Abstract:
:Increased levels of low density lipoprotein (LDL) cholesterol and triglyceride, and low levels of high density lipoprotein (HDL) cholesterol, are associated with increased risk of coronary heart disease (CHD). Only a minor part of the variation in lipids can be explained by defects in single genes of large effect; the bulk of variation in most cases is due to the interaction of polygenes and environment. This paper describes a strategy for unravelling such complex genetic effects in the population at large. A person's risk of developing CHD is, however, not determined by levels of circulating lipids alone, but by a number of factors which contribute to his or her global risk. Based on the data of the Münster Heart Study (PROCAM), a multiple logistic function using nine independent variables for the prediction of risk has been developed. This function allows an almost 40-fold degree discrimination in risk between persons in the lowest and highest quintiles of the algorithm. Data from the Münster Heart Study and other prospective studies indicates a log-linear relationship between LDL cholesterol and CHD risk. The results of recent large scale intervention trials indicate that this relationship also holds true for LDL levels which are achieved by treatment. This indicates that the benefit achieved by cholesterol lowering is greatest at high baseline LDL cholesterol levels, and that at least for LDL cholesterol levels of > or = 80 mg. dl-1, there is no theoretical threshold below which lowering of LDL cholesterol cannot be expected to reduce CHD risk. However, at low LDL cholesterol levels the benefits of treatment may be outweighed by side-effects and by practical cost-benefit considerations. These issues are also discussed in detail in the present report.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Cullen P,Funke H,Schulte H,Assmann Gsubject
Has Abstractpub_date
1998-04-01 00:00:00pages
C5-11eissn
0195-668Xissn
1522-9645journal_volume
19 Suppl Cpub_type
杂志文章abstract:BACKGROUND:the prototype of a transoesophageal echocardiographic transducer with a rotatable cross-sectional scanning plane underwent initial evaluation. METHODS:the 5 MHz, phased array, 64 element transducer is incorporated into a 16 by 11 by 40 mm echoscope tip. The instrument also has pulsed wave and colour flow Do...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a060338
更新日期:1992-09-01 00:00:00
abstract::An investigation was undertaken to assess the value of adding streptokinase therapy to standard penicillin treatment of artificially induced infective endocarditis due to Streptococcus sanguis. In pigs a low-grade infection could be induced which closely simulated streptococcal endocarditis in man, but for technical r...
journal_title:European heart journal
pub_type: 临床试验,杂志文章
doi:10.1093/oxfordjournals.eurheartj.a062100
更新日期:1986-06-01 00:00:00
abstract::Eight young healthy male subjects, members of a Himalayan expedition, underwent 24 h Holter monitoring before departure, after 1 and 4 weeks at high altitude (5000 m) and after return to sea level. At high altitude, the circadian reciprocal changes in low and high frequency (LF, HF) were absent, with no significant re...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a060415
更新日期:1994-11-01 00:00:00
abstract:AIMS:The aim is to compare the coronary risk chart published by the European Task Force for Prevention of Coronary Heart Disease and produced using a Framingham risk function, with a risk function derived from an Italian population study. METHODS AND RESULTS:Coronary risk function in this study was the result of longi...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1053/euhj.1999.1864
更新日期:2000-03-01 00:00:00
abstract:AIMS:This study investigates whether increased right ventricular (RV) pressure in pulmonary hypertension (PH) impairs right coronary artery (RCA) flow and RV perfusion. METHODS:In 25 subjects, five patients with idiopathic pulmonary arterial hypertension, nine patients with chronic thromboembolic pulmonary arterial hy...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehm567
更新日期:2008-01-01 00:00:00
abstract:AIM:Cross-sectional studies reported associations between short leucocyte telomere length (LTL) and measures of vascular and cardiac damage. However, the contribution of LTL dynamics to the age-related process of cardiovascular (CV) remodelling remains unknown. In this study, we explored whether the rate of LTL shorten...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehu226
更新日期:2014-12-07 00:00:00
abstract:BACKGROUND:Electrocardiographic abnormalities and premature ventricular contractions are common in athletes and are generally benign. However, the specific outcome of high-level endurance athletes with frequent and complex ventricular arrhythmias is unclear. Also, information on the predictive accuracy of different inv...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/s0195-668x(03)00282-3
更新日期:2003-08-01 00:00:00
abstract::In 2008, The ESC Working Group on Myocardial and Pericardial Diseases proposed an updated classification of cardiomyopathies based on morphological and functional phenotypes and subcategories of familial/genetic and non-familial/non-genetic disease. In this position statement, we propose a framework for the clinical a...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehs397
更新日期:2013-05-01 00:00:00
abstract:AIMS:Induced pluripotent stem cells (iPSCs) provide a unique opportunity for the generation of patient-specific cells for use in disease modelling, drug screening, and regenerative medicine. The aim of this study was to compare human-induced pluripotent stem cells (hiPSCs) derived from different somatic cell sources re...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehs203
更新日期:2013-09-01 00:00:00
abstract::Haemodynamic effects of pharmacological doses of insulin during acute ischaemic heart failure were studied in 8 dogs. Severe depression of left ventricular function was induced by the injection of 50 micron plastic microspheres into the left main coronary artery. This was demonstrated by a significant increase in left...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061885
更新日期:1985-05-01 00:00:00
abstract::Aims Epidemiological studies reported two contrasting trends: on one hand, a significant improvement in the use of evidence-based treatments of patients discharged with a myocardial infarction (MI). On the other hand, the increasing number of elderly and co-morbid patients who are usually less treated. The aim of this...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehr410
更新日期:2012-02-01 00:00:00
abstract:AIM:Few epidemiological data are available describing the sudden death of persons in their prime. This study aims to elucidate when and how sudden death occurs among employees. METHODS:A total of 196775 employees from 10 workplaces in Central Japan were surveyed for non-traumatic sudden death during 1989-1995. Demogra...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1053/euhj.1998.1189
更新日期:1999-03-01 00:00:00
abstract::The purpose of this study was to describe the mechanism and determine predictive factors of mitral valve rupture requiring valve replacement following percutaneous mitral commissurotomy. Of the 350 consecutive patients treated by balloon mitral commissurotomy, the procedure was not completed in 16, and 11 developed ac...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/16.1.43
更新日期:1995-01-01 00:00:00
abstract::From 1978 to 1980, 260 healthy subjects, 40-79 years of age, underwent 24 h ambulatory electrocardiography in order to determine the prevalence and complexity of ventricular premature beats (VPBs) in adults without apparent heart disease. The number of types of VPBs seem in 5% or less were considered 'abnormal' and th...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a059946
更新日期:1991-05-01 00:00:00
abstract::The endothelium may play a role as a target and mediator of hypertension. Due to its anatomical position, it is very exposed to mechanical forces; as a source of vasoactive material it may participate in increasing peripheral vascular resistance and in promoting local ischaemia in the heart and brain. Morphological an...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/13.suppl_d.50
更新日期:1992-09-01 00:00:00
abstract:AIMS:Real-time MRI creates images with superb tissue contrast that may enable radiation-free catheterization. Simple procedures are the first step towards novel interventional procedures. We aim to perform comprehensive transfemoral diagnostic right heart catheterization in an unselected cohort of patients entirely usi...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehs189
更新日期:2013-02-01 00:00:00
abstract::Between January 1983 and December 1990, 20 patients aged 80 years or older underwent valvular surgery. The patients' ages varied from 80 to 87 years (mean, 82 +/- 1.5 years). The indication for operation was aortic stenosis in 19 patients, and mitral insufficiency after previous mitral valve replacement with a biopros...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a060205
更新日期:1992-04-01 00:00:00
abstract:INTRODUCTION:We investigated whether apolipoprotein A1 (ApoA1) could better identify patients with severe vessel damage than HDL-cholesterol in a population with recent acute myocardial infarction (AMI). METHODS:One hundred and forty-one male patients (mean age: 54.3 +/- 7.3 years) who had undergone coronary angiograp...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a060937
更新日期:1995-04-01 00:00:00
abstract::Pilots and new applicants with asymptomatic 'safe' WPW syndrome should be allowed to fly but not as pilot in sole command. Professional pilots with tachyarrhythmia related to a pre-excitation syndrome should usually be disqualified . Personnel who have undergone successful surgical treatment by ablation of an accessor...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/5.suppl_a.119
更新日期:1984-03-01 00:00:00
abstract::We conducted a survey by questionnaire to assess whether patients 'at risk' from infective endocarditis are aware of the need for good dental hygiene and antibiotic prophylaxis, and receive appropriate advice or treatment. Of 189 patients surveyed, half had told a dentist about their heart, 8% were aware of a dental p...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/14.6.812
更新日期:1993-06-01 00:00:00
abstract::Unstable angina is a high-risk phase of coronary heart disease defined by clinical symptoms. Electrocardiographic findings are heterogeneous and creatine kinase is only rarely elevated. However, troponin T and troponin I are found in about 30-40% of patients with angina at rest disclosing minor myocardial cell injury....
journal_title:European heart journal
pub_type: 杂志文章
doi:
更新日期:1998-11-01 00:00:00
abstract::The Alliance for Biomedical Research in Europe, co-founded by the European Society of Cardiology, has persuaded the European Parliament to move towards European Union-wide means of better directing and coordinating biomedical research, from the laboratory bench to the marketplace. ...
journal_title:European heart journal
pub_type: 新闻
doi:
更新日期:2014-04-01 00:00:00
abstract::We have evaluated overall and cardiac sympathetic activity in 47 patients undergoing coronary angiography, 27 with stable angina of at least 3 months duration, and 20 with unstable ischaemic symptoms within this period. Cardiac and overall sympathetic activity were assessed using radiotracer noradrenaline kinetic tech...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/14.6.751
更新日期:1993-06-01 00:00:00
abstract:AIMS:To identify variables predicting ejection fraction (EF) recovery and characterize prognosis of heart failure (HF) patients with EF recovery (HFrecEF). METHODS AND RESULTS:Retrospective study of adults referred for ≥2 echocardiograms separated by ≥6 months between 2008 and 2016 at the two largest echocardiography ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehz233
更新日期:2019-07-01 00:00:00
abstract::Aims Abciximab has previously been shown to enhance thrombolysis and improve myocardial perfusion when combined with reduced doses of alteplase. The purpose of the reteplase phase of TIMI 14 was to evaluate the effects of abciximab when used in combination with a reduced dose of reteplase for ST-elevation myocardial i...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1053/euhj.2000.2243
更新日期:2000-12-01 00:00:00
abstract:AIMS:In patients with ischaemic left ventricular (LV) dysfunction and viable myocardium, revascularization improves systolic function. Diastolic dysfunction is also present in such patients; however, whether revascularization improves diastolic function also is largely unknown. METHODS:Twenty-six patients with chronic...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehp125
更新日期:2009-06-01 00:00:00
abstract:AIMS:To test the hypothesis that increasing age in patients presenting with high-risk non-ST-segment elevation acute coronary syndromes (NSTE-ACS) does not adversely influence the benefit of an early invasive strategy on major adverse events at 6 months. METHODS AND RESULTS:We report clinical outcomes in young (<70), ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehn124
更新日期:2008-05-01 00:00:00
abstract::The present study was carried out to evaluate systolic and diastolic parameters in overweight and moderately obese, but otherwise healthy subjects, and in a lean control group, to determine whether degree and duration of obesity can influence left ventricular function. A total of 27 subjects, 17 overweight or with mod...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a060249
更新日期:1992-06-01 00:00:00
abstract:AIMS:To test whether N-terminal pro-B-type natriuretic peptide (NT-proBNP) was independently associated with, and improved the prediction of, cardiovascular disease (CVD) in a primary prevention cohort. METHODS AND RESULTS:In the West of Scotland Coronary Prevention Study (WOSCOPS), a cohort of middle-aged men with hy...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehs239
更新日期:2013-02-01 00:00:00
abstract:AIM:We sought to evaluate the incidence and electrophysiological features of the local slow potential preceding the surface QRS complex (pre-QRS potential) which was detected more frequently at successful sites of catheter ablation of left parietal concealed accessory pathways, than at unsuccessful sites. METHODS AND ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1053/euhj.1999.1688
更新日期:1999-12-01 00:00:00