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Association of estimated sleep duration and naps with mortality and cardiovascular events: a study of 116 632 people from 21 countries.

Abstract：

AIMS:To investigate the association of estimated total daily sleep duration and daytime nap duration with deaths and major cardiovascular events. METHODS AND RESULTS:We estimated the durations of total daily sleep and daytime naps based on the amount of time in bed and self-reported napping time and examined the associations between them and the composite outcome of deaths and major cardiovascular events in 116 632 participants from seven regions. After a median follow-up of 7.8 years, we recorded 4381 deaths and 4365 major cardiovascular events. It showed both shorter (≤6 h/day) and longer (>8 h/day) estimated total sleep durations were associated with an increased risk of the composite outcome when adjusted for age and sex. After adjustment for demographic characteristics, lifestyle behaviours and health status, a J-shaped association was observed. Compared with sleeping 6-8 h/day, those who slept ≤6 h/day had a non-significant trend for increased risk of the composite outcome [hazard ratio (HR), 1.09; 95% confidence interval, 0.99-1.20]. As estimated sleep duration increased, we also noticed a significant trend for a greater risk of the composite outcome [HR of 1.05 (0.99-1.12), 1.17 (1.09-1.25), and 1.41 (1.30-1.53) for 8-9 h/day, 9-10 h/day, and >10 h/day, Ptrend < 0.0001, respectively]. The results were similar for each of all-cause mortality and major cardiovascular events. Daytime nap duration was associated with an increased risk of the composite events in those with over 6 h of nocturnal sleep duration, but not in shorter nocturnal sleepers (≤6 h). CONCLUSION:Estimated total sleep duration of 6-8 h per day is associated with the lowest risk of deaths and major cardiovascular events. Daytime napping is associated with increased risks of major cardiovascular events and deaths in those with >6 h of nighttime sleep but not in those sleeping ≤6 h/night.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Wang C,Bangdiwala SI,Rangarajan S,Lear SA,AlHabib KF,Mohan V,Teo K,Poirier P,Tse LA,Liu Z,Rosengren A,Kumar R,Lopez-Jaramillo P,Yusoff K,Monsef N,Krishnapillai V,Ismail N,Seron P,Dans AL,Kruger L,Yeates K,Leach

doi

10.1093/eurheartj/ehy695

subject

Has Abstract

pub_date

2019-05-21 00:00:00

pages

1620-1629

issue

eissn

0195-668X

issn

1522-9645

pii

5229545

journal_volume

pub_type

杂志文章

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Association of estimated sleep duration and naps with mortality and cardiovascular events: a study of 116 632 people from 21 countries.