Association between the low activity genotype of catechol-O-methyltransferase and myocardial infarction in a hypertensive population.

abstract：AIM:To examine the association of left ventricular hypertrophy (LVH) on admission electrocardiography with adverse outcomes in acute coronary syndrome (ACS) patients. METHODS AND RESULTS:A total of 7443 non-ST-elevation ACS patients in Global Utilization of STrategies to Open occluded arteries (GUSTO) IV ACS trial had...

journal_title：European heart journal

authors： Westerhout CM,Lauer MS,James S,Fu Y,Wallentin L,Armstrong PW,GUSTO IV ACS Investigators.

更新日期：2007-09-01 00:00:00

abstract：AIMS:Coronary artery calcium (CAC) scoring has emerged as a tool for risk stratification and potentially for monitoring response to risk factor modification. Therefore, repeat measurements should provide robust results and low inter-scanner variability for allowing meaningful comparison. The purpose of this study was t...

journal_title：European heart journal

authors： Ghadri JR,Goetti R,Fiechter M,Pazhenkottil AP,Küest SM,Nkoulou RN,Windler C,Buechel RR,Herzog BA,Gaemperli O,Templin C,Kaufmann PA

更新日期：2011-08-01 00:00:00

abstract：AIMS:To perform a retrospective analysis of subgroups of patients enrolled into the European Myocardial Infarct Amiodarone Trial (EMIAT) in order to identify patients who might benefit from prophylactic amiodarone treatment and patients in whom amiodarone might be harmful. METHODS:Baseline characteristics of the 1486 ...

journal_title：European heart journal

authors： Janse MJ,Malik M,Camm AJ,Julian DG,Frangin GA,Schwartz PJ

更新日期：1998-01-01 00:00:00

abstract：AIMS:To study the implications of European guidelines on the use of antihypertensives and/or lipid-lowering drugs (LLDs) for primary prevention in a Norwegian population. METHODS AND RESULTS:The Tromsø study is a population-based study in the municipality Tromsø, Norway (from 1974 to till now). This analysis includes ...

journal_title：European heart journal

authors： Hartz I,Njølstad I,Eggen AE

更新日期：2005-12-01 00:00:00

abstract：:The first marathon run as an athletic event took place in the context of the Olympic Games in 1896 in Athens, Greece. Today, participation in a 'marathon run' has become a global phenomenon attracting young professional athletes as well as millions of mainly middle-aged amateur athletes worldwide each year. One of the...

journal_title：European heart journal

authors： Predel HG

更新日期：2014-11-21 00:00:00

abstract：:The clinical expert consensus statement on takotsubo syndrome (TTS) part II focuses on the diagnostic workup, outcome, and management. The recommendations are based on interpretation of the limited clinical trial data currently available and experience of international TTS experts. It summarizes the diagnostic approac...

journal_title：European heart journal

authors： Ghadri JR,Wittstein IS,Prasad A,Sharkey S,Dote K,Akashi YJ,Cammann VL,Crea F,Galiuto L,Desmet W,Yoshida T,Manfredini R,Eitel I,Kosuge M,Nef HM,Deshmukh A,Lerman A,Bossone E,Citro R,Ueyama T,Corrado D,Kurisu S,

更新日期：2018-06-07 00:00:00

abstract：:The implementation of molecular biological approaches has led to the discovery of single genetic variations that contribute to the development of cardiac failure. In the present review, the characteristics that are invariably associated with the development of failure in experimental animals and clinical studies are d...

journal_title：European heart journal

authors： Lips DJ,deWindt LJ,van Kraaij DJ,Doevendans PA

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:The CONSENSUS trial was the first study to show prognostic improvement by an ACE inhibitor. Patients in NYHA class IV heart failure were treated with enalapril or placebo. After study completion (average 183 days) all patients were offered open-label enalapril therapy. This paper reports on the survival at t...

journal_title：European heart journal

authors： Swedberg K,Kjekshus J,Snapinn S

更新日期：1999-01-01 00:00:00

abstract：AIMS:To determine very long-term survival and incidence of recurrent interventions following aorto-coronary bypass surgery using venous grafts. METHODS AND RESULTS:A group of 1041 consecutive patients operated upon between 1971 and 1980 were followed for a median of 19 years (range 13-26). Peri-operative mortality was...

journal_title：European heart journal

authors： Veldkamp RF,Valk SD,van Domburg RT,van Herwerden LA,Meeter K

更新日期：2000-05-01 00:00:00

abstract：AIMS:Dysregulation of the bone morphogenetic protein receptor type 2 (BMPR2) is a hallmark feature that has been described in several forms of pulmonary hypertension. We recently identified the microRNA miR-20a within a highly conserved pathway as a regulator of the expression of BMPR2. To address the pathophysiologica...

journal_title：European heart journal

authors： Brock M,Samillan VJ,Trenkmann M,Schwarzwald C,Ulrich S,Gay RE,Gassmann M,Ostergaard L,Gay S,Speich R,Huber LC

更新日期：2014-12-01 00:00:00

abstract：:Acute myocardial infarction remains the principal cause of death in people aged over 40 years, despite the reductions in coronary heart disease (CHD) mortality that have been observed over the past 25 years in many European countries. Consequently, there is considerable potential to decrease further the risk of cardio...

journal_title：European heart journal

authors： Shepherd J

更新日期：1998-10-01 00:00:00

abstract：:The endothelium may play a role as a target and mediator of hypertension. Due to its anatomical position, it is very exposed to mechanical forces; as a source of vasoactive material it may participate in increasing peripheral vascular resistance and in promoting local ischaemia in the heart and brain. Morphological an...

journal_title：European heart journal

authors： Lüscher TF

更新日期：1992-09-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) can be a rapidly progressive disorder and is associated with high rate of mortality, despite medical intervention. With the availability of effective therapy, early disease detection is an important strategic objective to improve treatment outcomes. Resting echocardiography is cur...

journal_title：European heart journal

authors： Lau EM,Manes A,Celermajer DS,Galiè N

更新日期：2011-10-01 00:00:00

abstract：:A time-domain signal-averaged ECG was performed in 52 patients with arrhythmogenic right ventricular dysplasia (ARVD) proven by angiography, in 45 control subjects with normal hearts, and in 132 patients with various types of ventricular arrhythmias and no evidence of cardiac disease during routine cardiac examination...

journal_title：European heart journal

authors： Leclercq JF,Coumel P

更新日期：1993-09-01 00:00:00

abstract：:The effect of diuretic dose on the haemodynamic response to captopril was assessed in nine patients with chronic cardiac failure. Each patient was given an intravenous dose of captopril while maintained on (a) a low dose diuretic regime, and (b) a high dose diuretic regime. Activity of the renin angiotensin aldosteron...

journal_title：European heart journal

authors： Flapan AD,Davies E,Williams BC,Shaw TR,Edwards CR

更新日期：1992-07-01 00:00:00

abstract：:The early termination of clinical trials, for either benefit or harm, often generates undue enthusiasm or alarm. The enhanced publicity attending early termination of a trial promotes inappropriate interpretations because of the inherent difficulty of a prompt and comprehensive data review. Furthermore, the process of...

journal_title：European heart journal

authors：

更新日期：1994-06-01 00:00:00

abstract：Aims:Epidemiological studies strongly suggest a link between stress, depression, and cardiovascular diseases (CVDs); the mechanistic correlation, however, is poorly understood. A single-nucleotide polymorphism in the BDNF gene (BDNFVal66Met), associated with depression and anxiety, has been proposed as a genetic risk f...

journal_title：European heart journal

authors： Amadio P,Colombo GI,Tarantino E,Gianellini S,Ieraci A,Brioschi M,Banfi C,Werba JP,Parolari A,Lee FS,Tremoli E,Barbieri SS

更新日期：2017-05-07 00:00:00

abstract：:An elevation of the cardiopulmonary baroreflex control of the forearm vascular resistances due to an impairment of the arterial baroreflex has been postulated in borderline hypertension. The purpose of the study is to verify this hypothesis. The arterial baroreflex sensitivity, measured by the phenylephrine method is ...

journal_title：European heart journal

authors： Bovy P,Juchmes J,Fossion A

更新日期：1983-11-01 00:00:00

abstract：:Increased arteriolar tone is the pathophysiological hallmark of essential hypertension and is determined by the intracellular free calcium concentration in the vascular smooth muscle cell. Calcium influx is an important determinant of vasoconstriction and excess calcium influx-dependent vasoconstriction has been shown...

journal_title：European heart journal

authors： Erne P,Conen D,Kiowski W,Bolli P,Müller FB,Bühler FR

更新日期：1987-11-01 00:00:00

abstract：:The steady state plasma concentrations of the two platelet-specific proteins beta-thromboglobulin (BTG) and platelet factor 4 (PF4) were determined in two groups of females: 36 acute myocardial infarction (AMI) survivors, and 38 age-matched control subjects. For the AMI patients the mean BTG and PF4 values were 57 +/-...

journal_title：European heart journal

authors： Kutti J,Johansson S,Eriksson KA,Sigvaldason A,Vedin A,Wadenvik H,Wilhelmsson C

更新日期：1983-05-01 00:00:00

abstract：AIM:Unstable coronary artery disease (CAD) is a multifactorial disease involving both thrombotic and inflammatory processes. We have assessed the time-course and the influence of thrombin inhibitors on changes in fibrinogen and C-reactive protein levels, and their relation to myocardial ischaemia in unstable CAD. METH...

journal_title：European heart journal

authors： Oldgren J,Wallentin L,Grip L,Linder R,Nørgaard BL,Siegbahn A

更新日期：2003-01-01 00:00:00

abstract：AIMS:Early and late microvascular obstruction (MO) assessed by magnetic resonance imaging (MRI) are prognostic markers for combined clinical endpoints after ST-elevation myocardial infarction (STEMI). However, there are only limited data for hard endpoints and no consensus exists which of the two best predicts clinical...

journal_title：European heart journal

authors： de Waha S,Desch S,Eitel I,Fuernau G,Zachrau J,Leuschner A,Gutberlet M,Schuler G,Thiele H

更新日期：2010-11-01 00:00:00

abstract：AIMS:To identify changes in multidirectional strain and strain rate (SR) in patients with aortic stenosis (AS). METHODS AND RESULTS:A total of 420 patients (age 66.1 ± 14.5 years, 60.7% men) with aortic sclerosis, mild, moderate, and severe AS with preserved left ventricular (LV) ejection fraction [(EF), ≥50%] were in...

journal_title：European heart journal

authors： Ng AC,Delgado V,Bertini M,Antoni ML,van Bommel RJ,van Rijnsoever EP,van der Kley F,Ewe SH,Witkowski T,Auger D,Nucifora G,Schuijf JD,Poldermans D,Leung DY,Schalij MJ,Bax JJ

更新日期：2011-06-01 00:00:00

abstract：AIMS:Combined quantitative coronary angiography and intracoronary Doppler flow velocity measurements were performed to study the underlying haemodynamic mechanisms leading to myocardial ischaemia in patients with myocardial bridging in the absence of coronary artery disease. METHODS AND RESULTS:In 42 symptomatic patie...

journal_title：European heart journal

authors： Schwarz ER,Klues HG,vom Dahl J,Klein I,Krebs W,Hanrath P

更新日期：1997-03-01 00:00:00

abstract：AIMS:To examine the relations between genetic loci, plasma lipoprotein(a) [Lp(a)] levels, and cardiovascular disease (CVD) risk among diabetic patients and compare with the observations in the general population. METHODS AND RESULTS:In two prospective cohorts of patients with type 2 diabetes (n= 2308) from the Nurses'...

journal_title：European heart journal

authors： Qi Q,Workalemahu T,Zhang C,Hu FB,Qi L

更新日期：2012-02-01 00:00:00

abstract：:Contradictory two-dimensional echocardiographic findings have been reported in relation to the role of prolapse of the mitral valve and lack of systolic leaflet coaptation in mitral regurgitation secondary to coronary heart disease. A prospective study of 22 patients with chronic coronary heart disease and mitral regu...

journal_title：European heart journal

authors： Ballester M,Tasca R,Marin L,Rees S,Rickards A,McDonald L

更新日期：1983-08-01 00:00:00

abstract：Aims:Naturally secreted nanovesicles known as exosomes are required for the regenerative effects of cardiosphere-derived cells (CDCs), and exosomes mimic the benefits of CDCs in rodents. Nevertheless, exosomes have not been studied in a translationally realistic large-animal model. We sought to optimize delivery and as...

journal_title：European heart journal

authors： Gallet R,Dawkins J,Valle J,Simsolo E,de Couto G,Middleton R,Tseliou E,Luthringer D,Kreke M,Smith RR,Marbán L,Ghaleh B,Marbán E

更新日期：2017-01-14 00:00:00

abstract：AIMS:Takotsubo syndrome (TTS) is characterized by acute left ventricular dysfunction often triggered by emotional or physical stress. Severe activation of the sympathetic nervous system with catecholamine release caused by a dysfunctional limbic system has been proposed as a potential mechanism. We hypothesize that bra...

journal_title：European heart journal

authors： Templin C,Hänggi J,Klein C,Topka MS,Hiestand T,Levinson RA,Jurisic S,Lüscher TF,Ghadri JR,Jäncke L

更新日期：2019-04-14 00:00:00

abstract：:We have studied regional left ventricular (LV) wall motion with M-mode, cross-sectional (2D) echocardiography and LV angiography in 50 patients with a recent myocardial infarction. Regional LV wall motion was evaluated according to a 9-segment model. 2D echocardiography permitted information from all, M-mode echocardi...

journal_title：European heart journal

authors： Lindvall K,Hamsten A,Landou C,Szamosi A,de Faire U

更新日期：1984-07-01 00:00:00

abstract：:Subclinical thyroid dysfunction comprises subclinical hypothyroidism (SHypo), defined as elevated thyroid-stimulating hormone (TSH) by normal free thyroxine (FT4), and subclinical hyperthyroidism (SHyper) with decreased or undetectable TSH and normal FT4. Up to 10% of the elderly have SHypo, which is usually asymptoma...

journal_title：European heart journal

authors： Floriani C,Gencer B,Collet TH,Rodondi N

更新日期：2018-02-14 00:00:00