Protective effect of atorvastatin on acute systemic inflammation-induced endothelial dysfunction in hypercholesterolaemic subjects.

abstract：AIMS:The evidence base for fasting plasma glucose (FPG) in the non-diabetic range as a risk factor for cardiovascular disease (CVD) is inconclusive. We investigated this question in the West of Scotland Coronary Prevention Study (WOSCOPS). METHODS AND RESULTS:In WOSCOPS, we related FPG in 6447 men (mean age 55 years) ...

journal_title：European heart journal

authors： Preiss D,Welsh P,Murray HM,Shepherd J,Packard C,Macfarlane P,Cobbe S,Ford I,Sattar N

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Atrial abnormalities in patients with progressive systemic sclerosis have not been evaluated in terms of intra-atrial conduction. We hypothesized that a delay in atrial conduction in these patients might produce diastolic abnormalities as well as atrial arrhythmias. OBJECTIVE:To evaluate the atrial function...

journal_title：European heart journal

authors： Mizuno R,Fujimoto S,Nakano H,Nakajima T,Kimura A,Nakagawa Y,Dohi K

更新日期：1997-12-01 00:00:00

abstract：:Thrombolytic therapy is a practical, effective approach to the management of acute myocardial infarction that is widely used in Europe today. Early European trials demonstrated a clear reduction in mortality in patients who received thrombolytic therapy compared with those given conventional treatment. The findings of...

journal_title：European heart journal

authors： Vahanian A

更新日期：1996-09-01 00:00:00

abstract：AIMS:A higher intake of fruits and vegetables has been associated with a lower risk of ischaemic heart disease (IHD), but there is some uncertainty about the interpretation of this association. The objective was to assess the relation between fruit and vegetable intake and risk of mortality from IHD in the European Pro...

journal_title：European heart journal

authors： Crowe FL,Roddam AW,Key TJ,Appleby PN,Overvad K,Jakobsen MU,Tjønneland A,Hansen L,Boeing H,Weikert C,Linseisen J,Kaaks R,Trichopoulou A,Misirli G,Lagiou P,Sacerdote C,Pala V,Palli D,Tumino R,Panico S,Bueno-de-Mesqu

更新日期：2011-05-01 00:00:00

abstract：:The concept of coronary vascular reserve stems from the description of coronary autoregulation by Mosher in 1964. Schematically, the coronary blood flow at rest depends on the determinants of myocardial oxygen demand (heart rate, contractility and ventricular load). If maximal coronary vasodilation is produced, it res...

journal_title：European heart journal

authors： Nitenberg A,Antony I

更新日期：1995-08-01 00:00:00

abstract：AIMS:Anecdotal observations suggest that sub-clinical electrophysiological manifestations of arrhythmogenic right ventricular cardiomyopathy (ARVC) develop before detectable structural changes ensue on cardiac imaging. To test this hypothesis, we investigated a murine model with conditional cardiac genetic deletion of ...

journal_title：European heart journal

authors： Gomes J,Finlay M,Ahmed AK,Ciaccio EJ,Asimaki A,Saffitz JE,Quarta G,Nobles M,Syrris P,Chaubey S,McKenna WJ,Tinker A,Lambiase PD

更新日期：2012-08-01 00:00:00

abstract：:This report concerns a patient with cardiac manifestation of Whipple's disease. For the first time, the gene that encodes the 16s rRNA of Tropheryma whippelii was identified in a native aortic valve by means of a polymerase chain reaction technique. DNA amplification gives evidence of Tropheryma whippelii as a causati...

journal_title：European heart journal

authors： Wendler D,Mendoza E,Schleiffer T,Zander M,Maier M

更新日期：1995-03-01 00:00:00

abstract：:Streptococcus adjacens and S. defectivus are two recently individualized species of viridans streptococci. Both species were previously designated as nutritionally variant streptococci and characterized by their growth as small satellite colonies supported by 'helper' bacteria, or requiring complex media enriched with...

journal_title：European heart journal

authors： Bouvet A

更新日期：1995-04-01 00:00:00

abstract：AIMS:The extent to which hospital and geographic characteristics influence the time course of uptake of evidence from key clinical trials and practice guidelines is unknown. The gap between evidence and practice is well recognized but the factors influencing this disjunction, and the extent to which such factors are mo...

journal_title：European heart journal

authors： Fox KA,Goodman SG,Anderson FA Jr,Granger CB,Moscucci M,Flather MD,Spencer F,Budaj A,Dabbous OH,Gore JM,GRACE Investigators.

更新日期：2003-08-01 00:00:00

abstract：AIMS:To evaluate the predictive value and optimum dichotomy limits for different combinations of prognostic indicators for the prediction of arrhythmic events and cardiac mortality in post-infarction patients. BACKGROUND:Studies of new interventions based on risk stratification after myocardial infarction have often u...

journal_title：European heart journal

authors： Redwood SR,Odemuyiwa O,Hnatkova K,Staunton A,Poloniecki I,Camm AJ,Malik M

更新日期：1997-08-01 00:00:00

abstract：:The implementation of molecular biological approaches has led to the discovery of single genetic variations that contribute to the development of cardiac failure. In the present review, the characteristics that are invariably associated with the development of failure in experimental animals and clinical studies are d...

journal_title：European heart journal

authors： Lips DJ,deWindt LJ,van Kraaij DJ,Doevendans PA

更新日期：2003-05-01 00:00:00

abstract：:Transluminal coronary angioplasty (PTCA) is a well defined controlled model inducing regional myocardial ischaemia in man. Direct cardiac anti-ischaemic effects of anti-anginal drugs can be assessed by intracoronary injection of small doses which do not affect systemic parameters. Trimetazidine (TMZ) has recently been...

journal_title：European heart journal

authors： Kober G,Pennaforte S,Buck T,Sievert H,Vallbracht C

更新日期：1993-11-01 00:00:00

abstract：AIMS:We investigated the role of asymmetric dimethylarginine (ADMA) for clinical outcome of patients with unstable angina. METHODS AND RESULTS:Forty-five patients with stable angina, 36 patients with unstable angina, and 40 healthy controls were included in this study. Coronary artery disease (CAD) patients were prosp...

journal_title：European heart journal

authors： Krempl TK,Maas R,Sydow K,Meinertz T,Böger RH,Kähler J

更新日期：2005-09-01 00:00:00

abstract：:The optimal length of clopidogrel therapy in patients with acute coronary syndromes or in those who have undergone percutaneous coronary intervention (PCI) remains controversial. We therefore sought to determine the risk of both perioperative and premature discontinuation of clopidogrel. PubMed and EMBASE databases we...

journal_title：European heart journal

authors： Gaglia MA Jr,Waksman R

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Polymorphisms within renin angiotensin system genes have been investigated as risk factors for coronary artery disease in different populations with contradicting results. The aim of this study was to investigate the genotype distribution and the allele frequencies of ACE, AT1R and AGT gene polymorphisms as ...

journal_title：European heart journal

authors： Fatini C,Abbate R,Pepe G,Battaglini B,Gensini F,Ruggiano G,Gensini GF,Guazzelli R

更新日期：2000-04-01 00:00:00

abstract：AIMS:Clonal haematopoiesis of indeterminate potential (CHIP), defined as the presence of an expanded somatic blood cell clone without other haematological abnormalities, was recently shown to increase with age and is associated with coronary artery disease and calcification. The most commonly mutated CHIP genes, DNMT3A...

journal_title：European heart journal

authors： Mas-Peiro S,Hoffmann J,Fichtlscherer S,Dorsheimer L,Rieger MA,Dimmeler S,Vasa-Nicotera M,Zeiher AM

更新日期：2020-02-21 00:00:00

abstract：AIMS:Hypertrophic cardiomyopathy (HCM) is a disease with marked regional differences in wall thickness. However, the relation between myocardial function and wall thickness has not been well studied. Ultrasonic strain rate (SR) imaging makes it possible to study the regional myocardial deformation. We investigated whet...

journal_title：European heart journal

authors： Ganame J,Mertens L,Eidem BW,Claus P,D'hooge J,Havemann LM,McMahon CJ,Elayda MA,Vaughn WK,Towbin JA,Ayres NA,Pignatelli RH

更新日期：2007-12-01 00:00:00

abstract：AIM:We sought to evaluate the incidence and electrophysiological features of the local slow potential preceding the surface QRS complex (pre-QRS potential) which was detected more frequently at successful sites of catheter ablation of left parietal concealed accessory pathways, than at unsuccessful sites. METHODS AND ...

journal_title：European heart journal

authors： Miyauchi Y,Kobayashi Y,Ino T,Atarashi H

更新日期：1999-12-01 00:00:00

abstract：:The study of 'atrial vulnerability' is often clinically indicated but it requires the use of invasive intracardiac stimulation. The purpose of the study was to assess the use of oesophageal pacing in the evaluation of atrial tachyarrhythmias (ATA). Fifty-five patients with documented ATA (group I) and 60 without (grou...

journal_title：European heart journal

authors： Brembilla-Perrot B

更新日期：1994-08-01 00:00:00

abstract：AIMS:Women, particularly younger women, hospitalized with acute myocardial infarction have been found to have poorer prognosis than men. A large proportion of deaths due to myocardial infarction, however, occur in the pre-hospital phase. We set out to analyse age-specific sex differences in survival after myocardial in...

journal_title：European heart journal

authors： Rosengren A,Spetz CL,Köster M,Hammar N,Alfredsson L,Rosén M

更新日期：2001-02-01 00:00:00

abstract：AIMS:To compare the precursor of atrial and brain natriuretic peptide (N-ANP, N-BNP), brain natriuretic peptide (BNP), big endothelin-1, the 6-min walk test and the Minnesota Living with Heart Failure Questionnaire (LHFQ) with regard to short-term outcome in an ambulatory heart failure population. METHODS AND RESULTS:...

journal_title：European heart journal

authors： Hülsmann M,Berger R,Sturm B,Bojic A,Woloszczuk W,Bergler-Klein J,Pacher R

更新日期：2002-06-01 00:00:00

abstract：AIMS:It is reported that one third of patients with heart failure have normal left ventricular systolic function, and may or may not have left ventricular diastolic dysfunction. We sought to define the prevalence of left ventricular diastolic filling abnormalities in a large unselected group of patients, unlike the dia...

journal_title：European heart journal

authors： Davie AP,Francis CM,Caruana L,Sutherland GR,McMurray JJ

更新日期：1997-06-01 00:00:00

abstract：AIM:Unstable coronary artery disease (CAD) is a multifactorial disease involving both thrombotic and inflammatory processes. We have assessed the time-course and the influence of thrombin inhibitors on changes in fibrinogen and C-reactive protein levels, and their relation to myocardial ischaemia in unstable CAD. METH...

journal_title：European heart journal

authors： Oldgren J,Wallentin L,Grip L,Linder R,Nørgaard BL,Siegbahn A

更新日期：2003-01-01 00:00:00

abstract：:Clinicians have long suspected that hypertrophied hearts have an inadequate coronary circulation. This clinical suspicion resulted from the observation that a large proportion of patients with left ventricular hypertrophy who have normal coronary arteriograms complain of angina and have ischaemia-like ST segment depre...

journal_title：European heart journal

authors： Kaski JC

更新日期：1993-11-01 00:00:00

abstract：:The cytokine hypothesis presently suggests that an excessive production of pro-inflammatory cytokines, such as tumour necrosis factor alpha (TNF) and interleukin 6 (IL6), contributes to the pathogenesis of heart failure. The concept, successfully proved in genetically modified animal models, failed to translate to hum...

journal_title：European heart journal

authors： Lecour S,James RW

更新日期：2011-03-01 00:00:00

abstract：Aims:Pulmonary hypertension (PH) and pulmonary vascular disease (PVD) are common and associated with adverse outcomes in heart failure with preserved ejection fraction (HFpEF). Little is known about the impact of PVD on the pathophysiology of exercise intolerance. Methods and results:Heart failure with preserved eject...

journal_title：European heart journal

authors： Gorter TM,Obokata M,Reddy YNV,Melenovsky V,Borlaug BA

更新日期：2018-08-07 00:00:00

abstract：:In a prospective study, an elderly group of patients (n = 63, 47 male, 16 female, age 40-65 years) was examined before and after open-heart surgery under cardiopulmonary bypass: postoperatively, 19 patients (30%) showed no clinical neuropsychiatric symptoms, whereas in 35 patients (56%) mild or transient neurological ...

journal_title：European heart journal

authors： Zeitlhofer J,Asenbaum S,Spiss C,Wimmer A,Mayr N,Wolner E,Deecke L

更新日期：1993-07-01 00:00:00

abstract：:Isolated quadricuspid aortic valve is very rare. The identification of this malformation can be made by cross-sectional echocardiography. Two cases of quadricuspid aortic valve diagnosed by cross-sectional echocardiography are described. ...

journal_title：European heart journal

authors： Chamsi-Pasha H,Barnes PC,Beton DC

更新日期：1988-11-01 00:00:00

abstract：:Between January 1983 and December 1990, 20 patients aged 80 years or older underwent valvular surgery. The patients' ages varied from 80 to 87 years (mean, 82 +/- 1.5 years). The indication for operation was aortic stenosis in 19 patients, and mitral insufficiency after previous mitral valve replacement with a biopros...

journal_title：European heart journal

authors： Pasic M,Carrel T,Laske A,Bauer E,Turina J,Jenni R,von Segesser L,Turina M

更新日期：1992-04-01 00:00:00

abstract：:Simultaneous two-channel Holter monitoring, with a direct recording system, and maximal exercise testing with a 12-lead precordial electrocardiographic mapping system were performed in 50 patients with chest pain (41 with documented coronary artery disease, 9 without). The exploring Holter leads were placed to corresp...

journal_title：European heart journal

authors： Egstrup K

更新日期：1988-04-01 00:00:00