The non-synonymous coding IKr-channel variant KCNH2-K897T is associated with atrial fibrillation: results from a systematic candidate gene-based analysis of KCNH2 (HERG).

abstract：AIMS:Cardiac angiotensin-I converting enzyme (ACE) activity is influenced by the ACE I/D polymorphism. Evidence suggests that the DD-genotype may be a risk factor for cardiac hypertrophy and heart failure, especially in hypertensive subjects. We assessed the relation between the ACE I/D polymorphism and the risk of inc...

journal_title：European heart journal

authors： Schut AF,Bleumink GS,Stricker BH,Hofman A,Witteman JC,Pols HA,Deckers JW,Deinum J,van Duijn CM

更新日期：2004-12-01 00:00:00

abstract：:Antithrombotic therapy and invasive risk stratification in selected high-risk patients have improved outcomes from non-ST-segment elevation acute coronary syndromes (NSTE-ACS), but carry a risk of bleeding and blood transfusion. Although the true incidence of bleeding depends on the population studied (i.e. clinical t...

journal_title：European heart journal

authors： Rao SV,Eikelboom JA,Granger CB,Harrington RA,Califf RM,Bassand JP

更新日期：2007-05-01 00:00:00

abstract：:The pharmacokinetics of glyceryl trinitrate are still not completely understood. The substance disappears rapidly from plasma largely by extrahepatic mechanisms. It is converted in glyceryl dinitrates and glyceryl mononitrates. After transdermal application of a controlled delivery system, plasma concentrations of gly...

journal_title：European heart journal

authors： Bogaert MG

更新日期：1988-01-01 00:00:00

abstract：:Morphological changes in human myocardium associated with pressure overload-induced left ventricular hypertrophy were studied in 22 normal and 21 hypertrophic hearts obtained at autopsy. Samples were obtained from the left lateral ventricular wall, half way between the apex and the base. Myocyte dimensions, polyploidi...

journal_title：European heart journal

authors： Vliegen HW,van der Laarse A,Cornelisse CJ,Eulderink F

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Recent identification of mutations in the beta-myosin heavy chain gene (MYH7), a major responsible gene for HCM, has provided the opportunity to characterize genotype-phenotype correlation in HCM families. In this study we analysed the phenotypic expression of two beta-myosin heavy chain (beta MHC) mutations...

journal_title：European heart journal

authors： Marian AJ,Mares A Jr,Kelly DP,Yu QT,Abchee AB,Hill R,Roberts R

更新日期：1995-03-01 00:00:00

abstract：AIMS:Drug-eluting stents (DES) represent a major advance in interventional cardiology. Along with the success shown, current DES also present limitations related to the presence of polymer-coating, fixed drug, and dose used. With the ISAR (Individualized Drug-Eluting Stent System to Abrogate Restenosis) project, a DES ...

journal_title：European heart journal

authors： Hausleiter J,Kastrati A,Wessely R,Dibra A,Mehilli J,Schratzenstaller T,Graf I,Renke-Gluszko M,Behnisch B,Dirschinger J,Wintermantel E,Schömig A,investigators of the individualizable durg-eluting Stent System to Abrogate Restenosi

更新日期：2005-08-01 00:00:00

abstract：:Cardiac troponins (cTns) I and T have long been the most successful cardiac-specific circulating biomarkers in cardiovascular (CV) medicine, having changed dramatically the diagnosis of acute myocardial infarction, while being independent predictors of outcome in several cardiac conditions and non-cardiac conditions. ...

journal_title：European heart journal

authors： Farmakis D,Mueller C,Apple FS

更新日期：2020-11-01 00:00:00

abstract：:The European Myocardial Infarction Project (E.M.I.P.) participants have evaluated out-of-hospital coronary care services in different cities within the E.E.C. and concluded that these facilities would support a study within these European centres on pre-hospital intervention in myocardial infarction. Based on a pilot ...

journal_title：European heart journal

authors：

更新日期：1988-02-01 00:00:00

abstract：AIMS:Here, the aim is to assess long-term clinical variation (CV) of N-terminal pro-brain natriuretic peptide (NT-proBNP) in stable chronic heart failure (CHF) patients. The proposed use of NT-proBNP for monitoring of CHF patients will require accurate information about long-term CV of the peptide. METHODS AND RESULTS...

journal_title：European heart journal

authors： Schou M,Gustafsson F,Kjaer A,Hildebrandt PR

更新日期：2007-01-01 00:00:00

abstract：AIM:Decreasing cholesterol levels in Western populations is the main reason for decreasing mortality due to coronary heart disease. Our aim was to analyze trends in cholesterol levels in the population during a period of 20 years in relation to previous cardiovascular disease (CVD), other cardiovascular risk factors, a...

journal_title：European heart journal

authors： Eriksson M,Forslund AS,Jansson JH,Söderberg S,Wennberg M,Eliasson M

更新日期：2016-07-01 00:00:00

abstract：AIMS:There have been substantial declines in cerebrovascular disease mortality across much of Europe, mirroring trends in deaths from cardiovascular disease as a whole. No study has investigated trends in cerebrovascular disease, and its subtypes within all European countries. This study aimed to examine sex-specific t...

journal_title：European heart journal

authors： Shah R,Wilkins E,Nichols M,Kelly P,El-Sadi F,Wright FL,Townsend N

更新日期：2019-03-01 00:00:00

abstract：:Heart rate and age are independent variables associated with the pattern of normal left ventricular filling. Since heart rate variability also varies with age, the relationship between these and left ventricular filling in normal subjects was assessed. In 31 subjects (age range 21 to 71 years), power spectral analysis...

journal_title：European heart journal

authors： Finkelhor RS,Karwa P,Kaufman ES,Bahler RC

更新日期：1995-11-01 00:00:00

abstract：AIMS:Circulating progenitor cells (PC) may contribute to myocardial recovery following infarction. Growth factors including VEGF are produced during ischaemia and stimulate PC release and activation. In this study, we focused on the functional chemotactic response of PC to VEGF in subjects early after myocardial ischae...

journal_title：European heart journal

authors： Vöö S,Eggermann J,Dunaeva M,Ramakers-van Oosterhoud C,Waltenberger J

更新日期：2008-01-01 00:00:00

abstract：:After single chamber atrial pacemaker implantation, serial electrophysiologic studies were performed noninvasively at intervals of 3 months over a total period of 3 years in 24 patients with symptomatic sinus node dysfunction. All patients underwent invasive electrophysiologic studies before pacemaker implantation and...

journal_title：European heart journal

authors： van Mechelen R,Segers A,Hagemeijer F

更新日期：1984-08-01 00:00:00

abstract：AIMS:Statins have modest adverse effects on glycaemic control. Alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, lowers low-density lipoprotein cholesterol. This study assessed the effects of alirocumab on new-onset diabetes and pre-diabetes incidence in individuals without diabetes at baseline. M...

journal_title：European heart journal

authors： Colhoun HM,Ginsberg HN,Robinson JG,Leiter LA,Müller-Wieland D,Henry RR,Cariou B,Baccara-Dinet MT,Pordy R,Merlet L,Eckel RH

更新日期：2016-10-14 00:00:00

abstract：AIMS:Elevated resting heart rate (RHR) is a known, independent cardiovascular (CV) risk factor, but is not included in risk estimation systems, including Systematic COronary Risk Evaluation (SCORE). We aimed to derive risk estimation systems including RHR as an extra variable and assess the value of this addition. MET...

journal_title：European heart journal

authors： Cooney MT,Vartiainen E,Laatikainen T,Joulevi A,Dudina A,Graham I

更新日期：2010-09-01 00:00:00

abstract：Aims:Optimal blood pressure for prevention of cardiovascular (CV) events in patients with Type 2 diabetes mellitus (T2DM) remains uncertain and there is concern for increased risk with low diastolic blood pressure (DBP). This study analysed the association between blood pressure and CV outcomes in high-risk patients wi...

journal_title：European heart journal

authors： Bergmark BA,Scirica BM,Steg PG,Fanola CL,Gurmu Y,Mosenzon O,Cahn A,Raz I,Bhatt DL,SAVOR-TIMI 53 Investigators.

更新日期：2018-06-21 00:00:00

abstract：:This treatise reviews two-dimensional echocardiographic criteria which have been developed to describe and distinguish reversible vs irreversible myocardial ischaemia. It also discusses the new pathophysiologic concepts such as 'hibernating' and 'decapitated' myocardium, and also 'reperfusion injury' and 'stunned' myo...

journal_title：European heart journal

authors： Corday E,Hajduczki I,O'Byrne GT,Kar S,Areeda J,Corday SR

更新日期：1988-04-01 00:00:00

abstract：AIMS :Balance between inflammatory and reparative leucocytes allows optimal healing after myocardial infarction (MI). Interindividual heterogeneity evokes variable functional outcome complicating targeted therapy. We aimed to characterize infarct chemokine CXC-motif receptor 4 (CXCR4) expression using positron emission...

journal_title：European heart journal

authors： Hess A,Derlin T,Koenig T,Diekmann J,Wittneben A,Wang Y,Wester HJ,Ross TL,Wollert KC,Bauersachs J,Bengel FM,Thackeray JT

更新日期：2020-10-01 00:00:00

abstract：:This report of an ESC Study Group reviews current knowledge on myocardial hibernation and relevant imaging techniques, and provides an algorithm for investigation and management when a patient presents with ischaemic left ventricular dysfunction. It covers the definitions of myocardial viability, stunning and hibernat...

journal_title：European heart journal

authors： Underwood SR,Bax JJ,vom Dahl J,Henein MY,Knuuti J,van Rossum AC,Schwarz ER,Vanoverschelde JL,van der Wall EE,Wijns W,Study Group of the European Society of Cardiology.

更新日期：2004-05-01 00:00:00

abstract：AIMS:This ancillary analysis of the GISSI-HF database aims at assessing the effect of rosuvastatin on the occurrence of atrial fibrillation (AF) in patients with chronic heart failure (HF) who were not in AF at study entry. METHODS AND RESULTS:GISSI-HF was a double-blind, placebo-controlled trial testing n-3 PUFA and ...

journal_title：European heart journal

authors： Maggioni AP,Fabbri G,Lucci D,Marchioli R,Franzosi MG,Latini R,Nicolosi GL,Porcu M,Cosmi F,Stefanelli S,Tognoni G,Tavazzi L,GISSI-HF Investigators.

更新日期：2009-10-01 00:00:00

abstract：AIMS:We describe a new strategic stepwise mapping approach for fast and accurate identification and ablation of ectopic atrial foci using an electroanatomic mapping system. METHODS AND RESULTS:Mapping procedures started with the acquisition of four points at the superior/septal part of the tricuspid annulus. According...

journal_title：European heart journal

authors： Wetzel U,Hindricks G,Schirdewahn P,Dorszewski A,Fleck A,Heinke F,Kottkamp H

更新日期：2002-09-01 00:00:00

abstract：:Since fatty acids provide the majority of myocardial energy requirements under basal conditions, an alteration in the global or regional utilization of these substrates may be an early indicator of myocardial disease. To determine areas of potential clinical utility of fatty acid imaging, we synthesized a radioiodinat...

journal_title：European heart journal

authors： Livni E,Elmaleh DR,Barlai-Kovach MM,Goodman MM,Knapp FF Jr,Strauss HW

更新日期：1985-08-01 00:00:00

abstract：AIMS:No-reflow after a primary percutaneous coronary intervention (PCI) is associated with a high incidence of left ventricular (LV) failure and a poor prognosis. Endothelin-1 (ET-1) is a potent endothelium-derived vasoconstrictor peptide and an important modulator of neutrophil function. Elevated systemic ET-1 levels ...

journal_title：European heart journal

authors： Niccoli G,Lanza GA,Shaw S,Romagnoli E,Gioia D,Burzotta F,Trani C,Mazzari MA,Mongiardo R,De Vita M,Rebuzzi AG,Lüscher TF,Crea F

更新日期：2006-08-01 00:00:00

abstract：AIMS:There is no cure for pulmonary arterial hypertension, but current approved treatment options include prostanoids, endothelin-receptor antagonists, and phosphodiesterase type-5 inhibitors. The effect on survival of these compounds has not been appropriately assessed in individual trials because of small sample size...

journal_title：European heart journal

authors： Galiè N,Manes A,Negro L,Palazzini M,Bacchi-Reggiani ML,Branzi A

更新日期：2009-02-01 00:00:00

abstract：AIMS:Real-time MRI creates images with superb tissue contrast that may enable radiation-free catheterization. Simple procedures are the first step towards novel interventional procedures. We aim to perform comprehensive transfemoral diagnostic right heart catheterization in an unselected cohort of patients entirely usi...

journal_title：European heart journal

authors： Ratnayaka K,Faranesh AZ,Hansen MS,Stine AM,Halabi M,Barbash IM,Schenke WH,Wright VJ,Grant LP,Kellman P,Kocaturk O,Lederman RJ

更新日期：2013-02-01 00:00:00

abstract：:In a prospective serial study of 96 patients with acute myocardial infarction, two dimensional echocardiography identified left ventricular thrombus in 18 patients. The majority of thrombi (15) developed within the first 4 days after admission. In three patients thrombi were identified for the first time 4 months afte...

journal_title：European heart journal

authors： Visser CA,Kan G,Lie KI,Durrer D

更新日期：1983-05-01 00:00:00

abstract：AIM:We tested the hypothesis that dapagliflozin may regress left ventricular hypertrophy (LVH) in people with type 2 diabetes (T2D). METHODS AND RESULTS:We randomly assigned 66 people (mean age 67 ± 7 years, 38 males) with T2D, LVH, and controlled blood pressure (BP) to receive dapagliflozin 10 mg once daily or placeb...

journal_title：European heart journal

authors： Brown AJM,Gandy S,McCrimmon R,Houston JG,Struthers AD,Lang CC

更新日期：2020-09-21 00:00:00

abstract：:The primary success rate and incidence of major complications have been retrospectively assessed in a consecutive series of 224 patients undergoing percutaneous transluminal coronary angioplasty (PTCA) in one centre. The patients have been divided into three groups; those with angina and no previous myocardial infarct...

journal_title：European heart journal

authors： Perry RA,Seth A,Singh A,Shiu MF

更新日期：1988-01-01 00:00:00

abstract：:The value of measurements of the fibrinolytic factors, tissue plasminogen activator and plasminogen activator inhibitor, for predicting death and non-fatal cardiovascular events was studied in 213 consecutive patients with angiographically documented coronary artery disease. In the course of 4-year follow-up, 47 patie...

journal_title：European heart journal

authors： Jansson JH,Nilsson TK,Olofsson BO

更新日期：1991-02-01 00:00:00