Peptides in coronary circulation: basis for therapeutic strategies.

abstract：:The concept of coronary vascular reserve stems from the description of coronary autoregulation by Mosher in 1964. Schematically, the coronary blood flow at rest depends on the determinants of myocardial oxygen demand (heart rate, contractility and ventricular load). If maximal coronary vasodilation is produced, it res...

journal_title：European heart journal

authors： Nitenberg A,Antony I

更新日期：1995-08-01 00:00:00

abstract：AIMS:To assess safety, feasibility and short term outcome of pulmonary vein (PV) isolation in paroxysmal atrial fibrillation (AF) with a cryoballoon. METHODS:We consecutively treated 57 patients with a double lumen 23 or 28 mm cryoballoon. The acute results, complications and follow-up over the first three months were...

journal_title：European heart journal

authors： Van Belle Y,Janse P,Rivero-Ayerza MJ,Thornton AS,Jessurun ER,Theuns D,Jordaens L

更新日期：2007-09-01 00:00:00

abstract：AIMS:We examined the left lateral ridge (LLR) between the orifices of the left pulmonary veins and the left atrial appendage for a better understanding of its structural composition relevant to ablations for atrial fibrillation (AF). METHODS AND RESULTS:The LLR and its surrounding areas were studied in 40 heart specim...

journal_title：European heart journal

authors： Cabrera JA,Ho SY,Climent V,Sánchez-Quintana D

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Antiarrhythmic drugs are still used for the treatment of ventricular tachyarrhythmias, in combination with implantable cardioverter-defibrillators or without them. AIM OF THE STUDY:In a double-blind randomized crossover design, the short- and long-term efficacy and safety of oral dofetilide or oral sotalol ...

journal_title：European heart journal

authors： Boriani G,Lubinski A,Capucci A,Niederle R,Kornacewicz-Jack Z,Wnuk-Wojnar AM,Borggrefe M,Brachmann J,Biffi M,Butrous GS,Ventricular Arrhythmias Dofetilide Investigators.

更新日期：2001-12-01 00:00:00

abstract：AIMS:In patients with atrial fibrillation, minor troponin I elevation is regularly detected; however, the prognostic significance of this finding is unknown. We therefore sought to examine the prognostic value of elevated troponin I in patients with atrial fibrillation. METHODS AND RESULTS:A prospective study was cond...

journal_title：European heart journal

authors： van den Bos EJ,Constantinescu AA,van Domburg RT,Akin S,Jordaens LJ,Kofflard MJ

更新日期：2011-03-01 00:00:00

abstract：AIMS:To investigate whether the benefit of thrombolytic therapy was sustained beyond the first decade. We report the 10-14 year outcome of 533 patients who were randomized to treatment with intracoronary streptokinase or to conventional therapy during the years 1980-1985. METHODS AND RESULTS:Details of survival and ca...

journal_title：European heart journal

authors： Maas AC,van Domburg RT,Deckers JW,Vermeer F,Remme WJ,Kamp O,Manger Cats V,Simoons ML

更新日期：1999-06-01 00:00:00

abstract：AIMS:Cardiac biomarkers are routinely elevated after uncomplicated cardiac surgery to levels considered diagnostic of myocardial infarction in ambulatory populations. We investigated the diagnostic power of electrocardiogram (ECG) and cardiac biomarker criteria to predict clinically relevant myocardial injury using ben...

journal_title：European heart journal

authors： Muehlschlegel JD,Perry TE,Liu KY,Nascimben L,Fox AA,Collard CD,Avery EG,Aranki SF,D'Ambra MN,Shernan SK,Body SC,CABG Genomics Investigators.

更新日期：2009-07-01 00:00:00

abstract：:In the interpretation of the effect of a drug or intervention in a single patient, it is desirable to know the spontaneous fluctuations of the variable under study. A few studies have determined pulmonary haemodynamic variability in acute and short-term intervals. It seems reasonable to adopt a confidence limit of 6 m...

journal_title：European heart journal

authors： Schrijen F,Jezková J

更新日期：1988-09-01 00:00:00

abstract：AIMS:Oral glucose-lowering medications are associated with excess risk of heart failure (HF). Given the absence of comparative data among drug classes, we performed a retrospective study in 32 Health Services of 16 Italian regions accounting for a population of 18 million individuals, to assess the association between ...

journal_title：European heart journal

authors： Fadini GP,Avogaro A,Degli Esposti L,Russo P,Saragoni S,Buda S,Rosano G,Pecorelli S,Pani L,OsMed Health-DB Network.

更新日期：2015-09-21 00:00:00

abstract：AIMS:Chronic kidney disease (CKD) was found to be an independent risk factor for all-cause mortality as well as adverse cardiovascular disease (CVD) events in high-risk populations. Findings from population-based studies are scarce and inconsistent. We investigated the gender-specific association of CKD with all-cause ...

journal_title：European heart journal

authors： Meisinger C,Döring A,Löwel H,KORA Study Group.

更新日期：2006-05-01 00:00:00

abstract：AIMS:Evidence is accumulating that inflammation plays a role in the pathophysiology of heart failure. Lipoprotein-associated phospholipase A2 (Lp-PLA2) has pro-inflammatory properties. We investigated whether Lp-PLA2 activity is associated with heart failure. METHODS AND RESULTS:Lp-PLA2 activity was determined in a ra...

journal_title：European heart journal

authors： van Vark LC,Kardys I,Bleumink GS,Knetsch AM,Deckers JW,Hofman A,Stricker BH,Witteman JC

更新日期：2006-10-01 00:00:00

abstract：:A patient with a three-year history of recurrent pulmonary embolism is presented. Thromboembolic pulmonary hypertension was proven in the final stage of disease in the presence of repeated episodes of systemic embolic events. Paradoxical embolism was assumed to be present on the basis of blood-gas analysis and contras...

journal_title：European heart journal

authors： Lang I,Steurer G,Weissel M,Burghuber OC

更新日期：1988-06-01 00:00:00

abstract：AIMS:Large randomized trials have shown that beta-blockers reduce mortality and hospital admissions in patients with heart failure. The effects of beta-blockers in elderly patients with a broad range of left ventricular ejection fraction are uncertain. The SENIORS study was performed to assess effects of the beta-block...

journal_title：European heart journal

authors： Flather MD,Shibata MC,Coats AJ,Van Veldhuisen DJ,Parkhomenko A,Borbola J,Cohen-Solal A,Dumitrascu D,Ferrari R,Lechat P,Soler-Soler J,Tavazzi L,Spinarova L,Toman J,Böhm M,Anker SD,Thompson SG,Poole-Wilson PA,SENIORS In

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVES:The Cholesterol Lowering Atherosclerosis PTCA Trial (CLAPT) is a prospective, randomized trial with blinded angiographic end-points to assess the effect of 2-year's treatment with lovastatin initiated 4 weeks prior to PTCA, compared to usual care on non-dilated coronary segments and on dilated coronary lesio...

journal_title：European heart journal

authors： Kleemann A,Eckert S,von Eckardstein A,Lepper W,Schernikau U,Gleichmann U,Hanrath P,Fleck E,Neiss A,Kerber S,Assmann G,Breithardt G,CLAPT Study.

更新日期：1999-10-01 00:00:00

abstract：AIMS:We investigated the role of asymmetric dimethylarginine (ADMA) for clinical outcome of patients with unstable angina. METHODS AND RESULTS:Forty-five patients with stable angina, 36 patients with unstable angina, and 40 healthy controls were included in this study. Coronary artery disease (CAD) patients were prosp...

journal_title：European heart journal

authors： Krempl TK,Maas R,Sydow K,Meinertz T,Böger RH,Kähler J

更新日期：2005-09-01 00:00:00

abstract：AIM:To evaluate the effect of alirocumab on frequency of standard apheresis treatments [weekly or every 2 weeks (Q2W)] in heterozygous familial hypercholesterolaemia (HeFH). METHODS AND RESULTS:ODYSSEY ESCAPE (NCT02326220) was a double-blind study in 62 HeFH patients undergoing regular weekly or Q2W lipoprotein aphere...

journal_title：European heart journal

authors： Moriarty PM,Parhofer KG,Babirak SP,Cornier MA,Duell PB,Hohenstein B,Leebmann J,Ramlow W,Schettler V,Simha V,Steinhagen-Thiessen E,Thompson PD,Vogt A,von Stritzky B,Du Y,Manvelian G

更新日期：2016-12-21 00:00:00

abstract：:Advanced coronary artery disease (CAD), impaired left ventricular function and prolongation of the QT-interval are considered risk factors for sudden cardiac death in CAD-patients. So far, however, there are no studies investigating in detail whether there is a correlation between the QT-interval and changes in corona...

journal_title：European heart journal

authors： Krämer B,Brill M,Brühn A,Kübler W

更新日期：1986-01-01 00:00:00

abstract：:Coronary arteries of anomalous origin with subsequent coursing between the aorta and pulmonary trunk can cause ischaemia, infarction or sudden death. However, reports of surgical correction are sparse due to the rarity of ante-mortem diagnosis. We report two cases in which symptoms were related to anomalous origin of ...

journal_title：European heart journal

authors： Thomas D,Salloum J,Montalescot G,Drobinski G,Artigou JY,Grosgogeat Y

更新日期：1991-07-01 00:00:00

abstract：AIMS:To evaluate the efficacy of atrial pacing in the suppression of early reinitiation of atrial fibrillation after successful internal cardioversion. METHODS AND RESULTS:The efficacy of atrial pacing in suppressing early reinitiation of atrial fibrillation was studied in 12 of 45 (29%) patients with early reinitiati...

journal_title：European heart journal

authors： Tse HF,Lau CP,Ayers GM

更新日期：2000-07-01 00:00:00

abstract：AIMS:Phenotypic heterogeneity and incomplete penetrance are common in patients with hypertrophic cardiomyopathy (HCM). We aim to improve the understanding in genotype-phenotype correlations in HCM, particularly the contribution of an MYL2 founder mutation and risk factors to left ventricular hypertrophic remodelling. ...

journal_title：European heart journal

authors： Claes GR,van Tienen FH,Lindsey P,Krapels IP,Helderman-van den Enden AT,Hoos MB,Barrois YE,Janssen JW,Paulussen AD,Sels JW,Kuijpers SH,van Tintelen JP,van den Berg MP,Heesen WF,Garcia-Pavia P,Perrot A,Christiaans I,Salem

更新日期：2016-06-14 00:00:00

abstract：BACKGROUND:Mortality from cardiac surgery is an essential indicator of quality and forms the basis of treatment strategy decisions in eligible patients. No contemporary complete data on unselected adult cardiac surgery patients are available in Germany. METHODS AND RESULTS:A registry was started in June 1997 of all pa...

journal_title：European heart journal

authors： Vogt A,Grube E,Glunz HG,Hauptmann KE,Sechtem U,Mäurer W,Tebbe U,Heinrich KW,Engel HJ,Kettner W,Krawietz W,Neuhaus KL

更新日期：2000-01-01 00:00:00

abstract：:The natriuretic peptides are important tools to establish diagnosis and prognosis in heart failure (HF). With application of therapies for HF, changes in both B-type natriuretic peptide (BNP) and its amino terminal cleavage fragment (NT-proBNP) parallel the benefits of the HF therapy applied. This dynamic nature of BN...

journal_title：European heart journal

authors： Troughton R,Michael Felker G,Januzzi JL Jr

更新日期：2014-01-01 00:00:00

abstract：:Left ventricular volume and ejection fraction were measured by 2-dimensional echocardiography from 2 orthogonal apical long axis views in 90 patients admitted with acute transmural myocardial infarction. Results were correlated with worst Killip class during hospital stay, enzymatic infarct size (peak CK-MB) and morta...

journal_title：European heart journal

authors： Kan G,Visser CA,Lie KI,Durrer D

更新日期：1984-03-01 00:00:00

abstract：:Increased sympathetic tone is found in about 30% of patients with hypertension. This abnormality is closely associated with the metabolic syndrome of dyslipidaemia and hyperinsulinaemia. In this short review we discuss the mechanisms by which sympathetic over-activity could cause the metabolic syndrome. Sympathetic st...

journal_title：European heart journal

authors： Julius S

更新日期：1998-06-01 00:00:00

abstract：AIMS:Morphological characteristics of non-significant coronary plaques (NSCPs) that develop rapid progression have not been fully elucidated. The aim of this study was to clarify the morphological characteristics of NSCPs in patients with coronary artery disease (CAD) using intravascular optical coherence tomography (O...

journal_title：European heart journal

authors： Uemura S,Ishigami K,Soeda T,Okayama S,Sung JH,Nakagawa H,Somekawa S,Takeda Y,Kawata H,Horii M,Saito Y

更新日期：2012-01-01 00:00:00

abstract：AIMS:The relative benefits of computed tomography coronary angiography (CTCA)-guided management in women and men with suspected angina due to coronary heart disease (CHD) are uncertain. METHODS AND RESULTS:In this post hoc analysis of an open-label parallel-group multicentre trial, we recruited 4146 patients referred ...

journal_title：European heart journal

authors： Mangion K,Adamson PD,Williams MC,Hunter A,Pawade T,Shah ASV,Lewis S,Boon NA,Flather M,Forbes J,McLean S,Roditi G,van Beek EJR,Timmis AD,Newby DE,McAllister DA,Berry C

更新日期：2020-04-01 00:00:00

abstract：Aims:The aim of this study is to develop models to aid the decision to prolong dual antiplatelet therapy (DAPT) that requires balancing an individual patient's potential benefits and harms. Methods and results:Using population-based electronic health records (EHRs) (CALIBER, England, 2000-10), of patients evaluated 1 ...

journal_title：European heart journal

authors： Pasea L,Chung SC,Pujades-Rodriguez M,Moayyeri A,Denaxas S,Fox KAA,Wallentin L,Pocock SJ,Timmis A,Banerjee A,Patel R,Hemingway H

更新日期：2017-04-07 00:00:00

abstract：:Transthoracic echocardiography and continuous wave Doppler were prospectively performed in 132 out-patients with suspicion of pulmonary embolism, and who had no previous history of severe cardiac or pulmonary disease. Bedside echocardiography determined diagnosis other than pulmonary embolism in 55 patients. Further s...

journal_title：European heart journal

authors： Nazeyrollas P,Metz D,Jolly D,Maillier B,Jennesseaux C,Maes D,Chabert JP,Chapoutot L,Elaerts J

更新日期：1996-05-01 00:00:00

abstract：UNLABELLED:Left atrial spontaneous echo contrast, detected by transoesophageal echocardiography in patients with non-valvular atrial fibrillation reflects slow blood flow and is associated with an increased risk of cardio-embolism. The purpose of this study was to find echo/Doppler predictors of left atrial spontaneous...

journal_title：European heart journal

authors： Pop GA,Meeder HJ,Roelandt JR,van Oudenaarden W,Bulens C,Verweij W,Gijsbers C,van Domburg R,Koudstaal PJ

更新日期：1994-11-01 00:00:00

abstract：AIMS:In mechanical heart valve recipients, low-dose international normalized ratio (INR) self-management of oral anticoagulants can reduce the risk of developing thrombo-embolic events and improve long-term survival compared with INR control by a general practitioner. Here, we present data on the safety of low-dose INR...

journal_title：European heart journal

authors： Koertke H,Zittermann A,Tenderich G,Wagner O,El-Arousy M,Krian A,Ennker J,Taborski U,Klövekorn WP,Moosdorf R,Saggau W,Koerfer R

更新日期：2007-10-01 00:00:00