Abstract:
:The value of quantitative assessment of coronary artery dimensions at the site of the most critical coronary stenosis was assessed by comparison with the correspondent reactive hyperaemia as measured by digital subtraction angiography and with the functional results. Thirty-two coronary lesions were analysed and flow reserve data were obtained in an additional 11 vascular distributions without coronary obstruction in 19 patients. Minimal diameter less than 1.25 mm and minimal area less than 1.5 mm2 at the site of the stenosis best separated vascular distributions with inadequate hyperaemic response from those with sufficient reactive hyperaemia (chi 2 = 19.57; P less than 0.0001). Identification of lesion severity based on videodensitometric percentage area stenosis greater than 70% or percentage diameter stenosis greater than 50% yielded similar but poorer results (respectively chi 2 = 14.53; P less than 0.001 and chi 2 = 10.29; P less than 0.005). Additionally, when visually determined percentage stenosis was compared to the quantitatively assessed value, only a fair correlation was observed (r = 0.74), with visual overestimation of lesion severity by an average of 11.1 +/- 9.8% (mean +/- SD). Reactive hyperaemia in vessels with coronary obstruction could be described from minimal coronary dimensions by a quadratic equation but did not correlate closely in this patient population (r = 0.54 with minimal diameter and r = 0.58 with minimal area).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Legrand V,Mancini GB,Le Free MT,Vogel RAdoi
10.1093/oxfordjournals.eurheartj.a060056subject
Has Abstractpub_date
1992-01-01 00:00:00pages
95-101issue
1eissn
0195-668Xissn
1522-9645journal_volume
13pub_type
杂志文章abstract::The alterations of the beta-adrenoceptor adenylyl cyclase are reviewed. In failing myocardium, the down-regulation of beta 1-adrenoceptors is accompanied by a decrease in steady state mRNA levels, as studied with quantitative polymerase chain reactions in dilated and ischaemic cardiomyopathy. The density of beta 2-adr...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/15.suppl_d.30
更新日期:1994-12-01 00:00:00
abstract:AIM:Cross-sectional studies reported associations between short leucocyte telomere length (LTL) and measures of vascular and cardiac damage. However, the contribution of LTL dynamics to the age-related process of cardiovascular (CV) remodelling remains unknown. In this study, we explored whether the rate of LTL shorten...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehu226
更新日期:2014-12-07 00:00:00
abstract:AIMS:Prophylactic administration of N-acetylcysteine (NAC) (600mg orally twice daily), along with hydration, prevents contrast agent-associated nephrotoxicity (CAN) induced by a low dose of non-ionic, low-osmolality contrast dye. We tested whether a double dose of NAC is more effective to prevent CAN. METHODS AND RESU...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.ehj.2003.11.016
更新日期:2004-02-01 00:00:00
abstract:AIMS:In patients with atrial fibrillation, minor troponin I elevation is regularly detected; however, the prognostic significance of this finding is unknown. We therefore sought to examine the prognostic value of elevated troponin I in patients with atrial fibrillation. METHODS AND RESULTS:A prospective study was cond...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehq491
更新日期:2011-03-01 00:00:00
abstract::Eleven patients with an atrioventricular accessory pathway were studied by programmed electrical stimulation to determine if reentrant tachycardia could be prevented by delivery of either a single atrial extrastimulus, applied at a critical time after the tachycardia-initiating stimulus (or stimuli), or a train of sti...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061756
更新日期:1985-01-01 00:00:00
abstract:AIMS:To assess the impact of MultiPoint™ Pacing (MPP)-programmed according to the physician's discretion-in non-responders to standard biventricular pacing after 6 months. METHODS AND RESULTS:The study enrolled 1921 patients receiving a quadripolar cardiac resynchronization therapy (CRT) system capable of MPP™ therapy...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/eurheartj/ehz109
更新日期:2019-09-14 00:00:00
abstract:AIMS:Despite the known benefits of regular exercise, the reasons why many coronary heart disease (CHD) patients engage in little physical activity are not well understood. This study identifies factors associated with low activity levels in individuals with chronic CHD participating in the STABILITY study, a global cli...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/eht258
更新日期:2013-11-01 00:00:00
abstract::To investigate the haemodynamic changes after physical training in patients with left ventricular aneurysm, 60 uncomplicated patients, mean age 51 +/- 10 years, underwent a maximal ergometric test in the supine position with haemodynamic monitoring (Swan-Ganz catheter) 37 +/- 10 days from acute myocardial infarction a...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/9.suppl_f.11
更新日期:1988-04-01 00:00:00
abstract::In order to assess the value of pulsed Doppler echocardiography in detection of valvular regurgitation, 63 patients were evaluated for aortic and/or mitral regurgitation using pulsed Doppler echocardiography and selective cineangiography. The Doppler study was considered as positive when a turbulent flow was detected ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061674
更新日期:1984-05-01 00:00:00
abstract:AIMS:The optimal timing of intervention in non-ST-elevation myocardial infarction (NSTEMI) remains uncertain. The aim of this multicentre trial was to assess whether an immediate invasive approach is superior to an early invasive or a selective invasive approach with respect to reduction of large infarction. METHODS A...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/eurheartj/ehr418
更新日期:2012-08-01 00:00:00
abstract:AIMS:The anti-anginal efficacy and safety of ranolazine in diabetic and non-diabetic patients included in the Combination Assessment of Ranolazine In Stable Angina (CARISA) trial (JAMA 2004;291:309) were studied. Glycaemic control was also assessed in CARISA and its long-term open-label extension study. METHODS AND RE...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/eurheartj/ehi495
更新日期:2006-01-01 00:00:00
abstract::Among 101 consecutive patients operated on for native infective aortic valve endocarditis (53 males, 48 females, mean age 39 years), 69 presented various forms of infectious extension to the surrounding areas. Twenty-six lesions were noted in the aortic roots: 18 annular abscesses, one abscess of the Valsalva sinus an...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/16.suppl_b.103
更新日期:1995-04-01 00:00:00
abstract:AIMS:In experimental studies the recovery of pressure distal to stenotic valve orifices has been well described. We evaluated the extent, determinants, and clinical importance of pressure recovery in patients with aortic valve stenosis. METHODS AND RESULTS:The study was performed in 37 patients with aortic valve steno...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1053/euhj.1998.1479
更新日期:1999-09-01 00:00:00
abstract:AIMS:Trans-fatty acids (TFAs) are generated by the food industry and also occur naturally in trace amounts in dairy products. For the latter, beneficial health effects have been claimed, while there are numerous reports about TFA of industrial origin being hazardous to human health. Therefore, we aimed to investigate t...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehv446
更新日期:2016-04-01 00:00:00
abstract::The efficacy and safety of a single infusion of cibenzoline, a class I antiarrhythmic drug, were assessed in 86 patients presenting with a supraventricular tachyarrhythmia following heart surgery in a placebo-controlled double-blind parallel study. Cibenzoline was effective in 13 patients (30%) vs three patients (6.9%...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1093/oxfordjournals.eurheartj.a060664
更新日期:1994-09-01 00:00:00
abstract::A 54 year old woman with isolated stenosis of the left coronary ostium died following cardiac catheterisation and emergency coronary artery bypass surgery. Histological examination showed the ostial narrowing to be a local and discrete plaque of atherosclerosis. Like most reported cases this patient was a young woman ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a062359
更新日期:1987-08-01 00:00:00
abstract::The aim of this study was to investigate the haemodynamic effects of amrinone in patients with pulmonary hypertension and impaired right ventricular function. Twelve patients with mitral stenosis (NYHA classification III and IV) took part in the study. The haemodynamic measurements were performed in the steady state u...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a062142
更新日期:1986-09-01 00:00:00
abstract:AIMS:Emerging evidence indicates that nuclear receptors play a critical regulatory role in cardiovascular physiology/pathology. Recently, farnesoid-X-receptor (FXR), a member of the metabolic nuclear receptor superfamily, has been demonstrated to be expressed in vascular cells, with important roles in vascular physiolo...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehs011
更新日期:2013-06-01 00:00:00
abstract::The left atrial appendage (LAA) is the main source of thromboembolism in patients with non-valvular atrial fibrillation (AF). As such, the LAA can be the target of specific occluding device therapies. Optimal management of patients with AF includes a comprehensive knowledge of the many aspects related to LAA structure...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehw159
更新日期:2017-03-21 00:00:00
abstract::The study of 'atrial vulnerability' is often clinically indicated but it requires the use of invasive intracardiac stimulation. The purpose of the study was to assess the use of oesophageal pacing in the evaluation of atrial tachyarrhythmias (ATA). Fifty-five patients with documented ATA (group I) and 60 without (grou...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a060632
更新日期:1994-08-01 00:00:00
abstract::The haemodynamic side-effects of ionic (amidotrizoate) and non-ionic (iopamidol) contrast media after injection into the right atrium were compared in experimental and clinical studies. Pulmonary hypertension was induced in 10 dogs by embolization of the pulmonary vascular bed with agar-agar solution (mean pulmonary a...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/oxfordjournals.eurheartj.a062219
更新日期:1987-12-01 00:00:00
abstract::Transient ischaemic episodes, defined as chest pain with ST segment elevation resolving in less than 15 min, have been encountered in 18 out of 130 patients during or in the 12h following percutaneous transluminal angioplasty (PTCA). During PTCA, ischaemic episodes occurred in 11 patients (8.5%) along with complete co...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061669
更新日期:1984-05-01 00:00:00
abstract:Aims:To elucidate the effects of intensive LDL-C lowering treatment with a standard dose of statin and ezetimibe in patients with dyslipidaemia and high risk of coronary events, targeting LDL-C less than 70 mg/dL (1.8 mmol/L), compared with standard LDL-C lowering lipid monotherapy targeting less than 100 mg/dL (2.6 mm...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/eurheartj/ehx162
更新日期:2017-08-01 00:00:00
abstract::The acute electrophysiologic effects of clinical doses of procainamide, lidocaine, metoprolol, digoxin and atropine upon the conduction of ventricular premature beats, were studied in 48 healthy volunteers. The conduction time of the first premature beat, induced 1 ms after the ventricular effective refractory period ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061755
更新日期:1985-01-01 00:00:00
abstract::A total of 546 patients with severe aortic stenosis (AS) were retrospectively reviewed to assess the efficacy of percutaneous transluminal valvuloplasty (PTV) and valve replacement (VR). Of these, 490 underwent VR between 1968 and 1986 (mean age 62 +/- 12 years, 71.7% were in NYHA class III or IV), 68.8% received mech...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/9.suppl_e.163
更新日期:1988-04-01 00:00:00
abstract:AIMS:To evaluate the prevalence, clinical significance, and prognosis of latent Brugada syndrome (BrS) in patients with new-onset atrial fibrillation (AF) unmasked by class 1C antiarrhythmic drugs. METHODS AND RESULTS:Between January 2000 and June 2008, all consecutive patients with new-onset AF, who after flecainide ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehp326
更新日期:2009-12-01 00:00:00
abstract::To assess the systolic and diastolic dysfunction of the left ventricle (LV) in relation to age and the severity of impairment in Duchenne muscular dystrophy (DMD), we performed M-mode, two-dimensional and pulsed-wave Doppler echocardiography in 45 male subjects with DMD aged 8 to 25 years and in 40 age-matched healthy...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/14.5.669
更新日期:1993-05-01 00:00:00
abstract:AIMS:To investigate the efficacy and outcome of emergency percutaneous coronary interventions (PCI) in patients with stent thrombosis. METHODS AND RESULTS:Between 1995 and 2003, 6058 patients underwent bare-metal stent implantation, of which 95 (1.6%) patients suffered from stent thrombosis. The timing of stent thromb...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehi135
更新日期:2005-06-01 00:00:00
abstract:AIMS:To investigate personality traits and sympatho-vagal modulation of heart rate variability (HRV) during acute myocardial infarction (AMI), assessing their relationships and their long-term prognostic value. METHODS AND RESULTS:Psychological traits and 24 h HRV were prospectively investigated in 246 patients at dis...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1093/eurheartj/ehi252
更新日期:2005-08-01 00:00:00
abstract::An elevation of the cardiopulmonary baroreflex control of the forearm vascular resistances due to an impairment of the arterial baroreflex has been postulated in borderline hypertension. The purpose of the study is to verify this hypothesis. The arterial baroreflex sensitivity, measured by the phenylephrine method is ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/4.suppl_g.41
更新日期:1983-11-01 00:00:00