The European Study of Epidemiology and Treatment of Cardiac Inflammatory Disease (ESETCID).

Abstract:

:Diagnosis of myocarditis has improved with the application of new techniques such as immunohistochemistry, polymerase chain reaction, in situ hybridization and Southern blot in endomyocardial biopsies. Treatment of inflammatory heart disease is still difficult and not yet validated by a study with patient numbers sufficient to allow statistical analysis. The European Study of Epidemiology and Treatment of Cardiac Inflammatory Disease (ESETCID) addresses problems of aetiology, pathogenesis and specific treatment of myocarditis. It is the first multicentre, double-blind placebo-controlled randomized study, apart from the Myocarditis Treatment Trial, to discriminate between different forms of myocarditis. Patients with cytomegalovirus-induced myocarditis are treated by hyperimmunoglobulin compared to placebo. Patients with enterovirus-positive myocarditis will receive interferon alpha vs placebo. Patients with virus-negative myocarditis, which is considered autoimmune, will be treated with immunosuppression compared to placebo. The primary endpoint of this study is an improvement in ejection fraction of more than 5%. This trial may give a better understanding of the course of myocarditis, leading to more specific treatment which may in turn reduce the number of patients with post-myocardial heart muscle disease who require heart transplantation as a final therapeutic remedy.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Maisch B,Hufnagel G,Schönian U,Hengstenberg C

doi

10.1093/eurheartj/16.suppl_o.173

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

173-5

eissn

0195-668X

issn

1522-9645

journal_volume

16 Suppl O

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Major differences among the three classes of calcium antagonists.

    abstract::The safety of calcium antagonists has recently become a controversial issue among cardiologists. Thus, the role of calcium antagonists in the treatment of myocardial infarction and in secondary cardiovascular prevention is under review. As a consequence, the concept that the words 'calcium antagonists' comprise variou...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/18.suppl_a.56

    authors: Ferrari R

    更新日期:1997-01-01 00:00:00

  • Anticoagulation in women with non-valvular atrial fibrillation in the stroke prevention using an oral thrombin inhibitor (SPORTIF) trials.

    abstract:AIMS:The risk of stroke is greater among women with atrial fibrillation (AF) than men. Warfarin protects against stroke, but treatment-related bleeding occurs more often in women than in men. METHODS AND RESULTS:SPORTIF III (open label, n=3410) and V (double-blind, n=3922) included 2257 women with AF and one or more s...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehl103

    authors: Gomberg-Maitland M,Wenger NK,Feyzi J,Lengyel M,Volgman AS,Petersen P,Frison L,Halperin JL

    更新日期:2006-08-01 00:00:00

  • Combined non-invasive functional and anatomical diagnostic work-up in clinical practice: the magnetic resonance and computed tomography in suspected coronary artery disease (MARCC) study.

    abstract:AIMS:The combined use of cardiac computed tomography (CT) coronary angiography (CTCA) and myocardial perfusion imaging allows the non-invasive evaluation of coronary morphology and function. Cardiovascular magnetic resonance (CMR) imaging has several advantages: it can simultaneously assess myocardial perfusion, ventri...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/eht077

    authors: Groothuis JG,Beek AM,Brinckman SL,Meijerink MR,van den Oever ML,Hofman MB,van Kuijk C,van Rossum AC

    更新日期:2013-07-01 00:00:00

  • Rates and predictors of hospital readmission after transcatheter aortic valve implantation.

    abstract:Aims:To analyse reasons, timing and predictors of hospital readmissions after transcatheter aortic valve implantation (TAVI). Methods and results:Patients included in the Bern TAVI Registry between August 2007 and June 2014 were analysed. Fine and Gray competing risk regression was used to identify factors predictive ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehx182

    authors: Franzone A,Pilgrim T,Arnold N,Heg D,Langhammer B,Piccolo R,Roost E,Praz F,Räber L,Valgimigli M,Wenaweser P,Jüni P,Carrel T,Windecker S,Stortecky S

    更新日期:2017-07-21 00:00:00

  • High on-thienopyridine platelet reactivity in elderly coronary patients: the SENIOR-PLATELET study.

    abstract:AIMS:The aim of this study was to compare on-thienopyridine platelet reactivity of elderly patients (≥75 years) vs. younger patients (<75 years). Elderly patients represent a growing and challenging segment of the coronary population for whom the effect of dual antiplatelet therapy on platelet inhibition has not been s...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehr407

    authors: Silvain J,Cayla G,Hulot JS,Finzi J,Kerneis M,O'Connor SA,Bellemain-Appaix A,Barthélémy O,Beygui F,Collet JP,Montalescot G

    更新日期:2012-05-01 00:00:00

  • Comparison between abnormalities in segmental endocardial motion and abnormalities in segmental wall thickening after anterior myocardial infarction. A cine-magnetic resonance study.

    abstract::In this study, two patterns of regional contract on of the left ventricle have been studied: endocardial motion and wall thickening, in order to check which of these was the most affected after myocardial infarction. The clinical relevance of this comparison was to assess which parameter of the regional contraction ab...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/oxfordjournals.eurheartj.a015069

    authors: Germain P,Roul G,Constantinesco A,Coulbois PM,Baruthio J,Mossard JM,Bareiss P,Sacrez A

    更新日期:1996-09-01 00:00:00

  • Efficacy and safety of reduced-dose non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation: a meta-analysis of randomized controlled trials.

    abstract:AIMS:Non-vitamin K antagonist oral anticoagulants (NOACs) require dose reductions according to patient or clinical factors for patients with atrial fibrillation (AF). In this meta-analysis, we aimed to assess outcomes with reduced-dose NOACs when given as pre-specified in pivotal trials. METHODS AND RESULTS:Aggregated...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析

    doi:10.1093/eurheartj/ehy802

    authors: Wang KL,Lopes RD,Patel MR,Büller HR,Tan DS,Chiang CE,Giugliano RP

    更新日期:2019-05-14 00:00:00

  • Arginase I enhances atherosclerotic plaque stabilization by inhibiting inflammation and promoting smooth muscle cell proliferation.

    abstract:AIMS:The aim of this study was to investigate the effect of Arginase I (ArgI) on plaque stabilization in unruptured atherosclerotic plaque and explore its mechanism. METHODS AND RESULTS:The atherosclerotic plaque model was established in New Zealand rabbits by balloon injury of abdominal arteries and a high cholestero...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/eht329

    authors: Wang XP,Zhang W,Liu XQ,Wang WK,Yan F,Dong WQ,Zhang Y,Zhang MX

    更新日期:2014-04-01 00:00:00

  • Risk prediction of cardiovascular death based on the QTc interval: evaluating age and gender differences in a large primary care population.

    abstract:AIMS:Using a large, contemporary primary care population we aimed to provide absolute long-term risks of cardiovascular death (CVD) based on the QTc interval and to test whether the QTc interval is of value in risk prediction of CVD on an individual level. METHODS AND RESULTS:Digital electrocardiograms from 173 529 pr...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehu081

    authors: Nielsen JB,Graff C,Rasmussen PV,Pietersen A,Lind B,Olesen MS,Struijk JJ,Haunsø S,Svendsen JH,Køber L,Gerds TA,Holst AG

    更新日期:2014-05-21 00:00:00

  • Worldwide experience with a totally subcutaneous implantable defibrillator: early results from the EFFORTLESS S-ICD Registry.

    abstract:AIMS:The totally subcutaneous implantable-defibrillator (S-ICD) is a new alternative to the conventional transvenous ICD system to minimize intravascular lead complications. There are limited data describing the long-term performance of the S-ICD. This paper presents the first large international patient population col...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehu112

    authors: Lambiase PD,Barr C,Theuns DA,Knops R,Neuzil P,Johansen JB,Hood M,Pedersen S,Kääb S,Murgatroyd F,Reeve HL,Carter N,Boersma L,EFFORTLESS Investigators.

    更新日期:2014-07-01 00:00:00

  • Outdoor light at night and risk of coronary heart disease among older adults: a prospective cohort study.

    abstract:AIMS:We estimated the association between outdoor light at night at the residence and risk of coronary heart disease (CHD) within a prospective cohort of older adults in Hong Kong. METHODS AND RESULTS:Over a median of 11 years of follow-up, we identified 3772 incident CHD hospitalizations and 1695 CHD deaths. Annual l...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehaa846

    authors: Sun S,Cao W,Ge Y,Ran J,Sun F,Zeng Q,Guo M,Huang J,Lee RS,Tian L,Wellenius GA

    更新日期:2020-11-17 00:00:00

  • Anticoagulant properties, clinical efficacy and safety of efegatran, a direct thrombin inhibitor, in patients with unstable angina.

    abstract:AIMS:Thrombin plays a key role in the clinical syndrome of unstable angina. We investigated the safety and efficacy of five dose levels of efegatran sulphate, a direct thrombin inhibitor, compared to heparin in patients with unstable angina. METHODS:Four hundred and thirty-two patients with unstable angina were enroll...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1053/euhj.1999.1477

    authors: Klootwijk P,Lenderink T,Meij S,Boersma H,Melkert R,Umans VA,Stibbe J,Müller EJ,Poortermans KJ,Deckers JW,Simoons ML

    更新日期:1999-08-01 00:00:00

  • Does exercise-induced myocardial ischaemia cause enhanced platelet activation and fibrin formation in patients with stable angina and severe coronary artery disease?

    abstract::In this study, betathromboglobulin (BTG) and fibrinopeptide A (FPA) in peripheral venous blood were measured in 20 patients with stable angina pectoris before and immediately after exercise-induced myocardial ischaemia; in 5 of the 20 patients stable angina was associated with typical peripheral artery disease. A tota...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/8.7.734

    authors: Gallino A,Häberli A,Straub PW,Steinbrunn W,Turina M,Rothlin ME

    更新日期:1987-07-01 00:00:00

  • Impact of diabetes mellitus on long-term survival in patients with congestive heart failure.

    abstract:AIMS:To test the hypothesis that diabetic status may be used as a prognostic indicator in heart failure (HF) patients. METHODS AND RESULTS:We studied 1246 consecutive patients with left ventricular dysfunction. All patients had a cardiopulmonary exercise test and an echocardiogram. Cardiac catheterisation was systemat...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ehj.2004.01.010

    authors: De Groote P,Lamblin N,Mouquet F,Plichon D,McFadden E,Van Belle E,Bauters C

    更新日期:2004-04-01 00:00:00

  • Clinical course and prognosis of patients with typical and atypical hypertrophic obstructive and with hypertrophic non-obstructive cardiomyopathy.

    abstract::In a total of 339 patients with hypertrophic cardiomyopathies (typical HOCM, n = 224; atypical HOCM, n = 30; HNCM, n = 80) the clinical course, the Sokolow-Lyon index in the ECG and the prognosis as demonstrated by cumulative survival rates were analysed to get more differentiated information for the characterization ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/4.suppl_f.145

    authors: Loogen F,Kuhn H,Gietzen F,Lösse B,Schulte HD,Bircks W

    更新日期:1983-11-01 00:00:00

  • Cardiac resynchronization therapy non-responder to responder conversion rate in the more response to cardiac resynchronization therapy with MultiPoint Pacing (MORE-CRT MPP) study: results from Phase I.

    abstract:AIMS:To assess the impact of MultiPoint™ Pacing (MPP)-programmed according to the physician's discretion-in non-responders to standard biventricular pacing after 6 months. METHODS AND RESULTS:The study enrolled 1921 patients receiving a quadripolar cardiac resynchronization therapy (CRT) system capable of MPP™ therapy...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehz109

    authors: Leclercq C,Burri H,Curnis A,Delnoy PP,Rinaldi CA,Sperzel J,Lee K,Calò L,Vicentini A,Concha JF,Thibault B

    更新日期:2019-09-14 00:00:00

  • Early two-dimensional echocardiographic measurement of left ventricular ejection fraction in acute myocardial infarction.

    abstract::Left ventricular volume and ejection fraction were measured by 2-dimensional echocardiography from 2 orthogonal apical long axis views in 90 patients admitted with acute transmural myocardial infarction. Results were correlated with worst Killip class during hospital stay, enzymatic infarct size (peak CK-MB) and morta...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061638

    authors: Kan G,Visser CA,Lie KI,Durrer D

    更新日期:1984-03-01 00:00:00

  • ACE inhibitors in non-ischaemic heart failure: results from the MEGA trials.

    abstract::Large-scale trials have demonstrated a consistent mortality reduction from angiotensin converting enzyme (ACE) inhibitor therapy for chronic heart failure. Nonetheless, the pharmacologic and physiologic mechanisms of this favourable affect and the appropriate target population remain controversial. ACE inhibitors exer...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/16.suppl_o.133

    authors: Cohn JN

    更新日期:1995-12-01 00:00:00

  • Afterload reduction by nifedipine--the acute haemodynamic response to exercise in hypertensive subjects.

    abstract::In 16 people with essential hypertension, heart rate (HR), blood pressure (BP) and relative cardiac volumes were measured at rest and during submaximal upright exercise before and after 10 mg of sublingual nifedipine using radionuclide ventriculography. In 10 patients who had had no previous therapy (BP 152/103 +/- 5/...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061863

    authors: Wathen CG,Hannan WJ,Turnbull LW,Muir AL

    更新日期:1985-04-01 00:00:00

  • Effects of ranolazine on exercise tolerance and HbA1c in patients with chronic angina and diabetes.

    abstract:AIMS:The anti-anginal efficacy and safety of ranolazine in diabetic and non-diabetic patients included in the Combination Assessment of Ranolazine In Stable Angina (CARISA) trial (JAMA 2004;291:309) were studied. Glycaemic control was also assessed in CARISA and its long-term open-label extension study. METHODS AND RE...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehi495

    authors: Timmis AD,Chaitman BR,Crager M

    更新日期:2006-01-01 00:00:00

  • Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study.

    abstract:AIMS:Anecdotal observations suggest that sub-clinical electrophysiological manifestations of arrhythmogenic right ventricular cardiomyopathy (ARVC) develop before detectable structural changes ensue on cardiac imaging. To test this hypothesis, we investigated a murine model with conditional cardiac genetic deletion of ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehr472

    authors: Gomes J,Finlay M,Ahmed AK,Ciaccio EJ,Asimaki A,Saffitz JE,Quarta G,Nobles M,Syrris P,Chaubey S,McKenna WJ,Tinker A,Lambiase PD

    更新日期:2012-08-01 00:00:00

  • Renal responses to atrial natriuretic factor in patients with congestive heart failure.

    abstract::It is now recognised after many years of speculation regarding the role of mammalian atria in the direct regulation of intravascular volume, that atrial myocites produce a peptide hormone that results in natriuresis and diuresis, under the condition of atrial distention. This atrial natriuretic factor (ANF) is secrete...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/9.suppl_h.29

    authors: Cody RJ,Atlas SA,Laragh JH

    更新日期:1988-06-01 00:00:00

  • Cardiovascular disease risk factors in relation to suicide mortality in Asia: prospective cohort study of over one million Korean men and women.

    abstract:AIMS:A potential role for cardiovascular disease (CVD) risk factors in the aetiology of suicide has not been comprehensively examined. In addition to being small in scale and poorly characterized, existing studies very rarely sample Asian populations in whom risk factor-suicide relationships may plausibly differ to Cau...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehr229

    authors: Jee SH,Kivimaki M,Kang HC,Park IS,Samet JM,Batty GD

    更新日期:2011-11-01 00:00:00

  • Influence of heart rate, respiration and recipient atrial contraction on pulsed wave transmitral Doppler flow indices in orthotopic heart transplant recipients.

    abstract:AIMS:The study set out to assess the relative contributions of donor heart rate, respiration and recipient atrial contraction on the mean of pulsed wave transmitral Doppler flow indices in orthotopic heart transplant recipients. This would provide information on the theoretical usefulness of pacemaker synchronization o...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a015149

    authors: Mannaerts H,Balk A,Roelandt J

    更新日期:1997-10-01 00:00:00

  • Choosing a particular oral anticoagulant and dose for stroke prevention in individual patients with non-valvular atrial fibrillation: part 2.

    abstract::The choice of oral anticoagulant (OAC) for patients with atrial fibrillation (AF) may be influenced by individual clinical features or by patterns of risk factors and comorbidities. We reviewed analyses of subgroups of patients from trials of vitamin K antagonists vs. non-vitamin K oral anticoagulants (NOACs) for stro...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehw069

    authors: Diener HC,Aisenberg J,Ansell J,Atar D,Breithardt G,Eikelboom J,Ezekowitz MD,Granger CB,Halperin JL,Hohnloser SH,Hylek EM,Kirchhof P,Lane DA,Verheugt FWA,Veltkamp R,Lip GYH

    更新日期:2017-03-21 00:00:00

  • Reduced blood pressure-lowering effect of catheter-based renal denervation in patients with isolated systolic hypertension: data from SYMPLICITY HTN-3 and the Global SYMPLICITY Registry.

    abstract:Aims:Catheter-based renal artery denervation (RDN) has been shown to lower blood pressure (BP) in certain patients with uncontrolled hypertension. Isolated systolic hypertension (ISH) (systolic BP [SBP] ≥140 mmHg and diastolic BP <90 mmHg), characterized by increased vascular stiffness, is the predominant hypertensive ...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehw325

    authors: Mahfoud F,Bakris G,Bhatt DL,Esler M,Ewen S,Fahy M,Kandzari D,Kario K,Mancia G,Weber M,Böhm M

    更新日期:2017-01-07 00:00:00

  • A brief history of the European Society of Cardiology.

    abstract::A look back on the history of the European Society of Cardiology which officially came into existence in 1950. ...

    journal_title:European heart journal

    pub_type: 历史文章,杂志文章

    doi:10.1093/eurheartj/ehv248

    authors:

    更新日期:2015-07-21 00:00:00

  • Lipoproteins and cardiovascular risk--from genetics to CHD prevention.

    abstract::Increased levels of low density lipoprotein (LDL) cholesterol and triglyceride, and low levels of high density lipoprotein (HDL) cholesterol, are associated with increased risk of coronary heart disease (CHD). Only a minor part of the variation in lipids can be explained by defects in single genes of large effect; the...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:

    authors: Cullen P,Funke H,Schulte H,Assmann G

    更新日期:1998-04-01 00:00:00

  • Subclinical thyroid dysfunction and cardiovascular diseases: 2016 update.

    abstract::Subclinical thyroid dysfunction comprises subclinical hypothyroidism (SHypo), defined as elevated thyroid-stimulating hormone (TSH) by normal free thyroxine (FT4), and subclinical hyperthyroidism (SHyper) with decreased or undetectable TSH and normal FT4. Up to 10% of the elderly have SHypo, which is usually asymptoma...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehx050

    authors: Floriani C,Gencer B,Collet TH,Rodondi N

    更新日期:2018-02-14 00:00:00

  • The consistency of the treatment effect of an ACE-inhibitor based treatment regimen in patients with vascular disease or high risk of vascular disease: a combined analysis of individual data of ADVANCE, EUROPA, and PROGRESS trials.

    abstract:AIMS:Angiotensin-converting enzyme (ACE) inhibitors have been shown to reduce cardiovascular risk in different groups of patients. Whether these effects can be generalized to the broad group of patients with vascular disease is unknown. Therefore, we undertook a combined analysis using individual data from ADVANCE, EUR...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehp103

    authors: Brugts JJ,Ninomiya T,Boersma E,Remme WJ,Bertrand M,Ferrari R,Fox K,MacMahon S,Chalmers J,Simoons ML

    更新日期:2009-06-01 00:00:00