Combined non-invasive functional and anatomical diagnostic work-up in clinical practice: the magnetic resonance and computed tomography in suspected coronary artery disease (MARCC) study.

Abstract:

AIMS:The combined use of cardiac computed tomography (CT) coronary angiography (CTCA) and myocardial perfusion imaging allows the non-invasive evaluation of coronary morphology and function. Cardiovascular magnetic resonance (CMR) imaging has several advantages: it can simultaneously assess myocardial perfusion, ventricular and valvular function, cardiomyopathy, and aortic disease and does not involve any additional ionizing radiation. We investigated the combined use of cardiac CT and CMR for the diagnostic evaluation of patients with suspected coronary artery disease (CAD) in clinical practice. METHODS AND RESULTS:A total of 192 patients with low or intermediate pre-test probability of CAD underwent CTCA and CMR. All patients with obstructive CAD on CTCA and/or myocardial ischaemia on CMR were referred for invasive coronary angiography (ICA). Fractional flow reserve was measured in case of intermediate lesions (30-70% diameter stenosis) on ICA. Additional cardiac and extra-cardiac findings by CTCA and CMR were registered. The combination of CTCA and CMR significantly improved specificity and overall accuracy (94 and 91%) for the detection of significant CAD compared with their use as a single technique (CTCA 39 and 57%, P < 0.0001; CMR 82 and 83%, P = 0.016). No events were recorded during follow-up (18 ± 6 months) in 104 patients who did not undergo ICA. Furthermore, the combined strategy provided an alternative diagnosis in 19 patients. CONCLUSION:The combined use of CTCA and CMR significantly improved specificity and overall diagnostic accuracy for the detection of significant CAD and allowed the detection of alternative (extra-)cardiac disease in patients without significant CAD.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Groothuis JG,Beek AM,Brinckman SL,Meijerink MR,van den Oever ML,Hofman MB,van Kuijk C,van Rossum AC

doi

10.1093/eurheartj/eht077

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

1990-8

issue

26

eissn

0195-668X

issn

1522-9645

pii

eht077

journal_volume

34

pub_type

杂志文章
  • Calcium antagonist induced vasodilation in peripheral, coronary and cerebral vasculature as important factors in the treatment of elderly hypertensives.

    abstract::Increased arteriolar tone is the pathophysiological hallmark of essential hypertension and is determined by the intracellular free calcium concentration in the vascular smooth muscle cell. Calcium influx is an important determinant of vasoconstriction and excess calcium influx-dependent vasoconstriction has been shown...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/8.suppl_k.49

    authors: Erne P,Conen D,Kiowski W,Bolli P,Müller FB,Bühler FR

    更新日期:1987-11-01 00:00:00

  • Effects of simvastatin on plasma lipid, lipoprotein and apolipoprotein concentrations in hypercholesterolaemia.

    abstract::The effect of 24 weeks of treatment with simvastatin, a new HMG coenzyme A reductase inhibitor (dosages of 20 and 40 mg day-1) on serum lipid, lipoprotein and apolipoprotein A-I and B concentrations as well as safety parameters and subjective side effects were studied in 11 patients with familial (FH) and 10 patients ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062541

    authors: Mölgaard J,von Schenck H,Olsson AG

    更新日期:1988-05-01 00:00:00

  • Innovations in imaging for chronic total occlusions: a glimpse into the future of angiography's blind-spot.

    abstract::Chronic total occlusions (CTOs) are a subset of lesions that present a considerable burden to cardiovascular patients. There exists a strong clinical desire to improve non-surgical options for CTO revascularization. While several techniques, devices, and guide wires have been developed and refined for use in CTOs, the...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehm634

    authors: Courtney BK,Munce NR,Anderson KJ,Thind AS,Leung G,Radau PE,Foster FS,Vitkin IA,Schwartz RS,Dick AJ,Wright GA,Strauss BH

    更新日期:2008-03-01 00:00:00

  • Myocardial reperfusion injury: looking beyond primary PCI.

    abstract::Coronary heart disease (CHD) is the leading cause of death and disability in Europe. For patients presenting with an acute ST-segment elevation myocardial infarction (STEMI), timely myocardial reperfusion using either thrombolytic therapy or primary percutaneous coronary intervention (PPCI) is the most effective thera...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/eht090

    authors: Fröhlich GM,Meier P,White SK,Yellon DM,Hausenloy DJ

    更新日期:2013-06-01 00:00:00

  • Serum gamma-glutamyltransferase predicts non-fatal myocardial infarction and fatal coronary heart disease among 28,838 middle-aged men and women.

    abstract:AIMS:Serum gamma-glutamyltransferase (GGT) concentration may be involved in atherosclerosis. This study examined if serum GGT predicted coronary heart disease (CHD), especially differentiating non-fatal myocardial infarction (MI) and fatal CHD event, among the general population or participants with type-2 diabetes. M...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehl086

    authors: Lee DH,Silventoinen K,Hu G,Jacobs DR Jr,Jousilahti P,Sundvall J,Tuomilehto J

    更新日期:2006-09-01 00:00:00

  • Effect of heart rate on transmitral flow velocity profile and Doppler measurements of mitral valve area in patients with mitral stenosis.

    abstract::To study the effect of heart rate changes on Doppler measurements of mitral valve area atrial pacing was performed in 14 patients with mitral stenosis and sinus rhythm. Continuous wave Doppler and haemodynamic measurements were performed simultaneously at rest and during pacing-induced tachycardia. (1) Mitral valve ar...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060139

    authors: Voelker W,Regele B,Dittmann H,Mauser M,Ickrath O,Schmid KM,Karsch KR

    更新日期:1992-02-01 00:00:00

  • Computed tomography stress myocardial perfusion imaging in patients considered for revascularization: a comparison with fractional flow reserve.

    abstract:AIMS:Adenosine stress computed tomography myocardial perfusion imaging (CTP) is an emerging non-invasive method for detecting myocardial ischaemia. Its value when compared with fractional flow reserve (FFR), a highly accurate index of ischaemia, is unknown. Our aim was to determine the diagnostic accuracy of CTP and it...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehr268

    authors: Ko BS,Cameron JD,Meredith IT,Leung M,Antonis PR,Nasis A,Crossett M,Hope SA,Lehman SJ,Troupis J,DeFrance T,Seneviratne SK

    更新日期:2012-01-01 00:00:00

  • Omics phenotyping in heart failure: the next frontier.

    abstract::This state-of-the-art review aims to provide an up-to-date look at breakthrough omic technologies that are helping to unravel heart failure (HF) disease mechanisms and heterogeneity. Genomics, transcriptomics, proteomics, and metabolomics in HF are reviewed in depth. In addition, there is a thorough, expert discussion...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehaa270

    authors: Bayes-Genis A,Liu PP,Lanfear DE,de Boer RA,González A,Thum T,Emdin M,Januzzi JL

    更新日期:2020-09-21 00:00:00

  • On-line monitoring of multiple precordial leads in high risk patients with coronary artery disease--a pilot study.

    abstract::In a pilot study, a computerized precordial mapping system monitored ischaemia on-line in 50 patients (40 with acute myocardial infarction and 10 with unstable angina, class IV (Canadian Cardiovascular Society). All had ST-segment depression or elevation greater than or equal to 0.2 mV in one or more precordial leads ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061637

    authors: von Essen R,Hinsen R,Louis R,Merx W,Silny J,Rau G,Effert S

    更新日期:1984-03-01 00:00:00

  • Lipoproteins of human peripheral lymph.

    abstract::The concentration of cholesterol in peripheral lymph is roughly one tenth of that in the blood plasma of the same subject. In lymph, there is virtually no very low density lipoprotein (VLDL), probably due to low permeability of the vascular endothelium for particles of this size. More than 95% of apo B-containing lipo...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/11.suppl_e.230

    authors: Reichl D

    更新日期:1990-08-01 00:00:00

  • Surgical septal myectomy decreases the risk for appropriate implantable cardioverter defibrillator discharge in obstructive hypertrophic cardiomyopathy.

    abstract:AIMS:To determine the impact of surgical myectomy on ventricular arrhythmias in obstructive hypertrophic cardiomyopathy (HCM). Left ventricular outflow tract obstruction (LVOTO) correlates with adverse outcomes, including sudden cardiac death (SCD) in patients with HCM. Surgical myectomy is the primary treatment strate...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehm117

    authors: McLeod CJ,Ommen SR,Ackerman MJ,Weivoda PL,Shen WK,Dearani JA,Schaff HV,Tajik AJ,Gersh BJ

    更新日期:2007-11-01 00:00:00

  • Epidemiology report: trends in sex-specific cerebrovascular disease mortality in Europe based on WHO mortality data.

    abstract:AIMS:There have been substantial declines in cerebrovascular disease mortality across much of Europe, mirroring trends in deaths from cardiovascular disease as a whole. No study has investigated trends in cerebrovascular disease, and its subtypes within all European countries. This study aimed to examine sex-specific t...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehy378

    authors: Shah R,Wilkins E,Nichols M,Kelly P,El-Sadi F,Wright FL,Townsend N

    更新日期:2019-03-01 00:00:00

  • Is hypertriglyceridaemia an independent risk factor for coronary heart disease? The epidemiological evidence.

    abstract::There has been considerable controversy over whether elevated levels of triglycerides, or hypertriglyceridaemia, is an independent risk factor in coronary heart disease (CHD). Discrepancies between findings of univariate and multivariate statistical analyses are likely to be due to the strong inverse correlation betwe...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:

    authors: Miller M

    更新日期:1998-07-01 00:00:00

  • Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifies novel heart-specific long non-coding RNAs.

    abstract:AIM:Heart disease is recognized as a consequence of dysregulation of cardiac gene regulatory networks. Previously, unappreciated components of such networks are the long non-coding RNAs (lncRNAs). Their roles in the heart remain to be elucidated. Thus, this study aimed to systematically characterize the cardiac long no...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehu180

    authors: Ounzain S,Micheletti R,Beckmann T,Schroen B,Alexanian M,Pezzuto I,Crippa S,Nemir M,Sarre A,Johnson R,Dauvillier J,Burdet F,Ibberson M,Guigó R,Xenarios I,Heymans S,Pedrazzini T

    更新日期:2015-02-07 00:00:00

  • Oxygen therapy in acute coronary syndrome: are the benefits worth the risk?

    abstract::Oxygen supplementation is a standard treatment for all patients who present with acute coronary syndrome, regardless of oxygen saturation levels. Most of the data regarding the function of oxygen in myocardial infarction is based on a limited number of basic and clinical studies. We performed a systematic literature r...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/eht110

    authors: Shuvy M,Atar D,Gabriel Steg P,Halvorsen S,Jolly S,Yusuf S,Lotan C

    更新日期:2013-06-01 00:00:00

  • Risk of dementia in stroke-free patients diagnosed with atrial fibrillation: data from a community-based cohort.

    abstract:AIMS:To estimate the incidence of dementia after the first atrial fibrillation (AF), and its impact on survival in a community-based cohort. METHODS AND RESULTS:Olmsted County, Minnesota adult residents diagnosed with first AF during 1986-2000 were identified, and followed until 2004. The primary outcome was new detec...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehm012

    authors: Miyasaka Y,Barnes ME,Petersen RC,Cha SS,Bailey KR,Gersh BJ,Casaclang-Verzosa G,Abhayaratna WP,Seward JB,Iwasaka T,Tsang TS

    更新日期:2007-08-01 00:00:00

  • High-sensitivity C-reactive protein, statin therapy, and risks of atrial fibrillation: an exploratory analysis of the JUPITER trial.

    abstract:AIMS:Increasing evidence supports a role for inflammation in promoting atrial fibrillation (AF) and statins have anti-inflammatory effects that may be relevant for the prevention of AF. However, studies of statin therapy and incident AF have yielded mixed results and not focused on individuals with an underlying pro-in...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehr460

    authors: Peña JM,MacFadyen J,Glynn RJ,Ridker PM

    更新日期:2012-02-01 00:00:00

  • Myocardial perfusion imaging with positron emission tomography and single photon emission computed tomography: frequency and causes of disparate results.

    abstract::The purpose of this study was to compare rubidium-82 PET with thallium-201 SPECT imaging in 150 patients. Both techniques followed a single dipyridamole-handgrip stress, and images were displayed using the same 3-dimensional format and quantitative colour scale. Coronary arteriography was employed to assign the correc...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a059838

    authors: Marwick TH,Go RT,MacIntyre WJ,Saha GB,Underwood DA

    更新日期:1991-10-01 00:00:00

  • Does coronary angioplasty replace, delay, or complement aortocoronary bypass surgery?

    abstract::In single vessel disease angioplasty can replace surgery in the majority of patients. In cases of recurrence at the site of angioplasty or in the case of progression elsewhere, a second intervention can be performed. Thus, in the majority of patients surgery can be replaced; in the minority it can be delayed. In patie...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/8.suppl_f.47

    authors: Kaltenbach M

    更新日期:1987-09-01 00:00:00

  • Adenosine technetium-99m sestamibi (SPECT) for the early assessment of jeopardized myocardium after acute myocardial infarction.

    abstract::The purpose of this study was to evaluate the accuracy of adenosine Tc-99m sestamibi single photon emission computed tomography (SPECT) in the detection of jeopardized myocardium early after acute myocardial infarction. Coronary arteriography and myocardial scintigraphy were performed in 50 consecutive patients with a...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061074

    authors: Claeys MJ,Vrints CJ,Krug B,Bosmans JM,Blockx PP,Bossaert LL,Snoeck JP

    更新日期:1995-09-01 00:00:00

  • Pathophysiology of supraventricular tachycardia.

    abstract::Supraventricular tachycardia is due to altered automaticity, triggered activity or most commonly, reentry. Atrial flutter is most frequently due to reentry with counterclockwise activation in the right atrium with the left atrium acting as a bystander. The small wavefronts demonstrated during atrial fibrillation are l...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/14.suppl_e.2

    authors: Shakespeare CF,Anderson M,Camm AJ

    更新日期:1993-09-01 00:00:00

  • Natriuretic peptide-guided heart failure management.

    abstract::The natriuretic peptides are important tools to establish diagnosis and prognosis in heart failure (HF). With application of therapies for HF, changes in both B-type natriuretic peptide (BNP) and its amino terminal cleavage fragment (NT-proBNP) parallel the benefits of the HF therapy applied. This dynamic nature of BN...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/eht463

    authors: Troughton R,Michael Felker G,Januzzi JL Jr

    更新日期:2014-01-01 00:00:00

  • Lipoproteins and cardiovascular risk--from genetics to CHD prevention.

    abstract::Increased levels of low density lipoprotein (LDL) cholesterol and triglyceride, and low levels of high density lipoprotein (HDL) cholesterol, are associated with increased risk of coronary heart disease (CHD). Only a minor part of the variation in lipids can be explained by defects in single genes of large effect; the...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:

    authors: Cullen P,Funke H,Schulte H,Assmann G

    更新日期:1998-04-01 00:00:00

  • Influence of captopril on the arterial baroreceptor reflex in patients with heart failure.

    abstract::In 16 male patients with heart failure (NYHA II-III), the influence of a single dose of 25 mg captopril on the carotid sinus baroreceptor reflex was examined. Blood pressure fell significantly by 11 +/- 1.7 mm Hg (P less than 0.001), whereas heart rate remained unchanged (85 +/- 3 vs. 83 +/- 3 beats min-1). Carotid si...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062411

    authors: Osterziel KJ,Röhrig N,Dietz R,Manthey J,Hecht J,Kübler W

    更新日期:1988-10-01 00:00:00

  • Fascicular tachycardia sensitive to calcium antagonists.

    abstract::Five patients with recurrent tachycardias exhibiting right bundle branch block with left axis deviation were referred for investigation. In each case, a supraventricular mechanism was suspected. During sinus rhythm the QRS morphology and axis (-10 to +60 degrees) and HV intervals were normal. Tachycardia was initiated...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061589

    authors: Ward DE,Nathan AW,Camm AJ

    更新日期:1984-11-01 00:00:00

  • From guidelines to clinical practice: the impact of hospital and geographical characteristics on temporal trends in the management of acute coronary syndromes. The Global Registry of Acute Coronary Events (GRACE).

    abstract:AIMS:The extent to which hospital and geographic characteristics influence the time course of uptake of evidence from key clinical trials and practice guidelines is unknown. The gap between evidence and practice is well recognized but the factors influencing this disjunction, and the extent to which such factors are mo...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1016/s0195-668x(03)00315-4

    authors: Fox KA,Goodman SG,Anderson FA Jr,Granger CB,Moscucci M,Flather MD,Spencer F,Budaj A,Dabbous OH,Gore JM,GRACE Investigators.

    更新日期:2003-08-01 00:00:00

  • Weight loss and mortality risk in patients with chronic heart failure in the candesartan in heart failure: assessment of reduction in mortality and morbidity (CHARM) programme.

    abstract:AIMS:The curiosity that leanness is associated with poor survival in patients with chronic heart failure (CHF) needs further insight by investigating the impact of weight loss on prognosis in a large sample of patients across a broad spectrum of both reduced and preserved left ventricular (LV) systolic function. METHO...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehn420

    authors: Pocock SJ,McMurray JJ,Dobson J,Yusuf S,Granger CB,Michelson EL,Ostergren J,Pfeffer MA,Solomon SD,Anker SD,Swedberg KB

    更新日期:2008-11-01 00:00:00

  • The Journal of Hypertension.

    abstract::Liaison with two important scientific societies in the field of hypertension improves contact with readers. ...

    journal_title:European heart journal

    pub_type: 新闻

    doi:

    authors: Taylor J

    更新日期:2012-05-01 00:00:00

  • Acute effects of angiotensin-converting enzyme inhibition on coronary vasomotion in hypertensive patients.

    abstract::Coronary vasodilator responses to pharmacological (acetylcholine) and physiological (cold pressor test and flow dependent dilation) stimuli are impaired in hypertensive patients. The ability of angiotensin-converting enzyme inhibitors to restore normal coronary responses in hypertension and the potential mechanisms in...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:

    authors: Nitenberg A,Antony I

    更新日期:1998-09-01 00:00:00

  • An increase in sudden unexpected cardiac deaths among young Swedish orienteers during 1979-1992.

    abstract:BACKGROUND:Sixteen cases of sudden unexpected cardiac death, 15 males and one female, are known to have occurred among young Swedish orienteers from 1979 to 1992, of which seven cases occurred between 1989 and 1992. This is considered to be indicative of an increased death rate. RESULTS:Histopathological evaluation sh...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a014972

    authors: Wesslén L,Påhlson C,Lindquist O,Hjelm E,Gnarpe J,Larsson E,Baandrup U,Eriksson L,Fohlman J,Engstrand L,Linglöf T,Nyström-Rosander C,Gnarpe H,Magnius L,Rolf C,Friman G

    更新日期:1996-06-01 00:00:00