Left ventricular systolic function assessment in secondary mitral regurgitation: left ventricular ejection fraction vs. speckle tracking global longitudinal strain.

Abstract:

AIMS:Left ventricular (LV) ejection fraction (LVEF) is currently considered for the decision making of patients with mitral regurgitation (MR). However, LVEF represents change in LV volume between end-diastole and end-systole but does not characterize the intrinsic function of the myocardium. In contrast, speckle-tracking global longitudinal strain (GLS) characterizes myocardial deformation. The present study evaluated whether LV GLS may detect further impairment in LV systolic function in dilated cardiomyopathy patients with and without severe secondary MR matched based on LVEF. METHODS AND RESULTS:Patients with non-ischaemic dilated cardiomyopathy (N = 150, 59 ± 12 years old, 58% male) were included: 75 patients with severe secondary MR and 75 patients with none or less than mild MR matched 1 : 1 according to LVEF. The LV systolic function was evaluated by LVEF (following Simpson's biplane method), forward ejection fraction (forward stroke volume relative to LV end-diastolic volume), and speckle-tracking GLS. By definition, LVEF was comparable between the two groups (patients with severe MR 31 ± 10 vs. patients with no/mild MR 31 ± 10%, P = 0.93). However, patients with severe MR had significantly lower forward ejection fraction (29 ± 14 vs. 40 ± 18%, P < 0.001) and more impaired GLS (-8.08 ± 3.33 vs. -9.78 ± 3.78%, P = 0.004) compared with their counterparts. The presence of severe secondary MR was significantly associated with worse LV GLS (β 1.32, 95% confidence interval 0.14-2.49, P = 0.03). CONCLUSION:In patients with severe secondary MR, speckle-tracking GLS shows more deteriorated LV systolic function than LVEF.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Kamperidis V,Marsan NA,Delgado V,Bax JJ

doi

10.1093/eurheartj/ehv680

subject

Has Abstract

pub_date

2016-03-07 00:00:00

pages

811-6

issue

10

eissn

0195-668X

issn

1522-9645

pii

ehv680

journal_volume

37

pub_type

杂志文章
  • Haemodynamic effects of enalaprilat and preload in acute severe heart failure complicating myocardial infarction.

    abstract::In this study, the acute haemodynamic effects of angiotensin converting enzyme (ACE) inhibition with intravenous enalaprilat alone or in combination with preload restoration were determined in patients with severe heart failure complicating acute myocardial infarction. Ten patients with raised pulmonary arterial wedge...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060537

    authors: Tohmo H,Karanko M,Korpilahti K

    更新日期:1994-04-01 00:00:00

  • Oxygen therapy in acute coronary syndrome: are the benefits worth the risk?

    abstract::Oxygen supplementation is a standard treatment for all patients who present with acute coronary syndrome, regardless of oxygen saturation levels. Most of the data regarding the function of oxygen in myocardial infarction is based on a limited number of basic and clinical studies. We performed a systematic literature r...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/eht110

    authors: Shuvy M,Atar D,Gabriel Steg P,Halvorsen S,Jolly S,Yusuf S,Lotan C

    更新日期:2013-06-01 00:00:00

  • Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure The Rotterdam Study.

    abstract:AIMS:To determine the prevalence, incidence rate, lifetime risk and prognosis of heart failure. METHODS AND RESULTS:The Rotterdam Study is a prospective population-based cohort study in 7983 participants aged > or =55. Heart failure was defined according to criteria of the European Society of Cardiology. Prevalence wa...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ehj.2004.06.038

    authors: Bleumink GS,Knetsch AM,Sturkenboom MC,Straus SM,Hofman A,Deckers JW,Witteman JC,Stricker BH

    更新日期:2004-09-01 00:00:00

  • Midlife blood pressure is associated with the severity of white matter hyperintensities: analysis of the UK Biobank cohort study.

    abstract:AIMS:White matter hyperintensities (WMH) progress with age and hypertension, but the key period of exposure to elevated blood pressure (BP), and the relative role of systolic BP (SBP) vs. diastolic BP (DBP), remains unclear. This study aims to determine the relationship between WMH and concurrent vs. past BP. METHODS ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehaa756

    authors: Wartolowska KA,Webb AJS

    更新日期:2020-11-26 00:00:00

  • Platelet glycoprotein IIb/IIIa receptor inhibition as adjunctive treatment during saphenous vein graft stenting: differential effects after randomization to occlusion or filter-based embolic protection.

    abstract:AIMS:Although embolic protection devices reduce complications during saphenous vein graft (SVG) stenting, adverse events still occur in approximately 10% of patients. IIb/IIIa antagonists have not been proven effective during SVG intervention. We hypothesized that adjunctive use of these agents might enhance the effica...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehi736

    authors: Jonas M,Stone GW,Mehran R,Hermiller J,Feldman R,Herrmann HC,Cox DA,Kuntz RE,Popma JJ,Rogers C,FilterWire EX Randomized Evalulation (FIRE) Investigators.

    更新日期:2006-04-01 00:00:00

  • Haemodynamic response to exercise in patients with chest pain and normal coronary angiograms.

    abstract::A series of 42 patients with chest pain but normal coronary angiograms and normal haemodynamics at rest were prospectively classified as typical angina (group 1, N = 9) or atypical angina (group 2, N = 16) or non-anginal chest pain (group 3, N = 17). All patients underwent radionuclide ventriculography and measurement...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062119

    authors: Wieshammer S,Delagardelle C,Sigel HA,Henze E,Kress P,Bitter F,Adam WE,Stauch M

    更新日期:1986-08-01 00:00:00

  • Tissue Doppler imaging predicts left ventricular dysfunction and mortality in a murine model of cardiac injury.

    abstract:AIMS:Currently available non-invasive imaging methods frequently fail to detect alterations in left ventricular (LV) function despite histological evidence of injury. Tissue Doppler imaging (TDI) can detect subtle LV dysfunction. The aim of this study was to investigate whether TDI indices can predict LV systolic dysfu...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehl013

    authors: Neilan TG,Jassal DS,Perez-Sanz TM,Raher MJ,Pradhan AD,Buys ES,Ichinose F,Bayne DB,Halpern EF,Weyman AE,Derumeaux G,Bloch KD,Picard MH,Scherrer-Crosbie M

    更新日期:2006-08-01 00:00:00

  • New-onset atrial fibrillation as first clinical manifestation of latent Brugada syndrome: prevalence and clinical significance.

    abstract:AIMS:To evaluate the prevalence, clinical significance, and prognosis of latent Brugada syndrome (BrS) in patients with new-onset atrial fibrillation (AF) unmasked by class 1C antiarrhythmic drugs. METHODS AND RESULTS:Between January 2000 and June 2008, all consecutive patients with new-onset AF, who after flecainide ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehp326

    authors: Pappone C,Radinovic A,Manguso F,Vicedomini G,Sala S,Sacco FM,Ciconte G,Saviano M,Ferrari M,Sommariva E,Sacchi S,Ciaccio C,Kallergis EM,Santinelli V

    更新日期:2009-12-01 00:00:00

  • Survival after coronary artery bypass grafting. Experience from 4661 patients.

    abstract::The duration of the reduction of mortality after coronary artery bypass grafting (CABG) is an important issue and this study was undertaken to evaluate time in relation to excess mortality among CABG patients compared with the general population. Survival was analysed in 4661 patients who had undergone their first iso...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060654

    authors: Ståhle E,Bergström R,Holmberg L,Edlund B,Nyström SO,Sjögren I,Hansson HE

    更新日期:1994-09-01 00:00:00

  • Intracoronary ultrasound following excimer-laser angioplasty. An in-vitro study in human coronary arteries.

    abstract:UNLABELLED:To study the ablation effects induced by excimer laser coronary angioplasty (ELCA), we examined 41 segments of nine isolated coronary arteries. An electronic intracoronary ultrasound device (ICUS: 20 MHz, 3.5F, Endosonics) was positioned coaxially within the vessel. Angioplasty was performed using a 1.7 mm E...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060884

    authors: Schmid KM,Xie D,Voelker W,Oberhoff M,Wehrmann M,Baumbach A,Haase KK,Karsch KR

    更新日期:1995-02-01 00:00:00

  • Combined non-invasive functional and anatomical diagnostic work-up in clinical practice: the magnetic resonance and computed tomography in suspected coronary artery disease (MARCC) study.

    abstract:AIMS:The combined use of cardiac computed tomography (CT) coronary angiography (CTCA) and myocardial perfusion imaging allows the non-invasive evaluation of coronary morphology and function. Cardiovascular magnetic resonance (CMR) imaging has several advantages: it can simultaneously assess myocardial perfusion, ventri...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/eht077

    authors: Groothuis JG,Beek AM,Brinckman SL,Meijerink MR,van den Oever ML,Hofman MB,van Kuijk C,van Rossum AC

    更新日期:2013-07-01 00:00:00

  • A short delay from out of hospital cardiac arrest to call for ambulance increases survival.

    abstract:AIM:To describe the relative impact on survival of the delay from estimated time of collapse to call for an ambulance among patients who suffer from a bystander witnessed out of hospital cardiac arrest of a cardiac aetiology. METHODS:A majority of all ambulance organizations in Sweden (covering 85% of Sweden inhabitan...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1016/s0195-668x(03)00475-5

    authors: Herlitz J,Engdahl J,Svensson L,Young M,Angquist KA,Holmberg S

    更新日期:2003-10-01 00:00:00

  • Strain rate imaging for functional quantification of the left atrium: atrial deformation predicts the maintenance of sinus rhythm after catheter ablation of atrial fibrillation.

    abstract:AIMS:The aim of the study was to investigate the atrial myocardial deformation properties using ultrasound strain rate (SR) imaging in patients after catheter ablation of atrial fibrillation (AF) and to compare its prognostic value in maintaining sinus rhythm. METHODS AND RESULTS:A total of 118 patients with AF (74 pa...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehn168

    authors: Schneider C,Malisius R,Krause K,Lampe F,Bahlmann E,Boczor S,Antz M,Ernst S,Kuck KH

    更新日期:2008-06-01 00:00:00

  • What is the role of the coronary circulation in congestive heart failure?

    abstract::Manifestations of congestive heart failure are frequently observed in patients with coronary disease. However, they may be predominant in patients who have sustained prior myocardial infarction, in whom left ventricular aneurysm or papillary muscle dysfunction may induce left ventricular dysfunction. A small group of ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/4.suppl_a.131

    authors: Bertrand ME,Lablanche JM,Thieuleux FA,Tilmant PY

    更新日期:1983-01-01 00:00:00

  • The diagnoses of patients admitted with acute chest pain but without myocardial infarction.

    abstract:OBJECTIVE:The purpose of this study was to describe the frequencies of various diagnoses in patients admitted with acute chest pain, but without acute myocardial infarction, and to evaluate a non-invasive screening programme for these patients. PATIENTS:A total of 204 consecutive non-acute myocardial infarction patien...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a014998

    authors: Fruergaard P,Launbjerg J,Hesse B,Jørgensen F,Petri A,Eiken P,Aggestrup S,Elsborg L,Mellemgaard K

    更新日期:1996-07-01 00:00:00

  • Assessment of mechanisms of ventricular arrhythmias from the surface ECG in 118 patients.

    abstract::Mechanisms of ventricular arrhythmias were assessed by the application of ECG criteria derived from experimental electrophysiology. These interval criteria describe for ideal and modulated parasystole, resetable spontaneous automaticity, early and delayed afterdepolarizations and reentry, how QRS complexes of ectopic ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062344

    authors: van Hemel NM,Swenne CA,Robles de Medina EO

    更新日期:1987-08-01 00:00:00

  • Inhibitory effect of acute and chronic administration of digitalis on the sick sinus node.

    abstract::We have determined the effects of the acute administration of intravenous (i.v.) digitalis administration (0.8 mg of digoxin in 5-10 min) on the electrophysiological variables of 12 normal subjects (group 1), 12 patients with asymptomatic sinus node bradycardia (group 2) and 34 patients with symptomatic sinus node dys...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062071

    authors: Bolognesi R,Benedini G,Ferrari R,Visioli O

    更新日期:1986-04-01 00:00:00

  • New diagnostic criteria for infective endocarditis. A study of sensitivity and specificity.

    abstract:OBJECTIVE:The purpose of this study was to determine the sensitivity and specificity of new criteria proposed by Duke University for case definition of infective endocarditis as compared to the previously accepted Von Reyn criteria. PATIENTS:A total of 143 consecutive suspected cases of infective endocarditis in 137 f...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a015411

    authors: Cecchi E,Parrini I,Chinaglia A,Pomari F,Brusasco G,Bobbio M,Trinchero R,Brusca A

    更新日期:1997-07-01 00:00:00

  • Happy heart syndrome: role of positive emotional stress in takotsubo syndrome.

    abstract:AIMS:Takotsubo syndrome (TTS) is typically provoked by negative stressors such as grief, anger, or fear leading to the popular term 'broken heart syndrome'. However, the role of positive emotions triggering TTS remains unclear. The aim of the present study was to analyse the prevalence and characteristics of patients w...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehv757

    authors: Ghadri JR,Sarcon A,Diekmann J,Bataiosu DR,Cammann VL,Jurisic S,Napp LC,Jaguszewski M,Scherff F,Brugger P,Jäncke L,Seifert B,Bax JJ,Ruschitzka F,Lüscher TF,Templin C,InterTAK Co-investigators:.

    更新日期:2016-10-01 00:00:00

  • CardioPulse: The future of coronary computer tomography angiography.

    abstract::Stephan Achenbach reviews the history of coronary computer tomography angiography and discusses its further evolution. ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:

    authors: Achenbach S

    更新日期:2016-02-21 00:00:00

  • Childhood appendectomy, tonsillectomy, and risk for premature acute myocardial infarction--a nationwide population-based cohort study.

    abstract:AIMS:Although inflammation contributes to cardiovascular disease, the associations of appendectomy and tonsillectomy, which remove mucosa-associated lymphoid tissue, with risk of acute myocardial infarction (AMI) are unknown. Our aim was to assess the association between these operations performed in childhood and AMI ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehr137

    authors: Janszky I,Mukamal KJ,Dalman C,Hammar N,Ahnve S

    更新日期:2011-09-01 00:00:00

  • Acute rise of circulating vascular endothelial growth factor-A in patients with coronary artery disease following cardiothoracic surgery.

    abstract:AIMS:Vascular endothelial growth factor-A (VEGF-A) is an angiogenic and vasoprotective molecule whose expression is modulated by hypoxia and inflammatory mediators. Here we have tested the hypothesis that plasma levels of VEGF-A are influenced by pre-existing coronary artery disease and by changes in circulating interl...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2001.3034

    authors: Cotton JM,Mathur A,Hong Y,Brown AS,Martin JF,Erusalimsky JD

    更新日期:2002-06-01 00:00:00

  • Risk scores for risk stratification in acute coronary syndromes: useful but simpler is not necessarily better.

    abstract:AIMS:Our objectives were (i) to compare the discriminatory performance of the Thrombolysis in Myocardial Infarction risk score (TIMI RS), Platelet glycoprotein IIb/IIIa in Unstable angina: Receptor Suppression Using Integrilin Therapy risk score (PURSUIT RS), and Global Registry of Acute Cardiac Events risk score (GRAC...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehm004

    authors: Yan AT,Yan RT,Tan M,Casanova A,Labinaz M,Sridhar K,Fitchett DH,Langer A,Goodman SG

    更新日期:2007-05-01 00:00:00

  • Regional myocardial deformation in children with hypertrophic cardiomyopathy: morphological and clinical correlations.

    abstract:AIMS:Hypertrophic cardiomyopathy (HCM) is a disease with marked regional differences in wall thickness. However, the relation between myocardial function and wall thickness has not been well studied. Ultrasonic strain rate (SR) imaging makes it possible to study the regional myocardial deformation. We investigated whet...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehm444

    authors: Ganame J,Mertens L,Eidem BW,Claus P,D'hooge J,Havemann LM,McMahon CJ,Elayda MA,Vaughn WK,Towbin JA,Ayres NA,Pignatelli RH

    更新日期:2007-12-01 00:00:00

  • Real-time MRI-guided right heart catheterization in adults using passive catheters.

    abstract:AIMS:Real-time MRI creates images with superb tissue contrast that may enable radiation-free catheterization. Simple procedures are the first step towards novel interventional procedures. We aim to perform comprehensive transfemoral diagnostic right heart catheterization in an unselected cohort of patients entirely usi...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehs189

    authors: Ratnayaka K,Faranesh AZ,Hansen MS,Stine AM,Halabi M,Barbash IM,Schenke WH,Wright VJ,Grant LP,Kellman P,Kocaturk O,Lederman RJ

    更新日期:2013-02-01 00:00:00

  • The Anglo-Scandinavian Cardiac Outcomes Trial: 11-year mortality follow-up of the lipid-lowering arm in the U.K.

    abstract:AIMS:The aim of this study was to determine the outcome benefits in those originally assigned atorvastatin in the Anglo-Scandinavian Cardiac Outcomes Trial-8 years after closure of the lipid-lowering arm (LLA) of the trial (ASCOT-LLA) among the U.K. population. METHODS AND RESULTS:ASCOT-LLA was a factorially designed ...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehr333

    authors: Sever PS,Chang CL,Gupta AK,Whitehouse A,Poulter NR,ASCOT Investigators.

    更新日期:2011-10-01 00:00:00

  • Left ventricular dysfunction, exercise capacity and activity recommendations.

    abstract::There is lack of consistent correlation between left ventricular function at rest, haemodynamic measurements at rest, symptomatic status and exercise tolerance. Haemodynamic data appear comparable in patients whose exercise tolerance is limited clinically by fatigue and by breathlessness. Selected patients with left v...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/9.suppl_f.63

    authors: Wenger NK

    更新日期:1988-04-01 00:00:00

  • Effects of diuretics on renal excretory function.

    abstract::From a clinicopharmacological standpoint, the urinary excretory potency of diuretics should be assessed comparatively, on the basis of placebo-controlled changes in 24 h natriuresis, following single oral doses administered to healthy adult subjects who are in steady-state habitual external sodium balance. The potency...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/eurheartj/13.suppl_g.15

    authors: Reyes AJ

    更新日期:1992-12-01 00:00:00

  • Role of GABAergic mechanisms in the central regulation of arterial pressure.

    abstract::Gamma aminobutyric acid (GABA) may represent the single most prevalent neurotransmitter in the mammalian central nervous system. Consequently, it should come as little surprise that the neural circuitry concerned with regulating systemic arterial pressure through the autonomic nervous system utilizes a number of GABAe...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/8.suppl_b.133

    authors: DiMicco JA,Abshire VM,Shekhar A,Wilbe JH Jr

    更新日期:1987-05-01 00:00:00

  • Guidelines for a successful European Society of Cardiology grant application.

    abstract::There is no certain way of obtaining one of the European Society of Cardiology grants for research or clinical training offered each year, but Prof. Stavros Konstantinides (Centre for Thrombosis and Haemostasis, Johannes Gutenberg University, Mainz, Germany), who chairs the European Society of Cardiology Credentials C...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:

    authors:

    更新日期:2014-05-14 00:00:00