Abstract:
AIMS:The role of cardiovascular risk factors and atherosclerosis in the aetiology of abdominal aortic aneurysms is not well understood. The aim of this study was to determine the association between atherosclerosis and aortic aneurysm in the general population and the extent to which cardiovascular risk factors might increase the risk of aneurysm independently of an effect on atherosclerotic disease. METHODS AND RESULTS:In the Edinburgh Artery Study, 1592 men and women aged 55-74 years were followed prospectively over a period of 5 years. Forty subjects were identified as having an abdominal aortic aneurysm and, for each, five controls were randomly selected. Case showed a higher prevalence of cardiovascular disease (P < or = 0.001) and had a lower ankle brachial pressure index (P < or = 0.01). Current and recent ex-cigarette smokers had an increased risk of aortic aneurysm compared with long time ex-smokers and never smokers (odds ratio 3.08, 95% CI 1.53 to 6.21). Adjustment for concurrent atherosclerotic disease reduced the odds ratio to 2.63 (95% CI 1.26 to 5.45). The risk of aortic aneurysm was not related to elevation in diastolic blood pressure or in serum cholesterol. CONCLUSIONS:These findings indicate that atherosclerotic disease is associated with risk of aortic aneurysm in the general population. In addition, cigarette smoking appears to have a direct effect on the risk of aortic aneurysm which is independent of atherosclerosis.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Lee AJ,Fowkes FG,Carson MN,Leng GC,Allan PLdoi
10.1093/oxfordjournals.eurheartj.a015314subject
Has Abstractpub_date
1997-04-01 00:00:00pages
671-6issue
4eissn
0195-668Xissn
1522-9645journal_volume
18pub_type
杂志文章abstract:AIMS:The aim of this study was to investigate the 12-month incidence, predictive factors, and prognosis of sustained ventricular tachycardia (VT) in chronic heart failure patients implanted with biventricular pacemakers without a back-up defibrillator (CRT-P), assessed by continuous intracardiac ventricular electrogram...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1093/eurheartj/ehp071
更新日期:2009-05-01 00:00:00
abstract:AIMS:Our objective was to create a simple prognostic risk score for patients with systolic heart failure and mild symptoms. We then assessed the efficacy of eplerenone across different categories of risk. METHODS AND RESULTS:The Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure trial (EMP...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/eurheartj/eht247
更新日期:2013-09-01 00:00:00
abstract::Clinicians have long suspected that hypertrophied hearts have an inadequate coronary circulation. This clinical suspicion resulted from the observation that a large proportion of patients with left ventricular hypertrophy who have normal coronary arteriograms complain of angina and have ischaemia-like ST segment depre...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:
更新日期:1993-11-01 00:00:00
abstract::Atrial fibrillation is often associated with atrial enlargement and stretch is known to cause electrophysiological alterations. Acute stretch may, depending on the moment at which it is applied, cause action potential shortening or induce both early and delayed afterdepolarizations which, when large enough, may initia...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/18.suppl_c.12
更新日期:1997-05-01 00:00:00
abstract:AIMS:To assess the impact of MultiPoint™ Pacing (MPP)-programmed according to the physician's discretion-in non-responders to standard biventricular pacing after 6 months. METHODS AND RESULTS:The study enrolled 1921 patients receiving a quadripolar cardiac resynchronization therapy (CRT) system capable of MPP™ therapy...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/eurheartj/ehz109
更新日期:2019-09-14 00:00:00
abstract:AIMS:To assess compliance to guidelines in the management of patients with atrial fibrillation. METHODS AND RESULTS:A total of 728 questionnaires were mailed to physicians with the intention of studying 'theoretical' compliance to practice guidelines. A retrospective evaluation of 200 records from consecutive patients...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1053/euhj.2000.2300
更新日期:2001-10-01 00:00:00
abstract::A time-domain signal-averaged ECG was performed in 52 patients with arrhythmogenic right ventricular dysplasia (ARVD) proven by angiography, in 45 control subjects with normal hearts, and in 132 patients with various types of ventricular arrhythmias and no evidence of cardiac disease during routine cardiac examination...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/14.suppl_e.80
更新日期:1993-09-01 00:00:00
abstract::In order to assess the value of pulsed Doppler echocardiography in detection of valvular regurgitation, 63 patients were evaluated for aortic and/or mitral regurgitation using pulsed Doppler echocardiography and selective cineangiography. The Doppler study was considered as positive when a turbulent flow was detected ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061674
更新日期:1984-05-01 00:00:00
abstract::Myocardial relaxation is an energy-dependent process. Indeed, adenosine triphosphate (ATP) is required to pump free myoplasmic calcium back into the sarcoplasmic reticulum. It is also necessary to extrude the calcium ions which enter the cell during the plateau phase of the action potential. The calcium-sodium exchang...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/11.suppl_c.30
更新日期:1990-05-01 00:00:00
abstract::Valvular heart disease is a significant, global cause of morbidity and mortality. In the ageing population of industrialized nations, degenerative aortic stenosis has become the most common native valve disorder. Although surgical aortic valve replacement is associated with excellent clinical outcomes, a large number ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehp260
更新日期:2009-09-01 00:00:00
abstract::During the long-term follow-up of patients with hypertrophic cardiomyopathy (HCM), some patients develop left ventricular (LV) wall motion abnormalities in the absence of fixed coronary artery disease. The purpose of this study is to clarify which clinical features in patients with HCM seem to influence gradual develo...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/14.12.1629
更新日期:1993-12-01 00:00:00
abstract::The electrocardiographic patterns, observed during 24-h Holter monitoring, of 10 patients (mean age 35 +/- 22 years) with first and second degree A-V block due to dual A-V nodal pathways are reported. Recordings were selected according to the presence of: sudden and persistent prolongation of the PR interval: sudden n...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a059904
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Antiarrhythmic drugs are still used for the treatment of ventricular tachyarrhythmias, in combination with implantable cardioverter-defibrillators or without them. AIM OF THE STUDY:In a double-blind randomized crossover design, the short- and long-term efficacy and safety of oral dofetilide or oral sotalol ...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1053/euhj.2001.2679
更新日期:2001-12-01 00:00:00
abstract:AIMS:Monocytes are critical mediators of healing following acute myocardial infarction (AMI), making them an interesting target to improve myocardial repair. The purpose of this study was a gain of insight into the source and recruitment of monocytes following AMI in humans. METHODS AND RESULTS:Post-mortem tissue spec...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/eht331
更新日期:2014-02-01 00:00:00
abstract::Forty patients with prosthetic valve endocarditis (PVE) presenting during a 12-year period at a single hospital were studied. Twenty-six were male and 14 female and ages ranged from 19 to 67 years. During the first six post-operative months, most episodes were caused by staphylococci (38%) and Gram negative bacilli (2...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/5.suppl_c.133
更新日期:1984-10-01 00:00:00
abstract::Increased sympathetic tone is found in about 30% of patients with hypertension. This abnormality is closely associated with the metabolic syndrome of dyslipidaemia and hyperinsulinaemia. In this short review we discuss the mechanisms by which sympathetic over-activity could cause the metabolic syndrome. Sympathetic st...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:
更新日期:1998-06-01 00:00:00
abstract:AIMS:Raised blood pressure (BP) is the biggest contributor to mortality and disease burden worldwide and fewer than half of those with hypertension are aware of it. May Measurement Month (MMM) is a global campaign set up in 2017, to raise awareness of high BP and as a pragmatic solution to a lack of formal screening wo...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehz300
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Recent identification of mutations in the beta-myosin heavy chain gene (MYH7), a major responsible gene for HCM, has provided the opportunity to characterize genotype-phenotype correlation in HCM families. In this study we analysed the phenotypic expression of two beta-myosin heavy chain (beta MHC) mutations...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a060920
更新日期:1995-03-01 00:00:00
abstract:AIMS:The aim of this study is to compare the efficacy of sirolimus-eluting stents (SES) on neointimal growth and vessel remodelling for in-stent restenosis versus de novo coronary artery lesions using serial intravascular ultrasound (IVUS). METHODS AND RESULTS:The study population consisted of 86 patients with in-sten...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1016/j.ehj.2003.10.012
更新日期:2004-01-01 00:00:00
abstract:AIMS:In Belgium, general practitioners (GPs) mainly manage oral anticoagulation therapy. To improve the quality of oral anticoagulation management by GPs and to compare different models and interventions, a randomized clinical trial was performed. METHODS AND RESULTS:Stratified randomization divided 66 GP-practices in...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/eurheartj/ehi327
更新日期:2005-10-01 00:00:00
abstract::The endothelium may play a role as a target and mediator of hypertension. Due to its anatomical position, it is very exposed to mechanical forces; as a source of vasoactive material it may participate in increasing peripheral vascular resistance and in promoting local ischaemia in the heart and brain. Morphological an...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/13.suppl_d.50
更新日期:1992-09-01 00:00:00
abstract:AIMS:A higher intake of fruits and vegetables has been associated with a lower risk of ischaemic heart disease (IHD), but there is some uncertainty about the interpretation of this association. The objective was to assess the relation between fruit and vegetable intake and risk of mortality from IHD in the European Pro...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1093/eurheartj/ehq465
更新日期:2011-05-01 00:00:00
abstract::Anthony N. DeMaria discusses the journal's history, its focus,and innovative ideas for Internet reading. ...
journal_title:European heart journal
pub_type: 杂志文章
doi:
更新日期:2012-02-01 00:00:00
abstract::Priorities for unanswered questions concerning major areas of cardiovascular disease are being sought by the British Cardiovascular Society, using the methods of the James Lind Alliance, which involves clinicians and patients in an equal partnership, reports Barry Shurlock PhD. ...
journal_title:European heart journal
pub_type: 新闻
doi:
更新日期:2015-06-01 00:00:00
abstract:AIMS:A potential role for cardiovascular disease (CVD) risk factors in the aetiology of suicide has not been comprehensively examined. In addition to being small in scale and poorly characterized, existing studies very rarely sample Asian populations in whom risk factor-suicide relationships may plausibly differ to Cau...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehr229
更新日期:2011-11-01 00:00:00
abstract:AIMS:Atrial fibrillation (AF) is associated with abnormal sarcoplasmic reticulum (SR) calcium release, which is promoted by adenosine A(2A) receptor (A(2A)R) activation. Here, we tested the hypothesis that abnormal calcium release in AF is linked to A(2A)R remodelling. METHODS AND RESULTS:Western blotting and quantita...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehq464
更新日期:2011-03-01 00:00:00
abstract:AIMS:No-reflow after a primary percutaneous coronary intervention (PCI) is associated with a high incidence of left ventricular (LV) failure and a poor prognosis. Endothelin-1 (ET-1) is a potent endothelium-derived vasoconstrictor peptide and an important modulator of neutrophil function. Elevated systemic ET-1 levels ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehl119
更新日期:2006-08-01 00:00:00
abstract:AIMS:Takotsubo syndrome (TTS) is typically provoked by negative stressors such as grief, anger, or fear leading to the popular term 'broken heart syndrome'. However, the role of positive emotions triggering TTS remains unclear. The aim of the present study was to analyse the prevalence and characteristics of patients w...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehv757
更新日期:2016-10-01 00:00:00
abstract:AIMS:To investigate the efficacy and outcome of emergency percutaneous coronary interventions (PCI) in patients with stent thrombosis. METHODS AND RESULTS:Between 1995 and 2003, 6058 patients underwent bare-metal stent implantation, of which 95 (1.6%) patients suffered from stent thrombosis. The timing of stent thromb...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehi135
更新日期:2005-06-01 00:00:00
abstract:AIMS:The purpose of this study was to identify novel genetic variants influencing circulating asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) levels and to evaluate whether they have a prognostic value on cardiovascular mortality. METHODS AND RESULTS:We conducted a genome-wide association stud...
journal_title:European heart journal
pub_type: 杂志文章,meta分析
doi:10.1093/eurheartj/eht447
更新日期:2014-02-01 00:00:00