Heterogeneity of endothelial dysfunction in hypertension.

Abstract:

:The endothelium may play a role as a target and mediator of hypertension. Due to its anatomical position, it is very exposed to mechanical forces; as a source of vasoactive material it may participate in increasing peripheral vascular resistance and in promoting local ischaemia in the heart and brain. Morphological and functional changes in the endothelium occur in experimental and human hypertension. However, the severity of the defect and the mechanisms involved among vascular beds and models of hypertension are heterogeneous. Endothelium-dependent relaxations are impaired in the aorta, carotid artery and in cerebral and mesenteric arterioles in hypertension. In the coronary circulation the defect is less pronounced. The mechanisms involve a reduced formation of nitric oxide, an enhanced production of prostaglandin H2 and an impaired responsiveness of vascular smooth muscle to nitric oxide. The role of endothelin in hypertension is controversial; circulating levels appear unaltered except in the presence of renal failure or atherosclerosis. The local vascular production of endothelin, however, may still be increased. The potentiating effects of threshold concentrations of endothelin on the vasoconstrictor response to noradrenaline are enhanced in hypertension. Thus, subtle and distinct endothelial function defects occur in hypertension, but not all vascular beds are similarly affected and different mechanisms contribute. Endothelial dysfunction may contribute to increased peripheral resistance, tissue ischaemia and cardiovascular complications.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Lüscher TF

doi

10.1093/eurheartj/13.suppl_d.50

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

50-5

eissn

0195-668X

issn

1522-9645

journal_volume

13 Suppl D

pub_type

杂志文章,评审
  • Transient acute ischaemic episodes during or immediately after percutaneous transluminal coronary angioplasty.

    abstract::Transient ischaemic episodes, defined as chest pain with ST segment elevation resolving in less than 15 min, have been encountered in 18 out of 130 patients during or in the 12h following percutaneous transluminal angioplasty (PTCA). During PTCA, ischaemic episodes occurred in 11 patients (8.5%) along with complete co...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061669

    authors: Danchin N,Cuilliere M,Cherrier F

    更新日期:1984-05-01 00:00:00

  • The value of time and frequency domain, and spectral temporal mapping analysis of the signal-averaged electrocardiogram in identification of patients with hypertrophic cardiomyopathy at increased risk of sudden death.

    abstract::Late potentials detected by the signal-averaged ECG (SAECG) identify post-infarction patients at risk from sustained ventricular tachycardia (VT) and sudden death. Hypertrophic cardiomyopathy (HCM) is also associated with increased risk of sudden death. In adults, episodes of non-sustained VT on ambulatory ECG monitor...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/14.7.941

    authors: Kulakowski P,Counihan PJ,Camm AJ,McKenna WJ

    更新日期:1993-07-01 00:00:00

  • Atorvastatin treatment improves survival and effects of implanted mesenchymal stem cells in post-infarct swine hearts.

    abstract:AIMS:To investigate whether Atorvastatin (Ator) treatment improves the cardiac micro-environment that facilitates survival and differentiation of bone-marrow-derived mesenchymal stem cells (MSCs) implanted in the post-infarct myocardium. METHODS AND RESULTS:Myocardial infarction was created by coronary ligation and im...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehn167

    authors: Yang YJ,Qian HY,Huang J,Geng YJ,Gao RL,Dou KF,Yang GS,Li JJ,Shen R,He ZX,Lu MJ,Zhao SH

    更新日期:2008-06-01 00:00:00

  • Prevalence and prognostic significance of cardiac arrhythmias detected by ambulatory electrocardiography in subjects 85 years of age.

    abstract::24 hour ambulatory electrocardiography was performed in a representative group of people born in 1897. Out of 73 people included in the study, 22 were without known heart disease, 15 had definite ischaemic heart disease (IHD) and 36 symptoms of possible cardiac origin. An R-R interval in excess of 2000 ms was seen in ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062107

    authors: Ingerslev J,Bjerregaard P

    更新日期:1986-07-01 00:00:00

  • Environmental tobacco smoke and cardiometabolic risk in young children: results from a survey in south-west Germany.

    abstract:AIMS:We explored the association between exposure to environmental tobacco smoke (ETS) and various cardiometabolic biomarkers in 10-year-old children. METHODS AND RESULTS:A population-based cross-sectional study was carried out. Data on ETS exposure and potential confounders were collected by parental questionnaire. A...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehp180

    authors: Nagel G,Arnold FJ,Wilhelm M,Link B,Zoellner I,Koenig W

    更新日期:2009-08-01 00:00:00

  • Inhibition of mitochondrial permeability transition to prevent the post-cardiac arrest syndrome: a pre-clinical study.

    abstract:AIMS:Resuscitated cardiac arrest (CA), leading to harmful cardiovascular dysfunction and multiple organ failure, includes a whole-body hypoxia-reoxygenation phenomenon. Opening of the mitochondrial permeability transition pore (mPTP) appears to be a pivotal event in ischaemia-reperfusion injury. We hypothesized that ph...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehq112

    authors: Cour M,Loufouat J,Paillard M,Augeul L,Goudable J,Ovize M,Argaud L

    更新日期:2011-01-01 00:00:00

  • Clopidogrel pre-treatment in stable angina: for all patients > 6 h before elective coronary angiography or only for angiographically selected patients a few minutes before PCI? A randomized multicentre trial PRAGUE-8.

    abstract:AIMS:To compare two different clopidogrel regimens on the outcomes of patients undergoing elective coronary angiography (CAG)+/-ad hoc percutaneous coronary intervention (PCI). METHODS AND RESULTS:Open-trial randomized 1028 patients with stable angina to group A ('non-selective'-clopidogrel 600 mg > 6 h before CAG; n ...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehn169

    authors: Widimsky P,Motovská Z,Simek S,Kala P,Pudil R,Holm F,Petr R,Bílková D,Skalická H,Kuchynka P,Poloczek M,Miklík R,Maly M,Aschermann M,PRAGUE-8 Trial Investigators.

    更新日期:2008-06-01 00:00:00

  • Electrocardiographic patterns during Holter monitoring in patients with first and second degree A-V block due to 'dual A-V nodal pathways'.

    abstract::The electrocardiographic patterns, observed during 24-h Holter monitoring, of 10 patients (mean age 35 +/- 22 years) with first and second degree A-V block due to dual A-V nodal pathways are reported. Recordings were selected according to the presence of: sudden and persistent prolongation of the PR interval: sudden n...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a059904

    authors: Di Biase M,Tritto M,Sabato G,Pitzalis MV,Rizzon P

    更新日期:1991-03-01 00:00:00

  • Role of programmed ventricular stimulation in patients with Brugada syndrome: a meta-analysis of worldwide published data.

    abstract:AIMS:Brugada syndrome (BS) is an ion channelopathy with the risk of sudden cardiac death. The role of programmed ventricular stimulation (PVS) in risk stratification has been controversially discussed. Therefore, we performed a meta-analysis on the prognostic role of PVS in BS. METHODS AND RESULTS:A Medline search unt...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/eurheartj/ehm116

    authors: Paul M,Gerss J,Schulze-Bahr E,Wichter T,Vahlhaus C,Wilde AA,Breithardt G,Eckardt L

    更新日期:2007-09-01 00:00:00

  • Serum lipoproteins as risk factors: recent epidemiologic studies in individuals with and without prevalent cardiovascular disease.

    abstract::Contrary to most prospective epidemiologic studies, an earlier report from the British Regional Heart Study (BRHS) suggested that high density lipoprotein (HDL)-cholesterol in men aged 40-59 years was not a significant, independent, predictive risk factor for coronary heart disease (CHD), controlling for the composite...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/11.suppl_h.21

    authors: Tyroler HA

    更新日期:1990-12-01 00:00:00

  • Effect of acupuncture in patients with angina pectoris.

    abstract::Twenty-one patients with stable effort angina pectoris were randomized in a crossover study to 4 weeks traditional Chinese acupuncture or placebo tablet treatment. The patients had at least five anginal attacks per week in spite of intensive treatment. Acupuncture was given three times per week at main points Neiguan ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a059865

    authors: Richter A,Herlitz J,Hjalmarson A

    更新日期:1991-02-01 00:00:00

  • The effects of beta blockers on exercise capacity and on training response in elderly subjects.

    abstract::Treatment of 8 hypertensive elderly subjects with atenolol or with labetalol did not affect exercise performance, except after the development of circulatory congestion in 1 patient. Treatment with beta blockers did not alter the response to an exercise training programme in 15 elderly patients with ischaemic heart di...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/5.suppl_e.117

    authors: Fagard R,Reybrouck T,Vanhees L,Cattaert A,Vanmeenen T,Grauwels R,Amery A

    更新日期:1984-11-01 00:00:00

  • Prediction of coronary heart disease in Europe. The 2nd report of the WHO-ERICA Project. ERICA Research Group.

    abstract::Out of 84,609 Europeans in the ERICA sample (EHJ 9, Suppl I) 18,931 had adequate 6-year follow-up data so that coronary heart disease (CHD) mortality could be assessed in relation to five risk factors (age, cholesterol, systolic blood pressure, body mass index and cigarette smoking) measured at baseline. In view of kn...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:

    authors:

    更新日期:1991-03-01 00:00:00

  • Substantial between-hospital variation in outcome following first emergency admission for heart failure.

    abstract:BACKGROUND:Following hospitalization with a range of cardiovascular disorders, substantial variation has been noted in clinical outcome, both between and within countries. OBJECTIVES:To examine the variation, between hospitals, in the clinical outcomes of death and readmission following hospitalization with heart fail...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2001.2890

    authors: Stewart S,Demers C,Murdoch DR,McIntyre K,MacLeod ME,Kendrick S,Capewell S,McMurray JJ

    更新日期:2002-04-01 00:00:00

  • Management of the patient with left ventricular hypertrophy.

    abstract::The management of left ventricular hypertrophy (LVH) presupposes that the patient is identified by echocardiography and is carefully evaluated for risk stratification, taking into consideration possible associated complications. The role of non-pharmacological treatment is limited, except in obese patients. Drug treat...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/14.suppl_d.22

    authors: de Divitiis O,Celentano A,De Simone G,Di Somma S,Galderisi M,Liguori V,de Divitiis M,Petitto M

    更新日期:1993-07-01 00:00:00

  • Stress-dependent dilated cardiomyopathy in mice with cardiomyocyte-restricted inactivation of cyclic GMP-dependent protein kinase I.

    abstract:AIMS:Cardiac hypertrophy is a common and often lethal complication of arterial hypertension. Elevation of myocyte cyclic GMP levels by local actions of endogenous atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) or by pharmacological inhibition of phosphodiesterase-5 was shown to counter-regulate p...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehr445

    authors: Frantz S,Klaiber M,Baba HA,Oberwinkler H,Völker K,Gaβner B,Bayer B,Abeβer M,Schuh K,Feil R,Hofmann F,Kuhn M

    更新日期:2013-04-01 00:00:00

  • A comparative evaluation of the effects of propafenone and lidocaine on early ventricular arrhythmias after acute myocardial infarction.

    abstract::A double-blind, placebo-controlled trial comparing the antiarrhythmic effects of lidocaine (given intravenously as a bolus injection of 100 mg followed by an infusion of 2 mg min-1) and propafenone (given as a bolus of 105 mg followed by 300 mg orally every 8 h) was conducted in the first 24 h following acute myocardi...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062428

    authors: Touboul P,Moleur P,Mathieu MP,Vrancea F,Ferry S,Kirkorian G,Atallah G,Marchand A,Stahl C,Zoheir F

    更新日期:1988-11-01 00:00:00

  • Iatrogenic left main coronary artery stenosis following aortic valve replacement.

    abstract::A case of severe iatrogenic fibrous left main coronary artery stenosis following aortic valve replacement (Hall-Kaster prosthesis) is documented clinically, angiographically and histologically. Reported histological data of this rare complication of valve replacement are reviewed. The onset of ischaemic symptoms in th...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062413

    authors: Prachar H,Mühlbauer J,Pollak H,Enenkel W

    更新日期:1988-10-01 00:00:00

  • Efficacy and safety of aspirin for primary prevention of cardiovascular events: a meta-analysis and trial sequential analysis of randomized controlled trials.

    abstract:AIMS:The role of aspirin in the primary prevention setting is continuously evolving. Recent randomized trials have challenged the role of aspirin in the primary prevention setting. METHODS AND RESULTS:Electronic databases were searched for randomized trials that compared aspirin vs. placebo (or control) in subjects wi...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析

    doi:10.1093/eurheartj/ehy813

    authors: Mahmoud AN,Gad MM,Elgendy AY,Elgendy IY,Bavry AA

    更新日期:2019-02-14 00:00:00

  • N-methylethanolamine attenuates cardiac fibrosis and improves diastolic function: inhibition of phospholipase D as a possible mechanism.

    abstract:AIM:Ventricular fibrosis is promoted by many effectors that chronically activate phospholipase D (PLD), and induces cardiac dysfunction and heart failure in cardiovascular diseases. Since ethanolamine is a product of PLD, we hypothesised that an administration of an analogue of ethanolamine, N-methylethanolamine (MEA),...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ehj.2004.05.003

    authors: Yamamoto K,Takahashi Y,Mano T,Sakata Y,Nishikawa N,Yoshida J,Oishi Y,Hori M,Miwa T,Inoue S,Masuyama T

    更新日期:2004-07-01 00:00:00

  • The immediate effect of nitroglycerin on total body blood volume distribution in patients with congestive heart failure: a non-invasive study.

    abstract::The effect of sublingually administered nitroglycerin (0.5 mg) on distribution of blood volume in 16 patients with congestive heart failure (NYHA class II and III), randomly assigned to placebo (N = 8) or nitroglycerin (N = 8) was studied 20 minutes after in vivo labelling of red blood cells with 99m-Tc pertechnetate....

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a062177

    authors: Schneider AJ,Teule GJ,Groeneveld AB,Nauta J,Luth WJ,Thijs LG

    更新日期:1987-10-01 00:00:00

  • Fibroblast activation protein is induced by inflammation and degrades type I collagen in thin-cap fibroatheromata.

    abstract:AIMS:Collagen degradation in atherosclerotic plaques with thin fibrous caps renders them more prone to rupture. Fibroblast activation protein (FAP) plays a role in arthritis and tumour formation through its collagenase activity. However, the significance of FAP in thin-cap human fibroatheromata remains unknown. METHOD...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehq519

    authors: Brokopp CE,Schoenauer R,Richards P,Bauer S,Lohmann C,Emmert MY,Weber B,Winnik S,Aikawa E,Graves K,Genoni M,Vogt P,Lüscher TF,Renner C,Hoerstrup SP,Matter CM

    更新日期:2011-11-01 00:00:00

  • Bleeding complications with the P2Y12 receptor antagonists clopidogrel and ticagrelor in the PLATelet inhibition and patient Outcomes (PLATO) trial.

    abstract::AIMS More intense platelet-directed therapy for acute coronary syndrome (ACS) may increase bleeding risk. The aim of the current analysis was to determine the rate, clinical impact, and predictors of major and fatal bleeding complications in the PLATO study. METHODS AND RESULTS PLATO was a randomized, double-blind, ac...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehr422

    authors: Becker RC,Bassand JP,Budaj A,Wojdyla DM,James SK,Cornel JH,French J,Held C,Horrow J,Husted S,Lopez-Sendon J,Lassila R,Mahaffey KW,Storey RF,Harrington RA,Wallentin L

    更新日期:2011-12-01 00:00:00

  • Lesion morphology assessed by pre-interventional intravascular ultrasound does not predict the incidence of severe coronary artery dissections.

    abstract:AIMS:Coronary artery dissections are common findings following percutaneous transluminal coronary angioplasty and occur with an incidence of approximately 20% to 40%. The purpose of this study was to evaluate the impact of intravascular ultrasound for the prediction of severe dissections by pre-interventional analysis ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1997.0799

    authors: Athanasiadis A,Haase KK,Wullen B,Treusch AW,Mahrholdt H,Voelker W,Baumbach A,Oberhoff M,Karsch KR

    更新日期:1998-06-01 00:00:00

  • Effect of exercise training in patients with an implantable cardioverter defibrillator.

    abstract:AIMS:Little research exists on exercise performance and training in patients with an implemented cardioverter defibrillator (ICD) and only in a limited number of patients. This study aims to investigate the effect of exercise training in ICD patients in comparison to the effects in other cardiac patients without an ICD...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ehj.2004.04.034

    authors: Vanhees L,Kornaat M,Defoor J,Aufdemkampe G,Schepers D,Stevens A,Van Exel H,Van Den Beld J,Heidbüchel H,Fagard R

    更新日期:2004-07-01 00:00:00

  • The long-term impact of the angiotensin-converting enzyme inhibitor trandolapril on mortality and hospital admissions in patients with left ventricular dysfunction after a myocardial infarction: follow-up to 12 years.

    abstract:AIMS:To investigate the long-term benefits of treatment with angiotensin-converting enzyme (ACE)-inhibitors in patients with myocardial infarction (MI) and left ventricular dysfunction (LVD). METHODS AND RESULTS:In the trandolapril cardiac evaluation (TRACE) study, 1749 patients with LVD (ejection fraction< or =35%) w...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehi021

    authors: Buch P,Rasmussen S,Abildstrom SZ,Køber L,Carlsen J,Torp-Pedersen C,TRACE investigators.

    更新日期:2005-01-01 00:00:00

  • Non-invasive estimation of the diastolic elastic and viscoelastic properties of the left ventricle.

    abstract::The present study applies a non-invasive method to the quantitative evaluation of left ventricular stiffness in normal subjects and in patients with ischaemic heart disease (IHD). We have studied 20 patients with IHD and 25 healthy subjects. The third heart sound (S3) was detectable in all patients. We have correlated...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a059876

    authors: Baracca E,Longhini C,Aggio S,Brunazzi C,Aubert AE,Pansini R

    更新日期:1991-02-01 00:00:00

  • Intravenous streptokinase in acute myocardial infarction (I.S.A.M.): assessment of left ventricular function 1 and 7 months after infarction by radionuclide ventriculography.

    abstract::I.S.A.M. was a prospective, placebo-controlled, double-blind multicentre trial of high-dose short-term intravenous streptokinase in acute myocardial infarction (AMI) within 6 h of the onset of symptoms. Determination of left ventricular ejection fraction (LVEF) by radionuclide ventriculography was performed 1 and 7 mo...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1093/oxfordjournals.eurheartj.a059610

    authors: Voth E,Tebbe U,Schicha H,Neumann P,Schröder R,Neuhaus KL,Emrich D

    更新日期:1990-10-01 00:00:00

  • Plasma homocysteine in obstructive sleep apnoea.

    abstract:AIMS:Whether increased homocysteine is one mechanism linking obstructive sleep apnoea (OSA) to cardiovascular abnormalities is unclear. We hypothesised that plasma homocysteine would be higher in OSA patients than in control subjects, would increase further during sleep, and decrease after treatment with continuous pos...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ehj.2004.05.018

    authors: Svatikova A,Wolk R,Magera MJ,Shamsuzzaman AS,Phillips BG,Somers VK

    更新日期:2004-08-01 00:00:00

  • Effects of cold stimulation on coronary haemodynamics during exercise in patients with coronary artery disease.

    abstract::To assess if cold-induced vasoconstriction may persist during exercise and contribute to the development of myocardial ischaemia, we studied 11 patients with exertional angina and angiographically proven coronary artery disease, in all cases involving the proximal portion of the left anterior descending artery. Great ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061847

    authors: de Servi S,Mussini A,Angoli L,Ferrario M,Bramucci E,Gavazzi A,Ghio S,Ardissino D,Specchia G

    更新日期:1985-03-01 00:00:00