Non-invasive coronary angiography with high resolution multidetector-row computed tomography. Results in 102 patients.

Abstract:

AIMS:A new generation of multidetector-row CT (MDCT) scanners allows complete coronary coverage using retrospective ECG gating and 1mm slices. The purpose of this study was to investigate the potential of high resolution MDCT angiography with retrospective gating for detection of coronary artery stenoses. METHODS AND RESULTS:A total of 102 patients underwent both conventional and MDCT coronary angiography. After intravenous injection of a non-ionic contrast medium the entire heart was scanned within a single breath hold using 1mm slices. All MDCT data sets were reconstructed with retrospective gating at 20% to 80% in increments of 10% relative to the cardiac cycle. Two blinded independent reviewers analysed image quality for segments 1-4 (right coronary artery), 5-8 (left main, left anterior descending), and 11, 12 (left circumflex). These segments were evaluated for the presence or absence of significant (>or=50%) stenoses. The results were compared with those of invasive coronary angiography in a blinded fashion. Overall sensitivity for the detection of significant stenoses (>or=50%) were 0.86 (reader 1) and 0.93 (reader 2), specificity 0.96 (reader 1) and 0.97 (reader 2), negative predictive value 0.98 (reader 1) and 0.99 (reader 2). CONCLUSIONS:High resolution MDCT angiography with retrospective gating permits the non-invasive detection of coronary artery stenoses with high accuracy if image quality is optimized for each of the three major coronary arteries.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Kopp AF,Schroeder S,Kuettner A,Baumbach A,Georg C,Kuzo R,Heuschmid M,Ohnesorge B,Karsch KR,Claussen CD

doi

10.1053/euhj.2002.3264

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

1714-25

issue

21

eissn

0195-668X

issn

1522-9645

pii

S0195668X02932641

journal_volume

23

pub_type

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