Omics phenotyping in heart failure: the next frontier.

Abstract:

:This state-of-the-art review aims to provide an up-to-date look at breakthrough omic technologies that are helping to unravel heart failure (HF) disease mechanisms and heterogeneity. Genomics, transcriptomics, proteomics, and metabolomics in HF are reviewed in depth. In addition, there is a thorough, expert discussion regarding the value of omics in identifying novel disease pathways, advancing understanding of disease mechanisms, differentiating HF phenotypes, yielding biomarkers for diagnosis or prognosis, or identifying new therapeutic targets in HF. The combination of multiple omics technologies may create a more comprehensive picture of the factors and physiology involved in HF than achieved by either one alone and provides a rich resource for predictive phenotype modelling. However, the successful translation of omics tools as solutions to clinical HF requires that the observations are robust and reproducible and can be validated across multiple independent populations to ensure confidence in clinical decision-making.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Bayes-Genis A,Liu PP,Lanfear DE,de Boer RA,González A,Thum T,Emdin M,Januzzi JL

doi

10.1093/eurheartj/ehaa270

subject

Has Abstract

pub_date

2020-09-21 00:00:00

pages

3477-3484

issue

36

eissn

0195-668X

issn

1522-9645

pii

5825477

journal_volume

41

pub_type

杂志文章
  • Biological signals of cardiac hypertrophy.

    abstract::Chronic increases in haemodynamic load modify the expression of cardiac genes, leading to a new phenotype better adapted to the new functional demand. Several mechanisms such as the global activation of genes, the modulation of single genes and/or differential expression of multigene families may account for these mod...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/11.suppl_g.1

    authors: Samuel JL,Dubus I,Contard F,Schwartz K,Rappaport L

    更新日期:1990-11-01 00:00:00

  • Selection of dichotomy limits for multifactorial prediction of arrhythmic events and mortality in survivors of acute myocardial infarction.

    abstract:AIMS:To evaluate the predictive value and optimum dichotomy limits for different combinations of prognostic indicators for the prediction of arrhythmic events and cardiac mortality in post-infarction patients. BACKGROUND:Studies of new interventions based on risk stratification after myocardial infarction have often u...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a015439

    authors: Redwood SR,Odemuyiwa O,Hnatkova K,Staunton A,Poloniecki I,Camm AJ,Malik M

    更新日期:1997-08-01 00:00:00

  • Is atrial fibrillation an inflammatory disorder?

    abstract::There is mounting evidence to support the influence of inflammation in the pathogenesis of atrial fibrillation (AF). Indeed, AF is associated with increased levels of known inflammatory markers, even after adjustment for confounding factors. The renin-angiotensin-aldosterone system (RAAS) appears to play a key role in...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehi645

    authors: Boos CJ,Anderson RA,Lip GY

    更新日期:2006-01-01 00:00:00

  • Local hospital vs. core-laboratory interpretation of the admission electrocardiogram in acute coronary syndromes: increased mortality in patients with unrecognized ST-elevation myocardial infarction.

    abstract:AIMS:Previous analyses suggest only modest agreement between local site and core-laboratory (core-lab) electrocardiogram (ECG) interpretation in patients with acute coronary syndromes (ACSs); however, this has not been well examined outside of clinical trial populations. METHODS AND RESULTS:Patients (n = 5277 from 51 ...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehm503

    authors: Vijayaraghavan R,Yan AT,Tan M,Fitchett DH,Georgescu AA,Hassan Q,Langer A,Goodman SG,Canadian Acute Coronary Syndromes Registry Investigators.

    更新日期:2008-01-01 00:00:00

  • Evaluation of recombinant hirudin (CGP 39,393/TMREVASC) in the prevention of restenosis after percutaneous transluminal coronary angioplasty. Rationale and design of the HELVETICA trial, a multicentre randomized double blind heparin controlled study.

    abstract::One of the main areas of interest in interventional cardiology is the understanding, and ultimate prevention of restenosis after an initially successful percutaneous transluminal coronary angioplasty. Restenosis is the recurrence of luminal narrowing following angioplasty, and still frustrates the late results in the ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验,评审

    doi:10.1093/eurheartj/16.suppl_l.56

    authors: Herrman JP,Simon R,Umans VA,Peerboom PF,Keane D,Rijnierse JJ,Bach D,Kobi P,Kerry R,Close P

    更新日期:1995-11-01 00:00:00

  • Mortality and repeat interventions up until 20 years after aorto-coronary bypass surgery with saphenous vein grafts. A follow-up study of 1041 patients.

    abstract:AIMS:To determine very long-term survival and incidence of recurrent interventions following aorto-coronary bypass surgery using venous grafts. METHODS AND RESULTS:A group of 1041 consecutive patients operated upon between 1971 and 1980 were followed for a median of 19 years (range 13-26). Peri-operative mortality was...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1999.1867

    authors: Veldkamp RF,Valk SD,van Domburg RT,van Herwerden LA,Meeter K

    更新日期:2000-05-01 00:00:00

  • Dietary counselling has no effect on cardiovascular risk factors among Chinese Grade 1 hypertensive patients: a randomized controlled trial.

    abstract:AIMS:To evaluate the effectiveness of Dietary Approaches to Stop Hypertension (DASH) by one-off dietary counselling on reducing cardiovascular risk factors among Chinese Grade 1 hypertensive patients in primary care. METHODS AND RESULTS:A parallel-group, randomized controlled trial (ChiCTR-TRC-13003014) was conducted ...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehv329

    authors: Wong MC,Wang HH,Kwan MW,Fong BC,Chan WM,Zhang DX,Li ST,Yan BP,Coats AJ,Griffiths SM

    更新日期:2015-10-07 00:00:00

  • C-reactive protein: relation to total mortality, cardiovascular mortality and cardiovascular risk factors in men.

    abstract:BACKGROUND:There is much interest in reported associations between serum C-reactive protein and incident ischaemic heart disease. It is uncertain what this association represents. We aimed to assess the effect of confounding from a number of different sources in the Caerphilly Prospective Heart Disease Study and in par...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1999.1982

    authors: Mendall MA,Strachan DP,Butland BK,Ballam L,Morris J,Sweetnam PM,Elwood PC

    更新日期:2000-10-01 00:00:00

  • Three-dimensional imaging of the aortic valve and aortic root with computed tomography: new standards in an era of transcatheter valve repair/implantation.

    abstract::Valvular heart disease is a significant, global cause of morbidity and mortality. In the ageing population of industrialized nations, degenerative aortic stenosis has become the most common native valve disorder. Although surgical aortic valve replacement is associated with excellent clinical outcomes, a large number ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehp260

    authors: Schoenhagen P,Tuzcu EM,Kapadia SR,Desai MY,Svensson LG

    更新日期:2009-09-01 00:00:00

  • Adequacy of endogenous erythropoietin levels and mortality in anaemic heart failure patients.

    abstract:AIMS:We examined the adequacy of endogenous erythropoietin (EPO) levels for the degree of anaemia in patients with chronic heart failure (CHF) and its relation to prognosis. METHODS AND RESULTS:We studied 74 anaemic CHF patients from a cohort of 240 patients. The adequacy of endogenous EPO levels was assessed by deriv...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehn205

    authors: van der Meer P,Lok DJ,Januzzi JL,de la Porte PW,Lipsic E,van Wijngaarden J,Voors AA,van Gilst WH,van Veldhuisen DJ

    更新日期:2008-06-01 00:00:00

  • Nifedipine and alpha 1-adrenergic blockade in Raynaud's phenomenon.

    abstract::The efficacy of nifedipine and prazosin in the treatment of Raynaud's phenomenon was assessed in a prospective double-blind randomized cross-over trial in 15 patients. Each patient received one week of nifedipine 20 mg TID, one week of prazosin 1 mg TID, and 2 weeks of placebo. Nifedipine was shown to be effective in ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061923

    authors: Kahan A,Foult JM,Weber S,Amor B,Menkes CJ,Degeorges M

    更新日期:1985-08-01 00:00:00

  • Evaluation of three methods for quantifying valvular regurgitation using gated equilibrium radionuclide ventriculography.

    abstract::The non-invasive quantification of mitral and aortic regurgitation using the left-to-right stroke count ratio (SCR) calculated with gated equilibrium radionuclide ventriculography (RNV), is affected by the overlap of atria and ventricles and the consequent difficult definition of the ventricular regions of interest (R...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062176

    authors: Sciagrà R,Voth E,Tebbe U,Schicha H,Neuhaus KL

    更新日期:1987-10-01 00:00:00

  • Predictive value of high sensitivity C-reactive protein in patients with ST-elevation myocardial infarction treated with percutaneous coronary intervention.

    abstract:AIMS:To evaluate the predictive value of high sensitivity (hs) C-reactive protein levels on long-term survival in patients with ST-elevation myocardial infarction (STEMI) treated with primary PCI. METHODS AND RESULTS:We conducted a retrospective analysis of 758 STEMI patients (from January 2003 to December 2005), with...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehm338

    authors: Ortolani P,Marzocchi A,Marrozzini C,Palmerini T,Saia F,Taglieri N,Baldazzi F,Silenzi S,Bacchi-Reggiani ML,Guastaroba P,Grilli R,Branzi A

    更新日期:2008-05-01 00:00:00

  • International economic analysis of primary prevention of cardiovascular disease with pravastatin in WOSCOPS. West of Scotland Coronary Prevention Study.

    abstract:AIMS:The results of the West of Scotland Coronary Prevention Study (WOSCOPS) demonstrated the clinical benefit of using pravastatin for the primary prevention of cardiovascular disease in hypercholesterolaemic men. To inform decision makers, who must also consider costs, this study assesses the economic efficiency of s...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1999.1193

    authors: Caro J,Klittich W,McGuire A,Ford I,Pettitt D,Norrie J,Shepherd J

    更新日期:1999-02-01 00:00:00

  • Increased cardiac sympathetic nervous activity in patients with unstable coronary heart disease.

    abstract::We have evaluated overall and cardiac sympathetic activity in 47 patients undergoing coronary angiography, 27 with stable angina of at least 3 months duration, and 20 with unstable ischaemic symptoms within this period. Cardiac and overall sympathetic activity were assessed using radiotracer noradrenaline kinetic tech...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/14.6.751

    authors: McCance AJ,Thompson PA,Forfar JC

    更新日期:1993-06-01 00:00:00

  • Impedance cardiography during exercise in patients with coronary heart disease.

    abstract::Impedance cardiography may be a simple way of assessing left ventricular performance during exercise. Measurements were therefore made during exercise testing in 102 consecutive male patients with suspected coronary disease prior to cardiac catheterization. These were subsequently divided into four groups: group A, no...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/14.2.150

    authors: Thomas SH,Crowther A

    更新日期:1993-02-01 00:00:00

  • Attenuation of nitrate effect during an intermittent treatment regimen and the time course of nitrate tolerance.

    abstract::The long-term efficacy of transdermal nitrate therapy, in particular the ability of a single patch to provide 24 h prophylaxis against angina, has been questioned. Two mechanisms have been suggested for this loss of effect: the development of pharmacological tolerance, and premature patch exhaustion. This study was de...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/eurheartj/12.12.1266

    authors: James MA,Papouchado M,Jones JV

    更新日期:1991-12-01 00:00:00

  • Resting echocardiography and quantitative dipyridamole technetium-99m sestamibi tomography in the identification of cardiac allograft vasculopathy and the prediction of long-term prognosis after heart transplantation.

    abstract:AIMS:To evaluate the accuracy of echocardiography in conjunction with quantitative high-dose dipyridamole technetium-99m sestamibi tomography (SPECT) in detecting coronary allograft vasculopathy. METHODS AND RESULTS:Seventy-eight consecutive heart transplant recipients underwent echocardiography while at rest and high...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2000.2422

    authors: Ciliberto GR,Ruffini L,Mangiavacchi M,Parolini M,Sara R,Massa D,De Maria R,Gronda E,Vitali E,Parodi O

    更新日期:2001-06-01 00:00:00

  • Acute haemodynamic effects of the beta 1-adrenoceptor partial agonist xamoterol at rest and during supine exercise in patients with left ventricular dysfunction due to ischaemic heart disease: a double-blind randomized trial.

    abstract::The effects of xamoterol 0.2 mg kg-1 i.v. and placebo on left ventricular function at rest and on exercise were compared in patients with left ventricular dysfunction due to ischaemic heart disease. Improvements were seen in systolic and diastolic function at rest, and at up to 50% of maximal exercise, without evidenc...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/eurheartj/11.suppl_a.48

    authors: de Feyter PJ,Serruys PW

    更新日期:1990-04-01 00:00:00

  • Myocardial beta-adrenoceptor down-regulation early after infarction is associated with long-term incidence of congestive heart failure.

    abstract:AIMS:Adverse left ventricular (LV) remodelling after myocardial infarction (MI) frequently leads to congestive heart failure (CHF). We have previously shown that myocardial beta-adrenoceptor density (beta-ARD) is reduced soon after acute MI and correlates with LV dilatation in the short term. The aim of the present stu...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehq138

    authors: Gaemperli O,Liga R,Spyrou N,Rosen SD,Foale R,Kooner JS,Rimoldi OE,Camici PG

    更新日期:2010-07-01 00:00:00

  • Substantial between-hospital variation in outcome following first emergency admission for heart failure.

    abstract:BACKGROUND:Following hospitalization with a range of cardiovascular disorders, substantial variation has been noted in clinical outcome, both between and within countries. OBJECTIVES:To examine the variation, between hospitals, in the clinical outcomes of death and readmission following hospitalization with heart fail...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2001.2890

    authors: Stewart S,Demers C,Murdoch DR,McIntyre K,MacLeod ME,Kendrick S,Capewell S,McMurray JJ

    更新日期:2002-04-01 00:00:00

  • The European Study of Epidemiology and Treatment of Cardiac Inflammatory Disease (ESETCID).

    abstract::Diagnosis of myocarditis has improved with the application of new techniques such as immunohistochemistry, polymerase chain reaction, in situ hybridization and Southern blot in endomyocardial biopsies. Treatment of inflammatory heart disease is still difficult and not yet validated by a study with patient numbers suff...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/16.suppl_o.173

    authors: Maisch B,Hufnagel G,Schönian U,Hengstenberg C

    更新日期:1995-12-01 00:00:00

  • Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study.

    abstract:AIMS:Anecdotal observations suggest that sub-clinical electrophysiological manifestations of arrhythmogenic right ventricular cardiomyopathy (ARVC) develop before detectable structural changes ensue on cardiac imaging. To test this hypothesis, we investigated a murine model with conditional cardiac genetic deletion of ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehr472

    authors: Gomes J,Finlay M,Ahmed AK,Ciaccio EJ,Asimaki A,Saffitz JE,Quarta G,Nobles M,Syrris P,Chaubey S,McKenna WJ,Tinker A,Lambiase PD

    更新日期:2012-08-01 00:00:00

  • Heterogeneity of endothelial dysfunction in hypertension.

    abstract::The endothelium may play a role as a target and mediator of hypertension. Due to its anatomical position, it is very exposed to mechanical forces; as a source of vasoactive material it may participate in increasing peripheral vascular resistance and in promoting local ischaemia in the heart and brain. Morphological an...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/13.suppl_d.50

    authors: Lüscher TF

    更新日期:1992-09-01 00:00:00

  • Cardioprotective effect of calcineurin inhibition in an animal model of renal disease.

    abstract:AIMS:Chronic kidney disease is directly associated with cardiovascular complications. Heart remodelling, including fibrosis, hypertrophy, and decreased vascularization, is frequently present in renal diseases. Our objective was to investigate the impact of calcineurin inhibitors (CNI) on cardiac remodelling and functio...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehq436

    authors: Di Marco GS,Reuter S,Kentrup D,Ting L,Ting L,Grabner A,Jacobi AM,Pavenstädt H,Baba HA,Tiemann K,Brand M

    更新日期:2011-08-01 00:00:00

  • Microalbuminuria during acute myocardial infarction; a strong predictor for 1-year mortality.

    abstract:AIMS:Urinary albumin excretion increases during acute myocardial infarction but little is known on the prognostic significance and the pathophysiological mechanisms of microalbuminuria in this clinical setting. The primary aim of the study was to examine whether urinary albumin excretion has predictive power for 1-year...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2000.2582

    authors: Berton G,Cordiano R,Palmieri R,Cucchini F,De Toni R,Palatini P

    更新日期:2001-08-01 00:00:00

  • N-terminal pro-B-type natriuretic peptide and the prediction of primary cardiovascular events: results from 15-year follow-up of WOSCOPS.

    abstract:AIMS:To test whether N-terminal pro-B-type natriuretic peptide (NT-proBNP) was independently associated with, and improved the prediction of, cardiovascular disease (CVD) in a primary prevention cohort. METHODS AND RESULTS:In the West of Scotland Coronary Prevention Study (WOSCOPS), a cohort of middle-aged men with hy...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehs239

    authors: Welsh P,Doolin O,Willeit P,Packard C,Macfarlane P,Cobbe S,Gudnason V,Di Angelantonio E,Ford I,Sattar N

    更新日期:2013-02-01 00:00:00

  • Acute rise of circulating vascular endothelial growth factor-A in patients with coronary artery disease following cardiothoracic surgery.

    abstract:AIMS:Vascular endothelial growth factor-A (VEGF-A) is an angiogenic and vasoprotective molecule whose expression is modulated by hypoxia and inflammatory mediators. Here we have tested the hypothesis that plasma levels of VEGF-A are influenced by pre-existing coronary artery disease and by changes in circulating interl...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2001.3034

    authors: Cotton JM,Mathur A,Hong Y,Brown AS,Martin JF,Erusalimsky JD

    更新日期:2002-06-01 00:00:00

  • Combined non-invasive functional and anatomical diagnostic work-up in clinical practice: the magnetic resonance and computed tomography in suspected coronary artery disease (MARCC) study.

    abstract:AIMS:The combined use of cardiac computed tomography (CT) coronary angiography (CTCA) and myocardial perfusion imaging allows the non-invasive evaluation of coronary morphology and function. Cardiovascular magnetic resonance (CMR) imaging has several advantages: it can simultaneously assess myocardial perfusion, ventri...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/eht077

    authors: Groothuis JG,Beek AM,Brinckman SL,Meijerink MR,van den Oever ML,Hofman MB,van Kuijk C,van Rossum AC

    更新日期:2013-07-01 00:00:00

  • Contractility sensor-guided optimization of cardiac resynchronization therapy: results from the RESPOND-CRT trial.

    abstract:Aims:Although cardiac resynchronization therapy (CRT) is effective in patients with systolic heart failure (HF) and a wide QRS interval, a substantial proportion of patients remain non-responsive. The SonR contractility sensor embedded in the right atrial lead enables individualized automatic optimization of the atriov...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehw526

    authors: Brugada J,Delnoy PP,Brachmann J,Reynolds D,Padeletti L,Noelker G,Kantipudi C,Rubin Lopez JM,Dichtl W,Borri-Brunetto A,Verhees L,Ritter P,Singh JP,RESPOND CRT Investigators.

    更新日期:2017-03-07 00:00:00