Abstract:
AIMS:The combined use of cardiac computed tomography (CT) coronary angiography (CTCA) and myocardial perfusion imaging allows the non-invasive evaluation of coronary morphology and function. Cardiovascular magnetic resonance (CMR) imaging has several advantages: it can simultaneously assess myocardial perfusion, ventricular and valvular function, cardiomyopathy, and aortic disease and does not involve any additional ionizing radiation. We investigated the combined use of cardiac CT and CMR for the diagnostic evaluation of patients with suspected coronary artery disease (CAD) in clinical practice. METHODS AND RESULTS:A total of 192 patients with low or intermediate pre-test probability of CAD underwent CTCA and CMR. All patients with obstructive CAD on CTCA and/or myocardial ischaemia on CMR were referred for invasive coronary angiography (ICA). Fractional flow reserve was measured in case of intermediate lesions (30-70% diameter stenosis) on ICA. Additional cardiac and extra-cardiac findings by CTCA and CMR were registered. The combination of CTCA and CMR significantly improved specificity and overall accuracy (94 and 91%) for the detection of significant CAD compared with their use as a single technique (CTCA 39 and 57%, P < 0.0001; CMR 82 and 83%, P = 0.016). No events were recorded during follow-up (18 ± 6 months) in 104 patients who did not undergo ICA. Furthermore, the combined strategy provided an alternative diagnosis in 19 patients. CONCLUSION:The combined use of CTCA and CMR significantly improved specificity and overall diagnostic accuracy for the detection of significant CAD and allowed the detection of alternative (extra-)cardiac disease in patients without significant CAD.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Groothuis JG,Beek AM,Brinckman SL,Meijerink MR,van den Oever ML,Hofman MB,van Kuijk C,van Rossum ACdoi
10.1093/eurheartj/eht077subject
Has Abstractpub_date
2013-07-01 00:00:00pages
1990-8issue
26eissn
0195-668Xissn
1522-9645pii
eht077journal_volume
34pub_type
杂志文章abstract::Increased arteriolar tone is the pathophysiological hallmark of essential hypertension and is determined by the intracellular free calcium concentration in the vascular smooth muscle cell. Calcium influx is an important determinant of vasoconstriction and excess calcium influx-dependent vasoconstriction has been shown...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/8.suppl_k.49
更新日期:1987-11-01 00:00:00
abstract::The effect of 24 weeks of treatment with simvastatin, a new HMG coenzyme A reductase inhibitor (dosages of 20 and 40 mg day-1) on serum lipid, lipoprotein and apolipoprotein A-I and B concentrations as well as safety parameters and subjective side effects were studied in 11 patients with familial (FH) and 10 patients ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a062541
更新日期:1988-05-01 00:00:00
abstract::Chronic total occlusions (CTOs) are a subset of lesions that present a considerable burden to cardiovascular patients. There exists a strong clinical desire to improve non-surgical options for CTO revascularization. While several techniques, devices, and guide wires have been developed and refined for use in CTOs, the...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/ehm634
更新日期:2008-03-01 00:00:00
abstract::Coronary heart disease (CHD) is the leading cause of death and disability in Europe. For patients presenting with an acute ST-segment elevation myocardial infarction (STEMI), timely myocardial reperfusion using either thrombolytic therapy or primary percutaneous coronary intervention (PPCI) is the most effective thera...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/eht090
更新日期:2013-06-01 00:00:00
abstract:AIMS:Serum gamma-glutamyltransferase (GGT) concentration may be involved in atherosclerosis. This study examined if serum GGT predicted coronary heart disease (CHD), especially differentiating non-fatal myocardial infarction (MI) and fatal CHD event, among the general population or participants with type-2 diabetes. M...
journal_title:European heart journal
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doi:10.1093/eurheartj/ehl086
更新日期:2006-09-01 00:00:00
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journal_title:European heart journal
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doi:10.1093/oxfordjournals.eurheartj.a060139
更新日期:1992-02-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehr268
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abstract::This state-of-the-art review aims to provide an up-to-date look at breakthrough omic technologies that are helping to unravel heart failure (HF) disease mechanisms and heterogeneity. Genomics, transcriptomics, proteomics, and metabolomics in HF are reviewed in depth. In addition, there is a thorough, expert discussion...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehaa270
更新日期:2020-09-21 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061637
更新日期:1984-03-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/11.suppl_e.230
更新日期:1990-08-01 00:00:00
abstract:AIMS:To determine the impact of surgical myectomy on ventricular arrhythmias in obstructive hypertrophic cardiomyopathy (HCM). Left ventricular outflow tract obstruction (LVOTO) correlates with adverse outcomes, including sudden cardiac death (SCD) in patients with HCM. Surgical myectomy is the primary treatment strate...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehm117
更新日期:2007-11-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehy378
更新日期:2019-03-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
doi:
更新日期:1998-07-01 00:00:00
abstract:AIM:Heart disease is recognized as a consequence of dysregulation of cardiac gene regulatory networks. Previously, unappreciated components of such networks are the long non-coding RNAs (lncRNAs). Their roles in the heart remain to be elucidated. Thus, this study aimed to systematically characterize the cardiac long no...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehu180
更新日期:2015-02-07 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
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更新日期:2013-06-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehm012
更新日期:2007-08-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1093/eurheartj/ehr460
更新日期:2012-02-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a059838
更新日期:1991-10-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/8.suppl_f.47
更新日期:1987-09-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061074
更新日期:1995-09-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/14.suppl_e.2
更新日期:1993-09-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:
更新日期:1998-04-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a062411
更新日期:1988-10-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061589
更新日期:1984-11-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/s0195-668x(03)00315-4
更新日期:2003-08-01 00:00:00
abstract:AIMS:The curiosity that leanness is associated with poor survival in patients with chronic heart failure (CHF) needs further insight by investigating the impact of weight loss on prognosis in a large sample of patients across a broad spectrum of both reduced and preserved left ventricular (LV) systolic function. METHO...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2008-11-01 00:00:00
abstract::Liaison with two important scientific societies in the field of hypertension improves contact with readers. ...
journal_title:European heart journal
pub_type: 新闻
doi:
更新日期:2012-05-01 00:00:00
abstract::Coronary vasodilator responses to pharmacological (acetylcholine) and physiological (cold pressor test and flow dependent dilation) stimuli are impaired in hypertensive patients. The ability of angiotensin-converting enzyme inhibitors to restore normal coronary responses in hypertension and the potential mechanisms in...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:Sixteen cases of sudden unexpected cardiac death, 15 males and one female, are known to have occurred among young Swedish orienteers from 1979 to 1992, of which seven cases occurred between 1989 and 1992. This is considered to be indicative of an increased death rate. RESULTS:Histopathological evaluation sh...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a014972
更新日期:1996-06-01 00:00:00