Intravascular ultrasound assessment of remodelling and reference segment plaque burden in type-2 diabetic patients.

Abstract:

AIMS:Intravascular ultrasound (IVUS) assesses arterial remodelling by comparing the lesion external elastic membrane (EEM) with the reference segments; however, reference segments are rarely disease-free. The aim was to assess lesion and reference segment remodelling and plaque burden in patients with type-2 diabetes mellitus. METHODS AND RESULTS:We used pre-intervention IVUS to study 62 de novo lesions in 43 patients with type-2 diabetes mellitus. The lesion site was the image slice with the smallest lumen cross-sectional area (CSA). The proximal and distal reference segments were the most normal-looking segments within 5 mm proximal and distal to the lesion. Plaque burden was measured as plaque CSA/EEM CSA. The remodelling index was defined as lesion EEM CSA/mean reference EEM CSA. Reference segment plaque burden measured 0.54 +/- 0.09. The majority of lesions (83.9%) had negative remodelling (lesion EEM < reference). Similarly, the slope of the regression line relating EEM to plaque CSA within the lesion was less than the reference substantiating negative remodelling. The reference segment plaque burden correlated inversely with the difference between IVUS lumen and quantitative coronary angiographic artery size [slope = -0.12 (95% CI -0.17 to -0.07); P < 0.001] in all patients with type-2 diabetes mellitus. CONCLUSION:Lesions in type-2 diabetic patients are different from previous reports in non-diabetics. Lesions in type-2 diabetics are characterized by a large reference segment plaque burden and negative lesion site remodelling. These IVUS findings may explain the angiographic appearance of small arteries in diabetic patients.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Jensen LO,Thayssen P,Mintz GS,Maeng M,Junker A,Galloe A,Christiansen EH,Hoffmann SK,Pedersen KE,Hansen HS,Hansen KN

doi

10.1093/eurheartj/ehm175

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

1759-64

issue

14

eissn

0195-668X

issn

1522-9645

pii

ehm175

journal_volume

28

pub_type

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