Abnormal calcium handling in atrial fibrillation is linked to up-regulation of adenosine A2A receptors.

abstract：OBJECTIVES:The Cholesterol Lowering Atherosclerosis PTCA Trial (CLAPT) is a prospective, randomized trial with blinded angiographic end-points to assess the effect of 2-year's treatment with lovastatin initiated 4 weeks prior to PTCA, compared to usual care on non-dilated coronary segments and on dilated coronary lesio...

journal_title：European heart journal

authors： Kleemann A,Eckert S,von Eckardstein A,Lepper W,Schernikau U,Gleichmann U,Hanrath P,Fleck E,Neiss A,Kerber S,Assmann G,Breithardt G,CLAPT Study.

更新日期：1999-10-01 00:00:00

abstract：Aims:Vascular ageing is characterized by arterial stiffening, dilation, and arterial wall thickening. We investigated the extent to which these changes are related and their heritability during 5 year follow-up in the Twins UK cohort. Methods and results:Carotid-femoral pulse wave velocity (PWVcf), carotid diameter, c...

journal_title：European heart journal

authors： Cecelja M,Jiang B,Keehn L,Hussain T,Silva Vieira M,Phinikaridou A,Greil G,Spector TD,Chowienczyk P

更新日期：2018-06-21 00:00:00

abstract：AIMS:Right ventricular dysfunction (RVD) is an important determinant of functional status and survival in various diseases states. Data are sparse on the epidemiology and outcome of patients with severe RVD. This study examined the characteristics, aetiology, and survival of patients with severe RVD. METHODS AND RESUL...

journal_title：European heart journal

authors： Padang R,Chandrashekar N,Indrabhinduwat M,Scott CG,Luis SA,Chandrasekaran K,Michelena HI,Nkomo VT,Pislaru SV,Pellikka PA,Kane GC

更新日期：2020-03-21 00:00:00

abstract：AIMS:Induced pluripotent stem cells (iPSCs) provide a unique opportunity for the generation of patient-specific cells for use in disease modelling, drug screening, and regenerative medicine. The aim of this study was to compare human-induced pluripotent stem cells (hiPSCs) derived from different somatic cell sources re...

journal_title：European heart journal

authors： Streckfuss-Bömeke K,Wolf F,Azizian A,Stauske M,Tiburcy M,Wagner S,Hübscher D,Dressel R,Chen S,Jende J,Wulf G,Lorenz V,Schön MP,Maier LS,Zimmermann WH,Hasenfuss G,Guan K

更新日期：2013-09-01 00:00:00

abstract：:The study was designed to examine the safety and efficacy of acute interventional use of captopril on left ventricular volumes, ventricular arrhythmias and neurohormones during thrombolysis in patients with a first anterior myocardial infarction, within 6 h of onset of symptoms. Left ventricular dysfunction and progno...

journal_title：European heart journal

authors： Kingma JH,van Gilst WH,Peels CH,Dambrink JH,Verheugt FW,Wielenga RP

更新日期：1994-07-01 00:00:00

abstract：:Impaired relaxation of the ventricle has been described in hypertrophy and in ischemic heart disease. Some of these abnormalities are transient, but all occur at an early stage of the disease. The underlying mechanisms may vary depending on the etiology of the disease, and, except for ischemic heart disease, true myoc...

journal_title：European heart journal

authors： Brutsaert DL

更新日期：1983-01-01 00:00:00

abstract：AIMS:The aim of this study was to compare on-thienopyridine platelet reactivity of elderly patients (≥75 years) vs. younger patients (<75 years). Elderly patients represent a growing and challenging segment of the coronary population for whom the effect of dual antiplatelet therapy on platelet inhibition has not been s...

journal_title：European heart journal

authors： Silvain J,Cayla G,Hulot JS,Finzi J,Kerneis M,O'Connor SA,Bellemain-Appaix A,Barthélémy O,Beygui F,Collet JP,Montalescot G

更新日期：2012-05-01 00:00:00

abstract：:Infective endocarditis is associated with significant morbidity and mortality, with valvular destruction and congestive heart failure being more common in patients with echocardiographically discernible vegetations. The transoesophageal approach affords consistently high quality images with excellent structural resolu...

journal_title：European heart journal

authors： Rohmann S,Erbel R,Görge G,Makowski T,Mohr-Kahaly S,Nixdorff U,Drexler M,Meyer J

更新日期：1992-04-01 00:00:00

abstract：:In 103 hearts with various forms of cardiac muscle hypertrophy the following parameters were estimated: diameter, length, volume, density and number of myocytes, and density of myocyte nuclei. The values of all histometric parameters correlated well with left ventricular (LV) weight up to 350 g. In heavier hearts thes...

journal_title：European heart journal

authors： Grajek S,Lesiak M,Pyda M,Zajac M,Paradowski S,Kaczmarek E

更新日期：1993-01-01 00:00:00

abstract：:Clinicians have long suspected that hypertrophied hearts have an inadequate coronary circulation. This clinical suspicion resulted from the observation that a large proportion of patients with left ventricular hypertrophy who have normal coronary arteriograms complain of angina and have ischaemia-like ST segment depre...

journal_title：European heart journal

authors： Kaski JC

更新日期：1993-11-01 00:00:00

abstract：:There has been considerable controversy over whether elevated levels of triglycerides, or hypertriglyceridaemia, is an independent risk factor in coronary heart disease (CHD). Discrepancies between findings of univariate and multivariate statistical analyses are likely to be due to the strong inverse correlation betwe...

journal_title：European heart journal

authors： Miller M

更新日期：1998-07-01 00:00:00

abstract：:All citizens (N = 22066) aged 16 to 65 of a medium-sized Belgian town were personally invited to CPR training sessions held in their neighbourhood. 1152 responded by attending a training session. Those who did not so respond were surveyed (random sample N = 600) for reasons of their not coming. The sample fitted well ...

journal_title：European heart journal

authors： Lejeune PO,Delooz HH

更新日期：1987-03-01 00:00:00

abstract：AIMS:The very long-term outcome of patients who survive the first few years after receiving cardiac resynchronization therapy (CRT) has not been well described thus far. We aimed to provide long-term outcomes, especially with regard to the occurrence of sudden cardiac death (SCD), in CRT patients without (CRT-P) and wi...

journal_title：European heart journal

authors： Barra S,Duehmke R,Providência R,Narayanan K,Reitan C,Roubicek T,Polasek R,Chow A,Defaye P,Fauchier L,Piot O,Deharo JC,Sadoul N,Klug D,Garcia R,Dockrill S,Virdee M,Pettit S,Agarwal S,Borgquist R,Marijon E,Boveda

更新日期：2019-07-01 00:00:00

abstract：:During a 3-year period 2500 asymptomatic male aviators were screened routinely for coronary artery disease by maximal bicycle exercise testing. In 55 cases (2.1%) the exercise ECG was abnormal (40 subjects exhibited ST depression, 14 ventricular ectopic activity and in one subject both abnormalities were observed). Fu...

journal_title：European heart journal

authors： Pedersen F,Sandøe E,Laerkeborg A

更新日期：1991-07-01 00:00:00

abstract：AIMS:There is little evidence to inform routine practice in the use of coronary angiography and revascularization procedures after acute myocardial infarction. Large differences in the uptake of these procedures have been reported but representative data are scarce. Outcome studies have produced opposing conclusions co...

journal_title：European heart journal

authors： Woods KL,Ketley D,Agusti A,Hagn C,Kala R,Karatzas NB,Leizorowicz A,Reikvam A,Schilling J,Seabra-Gomes R,Vasiliauskas D,Wilhelmsen L

更新日期：1998-09-01 00:00:00

abstract：:MitraClip therapy consists of percutaneous edge-to-edge coaptation of the mitral leaflets that is analogous to the surgical Alfieri technique. The safety profile of the MitraClip device is favourable, and survival outcomes in high-surgical-risk patients are superior to historical controls. However, questions remain re...

journal_title：European heart journal

authors： Rogers JH,Franzen O

更新日期：2011-10-01 00:00:00

abstract：:In the interpretation of the effect of a drug or intervention in a single patient, it is desirable to know the spontaneous fluctuations of the variable under study. A few studies have determined pulmonary haemodynamic variability in acute and short-term intervals. It seems reasonable to adopt a confidence limit of 6 m...

journal_title：European heart journal

authors： Schrijen F,Jezková J

更新日期：1988-09-01 00:00:00

abstract：:24 hour ambulatory electrocardiography was performed in a representative group of people born in 1897. Out of 73 people included in the study, 22 were without known heart disease, 15 had definite ischaemic heart disease (IHD) and 36 symptoms of possible cardiac origin. An R-R interval in excess of 2000 ms was seen in ...

journal_title：European heart journal

authors： Ingerslev J,Bjerregaard P

更新日期：1986-07-01 00:00:00

abstract：:Electrophysiological properties were studied in a heterotopic heart transplant model developed in 44 dogs (Group I). Cycle length was 359.5 +/- 55.2 ms in the recipient heart and 500.9 +/- 77.9 ms in the donor heart (P less than 0.001). Sinoatrial conduction time was 38.6 +/- 13.6 ms in the recipient heart and 38.6 +/...

journal_title：European heart journal

authors： Alvarez L,Escudero C,Alzueta J,Silva L,Márquez-Montes J,Castillo-Olivares JL

更新日期：1990-06-01 00:00:00

abstract：AIM:To describe the relative impact on survival of the delay from estimated time of collapse to call for an ambulance among patients who suffer from a bystander witnessed out of hospital cardiac arrest of a cardiac aetiology. METHODS:A majority of all ambulance organizations in Sweden (covering 85% of Sweden inhabitan...

journal_title：European heart journal

authors： Herlitz J,Engdahl J,Svensson L,Young M,Angquist KA,Holmberg S

更新日期：2003-10-01 00:00:00

abstract：AIMS:Increased cardiovascular morbidity is manifested a long time after the repair of aortic coarctation (CoA). By way of impaired flow-mediated vasodilation (FMD) and increased intima media thickness (IMT), surrogate parameters of atherosclerosis, cardiovascular risk factors (RFs) can be correlated with early vascular...

journal_title：European heart journal

authors： Meyer AA,Joharchi MS,Kundt G,Schuff-Werner P,Steinhoff G,Kienast W

更新日期：2005-03-01 00:00:00

abstract：:Twenty-nine men with chronic stable angina pectoris were investigated using stress electrocardiography (ECG) and stress transthoracic echocardiography by means of transoesophageal stimulation of the left atrium. At rest and after each stimulated frequency, ECG and 2-dimensional echocardiography combined with Doppler w...

journal_title：European heart journal

authors： Meluzín J,Novák M,Julínek J,Rihácek I,Urbánek D,Koukalová H,Toman J

更新日期：1993-10-01 00:00:00

abstract：AIMS:Targeting interleukin-1 (IL-1) represents a novel therapeutic approach to atherosclerosis. CANTOS demonstrated the benefits of IL-1β neutralization in patients post-myocardial infarction with residual inflammatory risk. Yet, some mouse data have shown a prominent role of IL-1α rather than IL-1β in atherosclerosis,...

journal_title：European heart journal

authors： Vromman A,Ruvkun V,Shvartz E,Wojtkiewicz G,Santos Masson G,Tesmenitsky Y,Folco E,Gram H,Nahrendorf M,Swirski FK,Sukhova GK,Libby P

更新日期：2019-08-07 00:00:00

abstract：:Atrial fibrillation is often associated with atrial enlargement and stretch is known to cause electrophysiological alterations. Acute stretch may, depending on the moment at which it is applied, cause action potential shortening or induce both early and delayed afterdepolarizations which, when large enough, may initia...

journal_title：European heart journal

authors： Janse MJ

更新日期：1997-05-01 00:00:00

abstract：AIMS:Aortic stenosis causes cardiac hypertrophy and fibrosis, which often persists despite pressure unloading after aortic valve replacement. The persistence of myocardial fibrosis in particular leads to impaired cardiac function and increased mortality. We investigated whether granulocyte colony-stimulating factor (G-...

journal_title：European heart journal

authors： Szardien S,Nef HM,Voss S,Troidl C,Liebetrau C,Hoffmann J,Rauch M,Mayer K,Kimmich K,Rolf A,Rixe J,Troidl K,Kojonazarov B,Schermuly RT,Kostin S,Elsässer A,Hamm CW,Möllmann H

更新日期：2012-03-01 00:00:00

abstract：:The implementation of molecular biological approaches has led to the discovery of single genetic variations that contribute to the development of cardiac failure. In the present review, the characteristics that are invariably associated with the development of failure in experimental animals and clinical studies are d...

journal_title：European heart journal

authors： Lips DJ,deWindt LJ,van Kraaij DJ,Doevendans PA

更新日期：2003-05-01 00:00:00

abstract：:This report of an ESC Study Group reviews current knowledge on myocardial hibernation and relevant imaging techniques, and provides an algorithm for investigation and management when a patient presents with ischaemic left ventricular dysfunction. It covers the definitions of myocardial viability, stunning and hibernat...

journal_title：European heart journal

authors： Underwood SR,Bax JJ,vom Dahl J,Henein MY,Knuuti J,van Rossum AC,Schwarz ER,Vanoverschelde JL,van der Wall EE,Wijns W,Study Group of the European Society of Cardiology.

更新日期：2004-05-01 00:00:00

abstract：AIMS:Pericardial effusion (PE) is a common finding in cardiac patients with chronic heart failure. The prognostic relevance of a small, haemodynamically non-compromising PE in such patients, however, remains to be determined. METHODS AND RESULTS:All patients referred to our heart failure clinic and having a baseline e...

journal_title：European heart journal

authors： Fröhlich GM,Keller P,Schmid F,Wolfrum M,Osranek M,Falk C,Noll G,Enseleit F,Reinthaler M,Meier P,Lüscher TF,Ruschitzka F,Tanner FC

更新日期：2013-05-01 00:00:00

abstract：:The epidemic of cardiovascular disease (CVD) is a global phenomenon, and the magnitude of its increase in incidence and prevalence in low- and middle-income countries (LIMIC) has potentially major implications for those high-income countries that characterize much of the developed world. Cardiovascular disease remains...

journal_title：European heart journal

authors： Gersh BJ,Sliwa K,Mayosi BM,Yusuf S

更新日期：2010-03-01 00:00:00

abstract：AIMS:Growth-differentiation factor-15 (GDF-15) has emerged as a biomarker of increased mortality and recurrent myocardial infarction (MI) in patients diagnosed with non-ST-elevation acute coronary syndrome. We explored the usefulness of GDF-15 for early risk stratification in 479 unselected patients with acute chest pa...

journal_title：European heart journal

authors： Eggers KM,Kempf T,Allhoff T,Lindahl B,Wallentin L,Wollert KC

更新日期：2008-10-01 00:00:00