Angiotensin converting enzyme insertion/deletion polymorphism and the risk of heart failure in hypertensive subjects.

Abstract:

AIMS:Cardiac angiotensin-I converting enzyme (ACE) activity is influenced by the ACE I/D polymorphism. Evidence suggests that the DD-genotype may be a risk factor for cardiac hypertrophy and heart failure, especially in hypertensive subjects. We assessed the relation between the ACE I/D polymorphism and the risk of incident heart failure in normotensive and hypertensive subjects. METHODS AND RESULTS:We investigated 4264 normotensive and 2174 hypertensive participants of the Rotterdam Study, a population based prospective cohort study. All subjects were available for follow-up from 1990 until 2000. Incidence rates (IR) of heart failure in normotensive subjects were the same over all genotype strata (10 per 1000 person-years). In hypertensive subjects, the IR increased with the number of D-alleles present (II: IR=13, ID: IR=18 and DD: IR=20 per 1000 person-years). Hypertensive subjects carrying the II-genotype did not have an increased risk of heart failure compared to normotensive II subjects. However, hypertensive subjects carrying one or two copies of the D-allele did have a significantly increased risk of heart failure (ID: RR: 1.4 (1.1-1.9) and DD: RR: 1.5 (1.2-2.1)). CONCLUSION:Our findings suggest that the ACE I/D polymorphism may play a modifying role in the development of heart failure in hypertensive subjects.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Schut AF,Bleumink GS,Stricker BH,Hofman A,Witteman JC,Pols HA,Deckers JW,Deinum J,van Duijn CM

doi

10.1016/j.ehj.2004.08.026

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

2143-8

issue

23

eissn

0195-668X

issn

1522-9645

pii

S0195-668X(04)00646-3

journal_volume

25

pub_type

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