ACE inhibitors in non-ischaemic heart failure: results from the MEGA trials.

Abstract:

:Large-scale trials have demonstrated a consistent mortality reduction from angiotensin converting enzyme (ACE) inhibitor therapy for chronic heart failure. Nonetheless, the pharmacologic and physiologic mechanisms of this favourable affect and the appropriate target population remain controversial. ACE inhibitors exert vasodilator, neurohormonal inhibiting and growth inhibiting effects that may contribute to the clinical response. They improve pump function and prevent ventricular remodelling, but they also may exert an antiarrhythmic effect. They may prevent coronary ischaemic events but appear to reduce cardiovascular event rates even more in non-ischaemic than in ischaemic heart disease. Their efficacy in early stages of asymptomatic heart disease and the optimal dose of the drugs for long-term benefit require further study.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Cohn JN

doi

10.1093/eurheartj/16.suppl_o.133

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

133-6

eissn

0195-668X

issn

1522-9645

journal_volume

16 Suppl O

pub_type

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