Progress in the diagnosis of unstable angina and perspectives for treatment.

Abstract:

:Unstable angina is a high-risk phase of coronary heart disease defined by clinical symptoms. Electrocardiographic findings are heterogeneous and creatine kinase is only rarely elevated. However, troponin T and troponin I are found in about 30-40% of patients with angina at rest disclosing minor myocardial cell injury. Several studies in recent years have documented that troponins are the best markers to identify high-risk patients when other life-threatening, non-cardiac diseases are excluded. In addition, first evidence is provided that only these patients benefit from prolonged treatment with low molecular weight heparin or glycoprotein IIb/IIIa receptor blockers. Therefore, this new diagnostic potential should be made available to emergency rooms for risk stratification and in the future to guide therapeutic decision making.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Hamm CW

subject

Has Abstract

pub_date

1998-11-01 00:00:00

pages

N48-50

eissn

0195-668X

issn

1522-9645

journal_volume

19 Suppl N

pub_type

杂志文章
  • Effect of acute atrial fibrillation on phasic coronary blood flow pattern and flow reserve in humans.

    abstract:AIMS:To assess the effect of experimentally induced atrial fibrillation on coronary flow in humans. METHODS AND RESULTS:In 16 patients (10 men, mean age 43+/-13 years) with normal coronary vessels, baseline and hyperaemic blood pressure and Doppler phasic coronary flow velocity were measured, using a 0.014 inch intrac...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2001.2894

    authors: Kochiadakis GE,Skalidis EI,Kalebubas MD,Igoumenidis NE,Chrysostomakis SI,Kanoupakis EM,Simantirakis EN,Vardas PE

    更新日期:2002-05-01 00:00:00

  • Regional 99mTc-methoxyisobutyl-isonitrile-uptake at rest in patients with myocardial infarcts: comparison with morphological and functional parameters obtained from gradient-echo magnetic resonance imaging.

    abstract::It is not yet clear whether 99mTc-methoxyisobutyl-isonitrile (MIBI)-uptake is a reliable indicator of myocardial viability, and a threshold value, differentiating viable from scarred myocardium, in comparison to a morphological and functional standard of reference has not been defined. MIBI-uptake was quantified in 80...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060386

    authors: Baer FM,Smolarz K,Theissen P,Voth E,Schicha H,Sechtem U

    更新日期:1994-01-01 00:00:00

  • Picotamide, a combined inhibitor of thromboxane A2 synthase and receptor, reduces 2-year mortality in diabetics with peripheral arterial disease: the DAVID study.

    abstract:AIMS:Patients with diabetes are at excessive risk of mortality and cardiovascular morbidity. Previous studies suggest that aspirin may be less effective in diabetic patients. In this multi-centre, randomized, double blind trial picotamide, a dual inhibitor of thromboxane A2 synthase and receptor, was compared with aspi...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ehj.2004.07.013

    authors: Neri Serneri GG,Coccheri S,Marubini E,Violi F,Drug Evaluation in Atherosclerotic Vascular Disease in Diabetics (DAVID) Study Group.

    更新日期:2004-10-01 00:00:00

  • The value of the coefficient of variation in assessing repeat variation in ECG measurements.

    abstract:AIMS:The coefficient of variation is a popular measure for describing the amount of repeat variability present in ECG measurements from recording to recording. However, it can be misleading. The aim of the present study was to assess repeat variation (reclassification) in computer measured ECG criteria, i.e. positive t...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1997.0741

    authors: McLaughlin SC,Aitchison TC,Macfarlane PW

    更新日期:1998-02-01 00:00:00

  • Personalized cardiovascular disease prevention by applying individualized prediction of treatment effects.

    abstract::Large-scale randomized clinical trials have established the efficacy of cholesterol-lowering, blood pressure-lowering, and anti-platelet therapy to prevent cardiovascular diseases. A challenge for clinicians is to apply group-level evidence from these trials to individual patients. Trials typically report a single tre...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehu004

    authors: van der Leeuw J,Ridker PM,van der Graaf Y,Visseren FL

    更新日期:2014-04-01 00:00:00

  • Use of coronary angiography and revascularization procedures following acute myocardial infarction. A European perspective.

    abstract:AIMS:There is little evidence to inform routine practice in the use of coronary angiography and revascularization procedures after acute myocardial infarction. Large differences in the uptake of these procedures have been reported but representative data are scarce. Outcome studies have produced opposing conclusions co...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析

    doi:10.1053/euhj.1998.1027

    authors: Woods KL,Ketley D,Agusti A,Hagn C,Kala R,Karatzas NB,Leizorowicz A,Reikvam A,Schilling J,Seabra-Gomes R,Vasiliauskas D,Wilhelmsen L

    更新日期:1998-09-01 00:00:00

  • Sudden death in patients and relatives with the syndrome of right bundle branch block, ST segment elevation in the precordial leads V(1)to V(3)and sudden death.

    abstract:BACKGROUND:The syndrome with an electrocardiographic pattern of right bundle branch block, ST segment elevation in leads V(1)to V(3)and sudden death is genetically determined and caused by mutations in the cardiac sodium channel. The inheritance of the disease is autosomal dominant. Sudden death may, however, occur fro...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1999.1751

    authors: Brugada P,Brugada R,Brugada J

    更新日期:2000-02-01 00:00:00

  • Exercise-related out-of-hospital cardiac arrest in the general population: incidence and prognosis.

    abstract:AIMS:Although regular physical activity has beneficial cardiovascular effects, exercise can trigger an acute cardiac event. We aimed to determine the incidence and prognosis of exercise-related out-of-hospital cardiac arrest (OHCA) in the general population. METHODS AND RESULTS:We prospectively collected all OHCAs in ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/eht401

    authors: Berdowski J,de Beus MF,Blom M,Bardai A,Bots ML,Doevendans PA,Grobbee DE,Tan HL,Tijssen JG,Koster RW,Mosterd A

    更新日期:2013-12-01 00:00:00

  • Effect of clopidogrel on 1-year mortality in hospital survivors of acute ST-segment elevation myocardial infarction in clinical practice.

    abstract:AIMS:We sought to assess the effect of clopidogrel on clinical events 1 year after discharge in survivors of ST-elevation myocardial infarction (STEMI) in clinical practice. METHODS AND RESULTS:We analysed data of consecutive survivors of acute STEMI and either concomitant therapy with aspirin or aspirin plus clopidog...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehl317

    authors: Zeymer U,Gitt AK,Jünger C,Heer T,Wienbergen H,Koeth O,Bauer T,Mark B,Zahn R,Gottwik M,Senges J,Acute COronary Syndromes (ACOS) registry investigators.

    更新日期:2006-11-01 00:00:00

  • Relations of plasma total TIMP-1 levels to cardiovascular risk factors and echocardiographic measures: the Framingham heart study.

    abstract:AIMS:Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a key regulator of extracellular matrix degradation. We examined relations of plasma total TIMP-1 to cardiovascular risk factors and echocardiographic left ventricular (LV) structure and function in a community-based sample. METHODS AND RESULTS:We studied 1069 ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ehj.2004.05.029

    authors: Sundström J,Evans JC,Benjamin EJ,Levy D,Larson MG,Sawyer DB,Siwik DA,Colucci WS,Wilson PW,Vasan RS

    更新日期:2004-09-01 00:00:00

  • Cardiovascular magnetic resonance in immune checkpoint inhibitor-associated myocarditis.

    abstract:AIMS:Myocarditis is a potentially fatal complication of immune checkpoint inhibitors (ICI). Sparse data exist on the use of cardiovascular magnetic resonance (CMR) in ICI-associated myocarditis. In this study, the CMR characteristics and the association between CMR features and cardiovascular events among patients with...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehaa051

    authors: Zhang L,Awadalla M,Mahmood SS,Nohria A,Hassan MZO,Thuny F,Zlotoff DA,Murphy SP,Stone JR,Golden DLA,Alvi RM,Rokicki A,Jones-O'Connor M,Cohen JV,Heinzerling LM,Mulligan C,Armanious M,Barac A,Forrestal BJ,Sullivan RJ,

    更新日期:2020-05-07 00:00:00

  • Prognostic influence of mitral regurgitation prior to a first myocardial infarction.

    abstract:AIMS:Mitral regurgitation (MR) following an acute myocardial infarction (AMI) confers an adverse prognosis during long-term follow-up. There are no studies evaluating the influence of pre-AMI MR in the short- and long-term prognosis of such patients. Our aim was to assess the prognostic value of pre-AMI MR in the short...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehi065

    authors: Zamorano J,de Isla LP,Oliveros L,Almería C,Rodrigo JL,Aubele A,Banchs J,Macaya C

    更新日期:2005-02-01 00:00:00

  • Improved monitoring of myocardial ischaemia during major vascular surgery using transoesophageal echocardiography.

    abstract::As regional wall motion abnormality (RWA) is the first sign of ischaemia, transoesophageal echocardiography was evaluated as a monitoring device in 51 patients undergoing abdominal aortic surgery. Wall motion of the entire left ventricular wall (nine segments) was semiquantitatively evaluated 15 min before and after a...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060309

    authors: Koolen JJ,Visser CA,Reichert SL,Jaarsma WJ,Kromhout JG,van Wezel HB,Dunning AJ

    更新日期:1992-08-01 00:00:00

  • The effects of beta blockers on exercise capacity and on training response in elderly subjects.

    abstract::Treatment of 8 hypertensive elderly subjects with atenolol or with labetalol did not affect exercise performance, except after the development of circulatory congestion in 1 patient. Treatment with beta blockers did not alter the response to an exercise training programme in 15 elderly patients with ischaemic heart di...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/5.suppl_e.117

    authors: Fagard R,Reybrouck T,Vanhees L,Cattaert A,Vanmeenen T,Grauwels R,Amery A

    更新日期:1984-11-01 00:00:00

  • Catheter ablation of accessory pathways in children.

    abstract::The efficacy and safety of catheter ablation of accessory pathways (AP) was studied in 79 children (age, 4-16 years), using DC shocks (n = 25) or radiofrequency energy (n = 54). All patients had documented arrhythmias including ventricular fibrillation in four. Organic heart disease was present in four patients. AP lo...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060476

    authors: Haissaguerre M,Puel V,Bekheit S,Fisher B,Dartigues JF,Egloff P,Le Metayer P,Clementy J,Warin JF

    更新日期:1994-02-01 00:00:00

  • Prasugrel achieves greater inhibition of platelet aggregation and a lower rate of non-responders compared with clopidogrel in aspirin-treated patients with stable coronary artery disease.

    abstract:AIMS:This study was designed to compare the degree of inhibition of platelet aggregation (IPA) of prasugrel with that of clopidogrel in stable aspirin-treated patients with coronary artery disease (CAD). METHODS AND RESULTS:Subjects (n=101) were randomly assigned to the following loading dose (LD) (day 1)/maintenance ...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehi877

    authors: Jernberg T,Payne CD,Winters KJ,Darstein C,Brandt JT,Jakubowski JA,Naganuma H,Siegbahn A,Wallentin L

    更新日期:2006-05-01 00:00:00

  • Physiological cost of vocational activities after myocardial infarction.

    abstract::Oxygen consumption was measured during 30 min of work in 16 patients, after a myocardial infarction (anterior or posterior), and compared with 16 normal subjects, of the same age, involved in the same activities, in a steel factory. The VO2 at work of the patients was a little lower than in normals. The mean heart rat...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/9.suppl_l.54

    authors: Denolin H,Riviere A

    更新日期:1988-11-01 00:00:00

  • Radioiodinated beta-methyl phenyl fatty acids as potential tracers for myocardial imaging and metabolism.

    abstract::Since fatty acids provide the majority of myocardial energy requirements under basal conditions, an alteration in the global or regional utilization of these substrates may be an early indicator of myocardial disease. To determine areas of potential clinical utility of fatty acid imaging, we synthesized a radioiodinat...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/6.suppl_b.85

    authors: Livni E,Elmaleh DR,Barlai-Kovach MM,Goodman MM,Knapp FF Jr,Strauss HW

    更新日期:1985-08-01 00:00:00

  • Altered limbic and autonomic processing supports brain-heart axis in Takotsubo syndrome.

    abstract:AIMS:Takotsubo syndrome (TTS) is characterized by acute left ventricular dysfunction often triggered by emotional or physical stress. Severe activation of the sympathetic nervous system with catecholamine release caused by a dysfunctional limbic system has been proposed as a potential mechanism. We hypothesize that bra...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehz068

    authors: Templin C,Hänggi J,Klein C,Topka MS,Hiestand T,Levinson RA,Jurisic S,Lüscher TF,Ghadri JR,Jäncke L

    更新日期:2019-04-14 00:00:00

  • Angina with normal coronary arteries: diagnosis, pathophysiology and treatment.

    abstract::Approximately 20% of patients undergoing diagnostic coronary arteriography for acute or chronic cardiac ischaemia have angiographically normal coronary arteries. The mechanism behind this phenomenon is likely to be the result of a combination of functional or anatomical abnormalities in the coronary microcirculation, ...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/17.suppl_g.14

    authors: Chierchia SL,Fragasso G

    更新日期:1996-12-01 00:00:00

  • Influence of heart rate, respiration and recipient atrial contraction on pulsed wave transmitral Doppler flow indices in orthotopic heart transplant recipients.

    abstract:AIMS:The study set out to assess the relative contributions of donor heart rate, respiration and recipient atrial contraction on the mean of pulsed wave transmitral Doppler flow indices in orthotopic heart transplant recipients. This would provide information on the theoretical usefulness of pacemaker synchronization o...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a015149

    authors: Mannaerts H,Balk A,Roelandt J

    更新日期:1997-10-01 00:00:00

  • Management of the patient with left ventricular hypertrophy.

    abstract::The management of left ventricular hypertrophy (LVH) presupposes that the patient is identified by echocardiography and is carefully evaluated for risk stratification, taking into consideration possible associated complications. The role of non-pharmacological treatment is limited, except in obese patients. Drug treat...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/14.suppl_d.22

    authors: de Divitiis O,Celentano A,De Simone G,Di Somma S,Galderisi M,Liguori V,de Divitiis M,Petitto M

    更新日期:1993-07-01 00:00:00

  • The Belgian Improvement Study on Oral Anticoagulation Therapy: a randomized clinical trial.

    abstract:AIMS:In Belgium, general practitioners (GPs) mainly manage oral anticoagulation therapy. To improve the quality of oral anticoagulation management by GPs and to compare different models and interventions, a randomized clinical trial was performed. METHODS AND RESULTS:Stratified randomization divided 66 GP-practices in...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehi327

    authors: Claes N,Buntinx F,Vijgen J,Arnout J,Vermylen J,Fieuws S,Van Loon H

    更新日期:2005-10-01 00:00:00

  • Evaluation of recombinant hirudin (CGP 39,393/TMREVASC) in the prevention of restenosis after percutaneous transluminal coronary angioplasty. Rationale and design of the HELVETICA trial, a multicentre randomized double blind heparin controlled study.

    abstract::One of the main areas of interest in interventional cardiology is the understanding, and ultimate prevention of restenosis after an initially successful percutaneous transluminal coronary angioplasty. Restenosis is the recurrence of luminal narrowing following angioplasty, and still frustrates the late results in the ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验,评审

    doi:10.1093/eurheartj/16.suppl_l.56

    authors: Herrman JP,Simon R,Umans VA,Peerboom PF,Keane D,Rijnierse JJ,Bach D,Kobi P,Kerry R,Close P

    更新日期:1995-11-01 00:00:00

  • Beta-blocking agents in heart failure. Should they be used and how?

    abstract::Experience accumulated from several large trials strongly suggests that beta-blockers should be used for the management of chronic heart failure[87]. It is appropriate to add beta-blockade to conventional therapy such as diuretics, ACE inhibitors and digoxin, as this was the approach used in the major trials. It is ap...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/oxfordjournals.eurheartj.a014745

    authors: Cleland JG,Bristow MR,Erdmann E,Remme WJ,Swedberg K,Waagstein F

    更新日期:1996-11-01 00:00:00

  • Plasma concentrations of platelet-specific proteins in young female acute myocardial infarction survivors and their age-matched female controls.

    abstract::The steady state plasma concentrations of the two platelet-specific proteins beta-thromboglobulin (BTG) and platelet factor 4 (PF4) were determined in two groups of females: 36 acute myocardial infarction (AMI) survivors, and 38 age-matched control subjects. For the AMI patients the mean BTG and PF4 values were 57 +/-...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061465

    authors: Kutti J,Johansson S,Eriksson KA,Sigvaldason A,Vedin A,Wadenvik H,Wilhelmsson C

    更新日期:1983-05-01 00:00:00

  • Effect of site, summation and asynchronism of inputs on atrioventricular nodal conduction and refractoriness.

    abstract::The impulses coming from the sinus node synchronically penetrate the AV node via the crista terminalis and inter-atrial septum. Studies in superfused rabbit AV preparations suggest that the crista terminalis is a more effective input than the inter-atrial septum, and that the summation of both inputs facilitates AV no...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/14.10.1421

    authors: Sanchis J,Chorro FJ,Such L,Matamoros J,Monmeneu JV,Cortina J,López Merino V

    更新日期:1993-10-01 00:00:00

  • Protective effects of cardioplegia on diastolic function of hypertrophied rat hearts after hypothermic ischaemic arrest.

    abstract::This study was undertaken to assess the effects of hypothermia and chemical cardioplegia on the functional recovery of hypertrophied non-failing rat hearts subjected to an extended period of global ischaemia. Left ventricular hypertrophy was produced by constriction of the abdominal aorta. Hearts were studied an avera...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/5.suppl_f.347

    authors: Grousset C,Menasche P,Apstein CS,Mouas C,Marotte F,Piwnica A

    更新日期:1984-12-01 00:00:00

  • Risk prediction of cardiovascular death based on the QTc interval: evaluating age and gender differences in a large primary care population.

    abstract:AIMS:Using a large, contemporary primary care population we aimed to provide absolute long-term risks of cardiovascular death (CVD) based on the QTc interval and to test whether the QTc interval is of value in risk prediction of CVD on an individual level. METHODS AND RESULTS:Digital electrocardiograms from 173 529 pr...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehu081

    authors: Nielsen JB,Graff C,Rasmussen PV,Pietersen A,Lind B,Olesen MS,Struijk JJ,Haunsø S,Svendsen JH,Køber L,Gerds TA,Holst AG

    更新日期:2014-05-21 00:00:00

  • A smoker's paradox in patients hospitalized for heart failure: findings from OPTIMIZE-HF.

    abstract:AIMS:Cigarette smoking is a well-established risk factor for cardiovascular disease yet several studies have shown lower mortality after acute coronary syndromes in smokers compared with non-smokers, the so called 'smoker's paradox'. This study aimed to ascertain the relationship between smoking and clinical outcomes i...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehn210

    authors: Fonarow GC,Abraham WT,Albert NM,Stough WG,Gheorghiade M,Greenberg BH,O'Connor CM,Nunez E,Yancy CW,Young JB

    更新日期:2008-08-01 00:00:00