Genes for blood pressure: an opportunity to understand hypertension.

Abstract:

:Hypertension (HTN) is quantitatively the major cardiovascular risk factor and responsible for ∼50% of cardiovascular morbidity and mortality. Blood pressure (BP) is also a classical complex genetic trait with heritability estimates of 30-50%. Although much is known about BP regulation, the intrinsic origin of essential HTN remains obscure although many environmental factors are known. Analyses of rare monogenic syndromes of HTN have focused attention on pathways that involve renal sodium handling, and steroid hormone metabolism including the mineralocorticoid receptor activity. The genetic basis of common essential HTN on the other hand is only just becoming accessible through high-throughput approaches. Unbiased genome-wide analyses of BP genomics have identified 43 genetic variants associated with systolic, diastolic BP, and HTN. It is highly likely based on current findings that there are hundreds of such loci with small effects on BP, opening a perspective on the genetic architecture of BP that was unknown before. It is our hope that the knowledge of these and further loci will lead to improved understanding of BP pathophysiology and to the identification of new targets for drug therapy.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Ehret GB,Caulfield MJ

doi

10.1093/eurheartj/ehs455

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

951-61

issue

13

eissn

0195-668X

issn

1522-9645

pii

ehs455

journal_volume

34

pub_type

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