Radioiodinated beta-methyl phenyl fatty acids as potential tracers for myocardial imaging and metabolism.

Abstract:

:Since fatty acids provide the majority of myocardial energy requirements under basal conditions, an alteration in the global or regional utilization of these substrates may be an early indicator of myocardial disease. To determine areas of potential clinical utility of fatty acid imaging, we synthesized a radioiodinated modified fatty acid 14-(p-iodophenyl) beta methyltetradecanoic acid IPBMTA, which cannot undergo beta-oxidation. Preliminary biodistribution and imaging studies were performed in animals and man. These studies suggest that radioiodinated beta-methyl phenyl fatty acids localized rapidly in the myocardium and had prolonged myocardial retention time. The long residence time permits the recording of high quality planar and SPECT images.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Livni E,Elmaleh DR,Barlai-Kovach MM,Goodman MM,Knapp FF Jr,Strauss HW

doi

10.1093/eurheartj/6.suppl_b.85

subject

Has Abstract

pub_date

1985-08-01 00:00:00

pages

85-9

eissn

0195-668X

issn

1522-9645

journal_volume

6 Suppl B

pub_type

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