Extracellular matrix deposition in hypertensive hearts antifibrotic effects of ramipril.

abstract：:The 18 month mortality rate in 2180 patients excluded from the Danish Verapamil Infarction Trail II (DAVIT II) was 25.6%. In non-consenters (n = 368) this was 15.0% compared with 13.85 in 897 placebo-treated patients (hazard ratio 1.09 [P = 0.60] when adjusting for sex and age). The increased mortality rate in exclude...

journal_title：European heart journal

authors： Madsen JK,Hansen JF

更新日期：1993-03-01 00:00:00

abstract：:Human cytomegalovirus (CMV) can persist in many organs after primary infection. Not only is it suspected to cause morbidity during reactivation in patients under immunosuppression, but it may also induce long-term latency by chronic disease, e.g. in the myocardium. Endomyocardial biopsies of 27 patients with active my...

journal_title：European heart journal

authors： Schönian U,Crombach M,Maser S,Maisch B

更新日期：1995-12-01 00:00:00

abstract：:This report concerns a patient with cardiac manifestation of Whipple's disease. For the first time, the gene that encodes the 16s rRNA of Tropheryma whippelii was identified in a native aortic valve by means of a polymerase chain reaction technique. DNA amplification gives evidence of Tropheryma whippelii as a causati...

journal_title：European heart journal

authors： Wendler D,Mendoza E,Schleiffer T,Zander M,Maier M

更新日期：1995-03-01 00:00:00

abstract：:Acute myocardial infarction remains the principal cause of death in people aged over 40 years, despite the reductions in coronary heart disease (CHD) mortality that have been observed over the past 25 years in many European countries. Consequently, there is considerable potential to decrease further the risk of cardio...

journal_title：European heart journal

authors： Shepherd J

更新日期：1998-10-01 00:00:00

abstract：:On the occasion of a routine medical check-up 256 out of 1100 individuals with an accumulation of coronary risk factors were screened for silent myocardial ischaemia by exercise testing and Holter monitoring. Of these individuals 5.5% had a pathological exercise test, 7.4% had ischaemia-like events on the Holter ECG, ...

journal_title：European heart journal

authors： Osterspey A,Treis-Müller I,Günther H,Eggeling T,Siglow C,Gedicke V,Höpp H,Diewitz M,Osterhues H,Hilger HH

更新日期：1988-12-01 00:00:00

abstract：:Measurement of the pre-ejection period (PEP) can give valuable information on myocardial function in rats. Depressed cardiac function is accompanied by prolongation of PEP, which shortens when cardiac function improves. Left ventricular ejection time (LVET) may be shortened with ageing in spontaneously hypertensive ra...

journal_title：European heart journal

authors： Schoemaker RG,Smits JF

更新日期：1990-12-01 00:00:00

abstract：Aims:Inhalation of nitric oxide (iNO) during myocardial ischaemia and after reperfusion confers cardioprotection in preclinical studies via enhanced cyclic guanosine monophosphate (cGMP) signalling. We tested whether iNO reduces reperfusion injury in patients with ST-elevation myocardial infarction (STEMI; NCT01398384)...

journal_title：European heart journal

authors： Janssens SP,Bogaert J,Zalewski J,Toth A,Adriaenssens T,Belmans A,Bennett J,Claus P,Desmet W,Dubois C,Goetschalckx K,Sinnaeve P,Vandenberghe K,Vermeersch P,Lux A,Szelid Z,Durak M,Lech P,Zmudka K,Pokreisz P,Vranckx

更新日期：2018-08-01 00:00:00

abstract：AIMS:Dysregulation of the bone morphogenetic protein receptor type 2 (BMPR2) is a hallmark feature that has been described in several forms of pulmonary hypertension. We recently identified the microRNA miR-20a within a highly conserved pathway as a regulator of the expression of BMPR2. To address the pathophysiologica...

journal_title：European heart journal

authors： Brock M,Samillan VJ,Trenkmann M,Schwarzwald C,Ulrich S,Gay RE,Gassmann M,Ostergaard L,Gay S,Speich R,Huber LC

更新日期：2014-12-01 00:00:00

abstract：:Sixty patients (31 male, 29 female) were studied in a 4-week double-blind parallel dose-response study. Patients received amlodipine 1.25 mg (n = 12), 2.5 mg (n = 12), 5 mg (n = 12), 10 mg (n = 12) or placebo (n = 12) once a day. Anti-anginal efficacy was assessed by sequential treadmill testing 24 h post-dose, freque...

journal_title：European heart journal

authors： Cocco G,Alfiero R

更新日期：1991-02-01 00:00:00

abstract：AIMS:An abnormal left ventricular volume response during dobutamine echocardiography identified patients with severe coronary artery disease. The aim of the study was to assess the prognostic value of left ventricular volume changes during dobutamine stress echocardiography in 136 patients. METHODS AND RESULTS:Endpoin...

journal_title：European heart journal

authors： Coletta C,Galati A,Ricci R,Sestili A,Guagnozzi G,Re F,Ceci V

更新日期：1997-10-01 00:00:00

abstract：AIMS:The aim of this study was to evaluate the effect of valve surgery (VS) in infective endocarditis (IE) on 5-year mortality and to evaluate whether conflicting results reported by previous studies could be due to differences in their methodological approaches. METHODS AND RESULTS:Four hundred and forty-nine patient...

journal_title：European heart journal

authors： Bannay A,Hoen B,Duval X,Obadia JF,Selton-Suty C,Le Moing V,Tattevin P,Iung B,Delahaye F,Alla F,AEPEI Study Group.

更新日期：2011-08-01 00:00:00

abstract：:Heart disease frequently occurs in advanced acromegaly. In order to investigate cardiac mass and function in acromegaly in the absence of obvious cardiac disease, we performed Doppler echocardiography in 15 asymptomatic acromegalic patients (six of them had systemic hypertension). The data were compared with those of ...

journal_title：European heart journal

authors： Morvan D,Komajda M,Grimaldi A,Turpin G,Grosgogeat Y

更新日期：1991-06-01 00:00:00

abstract：AIMS:We recently found that resting muscle sympathetic nerve activity is inversely related to peak oxygen uptake (VO(2) peak) in patients with heart failure, suggesting a peripheral neurogenic limit to exercise in heart failure. No such relationship was observed in healthy controls. To determine whether this observatio...

journal_title：European heart journal

authors： Notarius CF,Azevedo ER,Parker JD,Floras JS

更新日期：2002-05-01 00:00:00

abstract：:The efficacy of nifedipine and prazosin in the treatment of Raynaud's phenomenon was assessed in a prospective double-blind randomized cross-over trial in 15 patients. Each patient received one week of nifedipine 20 mg TID, one week of prazosin 1 mg TID, and 2 weeks of placebo. Nifedipine was shown to be effective in ...

journal_title：European heart journal

authors： Kahan A,Foult JM,Weber S,Amor B,Menkes CJ,Degeorges M

更新日期：1985-08-01 00:00:00

abstract：AIMS:To investigate the ability of SYNTAX score and Clinical SYNTAX score (CSS) to predict very long-term outcomes in an all-comers population receiving drug-eluting stents. METHODS AND RESULTS:The SYNTAX score was retrospectively calculated in 848 patients enrolled in the SIRolimus-eluting stent compared with pacliTA...

journal_title：European heart journal

authors： Girasis C,Garg S,Räber L,Sarno G,Morel MA,Garcia-Garcia HM,Lüscher TF,Serruys PW,Windecker S

更新日期：2011-12-01 00:00:00

abstract：:A possibility that can be advanced to explain the antihypertensive effect of beta-blocking drugs is that they act through the baroreflex control of the cardiovascular system. In 38 essential hypertensive patients we measured 1) The lengthening and shortening in R-R interval caused by stimulation or deactivation of art...

journal_title：European heart journal

authors： Parati G,Pomidossi G,Grassi G,Gavazzi C,Ramirez A,Gregorini L,Mancia G

更新日期：1983-07-01 00:00:00

abstract：:Twenty-one patients with Noonan syndrome are presented. Telecanthus low-set ears, epicanthus and facial asymmetry were the commoner facial stigmata. Pterygium colli, pectus excavatum-carinatum and mild physical and mental retardation were also common features. Pulmonary stenosis and patent ductus arteriosus were the m...

journal_title：European heart journal

authors： Sanchez-Cascos A

更新日期：1983-04-01 00:00:00

abstract：AIMS:Calmodulinopathies are rare life-threatening arrhythmia syndromes which affect mostly young individuals and are, caused by mutations in any of the three genes (CALM 1-3) that encode identical calmodulin proteins. We established the International Calmodulinopathy Registry (ICalmR) to understand the natural history,...

journal_title：European heart journal

authors： Crotti L,Spazzolini C,Tester DJ,Ghidoni A,Baruteau AE,Beckmann BM,Behr ER,Bennett JS,Bezzina CR,Bhuiyan ZA,Celiker A,Cerrone M,Dagradi F,De Ferrari GM,Etheridge SP,Fatah M,Garcia-Pavia P,Al-Ghamdi S,Hamilton RM,Al-H

更新日期：2019-09-14 00:00:00

abstract：:Diagnosis of myocarditis has improved with the application of new techniques such as immunohistochemistry, polymerase chain reaction, in situ hybridization and Southern blot in endomyocardial biopsies. Treatment of inflammatory heart disease is still difficult and not yet validated by a study with patient numbers suff...

journal_title：European heart journal

authors： Maisch B,Hufnagel G,Schönian U,Hengstenberg C

更新日期：1995-12-01 00:00:00

abstract：:Patients who have experienced a myocardial infarction (MI) are at increased risk of sudden cardiac death (SCD). With the advent of implantable cardioverter-defibrillators (ICDs), accurate risk stratification has become very relevant. Numerous investigations have proven that a reduced left ventricular ejection fraction...

journal_title：European heart journal

authors： Dagres N,Hindricks G

更新日期：2013-07-01 00:00:00

abstract：:Left ventricular pressure overload results in the development of left ventricular hypertrophy (LVH) which is considered an adaptive mechanism of the heart to normalize systolic wall-stress. Impairment of both contractility and relaxation occurs, implying that the hypertrophied myocardium is very sensitive to ischaemia...

journal_title：European heart journal

authors： Viallard JF,Bonoron-Adele S,Dos Santos P,Coste P,Besse P

更新日期：1993-11-01 00:00:00

abstract：AIMS:The object of this study is to analyse the trends in coronary events in Finland during 1993-2002, correcting for the effect of troponins. METHODS AND RESULTS:A population-based myocardial infarction register recorded all coronary events (n=14 782) in four geographical areas of Finland during 1993-2002. Correction...

journal_title：European heart journal

authors： Salomaa V,Ketonen M,Koukkunen H,Immonen-Räihä P,Lehtonen A,Torppa J,Kuulasmaa K,Kesäniemi YA,Pyörälä K,FINAMI Study Group.

更新日期：2006-10-01 00:00:00

abstract：AIMS:The increasing number of adults with congenital heart disease (CHD) has prompted the development of recommendations for the management of these patients and for the organization of their healthcare. The aim of this report is to describe the delivery of care in Europe for adults with congenital cardiac anomalies. ...

journal_title：European heart journal

authors： Moons P,Engelfriet P,Kaemmerer H,Meijboom FJ,Oechslin E,Mulder BJ,Expert Committee of Euro Heart Survey on Adult Congenital Heart Disease.

更新日期：2006-06-01 00:00:00

abstract：AIMS:To evaluate the association between occupational and leisure-time physical activity (PA), ownership of goods promoting sedentary behaviour, and the risk of myocardial infarction (MI) in different socio-economic populations of the world. Studies in developed countries have found low PA as a risk factor for cardiova...

journal_title：European heart journal

authors： Held C,Iqbal R,Lear SA,Rosengren A,Islam S,Mathew J,Yusuf S

更新日期：2012-02-01 00:00:00

abstract：AIMS:This study investigates whether increased right ventricular (RV) pressure in pulmonary hypertension (PH) impairs right coronary artery (RCA) flow and RV perfusion. METHODS:In 25 subjects, five patients with idiopathic pulmonary arterial hypertension, nine patients with chronic thromboembolic pulmonary arterial hy...

journal_title：European heart journal

authors： van Wolferen SA,Marcus JT,Westerhof N,Spreeuwenberg MD,Marques KM,Bronzwaer JG,Henkens IR,Gan CT,Boonstra A,Postmus PE,Vonk-Noordegraaf A

更新日期：2008-01-01 00:00:00

abstract：:Nitrates and beta-blockers have been the mainstay in the therapy of chronic stable angina pectoris for many years. Since an important number of patients remains symptomatic, new potent anti-ischemic agents like the calcium antagonists fulfil a great clinical need. Combined therapy with beta-blockers and calcium antago...

journal_title：European heart journal

authors： Vanhaleweyk GL,Serruys PW,Hugenholtz PG

更新日期：1983-07-01 00:00:00

abstract：:Food constituents can either promote cardiovascular health or serve in its demise. In view of the lack of more effective pharmacological interventions in cardiovascular disease (CVDs), attention has focused on the potential protective effects of diet. Food components and their metabolites are emerging as major regulat...

journal_title：European heart journal

authors： Lionetti V,Tuana BS,Casieri V,Parikh M,Pierce GN

更新日期：2019-02-14 00:00:00

abstract：AIMS:This study investigated the effects of irbesartan vs. enalapril, with early vs. late treatment, on markers of inflammation and ischaemic heart disease in patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). METHODS AND RESULTS:Patients hospitalized with ischaemic symptoms and evidence of NSTE...

journal_title：European heart journal

authors： Montalescot G,Drexler H,Gallo R,Pearson T,Thoenes M,Bhatt DL

更新日期：2009-11-01 00:00:00

abstract：:Large-scale trials have demonstrated a consistent mortality reduction from angiotensin converting enzyme (ACE) inhibitor therapy for chronic heart failure. Nonetheless, the pharmacologic and physiologic mechanisms of this favourable affect and the appropriate target population remain controversial. ACE inhibitors exer...

journal_title：European heart journal

authors： Cohn JN

更新日期：1995-12-01 00:00:00

abstract：AIMS:Benefits and complications of postoperative implantable cardioverter-defibrillator tests are controversial matters. This study sought to assess the necessity of defibrillation function tests after implantation. METHODS AND RESULTS:We retrospectively analysed 1007 implantable cardioverter-defibrillator tests in 58...

journal_title：European heart journal

authors： Brunn J,Böcker D,Weber M,Castrucci M,Gradaus R,Borggrefe M,Breithardt G,Block M

更新日期：2000-01-01 00:00:00