Combined non-invasive functional and anatomical diagnostic work-up in clinical practice: the magnetic resonance and computed tomography in suspected coronary artery disease (MARCC) study.


AIMS:The combined use of cardiac computed tomography (CT) coronary angiography (CTCA) and myocardial perfusion imaging allows the non-invasive evaluation of coronary morphology and function. Cardiovascular magnetic resonance (CMR) imaging has several advantages: it can simultaneously assess myocardial perfusion, ventricular and valvular function, cardiomyopathy, and aortic disease and does not involve any additional ionizing radiation. We investigated the combined use of cardiac CT and CMR for the diagnostic evaluation of patients with suspected coronary artery disease (CAD) in clinical practice. METHODS AND RESULTS:A total of 192 patients with low or intermediate pre-test probability of CAD underwent CTCA and CMR. All patients with obstructive CAD on CTCA and/or myocardial ischaemia on CMR were referred for invasive coronary angiography (ICA). Fractional flow reserve was measured in case of intermediate lesions (30-70% diameter stenosis) on ICA. Additional cardiac and extra-cardiac findings by CTCA and CMR were registered. The combination of CTCA and CMR significantly improved specificity and overall accuracy (94 and 91%) for the detection of significant CAD compared with their use as a single technique (CTCA 39 and 57%, P < 0.0001; CMR 82 and 83%, P = 0.016). No events were recorded during follow-up (18 ± 6 months) in 104 patients who did not undergo ICA. Furthermore, the combined strategy provided an alternative diagnosis in 19 patients. CONCLUSION:The combined use of CTCA and CMR significantly improved specificity and overall diagnostic accuracy for the detection of significant CAD and allowed the detection of alternative (extra-)cardiac disease in patients without significant CAD.


Eur Heart J


European heart journal


Groothuis JG,Beek AM,Brinckman SL,Meijerink MR,van den Oever ML,Hofman MB,van Kuijk C,van Rossum AC




Has Abstract


2013-07-01 00:00:00














  • Lipoproteins in chronic kidney disease: from bench to bedside.

    abstract::Chronic kidney disease (CKD) is associated with high cardiovascular risk. CKD patients exhibit a specific lipoprotein pattern termed 'uraemic dyslipidaemia', which is characterized by rather normal low-density lipoprotein cholesterol, low high-density lipoprotein cholesterol, and high triglyceride plasma levels. All t...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Speer T,Ridker PM,von Eckardstein A,Schunk SJ,Fliser D

    更新日期:2021-01-04 00:00:00

  • High-sensitivity C-reactive protein: potential adjunct for risk stratification in patients with stable congestive heart failure.

    abstract:AIMS:To determine the potential adjunct of high-sensitivity (hs) C-reactive protein for risk stratification in patients with stable congestive heart failure (CHF). METHODS AND RESULTS:We studied 546 consecutive patients clinically stable with an ejection fraction <45% who were referred to our centre for evaluation of ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Lamblin N,Mouquet F,Hennache B,Dagorn J,Susen S,Bauters C,de Groote P

    更新日期:2005-11-01 00:00:00

  • Increased risk of atrial fibrillation in patients with coeliac disease: a nationwide cohort study.

    abstract:AIMS:Inflammatory markers are established risk factors for atrial fibrillation (AF), but the role of autoimmune diseases is unknown. The aim of the study was to examine the association between coeliac disease (CD) and AF in a large cohort of patients with biopsy-verified CD. METHODS AND RESULTS:We identified 28,637 pa...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Emilsson L,Smith JG,West J,Melander O,Ludvigsson JF

    更新日期:2011-10-01 00:00:00

  • Management and outcome of patients with established coronary artery disease: the Euro Heart Survey on coronary revascularization.

    abstract:AIMS:The purpose of the Euro Heart Survey Programme of the European Society of Cardiology is to evaluate to which extent clinical practice endorses existing guidelines as well as to identify differences in population profiles, patient management, and outcome across Europe. The current survey focuses on the invasive dia...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究


    authors: Lenzen MJ,Boersma E,Bertrand ME,Maier W,Moris C,Piscione F,Sechtem U,Stahle E,Widimsky P,de Jaegere P,Scholte op Reimer WJ,Mercado N,Wijns W,European Society of Cardiology.

    更新日期:2005-06-01 00:00:00

  • Heterogeneity of endothelial dysfunction in hypertension.

    abstract::The endothelium may play a role as a target and mediator of hypertension. Due to its anatomical position, it is very exposed to mechanical forces; as a source of vasoactive material it may participate in increasing peripheral vascular resistance and in promoting local ischaemia in the heart and brain. Morphological an...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Lüscher TF

    更新日期:1992-09-01 00:00:00

  • Outdoor light at night and risk of coronary heart disease among older adults: a prospective cohort study.

    abstract:AIMS:We estimated the association between outdoor light at night at the residence and risk of coronary heart disease (CHD) within a prospective cohort of older adults in Hong Kong. METHODS AND RESULTS:Over a median of 11 years of follow-up, we identified 3772 incident CHD hospitalizations and 1695 CHD deaths. Annual l...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Sun S,Cao W,Ge Y,Ran J,Sun F,Zeng Q,Guo M,Huang J,Lee RS,Tian L,Wellenius GA

    更新日期:2020-11-17 00:00:00

  • Afterload reduction by nifedipine--the acute haemodynamic response to exercise in hypertensive subjects.

    abstract::In 16 people with essential hypertension, heart rate (HR), blood pressure (BP) and relative cardiac volumes were measured at rest and during submaximal upright exercise before and after 10 mg of sublingual nifedipine using radionuclide ventriculography. In 10 patients who had had no previous therapy (BP 152/103 +/- 5/...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Wathen CG,Hannan WJ,Turnbull LW,Muir AL

    更新日期:1985-04-01 00:00:00

  • Evidence for obesity paradox in patients with acute coronary syndromes: a report from the Swedish Coronary Angiography and Angioplasty Registry.

    abstract:AIMS:The obesity paradox refers to the epidemiological evidence that obesity compared with normal weight is associated with counter-intuitive improved health in a variety of disease conditions. The aim of this study was to investigate the relationship between body mass index (BMI) and mortality in patients with acute c...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Angerås O,Albertsson P,Karason K,Råmunddal T,Matejka G,James S,Lagerqvist B,Rosengren A,Omerovic E

    更新日期:2013-02-01 00:00:00

  • Antibiotic treatment of streptococcal and enterococcal endocarditis: an overview.

    abstract::The management of streptococcal and enterococcal endocarditis has changed in recent years with the development of effective new regimens that are easier to administer, but resistance to commonly used antibiotics has appeared, especially among enterococci. Beta-lactam antibiotics either alone or in combination are suit...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Francioli P

    更新日期:1995-04-01 00:00:00

  • Single infusion of intravenous cibenzoline in the treatment of supraventricular tachyarrhythmias following heart surgery. A double-blind placebo-controlled parallel study.

    abstract::The efficacy and safety of a single infusion of cibenzoline, a class I antiarrhythmic drug, were assessed in 86 patients presenting with a supraventricular tachyarrhythmia following heart surgery in a placebo-controlled double-blind parallel study. Cibenzoline was effective in 13 patients (30%) vs three patients (6.9%...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Ollitrault J,Quilliet L,Scheck F,Lelong B,Richard A,Jarry G,Guize L

    更新日期:1994-09-01 00:00:00

  • Peptides in coronary circulation: basis for therapeutic strategies.

    abstract::Promising approaches towards new therapeutic strategies in coronary heart disease might emerge from an improved pathophysiological understanding of the role of certain peptides, which require a localizing event for their accumulation or expression in the coronary vasculature. Temporal myocardial ischaemia or hypoperfu...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Holtz J,Goetz RM

    更新日期:1991-12-01 00:00:00

  • The natural history of myocardium awaiting revascularisation in patients with impaired left ventricular function.

    abstract:AIMS:Our aim was to follow changes in myocardial function and physiology in patients awaiting coronary artery bypass surgery (CABG) and relate changes to post-revascularisation functional response. METHODS AND RESULTS:In 21 patients with CAD and LV dysfunction, myocardial glucose utilisation (MGU) and blood flow (MBF)...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Pitt M,Dutka D,Pagano D,Camici P,Bonser R

    更新日期:2004-03-01 00:00:00

  • Lentiginosis and right atrial myxoma.

    abstract::A right atrial myxoma was detected by cross-sectional echocardiography in a 21-year-old woman with cutaneous lentiginosis. The lentigines were present mainly on the right side of the trunk. ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Göksel S,Kural T

    更新日期:1989-08-01 00:00:00

  • The relationship of QRS morphology and mechanical dyssynchrony to long-term outcome following cardiac resynchronization therapy.

    abstract:AIMS:Because benefits of cardiac resynchronization therapy (CRT) appear to be less favourable in non-left bundle branch block (LBBB) patients, this prospective longitudinal study tested the hypothesis that QRS morphology and echocardiographic mechanical dyssynchrony were associated with long-term outcome after CRT. ME...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Hara H,Oyenuga OA,Tanaka H,Adelstein EC,Onishi T,McNamara DM,Schwartzman D,Saba S,Gorcsan J 3rd

    更新日期:2012-11-01 00:00:00

  • Association of low ankle brachial index with high mortality in primary care.

    abstract:AIMS:We aimed to assess the increased risk of death and severe vascular events in elderly individuals with subclinical or manifest peripheral arterial disease (PAD), evidenced by low ankle brachial index (ABI < 0.9) in primary care. METHODS AND RESULTS:In this monitored prospective observational study, 6880 representa...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究


    authors: Diehm C,Lange S,Darius H,Pittrow D,von Stritzky B,Tepohl G,Haberl RL,Allenberg JR,Dasch B,Trampisch HJ

    更新日期:2006-07-01 00:00:00

  • Pharmacokinetics of organic nitrates in man: an overview.

    abstract::The pharmacokinetics of glyceryl trinitrate are still not completely understood. The substance disappears rapidly from plasma largely by extrahepatic mechanisms. It is converted in glyceryl dinitrates and glyceryl mononitrates. After transdermal application of a controlled delivery system, plasma concentrations of gly...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Bogaert MG

    更新日期:1988-01-01 00:00:00

  • Coronary microembolization during early reperfusion: infarct extension, but protection by ischaemic postconditioning.

    abstract:AIMS:Reperfusion injury following acute myocardial infarction impacts not only on the myocardium but also on the coronary microcirculation, and microembolization from the culprit lesion contributes to microvascular obstruction. Prior experimental studies have not accounted for microembolization in ischaemia/reperfusion...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Skyschally A,Walter B,Heusch G

    更新日期:2013-11-01 00:00:00

  • Effect of irbesartan and enalapril in non-ST elevation acute coronary syndrome: results of the randomized, double-blind ARCHIPELAGO study.

    abstract:AIMS:This study investigated the effects of irbesartan vs. enalapril, with early vs. late treatment, on markers of inflammation and ischaemic heart disease in patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). METHODS AND RESULTS:Patients hospitalized with ischaemic symptoms and evidence of NSTE...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Montalescot G,Drexler H,Gallo R,Pearson T,Thoenes M,Bhatt DL

    更新日期:2009-11-01 00:00:00

  • Prevention of aortic dissection and aneurysm via an ALDH2-mediated switch in vascular smooth muscle cell phenotype.

    abstract:AIMS:Aortic aneurysm/dissection (AAD) is a life-threatening disorder lacking effective pharmacotherapeutic remedies. Aldehyde dehydrogenase 2 (ALDH2) polymorphism is tied with various risk factors for AAD including hypertension, atherosclerosis, and hypercholesterolaemia although direct correlation between the two rema...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Yang K,Ren J,Li X,Wang Z,Xue L,Cui S,Sang W,Xu T,Zhang J,Yu J,Liu Z,Shang H,Pang J,Huang X,Chen Y,Xu F

    更新日期:2020-07-07 00:00:00

  • Sudden cardiac death while taking amiodarone therapy: the role of abnormal repolarization.

    abstract::Torsade de pointes may occur as a complication of amiodarone therapy. We report a patient receiving amiodarone who was resuscitated from cardiovascular collapse and documented ventricular fibrillation. At subsequent electrophysiology study, while the patient was taking amiodarone therapy, monophasic action potentials ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Morgan JM,Lopes A,Rowland E

    更新日期:1991-10-01 00:00:00

  • Angiographic assessment of human coronary artery endothelial function by measurement of endothelium-dependent vasodilation.

    abstract::In isolated atherosclerotic human coronary arteries endothelium-dependent vascular relaxation is abolished with acetylcholine whereas another EDRF-dependent vasodilator, substance P, still produces significant relaxation. To study further these in vitro findings, graded doses of acetylcholine and substance P, which pr...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Bossaller C,Hehlert-Friedrich C,Jost S,Rafflenbeul W,Lichtlen P

    更新日期:1989-11-01 00:00:00

  • Mechanisms of antihypertensive action of beta-adrenergic blocking drugs: evidence against potentiation of baroreflexes.

    abstract::A possibility that can be advanced to explain the antihypertensive effect of beta-blocking drugs is that they act through the baroreflex control of the cardiovascular system. In 38 essential hypertensive patients we measured 1) The lengthening and shortening in R-R interval caused by stimulation or deactivation of art...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Parati G,Pomidossi G,Grassi G,Gavazzi C,Ramirez A,Gregorini L,Mancia G

    更新日期:1983-07-01 00:00:00

  • Performance of EuroSCORE in CABG and off-pump coronary artery bypass grafting: single institution experience and meta-analysis.

    abstract:AIMS:To assess EuroSCORE performance in predicting in-hospital mortality in on-pump coronary artery bypass grafting (CABG) and off-pump coronary artery bypass grafting (OPCAB). METHODS AND RESULTS:Additive and logistic EuroSCORE were computed for consecutive patients undergoing CABG (n = 3440, 75%) or OPCAB (n = 1140,...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析,评审


    authors: Parolari A,Pesce LL,Trezzi M,Loardi C,Kassem S,Brambillasca C,Miguel B,Tremoli E,Biglioli P,Alamanni F

    更新日期:2009-02-01 00:00:00

  • ST segment monitoring before, three weeks and six months after aortocoronary bypass surgery.

    abstract::ST segment monitoring by Holter ECG was conducted in 80 consecutive patients 2-4 weeks before aortocoronary bypass surgery and three weeks and six months after surgery. Preoperatively, all patients were under maximal medical therapy. In 31 out of 80 patients medical therapy could be stopped and thus 24-h ST monitoring...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Droste C,Lemmen S,Nitsche R,Betz P,Birnbaum D,Roskamm H

    更新日期:1988-12-01 00:00:00

  • Cardio-Oncology Services: rationale, organization, and implementation.

    abstract:AIMS:Anticancer therapies have extended the lives of millions of patients with malignancies, but for some this benefit is tempered by adverse cardiovascular (CV) effects. Cardiotoxicity may occur early or late after treatment initiation or termination. The extent of this cardiotoxicity is variable, depending on the typ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Lancellotti P,Suter TM,López-Fernández T,Galderisi M,Lyon AR,Van der Meer P,Cohen Solal A,Zamorano JL,Jerusalem G,Moonen M,Aboyans V,Bax JJ,Asteggiano R

    更新日期:2019-06-07 00:00:00

  • Relationship between the degree of coronary artery disease and of left ventricular function and the duration of the QT-interval in ECG.

    abstract::Advanced coronary artery disease (CAD), impaired left ventricular function and prolongation of the QT-interval are considered risk factors for sudden cardiac death in CAD-patients. So far, however, there are no studies investigating in detail whether there is a correlation between the QT-interval and changes in corona...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Krämer B,Brill M,Brühn A,Kübler W

    更新日期:1986-01-01 00:00:00

  • Supplementation with vitamins C and E suppresses leukocyte oxygen free radical production in patients with myocardial infarction.

    abstract::Clinical studies suggest that neutrophil activation during acute myocardial infarction (MI) aggravates tissue injury. Activated neutrophils are an important source of oxygen free radicals (OFR), the injurious effects of which are counteracted by endogenous antioxidants. We have previously shown in healthy subjects tha...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Herbaczyńska-Cedro K,K+osiewicz-Wasek B,Cedro K,Wasek W,Panczenko-Kresowska B,Wartanowicz M

    更新日期:1995-08-01 00:00:00

  • Selection of dichotomy limits for multifactorial prediction of arrhythmic events and mortality in survivors of acute myocardial infarction.

    abstract:AIMS:To evaluate the predictive value and optimum dichotomy limits for different combinations of prognostic indicators for the prediction of arrhythmic events and cardiac mortality in post-infarction patients. BACKGROUND:Studies of new interventions based on risk stratification after myocardial infarction have often u...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Redwood SR,Odemuyiwa O,Hnatkova K,Staunton A,Poloniecki I,Camm AJ,Malik M

    更新日期:1997-08-01 00:00:00

  • Effects of ranolazine on exercise tolerance and HbA1c in patients with chronic angina and diabetes.

    abstract:AIMS:The anti-anginal efficacy and safety of ranolazine in diabetic and non-diabetic patients included in the Combination Assessment of Ranolazine In Stable Angina (CARISA) trial (JAMA 2004;291:309) were studied. Glycaemic control was also assessed in CARISA and its long-term open-label extension study. METHODS AND RE...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Timmis AD,Chaitman BR,Crager M

    更新日期:2006-01-01 00:00:00

  • Sustained-release diltiazem versus metoprolol in stable angina pectoris.

    abstract::The efficacy of sustained-release diltiazem (diltiazem-SR) 120 mg b.i.d. was compared with metoprolol 100 mg b.i.d. in 12 patients with stable angina. Following a 1-week placebo period, patients received diltiazem-SR or metoprolol in two 3-week treatment periods, in a randomized double-blind crossover design. Total ex...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Posma JL,van Dijk RB,Lie KI

    更新日期:1989-10-01 00:00:00