Does exercise-induced myocardial ischaemia cause enhanced platelet activation and fibrin formation in patients with stable angina and severe coronary artery disease?

abstract：AIMS:We designed this study in order to determine the effect of insulin on cardiac function in overweight and obese subjects during exercise. METHODS AND RESULTS:The cardiac function of 62 normal glucose tolerant subjects, aged 30-40 and divided into normal weight (group 1, n=22, BMI 20-24.9 kg/m(2)), overweight (grou...

journal_title：European heart journal

authors： Sasso FC,Carbonara O,Nasti R,Marfella R,Esposito K,Rambaldi P,Mansi L,Salvatore T,Torella R,Cozzolino D

更新日期：2005-06-01 00:00:00

abstract：:To assess the prevalence of asymmetric septal hypertrophy (ASH) in hypertensive patients, 613 echocardiographic examinations performed over a period of one year were reviewed. Asymmetric septal hypertrophy (defined by an echocardiographic interventricular septum to left ventricular free wall thickness ratio of greater...

journal_title：European heart journal

authors： Wicker P,Roudaut R,Haissaguere M,Villega-Arino P,Clementy J,Dallocchio M

更新日期：1983-11-01 00:00:00

abstract：Aims:Short-term studies have reported left ventricular (LV) dilatation following surgical creation of arteriovenous fistulas (AVF) or arteriovenous grafts (AVGs), but chronic cardiac structural and functional changes have not been examined or related to clinical outcomes following AVF/AVG. We sought to characterize the...

journal_title：European heart journal

authors： Reddy YNV,Obokata M,Dean PG,Melenovsky V,Nath KA,Borlaug BA

更新日期：2017-06-21 00:00:00

abstract：:Diagnosis of myocarditis has improved with the application of new techniques such as immunohistochemistry, polymerase chain reaction, in situ hybridization and Southern blot in endomyocardial biopsies. Treatment of inflammatory heart disease is still difficult and not yet validated by a study with patient numbers suff...

journal_title：European heart journal

authors： Maisch B,Hufnagel G,Schönian U,Hengstenberg C

更新日期：1995-12-01 00:00:00

abstract：AIMS:Cardioprotective effects of erythropoietin (EPO) have been shown in experimental and smaller clinical studies. We performed a prospective, multicentre, randomized trial to assess the effects of a single high dose of EPO after primary coronary intervention (PCI) for an ST-elevation myocardial infarction (STEMI). Me...

journal_title：European heart journal

authors： Voors AA,Belonje AM,Zijlstra F,Hillege HL,Anker SD,Slart RH,Tio RA,van 't Hof A,Jukema JW,Peels HO,Henriques JP,Ten Berg JM,Vos J,van Gilst WH,van Veldhuisen DJ,HEBE III Investigators.

更新日期：2010-11-01 00:00:00

abstract：:The early termination of clinical trials, for either benefit or harm, often generates undue enthusiasm or alarm. The enhanced publicity attending early termination of a trial promotes inappropriate interpretations because of the inherent difficulty of a prompt and comprehensive data review. Furthermore, the process of...

journal_title：European heart journal

authors：

更新日期：1994-06-01 00:00:00

abstract：AIMS:The aim of this study was to evaluate (1) homocysteinemia and the prevalence of the C677T MTHFR polymorphism in Marfan patients and (2) whether the severity of cardiovascular manifestations is associated with homocysteinemia and/or C677T polymorphism. METHODS AND RESULTS:We studied 107 patients subdivided into th...

journal_title：European heart journal

authors： Giusti B,Porciani MC,Brunelli T,Evangelisti L,Fedi S,Gensini GF,Abbate R,Sani G,Yacoub M,Pepe G

更新日期：2003-11-01 00:00:00

abstract：:Transluminal coronary angioplasty (PTCA) is a well defined controlled model inducing regional myocardial ischaemia in man. Direct cardiac anti-ischaemic effects of anti-anginal drugs can be assessed by intracoronary injection of small doses which do not affect systemic parameters. Trimetazidine (TMZ) has recently been...

journal_title：European heart journal

authors： Kober G,Pennaforte S,Buck T,Sievert H,Vallbracht C

更新日期：1993-11-01 00:00:00

abstract：:Previous evidence indicates that cells generate molecules that alter transcription in response to stress. Accordingly, we conducted preliminary experiments to characterize these molecules. Extracts were prepared from normal and experimental canine hearts in which a 100 mmHg gradient was created across the ascending ao...

journal_title：European heart journal

authors： Hammond GL,Lai YK,Markert CL

更新日期：1984-12-01 00:00:00

abstract：:The structural properties of cardiac isomyosins from several species were compared using native gel electrophoresis, analysis of proteolytic digests, analysis of monoclonal antibody reactivity to specific proteolytic fragments on electroblots and S1 nuclease mapping with cDNA probes. The structure of specific regions ...

journal_title：European heart journal

authors： Clark WA,Everett AW,Chizzonite RA,Eisenberg BR,Zak R

更新日期：1984-12-01 00:00:00

abstract：:The electrocardiographic patterns, observed during 24-h Holter monitoring, of 10 patients (mean age 35 +/- 22 years) with first and second degree A-V block due to dual A-V nodal pathways are reported. Recordings were selected according to the presence of: sudden and persistent prolongation of the PR interval: sudden n...

journal_title：European heart journal

authors： Di Biase M,Tritto M,Sabato G,Pitzalis MV,Rizzon P

更新日期：1991-03-01 00:00:00

abstract：:The management of left ventricular hypertrophy (LVH) presupposes that the patient is identified by echocardiography and is carefully evaluated for risk stratification, taking into consideration possible associated complications. The role of non-pharmacological treatment is limited, except in obese patients. Drug treat...

journal_title：European heart journal

authors： de Divitiis O,Celentano A,De Simone G,Di Somma S,Galderisi M,Liguori V,de Divitiis M,Petitto M

更新日期：1993-07-01 00:00:00

abstract：AIMS:Thrombin plays a key role in the clinical syndrome of unstable angina. We investigated the safety and efficacy of five dose levels of efegatran sulphate, a direct thrombin inhibitor, compared to heparin in patients with unstable angina. METHODS:Four hundred and thirty-two patients with unstable angina were enroll...

journal_title：European heart journal

authors： Klootwijk P,Lenderink T,Meij S,Boersma H,Melkert R,Umans VA,Stibbe J,Müller EJ,Poortermans KJ,Deckers JW,Simoons ML

更新日期：1999-08-01 00:00:00

abstract：AIMS:To determine the sequence of critical cardiovascular events in the progression of heart failure, and whether aetiology or high-dose vs low-dose lisinopril affected these pathways. METHODS AND RESULTS:This was a post-hoc investigation of the ATLAS database, which comprised 3164 patients with chronic heart failure,...

journal_title：European heart journal

authors： Cleland JG,Thygesen K,Uretsky BF,Armstrong P,Horowitz JD,Massie B,Packer M,Poole-Wilson PA,Rydén L,ATLAS investigators.

更新日期：2001-09-01 00:00:00

abstract：:There is no certain way of obtaining one of the European Society of Cardiology grants for research or clinical training offered each year, but Prof. Stavros Konstantinides (Centre for Thrombosis and Haemostasis, Johannes Gutenberg University, Mainz, Germany), who chairs the European Society of Cardiology Credentials C...

journal_title：European heart journal

authors：

更新日期：2014-05-14 00:00:00

abstract：AIMS:Recent studies suggest an association between acute inflammation and deterioration of arterial function. The effect of acute inflammation on endothelial function and the role of treatment with statins have not been investigated in subjects with dyslipidaemia. METHODS AND RESULTS:In this randomized, placebo-contro...

journal_title：European heart journal

authors： Vlachopoulos C,Aznaouridis K,Dagre A,Vasiliadou C,Masoura C,Stefanadi E,Skoumas J,Pitsavos C,Stefanadis C

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Myocardial ischaemia occurs principally in the subendocardial layer, whereas conventional myocardial perfusion imaging provides no information on the transmural myocardial blood flow (MBF) distribution. Subendocardial perfusion measurements and quantification of the transmural perfusion gradient (TPG) could ...

journal_title：European heart journal

authors： Danad I,Raijmakers PG,Harms HJ,Heymans MW,van Royen N,Lubberink M,Boellaard R,van Rossum AC,Lammertsma AA,Knaapen P

更新日期：2014-08-14 00:00:00

abstract：AIMS:The choice of resynchronization therapy between with (CRT-D) and without (CRT-P) a defibrillator remains a contentious issue. Cause-of-death analysis among CRT-P, compared with CRT-D, patients could help evaluate the extent to which CRT-P patients would have additionally benefited from a defibrillator in a daily c...

journal_title：European heart journal

authors： Marijon E,Leclercq C,Narayanan K,Boveda S,Klug D,Lacaze-Gadonneix J,Defaye P,Jacob S,Piot O,Deharo JC,Perier MC,Mulak G,Hermida JS,Milliez P,Gras D,Cesari O,Hidden-Lucet F,Anselme F,Chevalier P,Maury P,Sadoul N,

更新日期：2015-11-01 00:00:00

abstract：:The primary success rate and incidence of major complications have been retrospectively assessed in a consecutive series of 224 patients undergoing percutaneous transluminal coronary angioplasty (PTCA) in one centre. The patients have been divided into three groups; those with angina and no previous myocardial infarct...

journal_title：European heart journal

authors： Perry RA,Seth A,Singh A,Shiu MF

更新日期：1988-01-01 00:00:00

abstract：AIMS:To evaluate the effect of thrombolysis on mortality and its causes in older patients with acute myocardial infarction (AMI). METHODS AND RESULTS:An analysis of 706 consecutive patients > or =75 years old with a first AMI enrolled in the PPRIMM75 registry showed that although there were important differences in ba...

journal_title：European heart journal

authors： Bueno H,Martínez-Sellés M,Pérez-David E,López-Palop R

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:In the acute phase of myocardial infarction (acute MI) marked endothelial damage occurs within the first 24h following thrombolysis with streptokinase. We investigated whether this is associated with a change in levels of vascular endothelial growth factor (VEGF, possibly marking angiogenesis) in the first 2...

journal_title：European heart journal

authors： Chung NA,Lydakis C,Belgore F,Blann AD,Lip GY

更新日期：2002-10-01 00:00:00

abstract：:For clinical prognosis, LV function is best described in terms of ejection fraction (EF) or end-systolic volume (ESV). Because deterioration of LV function is the most important adverse prognostic factor for patients after recovery from myocardial infarction, any agent which improves function should improve long-term ...

journal_title：European heart journal

authors： Norris RM,White HD

更新日期：1990-08-01 00:00:00

abstract：:An 83-year-old man was hospitalized due to general fatigue and dyspnoea. He was diagnosed as having complete atrioventricular (AV) block due to cardiac involvement by a malignant lymphoma. Eleven days after the initiation of chemotherapy, the complete AV block disappeared and only a first degree AV block remained. ...

journal_title：European heart journal

authors： Otsuji Y,Arima N,Fujiwara H,Saito K,Kisanuki A,Tanaka H

更新日期：1994-03-01 00:00:00

abstract：AIMS:Adults who engage in leisure-time physical activity (LTPA) have a reduced risk of developing heart failure. We hypothesized that high levels of LTPA are associated with diminished adverse age-related changes in cardiac structure and function. METHODS AND RESULTS:We studied 4342 Atherosclerosis Risk in Communities...

journal_title：European heart journal

authors： Hegde SM,Gonçalves A,Claggett B,Evenson KR,Cheng S,Shah AM,Folsom AR,Solomon SD

更新日期：2016-08-21 00:00:00

abstract：AIMS:Circulating microRNAs (miRs) may reflect pathophysiologically relevant processes in the atherosclerotically diseased coronary arterial wall. Given the unmet medical need to identify patients with an unstable plaque phenotype, we determined the relation of circulating atherosclerosis-regulatory miRs with plaque phe...

journal_title：European heart journal

authors： Leistner DM,Boeckel JN,Reis SM,Thome CE,De Rosa R,Keller T,Palapies L,Fichtlscherer S,Dimmeler S,Zeiher AM

更新日期：2016-06-07 00:00:00

abstract：:Intracranial mycotic aneurysms (IMA) occur in 1-3% of all infective endocarditis. Although spontaneous resolution was evidenced on serial angiograms in many asymptomatic cases, the prognosis, if they rupture, is reported to be worse and partly contingent on the therapeutic approach. Among 12 patients (six acute and si...

journal_title：European heart journal

authors： Monsuez JJ,Vittecoq D,Rosenbaum A,Goujon C,Wolff M,Witchitz S,Modai J

更新日期：1989-09-01 00:00:00

abstract：AIMS:To determine the effects of omega-3 polyunsaturated fatty acids (omega-3 PUFAs) from fish on the incidence of recurrent ventricular arrhythmia in implantable cardioverter defibrillator (ICD) patients by combining results from published trials. METHODS AND RESULTS:We searched in the Medline, EMBASE, and Cochrane d...

journal_title：European heart journal

authors： Brouwer IA,Raitt MH,Dullemeijer C,Kraemer DF,Zock PL,Morris C,Katan MB,Connor WE,Camm JA,Schouten EG,McAnulty J

更新日期：2009-04-01 00:00:00

abstract：AIMS:Several factors are known to increase risk for cerebrovascular disease and dementia, but there is limited evidence on associations between multiple vascular risk factors (VRFs) and detailed aspects of brain macrostructure and microstructure in large community-dwelling populations across middle and older age. METH...

journal_title：European heart journal

authors： Cox SR,Lyall DM,Ritchie SJ,Bastin ME,Harris MA,Buchanan CR,Fawns-Ritchie C,Barbu MC,de Nooij L,Reus LM,Alloza C,Shen X,Neilson E,Alderson HL,Hunter S,Liewald DC,Whalley HC,McIntosh AM,Lawrie SM,Pell JP,Tucker-Drob

更新日期：2019-07-21 00:00:00

abstract：:Five, ten and fifteen min after sublingual administration of 10mg isosorbide dinitrate (ISDN) in chewing capsules, in 10 patients with coronary artery disease, ISDN plasma levels were correlated with the dilation of epicardial coronary arteries as well as with changes in aortic blood pressure and heart rate. Due to th...

journal_title：European heart journal

authors： Jost S,Rafflenbeul W,Knop I,Bossaller C,Gulba D,Hecker H,Lippolt P,Lichtlen PR

更新日期：1989-11-01 00:00:00

abstract：:We studied the effects of a chronic increase in flow and of chronic hypertension on regional pulmonary blood volume and extravascular lung density (lung tissue and interstitial water per unit thoracic volume) in one group of patients with intracardiac, left-to-right shunt and in another group with Eisenmenger's syndro...

journal_title：European heart journal

authors： Wollmer P,Rozkovec A,Rhodes CG,Allan RM,Maseri A

更新日期：1984-11-01 00:00:00