Abstract:
AIMS:Several factors are known to increase risk for cerebrovascular disease and dementia, but there is limited evidence on associations between multiple vascular risk factors (VRFs) and detailed aspects of brain macrostructure and microstructure in large community-dwelling populations across middle and older age. METHODS AND RESULTS:Associations between VRFs (smoking, hypertension, pulse pressure, diabetes, hypercholesterolaemia, body mass index, and waist-hip ratio) and brain structural and diffusion MRI markers were examined in UK Biobank (N = 9722, age range 44-79 years). A larger number of VRFs was associated with greater brain atrophy, lower grey matter volume, and poorer white matter health. Effect sizes were small (brain structural R2 ≤1.8%). Higher aggregate vascular risk was related to multiple regional MRI hallmarks associated with dementia risk: lower frontal and temporal cortical volumes, lower subcortical volumes, higher white matter hyperintensity volumes, and poorer white matter microstructure in association and thalamic pathways. Smoking pack years, hypertension and diabetes showed the most consistent associations across all brain measures. Hypercholesterolaemia was not uniquely associated with any MRI marker. CONCLUSION:Higher levels of VRFs were associated with poorer brain health across grey and white matter macrostructure and microstructure. Effects are mainly additive, converging upon frontal and temporal cortex, subcortical structures, and specific classes of white matter fibres. Though effect sizes were small, these results emphasize the vulnerability of brain health to vascular factors even in relatively healthy middle and older age, and the potential to partly ameliorate cognitive decline by addressing these malleable risk factors.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Cox SR,Lyall DM,Ritchie SJ,Bastin ME,Harris MA,Buchanan CR,Fawns-Ritchie C,Barbu MC,de Nooij L,Reus LM,Alloza C,Shen X,Neilson E,Alderson HL,Hunter S,Liewald DC,Whalley HC,McIntosh AM,Lawrie SM,Pell JP,Tucker-Drobdoi
10.1093/eurheartj/ehz100subject
Has Abstractpub_date
2019-07-21 00:00:00pages
2290-2300issue
28eissn
0195-668Xissn
1522-9645pii
5371095journal_volume
40pub_type
杂志文章abstract:AIMS:To test whether N-terminal pro-B-type natriuretic peptide (NT-proBNP) was independently associated with, and improved the prediction of, cardiovascular disease (CVD) in a primary prevention cohort. METHODS AND RESULTS:In the West of Scotland Coronary Prevention Study (WOSCOPS), a cohort of middle-aged men with hy...
journal_title:European heart journal
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doi:10.1093/eurheartj/13.suppl_g.72
更新日期:1992-12-01 00:00:00
abstract::We assessed the incremental effect of cardiac catheterization upon the management of 93 adult patients with aortic and/or mitral valve disease, referred for surgical consideration. There were 52 patients with aortic valve disease, 29 with mitral valve disease and 12 with aortic and mitral valve disease. Prior to cardi...
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pub_type: 杂志文章
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更新日期:1993-09-01 00:00:00
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更新日期:2005-12-01 00:00:00
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更新日期:2016-04-14 00:00:00
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doi:10.1093/oxfordjournals.eurheartj.a060150
更新日期:1992-02-01 00:00:00
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2002-02-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/10.suppl_f.97
更新日期:1989-11-01 00:00:00
abstract:Aims:There are limited data on the clinical implications of total physiologic atherosclerotic burden assessed by invasive physiologic studies in patients with coronary artery disease. We investigated the prognostic implications of total physiologic atherosclerotic burden assessed by total sum of fractional flow reserve...
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doi:10.1093/eurheartj/ehx458
更新日期:2018-03-14 00:00:00
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更新日期:2009-02-01 00:00:00
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更新日期:2019-07-01 00:00:00
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更新日期:2005-05-01 00:00:00
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更新日期:2006-02-01 00:00:00
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更新日期:2007-05-01 00:00:00
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更新日期:2005-10-01 00:00:00
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更新日期:2010-04-01 00:00:00
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更新日期:2004-07-01 00:00:00
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1053/euhj.2001.2679
更新日期:2001-12-01 00:00:00