The prevalence of left ventricular diastolic filling abnormalities in patients with suspected heart failure.

Abstract:

AIMS:It is reported that one third of patients with heart failure have normal left ventricular systolic function, and may or may not have left ventricular diastolic dysfunction. We sought to define the prevalence of left ventricular diastolic filling abnormalities in a large unselected group of patients, unlike the diagnosis by exclusion in the small highly selected groups of patients studied previously. METHODS AND RESULTS:Patients were referred by general practitioners to an open-access echocardiography service for assessment of possible heart failure. Echocardiography included a Doppler study of transmitral flow at the tips of the mitral leaflets and calculation of an E/A ratio. Of 534 patients referred and assessed, 371 patients had normal systolic function and a measurable E/A ratio. These were compared with age-adjusted reference ranges to give 9 above the reference range and 19 below. This is only 10 more than would be expected if our patients were normal. In the same group of patients we found 96 cases of left ventricular systolic dysfunction, or 52 amongst the 423 with a measurable E/A ratio. CONCLUSION:Either left ventricular diastolic filling abnormalities are very much less common than previously supposed or the E/A ratio is almost useless for their detection.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Davie AP,Francis CM,Caruana L,Sutherland GR,McMurray JJ

doi

10.1093/oxfordjournals.eurheartj.a015387

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

981-4

issue

6

eissn

0195-668X

issn

1522-9645

journal_volume

18

pub_type

临床试验,杂志文章
  • Changes of fluid-dynamic parameters in peripheral stenoses with transcutaneous interventions.

    abstract:UNLABELLED:Peripheral vessels provide a useful in vivo haemodynamic model allowing evaluation of local intravascular fluid dynamics. Velocity measurements using a 0.018 inch Doppler-tipped angioplasty guidewire, quantitative angiography and laboratory data were gathered from 45 patients with a total of 48 percutaneous ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/16.suppl_j.60

    authors: Wellnhofer E,Biamino G,Sauer HU,Trebeljahr A,Stalke J,Ragg C,Oswald H,Gotze S,Fleck E,Felix R

    更新日期:1995-10-01 00:00:00

  • Prevalence and mechanism of streptokinase-induced platelet stimulation. Effect of acetylsalicylic acid.

    abstract::It was recently shown that streptokinase may induce clot formation in vivo by immunoglobulin G mediated platelet stimulation. We evaluated the in vitro effect of streptokinase on platelet function in 103 subjects, of whom 52 were < or = 30 years and 51 were > or = 50 years old. Although streptokinase inhibited platele...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060094

    authors: Terres W,Krüger K,Bleifeld W

    更新日期:1992-11-01 00:00:00

  • Everolimus-eluting bioresorbable vascular scaffolds for treatment of patients presenting with ST-segment elevation myocardial infarction: BVS STEMI first study.

    abstract:AIMS:We evaluated the feasibility and the acute performance of the everolimus-eluting bioresorbable vascular scaffolds (BVS) for the treatment of patients presenting with ST-segment elevation myocardial infarction (STEMI). METHODS AND RESULTS:The present investigation is a prospective, single-arm, single-centre study,...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/eht546

    authors: Diletti R,Karanasos A,Muramatsu T,Nakatani S,Van Mieghem NM,Onuma Y,Nauta ST,Ishibashi Y,Lenzen MJ,Ligthart J,Schultz C,Regar E,de Jaegere PP,Serruys PW,Zijlstra F,van Geuns RJ

    更新日期:2014-03-01 00:00:00

  • Reactive thrombocytosis and stroke following cardiopulmonary bypass surgery: case report on three patients.

    abstract::Reactive thrombocytosis following cardiopulmonary bypass surgery is generally considered to be a benign condition which is transient and does not require specific therapy. We describe three patients who developed stroke in association with reactive thrombocytosis in the late recovery period following cardiopulmonary b...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060642

    authors: Crowley JJ,Hannigan M,Daly K

    更新日期:1994-08-01 00:00:00

  • Associations between vascular risk factors and brain MRI indices in UK Biobank.

    abstract:AIMS:Several factors are known to increase risk for cerebrovascular disease and dementia, but there is limited evidence on associations between multiple vascular risk factors (VRFs) and detailed aspects of brain macrostructure and microstructure in large community-dwelling populations across middle and older age. METH...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehz100

    authors: Cox SR,Lyall DM,Ritchie SJ,Bastin ME,Harris MA,Buchanan CR,Fawns-Ritchie C,Barbu MC,de Nooij L,Reus LM,Alloza C,Shen X,Neilson E,Alderson HL,Hunter S,Liewald DC,Whalley HC,McIntosh AM,Lawrie SM,Pell JP,Tucker-Drob

    更新日期:2019-07-21 00:00:00

  • A comparison of two methods to measure coronary flow reserve in the setting of coronary angioplasty: intracoronary blood flow velocity measurements with a Doppler catheter, and digital subtraction cineangiography.

    abstract::Intracoronary blood flow velocity measurements with a Doppler balloon catheter and the radiographic assessment of myocardial perfusion with contrast media, before and after the intracoronary administration of papaverine, have previously been used to investigate regional coronary flow reserve. In the present study we a...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a059557

    authors: Serruys PW,Zijlstra F,Laarman GJ,Reiber HH,Beatt K,Roelandt J

    更新日期:1989-08-01 00:00:00

  • From traditional pharmacological towards nucleic acid-based therapies for cardiovascular diseases.

    abstract::Nucleic acid-based therapeutics are currently developed at large scale for prevention and management of cardiovascular diseases (CVDs), since: (i) genetic studies have highlighted novel therapeutic targets suggested to be causal for CVD; (ii) there is a substantial recent progress in delivery, efficacy, and safety of ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehaa229

    authors: Landmesser U,Poller W,Tsimikas S,Most P,Paneni F,Lüscher TF

    更新日期:2020-10-21 00:00:00

  • Four-day urocortin-I administration has sustained beneficial haemodynamic, hormonal, and renal effects in experimental heart failure.

    abstract:AIMS:To investigate the subacute effects of a sustained intravenous infusion of urocortin-I (Ucn-I) in experimental heart failure (HF). METHODS AND RESULTS:In eight sheep with pacing-induced HF, a 4-day infusion of Ucn-I (0.3 microg/kg/h) induced prompt (30 min) and sustained (4-day) increases in cardiac output (CO, D...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehi351

    authors: Rademaker MT,Charles CJ,Espiner EA,Frampton CM,Lainchbury JG,Richards AM

    更新日期:2005-10-01 00:00:00

  • Tissue plasminogen activator and other risk factors as predictors of cardiovascular events in patients with severe angina pectoris.

    abstract::The value of measurements of the fibrinolytic factors, tissue plasminogen activator and plasminogen activator inhibitor, for predicting death and non-fatal cardiovascular events was studied in 213 consecutive patients with angiographically documented coronary artery disease. In the course of 4-year follow-up, 47 patie...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a059862

    authors: Jansson JH,Nilsson TK,Olofsson BO

    更新日期:1991-02-01 00:00:00

  • Minor elevations in troponin I are associated with mortality and adverse cardiac events in patients with atrial fibrillation.

    abstract:AIMS:In patients with atrial fibrillation, minor troponin I elevation is regularly detected; however, the prognostic significance of this finding is unknown. We therefore sought to examine the prognostic value of elevated troponin I in patients with atrial fibrillation. METHODS AND RESULTS:A prospective study was cond...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehq491

    authors: van den Bos EJ,Constantinescu AA,van Domburg RT,Akin S,Jordaens LJ,Kofflard MJ

    更新日期:2011-03-01 00:00:00

  • Nonparoxysmal atrioventricular junctional rhythm. A clinical and electrophysiologic study.

    abstract::The patient, a 74-year-old man, developed a persistent nonparoxysmal junctional accelerated rhythm at rate of 60-75 beats min-1 because of chronic depressed sinus node function. Intravenous atropine resulted in no change of junctional pacemaker rate but i.v. isoproterenol significantly accelerated it suggesting that a...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061656

    authors: Santinelli V,Chiariello M,Condorelli M

    更新日期:1984-04-01 00:00:00

  • Risk stratification in asymptomatic severe aortic stenosis: a critical appraisal.

    abstract::Aortic stenosis is one of the most common forms of acquired valvular heart disease. The development of symptoms, namely syncope, angina, or heart failure, in patients with severe aortic stenosis predicts a high likelihood of mortality. Aortic valve replacement is the current standard of care. In truly asymptomatic pat...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehs190

    authors: Bhattacharyya S,Hayward C,Pepper J,Senior R

    更新日期:2012-10-01 00:00:00

  • Comparison between abnormalities in segmental endocardial motion and abnormalities in segmental wall thickening after anterior myocardial infarction. A cine-magnetic resonance study.

    abstract::In this study, two patterns of regional contract on of the left ventricle have been studied: endocardial motion and wall thickening, in order to check which of these was the most affected after myocardial infarction. The clinical relevance of this comparison was to assess which parameter of the regional contraction ab...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/oxfordjournals.eurheartj.a015069

    authors: Germain P,Roul G,Constantinesco A,Coulbois PM,Baruthio J,Mossard JM,Bareiss P,Sacrez A

    更新日期:1996-09-01 00:00:00

  • Prognostic value of plasma neuropeptide-Y in coronary care unit patients with and without acute myocardial infarction.

    abstract::Plasma neuropeptide Y-like immunoreactivity (NPY-LI) is elevated in patients with acute myocardial ischaemia and congestive heart failure (CHF) owing to increased activity of the sympathetic nervous system. The prognostic value of plasma NPY-LI with regard to mortality was studied in 324 random patients admitted to a ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060526

    authors: Ullman B,Hulting J,Lundberg JM

    更新日期:1994-04-01 00:00:00

  • The impact of early standard therapy on dyspnoea in patients with acute heart failure: the URGENT-dyspnoea study.

    abstract:AIMS:The vast majority of acute heart failure (AHF) trials to date have targeted dyspnoea. However, they enrolled patients relatively late and did not standardize their methods of dyspnoea measurement. URGENT Dyspnoea was designed to determine changes in dyspnoea in response to initial, standard therapy in patients pre...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehp458

    authors: Mebazaa A,Pang PS,Tavares M,Collins SP,Storrow AB,Laribi S,Andre S,Mark Courtney D,Hasa J,Spinar J,Masip J,Frank Peacock W,Sliwa K,Gayat E,Filippatos G,Cleland JG,Gheorghiade M

    更新日期:2010-04-01 00:00:00

  • Coronary microembolization during early reperfusion: infarct extension, but protection by ischaemic postconditioning.

    abstract:AIMS:Reperfusion injury following acute myocardial infarction impacts not only on the myocardium but also on the coronary microcirculation, and microembolization from the culprit lesion contributes to microvascular obstruction. Prior experimental studies have not accounted for microembolization in ischaemia/reperfusion...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehs434

    authors: Skyschally A,Walter B,Heusch G

    更新日期:2013-11-01 00:00:00

  • Comparison of the Framingham risk function-based coronary chart with risk function from an Italian population study.

    abstract:AIMS:The aim is to compare the coronary risk chart published by the European Task Force for Prevention of Coronary Heart Disease and produced using a Framingham risk function, with a risk function derived from an Italian population study. METHODS AND RESULTS:Coronary risk function in this study was the result of longi...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1999.1864

    authors: Menotti A,Puddu PE,Lanti M

    更新日期:2000-03-01 00:00:00

  • Diastolic mitral annular motion in normal subjects and patients with coronary artery disease.

    abstract::The purpose of this study was to evaluate the characteristics of mitral annular motion during diastole in 28 normal subjects, 40 patients with prior myocardial infarction (MI), and 23 patients with coronary artery disease but without prior MI. Mitral annular motion during diastole was obtained from the apex by M-mode ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061029

    authors: Ohte N,Narita H,Hashimoto T,Kobayashi K,Akita S,Fujinami T

    更新日期:1995-07-01 00:00:00

  • Resting echocardiography and quantitative dipyridamole technetium-99m sestamibi tomography in the identification of cardiac allograft vasculopathy and the prediction of long-term prognosis after heart transplantation.

    abstract:AIMS:To evaluate the accuracy of echocardiography in conjunction with quantitative high-dose dipyridamole technetium-99m sestamibi tomography (SPECT) in detecting coronary allograft vasculopathy. METHODS AND RESULTS:Seventy-eight consecutive heart transplant recipients underwent echocardiography while at rest and high...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2000.2422

    authors: Ciliberto GR,Ruffini L,Mangiavacchi M,Parolini M,Sara R,Massa D,De Maria R,Gronda E,Vitali E,Parodi O

    更新日期:2001-06-01 00:00:00

  • Myocardial viability. Stress echocardiography vs nuclear medicine.

    abstract::Myocardial dyssynergy does not necessarily indicate myocardial necrosis in patients with coronary artery disease. The differentiation between viable and non-viable tissue is of great clinical importance in order to make the most appropriate clinical decision in the individual patient. Several techniques are used to as...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/18.suppl_d.117

    authors: Piérard LA,Lancellotti P,Benoit T

    更新日期:1997-06-01 00:00:00

  • Effects of lovastatin on progression of non-dilated and dilated coronary segments and on restenosis in patients after PTCA. The cholesterol lowering atherosclerosis PTCA trial (CLAPT).

    abstract:OBJECTIVES:The Cholesterol Lowering Atherosclerosis PTCA Trial (CLAPT) is a prospective, randomized trial with blinded angiographic end-points to assess the effect of 2-year's treatment with lovastatin initiated 4 weeks prior to PTCA, compared to usual care on non-dilated coronary segments and on dilated coronary lesio...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1053/euhj.1999.1483

    authors: Kleemann A,Eckert S,von Eckardstein A,Lepper W,Schernikau U,Gleichmann U,Hanrath P,Fleck E,Neiss A,Kerber S,Assmann G,Breithardt G,CLAPT Study.

    更新日期:1999-10-01 00:00:00

  • Effects of insulin on left ventricular function during dynamic exercise in overweight and obese subjects.

    abstract:AIMS:We designed this study in order to determine the effect of insulin on cardiac function in overweight and obese subjects during exercise. METHODS AND RESULTS:The cardiac function of 62 normal glucose tolerant subjects, aged 30-40 and divided into normal weight (group 1, n=22, BMI 20-24.9 kg/m(2)), overweight (grou...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehi271

    authors: Sasso FC,Carbonara O,Nasti R,Marfella R,Esposito K,Rambaldi P,Mansi L,Salvatore T,Torella R,Cozzolino D

    更新日期:2005-06-01 00:00:00

  • Biological signals of cardiac hypertrophy.

    abstract::Chronic increases in haemodynamic load modify the expression of cardiac genes, leading to a new phenotype better adapted to the new functional demand. Several mechanisms such as the global activation of genes, the modulation of single genes and/or differential expression of multigene families may account for these mod...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/11.suppl_g.1

    authors: Samuel JL,Dubus I,Contard F,Schwartz K,Rappaport L

    更新日期:1990-11-01 00:00:00

  • The effects of intraventricular gradients on left ventricular ejection dynamics.

    abstract::The generation of abnormal gradients between the apical cavity and the subaortic valvular region of the left ventricle in patients with hypertrophic cardiomyopathy (HCM) has traditionally been equated to a dynamic obstruction to left ventricular outflow. To examine this concept in more detail, left ventricular ejectio...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/4.suppl_f.23

    authors: Murgo JP,Alter BR,Dorethy JF,Altobelli SA,Craig WE,McGranahan GM Jr

    更新日期:1983-11-01 00:00:00

  • Quantitative relationship between resting heart rate reduction and magnitude of clinical benefits in post-myocardial infarction: a meta-regression of randomized clinical trials.

    abstract:AIMS:The impact on mortality outcomes of beta-blockers and calcium blockers in post-myocardial infarction (MI) has been suggested to be related to resting heart rate (HR) reduction. A meta-regression of randomized clinical trials was carried out to assess this relationship using weighted meta-regression of logarithm of...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/eurheartj/ehm489

    authors: Cucherat M

    更新日期:2007-12-01 00:00:00

  • Percutaneous edge-to-edge MitraClip therapy in the management of mitral regurgitation.

    abstract::MitraClip therapy consists of percutaneous edge-to-edge coaptation of the mitral leaflets that is analogous to the surgical Alfieri technique. The safety profile of the MitraClip device is favourable, and survival outcomes in high-surgical-risk patients are superior to historical controls. However, questions remain re...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehr101

    authors: Rogers JH,Franzen O

    更新日期:2011-10-01 00:00:00

  • Atrial conduction abnormalities in patients with systemic progressive sclerosis.

    abstract:BACKGROUND:Atrial abnormalities in patients with progressive systemic sclerosis have not been evaluated in terms of intra-atrial conduction. We hypothesized that a delay in atrial conduction in these patients might produce diastolic abnormalities as well as atrial arrhythmias. OBJECTIVE:To evaluate the atrial function...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a015211

    authors: Mizuno R,Fujimoto S,Nakano H,Nakajima T,Kimura A,Nakagawa Y,Dohi K

    更新日期:1997-12-01 00:00:00

  • Physiological variation in the termination window of re-entry tachycardia studied by non-invasive programmed stimulation.

    abstract::In seven patients with re-entry tachycardias and the implanted antitachycardia device Tachylog (Siemens Elema, Sweden) the variation in the termination window related to posture and exertion was investigated. The investigations were performed on an outpatient basis utilizing the interactive pacing mode of the implante...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062605

    authors: Schmidinger H,Sowton E

    更新日期:1988-09-01 00:00:00

  • Abnormalities of left ventricular flow following mitral valve replacement: a colour flow Doppler study.

    abstract::Left ventricular flow patterns were studied at rest by colour flow Doppler echocardiography in 33 patients with mitral tilting-disc prostheses (group 1), in 38 patients with mitral tissue prostheses (group 2) and in 18 healthy volunteers (controls). A 'crossed' flow pattern was seen in 14 patients with mechanical (42%...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060494

    authors: Maire R,Ikram S,Odemuyiwa O,Groves PH,Lo SV,Banning AP,Hall RJ

    更新日期:1994-03-01 00:00:00

  • Scandinavia's journal for cardiologists and cardiothoracic surgeons.

    abstract::Scandinavian Cardiovascular Journal began as a journal for cardiothoracic surgery, but joining forces with cardiology has increased the impact factor and number of subscribers. ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:

    authors: Taylor J

    更新日期:2012-09-01 00:00:00