino A,Häberli A,Straub PW,Steinbrunn W,Turina M,Rothlin ME

    更新日期:1987-07-01 00:00:00

  • Lipoproteins and cardiovascular risk--from genetics to CHD prevention.

    abstract::Increased levels of low density lipoprotein (LDL) cholesterol and triglyceride, and low levels of high density lipoprotein (HDL) cholesterol, are associated with increased risk of coronary heart disease (CHD). Only a minor part of the variation in lipids can be explained by defects in single genes of large effect; the...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:

    authors: Cullen P,Funke H,Schulte H,Assmann G

    更新日期:1998-04-01 00:00:00

  • Thin-cap fibroatheroma and microchannel findings in optical coherence tomography correlate with subsequent progression of coronary atheromatous plaques.

    abstract:AIMS:Morphological characteristics of non-significant coronary plaques (NSCPs) that develop rapid progression have not been fully elucidated. The aim of this study was to clarify the morphological characteristics of NSCPs in patients with coronary artery disease (CAD) using intravascular optical coherence tomography (O...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehr284

    authors: Uemura S,Ishigami K,Soeda T,Okayama S,Sung JH,Nakagawa H,Somekawa S,Takeda Y,Kawata H,Horii M,Saito Y

    更新日期:2012-01-01 00:00:00

  • Potential time saving with pre-hospital intervention in acute myocardial infarction. Report of the European Myocardial Infarction Project (E.M.I.P) Sub-Committee.

    abstract::The European Myocardial Infarction Project (E.M.I.P.) participants have evaluated out-of-hospital coronary care services in different cities within the E.E.C. and concluded that these facilities would support a study within these European centres on pre-hospital intervention in myocardial infarction. Based on a pilot ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:

    authors:

    更新日期:1988-02-01 00:00:00

  • Regional myocardial perfusion reserve determined using myocardial perfusion magnetic resonance imaging showed a direct correlation with coronary flow velocity reserve by Doppler flow wire.

    abstract:AIMS:Quantitative analysis of rest-stress myocardial perfusion magnetic resonance imaging (MRI) can provide assessments of regional myocardial perfusion reserve (MPR). The purpose of this study was to compare regional MPR determined by myocardial perfusion MRI with coronary flow reserve (CFR) by intracoronary Doppler f...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehn521

    authors: Kurita T,Sakuma H,Onishi K,Ishida M,Kitagawa K,Yamanaka T,Tanigawa T,Kitamura T,Takeda K,Ito M

    更新日期:2009-02-01 00:00:00

  • A brief history of the European Society of Cardiology.

    abstract::A look back on the history of the European Society of Cardiology which officially came into existence in 1950. ...

    journal_title:European heart journal

    pub_type: 历史文章,杂志文章

    doi:10.1093/eurheartj/ehv248

    authors:

    更新日期:2015-07-21 00:00:00

  • Use of transthoracic Doppler echocardiography combined with clinical and electrocardiographic data to predict acute pulmonary embolism.

    abstract::Transthoracic echocardiography and continuous wave Doppler were prospectively performed in 132 out-patients with suspicion of pulmonary embolism, and who had no previous history of severe cardiac or pulmonary disease. Bedside echocardiography determined diagnosis other than pulmonary embolism in 55 patients. Further s...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a014946

    authors: Nazeyrollas P,Metz D,Jolly D,Maillier B,Jennesseaux C,Maes D,Chabert JP,Chapoutot L,Elaerts J

    更新日期:1996-05-01 00:00:00

  • Quantification of beta-adrenoceptors and beta-adrenoceptor kinase on protein and mRNA levels in heart failure.

    abstract::The alterations of the beta-adrenoceptor adenylyl cyclase are reviewed. In failing myocardium, the down-regulation of beta 1-adrenoceptors is accompanied by a decrease in steady state mRNA levels, as studied with quantitative polymerase chain reactions in dilated and ischaemic cardiomyopathy. The density of beta 2-adr...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/15.suppl_d.30

    authors: Böhm M,Lohse MJ

    更新日期:1994-12-01 00:00:00

  • The early termination of clinical trials: causes, consequences, and control. With special reference to trials in the field of arrhythmias and sudden death. Task Force of the Working Group on Arrhythmias of the European Society of Cardiology.

    abstract::The early termination of clinical trials, for either benefit or harm, often generates undue enthusiasm or alarm. The enhanced publicity attending early termination of a trial promotes inappropriate interpretations because of the inherent difficulty of a prompt and comprehensive data review. Furthermore, the process of...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:

    authors:

    更新日期:1994-06-01 00:00:00

  • Extracellular matrix deposition in hypertensive hearts antifibrotic effects of ramipril.

    abstract::Hypertension induced in rats by suprarenal banding has a blood pressure elevating effect that is accompanied by the occurrence of cardiac hypertrophy and fibrosis. This phenomenon is already present at 2 weeks after banding and persists up to 1.5 years. The increase in cardiac weight is mostly due to the development o...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/16.suppl_c.33

    authors: Nagasawa K,Zimmermann R,Münkel B,Linz W,Schölkens B,Schaper J

    更新日期:1995-05-01 00:00:00

  • Non-invasive coronary angiography with high resolution multidetector-row computed tomography. Results in 102 patients.

    abstract:AIMS:A new generation of multidetector-row CT (MDCT) scanners allows complete coronary coverage using retrospective ECG gating and 1mm slices. The purpose of this study was to investigate the potential of high resolution MDCT angiography with retrospective gating for detection of coronary artery stenoses. METHODS AND ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2002.3264

    authors: Kopp AF,Schroeder S,Kuettner A,Baumbach A,Georg C,Kuzo R,Heuschmid M,Ohnesorge B,Karsch KR,Claussen CD

    更新日期:2002-11-01 00:00:00

  • Prevalence and natural course of ectopic atrial tachycardia.

    abstract:AIMS:The purpose of this study was to calculate the prevalence of ectopic atrial tachycardia in a population of young asymptomatic males and to assess its natural course both in asymptomatic subjects and in symptomatic hospital patients. METHODS AND RESULTS:12-lead electrocardiograms (ECG) of 3554 consecutive males ap...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1998.1313

    authors: Poutiainen AM,Koistinen MJ,Airaksinen KE,Hartikainen EK,Kettunen RV,Karjalainen JE,Huikuri HV

    更新日期:1999-05-01 00:00:00

  • Monocyte subset accumulation in the human heart following acute myocardial infarction and the role of the spleen as monocyte reservoir.

    abstract:AIMS:Monocytes are critical mediators of healing following acute myocardial infarction (AMI), making them an interesting target to improve myocardial repair. The purpose of this study was a gain of insight into the source and recruitment of monocytes following AMI in humans. METHODS AND RESULTS:Post-mortem tissue spec...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/eht331

    authors: van der Laan AM,Ter Horst EN,Delewi R,Begieneman MP,Krijnen PA,Hirsch A,Lavaei M,Nahrendorf M,Horrevoets AJ,Niessen HW,Piek JJ

    更新日期:2014-02-01 00:00:00

  • Dobutamine stress--Doppler echocardiography before and after coronary angioplasty.

    abstract::To determine if dobutamine-induced myocardial ischaemia causes abnormalities in Doppler parameters of left ventricular ejection and filling and to assess early effects of successful coronary angioplasty (PTCA) on these parameters, dobutamine stress echocardiography and Doppler studies were performed once in 11 normal ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/14.8.1011

    authors: el-Said ES,Fioretti PM,Roelandt JR,McNeill AJ,Rijsterborgh H,Forster T,Di Mario C,Linker DT

    更新日期:1993-08-01 00:00:00

  • Anti-anginal, electrophysiologic and hemodynamic effects of combined beta-blocker/calcium antagonist therapy.

    abstract::Nitrates and beta-blockers have been the mainstay in the therapy of chronic stable angina pectoris for many years. Since an important number of patients remains symptomatic, new potent anti-ischemic agents like the calcium antagonists fulfil a great clinical need. Combined therapy with beta-blockers and calcium antago...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/4.suppl_d.117

    authors: Vanhaleweyk GL,Serruys PW,Hugenholtz PG

    更新日期:1983-07-01 00:00:00

  • Spinal electrical stimulation for intractable angina--long-term clinical outcome and safety.

    abstract::Spinal cord electrical stimulation is an alternative therapy for patients with chronic pain syndromes including angina. Although it has been shown to produce symptomatic relief and reduce ischaemia, doubts remain about its long-term safety. We report here for the first time the results of a follow-up study over a peri...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060589

    authors: Sanderson JE,Ibrahim B,Waterhouse D,Palmer RB

    更新日期:1994-06-01 00:00:00

  • Natural variability of pulmonary haemodynamics.

    abstract::In the interpretation of the effect of a drug or intervention in a single patient, it is desirable to know the spontaneous fluctuations of the variable under study. A few studies have determined pulmonary haemodynamic variability in acute and short-term intervals. It seems reasonable to adopt a confidence limit of 6 m...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/9.suppl_j.19

    authors: Schrijen F,Jezková J

    更新日期:1988-09-01 00:00:00