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Intravascular ultrasound evaluation after sirolimus eluting stent implantation for de novo and in-stent restenosis lesions.

Abstract：

AIMS:The aim of this study is to compare the efficacy of sirolimus-eluting stents (SES) on neointimal growth and vessel remodelling for in-stent restenosis versus de novo coronary artery lesions using serial intravascular ultrasound (IVUS). METHODS AND RESULTS:The study population consisted of 86 patients with in-stent restenosis (ISR) (n=41) or de novo lesions (n=45) treated with SES and evaluated by IVUS post-procedure and at follow-up. One 18-mm SES was used for de novo lesions while 16 patients with ISR received >1SES (total stented length 17.9 mm vs 22.0 mm respectively; P=0.004). At follow-up, no differences were observed between the ISR and de novo groups with respect to changes in the mean external elastic membrane (1.7% vs 1.3%; P=0.53), plaque behind the stent (1.2% vs 3.4%; P=0.49), and lumen areas (0.7% vs 1.9%; P=0.58). No positive remodelling or edge effect was observed. A gap between stents was observed in two patients with ISR, where more prominent, though non-obstructive, neointimal proliferation was noted. CONCLUSION:Sirolimus-eluting stenting is equally effective at inhibiting neointimal proliferation in de novo and ISR lesions without inducing edge restenosis or positive vascular remodelling.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Degertekin M,Lemos PA,Lee CH,Tanabe K,Sousa JE,Abizaid A,Regar E,Sianos G,van der Giessen WJ,de Feyter PJ,Wuelfert E,Popma JJ,Serruys PW

doi

10.1016/j.ehj.2003.10.012

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

32-8

issue

1

eissn

0195-668X

issn

1522-9645

pii

S0195668X03006882

journal_volume

25

pub_type

杂志文章

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