Benefits, challenges, and registerability of the polypill.

Abstract:

:Guidelines for the management of cardiovascular disease (CVD) stress the importance of treating global risk, rather than individual risk, factors. Patients at high cardiovascular (CV) risk, for example, benefit from a combination of aspirin, antihypertensive agents, lipid-lowering drugs, and possibly folic acid. As the number of medications that a patient requires increases, adherence and compliance to therapy are likely to decrease. The use of affordable, multiple-target, fixed-combination 'polypills', which concomitantly reduce multiple risk factors without increasing the pill burden or the risk of adverse effects, has the potential to improve CV risk factor management, thereby reducing the incidence of CVD. This review discusses the benefits of the polypill and the challenges and requirements for its success and registerability. Discussions with regulatory bodies are required in order to obtain some 'balance' between an overcautious registration approach and the potentially large public health benefits that are likely to arise from the use of polypills.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Sleight P,Pouleur H,Zannad F

doi

10.1093/eurheartj/ehi841

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

1651-6

issue

14

eissn

0195-668X

issn

1522-9645

pii

ehi841

journal_volume

27

pub_type

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