Abstract:
:Can intracoronary thrombolytic therapy (ITT) reduce the infarct size and improve regional and global left ventricular function and if so how long after recanalization does this improvement develop? 42 patients were treated with ITT, of whom 25 showed successful recanalization (group A) and 17 had persistent occlusion or reocclusion (group B). Both groups were examined five times during the first month after infarction with two-dimensional echocardiography. The 'asynergy index' improved in group A by 45% of initial pretreatment values, compared with no significant change in group B (P less than 0.005). The 'asynergy extent' improved in group A by 35%, while in group B again no change was observed (P less than 0.01). This improvement occurred slowly, significant differences being achieved by the 10th day. Entire normalization of left ventricular wall motion was observed in 5 patients (20%) from group A and in no patient from group B. We conclude that successful recanalization of the occluded coronary artery by ITT improves left ventricular wall motion in 80% of patients, with entire normalization of local function in 20% of cases. The improvement occurs slowly during the first 10 days.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Widimský P,Cervenka V,Gregor P,Vísek V,Sládková T,Dvorák J,Hrdlicka Sdoi
10.1093/oxfordjournals.eurheartj.a061937subject
Has Abstractpub_date
1985-09-01 00:00:00pages
759-65issue
9eissn
0195-668Xissn
1522-9645journal_volume
6pub_type
杂志文章abstract:AIMS:Vascular endothelial growth factor-A (VEGF-A) is an angiogenic and vasoprotective molecule whose expression is modulated by hypoxia and inflammatory mediators. Here we have tested the hypothesis that plasma levels of VEGF-A are influenced by pre-existing coronary artery disease and by changes in circulating interl...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1053/euhj.2001.3034
更新日期:2002-06-01 00:00:00
abstract:AIMS:To evaluate the prevalence, clinical significance, and prognosis of latent Brugada syndrome (BrS) in patients with new-onset atrial fibrillation (AF) unmasked by class 1C antiarrhythmic drugs. METHODS AND RESULTS:Between January 2000 and June 2008, all consecutive patients with new-onset AF, who after flecainide ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehp326
更新日期:2009-12-01 00:00:00
abstract:AIMS:To study the implications of European guidelines on the use of antihypertensives and/or lipid-lowering drugs (LLDs) for primary prevention in a Norwegian population. METHODS AND RESULTS:The Tromsø study is a population-based study in the municipality Tromsø, Norway (from 1974 to till now). This analysis includes ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehi556
更新日期:2005-12-01 00:00:00
abstract::The efficacy and safety of a single infusion of cibenzoline, a class I antiarrhythmic drug, were assessed in 86 patients presenting with a supraventricular tachyarrhythmia following heart surgery in a placebo-controlled double-blind parallel study. Cibenzoline was effective in 13 patients (30%) vs three patients (6.9%...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1093/oxfordjournals.eurheartj.a060664
更新日期:1994-09-01 00:00:00
abstract::Clinical management of refractory heart failure remains challenging, with a high rate of rehospitalizations despite advances in medical and device therapy. Care can be provided in person, via telehomecare (by telephone), or telemonitoring, which involves wireless technology for remote follow-up. Telemonitoring wireles...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/ehr005
更新日期:2011-06-01 00:00:00
abstract:AIMS:The aims of the GISSI Prognosis Registry were to describe the diagnostic strategies initiated in acute myocardial infarction patients by a representative sample of Italian cardiological centres, and to determine which clinical or hospital characteristics were associated with the initiation of invasive diagnostic o...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1053/euhj.1998.1236
更新日期:1998-12-01 00:00:00
abstract::Contradictory two-dimensional echocardiographic findings have been reported in relation to the role of prolapse of the mitral valve and lack of systolic leaflet coaptation in mitral regurgitation secondary to coronary heart disease. A prospective study of 22 patients with chronic coronary heart disease and mitral regu...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061521
更新日期:1983-08-01 00:00:00
abstract:AIMS:Patients with chronic heart failure (CHF) exhibit detrimental changes in skeletal muscle that contribute to their impaired physical performance. This study investigates the possibility of counteracting these changes by chronic low-frequency electrical stimulation (CLFS) of left and right thigh muscles. METHODS AN...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.ehj.2003.09.027
更新日期:2004-01-01 00:00:00
abstract:AIMS:Habitual cigarette smokers, paradoxically, present improved short-term prognosis after acute myocardial infarction, a phenomenon often termed "smoker's paradox". We sought to examine cigarette smokers' post-infarction survival advantage in a countrywide survey of unselected, consecutive patients presenting with ac...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1053/euhj.2000.2315
更新日期:2001-05-01 00:00:00
abstract::This case report describes the delayed improvement of left ventricular function by recanalization of an occluded coronary artery in a patient with intractable heart failure and three-vessel disease. The left anterior descending coronary artery was occluded distal to the first septal branch, the dominant right coronary...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a059698
更新日期:1990-03-01 00:00:00
abstract:AIMS:Major bleeding after percutaneous coronary intervention (PCI) is an independent risk factor for early and late mortality. We developed and validated a risk score predictive of major bleeding after PCI using the femoral approach. METHODS AND RESULTS:Baseline clinical and procedural variables from two contemporary,...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/eurheartj/ehm194
更新日期:2007-08-01 00:00:00
abstract:Aims:This study aimed to investigate the association between smoking cessation, post-cessation body mass index (BMI) change and risk of myocardial infarction (MI) and stroke in men. Methods and results:A prospective cohort study using the National Health Insurance Service (NHIS) data set collected from 2002 to 2013 wa...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehx761
更新日期:2018-05-01 00:00:00
abstract::The long-term efficacy of transdermal nitrate therapy, in particular the ability of a single patch to provide 24 h prophylaxis against angina, has been questioned. Two mechanisms have been suggested for this loss of effect: the development of pharmacological tolerance, and premature patch exhaustion. This study was de...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/eurheartj/12.12.1266
更新日期:1991-12-01 00:00:00
abstract::It is now recognised after many years of speculation regarding the role of mammalian atria in the direct regulation of intravascular volume, that atrial myocites produce a peptide hormone that results in natriuresis and diuresis, under the condition of atrial distention. This atrial natriuretic factor (ANF) is secrete...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/9.suppl_h.29
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND:The mechanism of persistent neurohormonal and cardiorespiratory reflex abnormalities in chronic heart failure remain unclear. Also, why chronic heart failure patients who develop cachexia demonstrate a particularly abnormal neurohormonal profile and have a high risk of death is not known. Impaired reflex con...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1053/euhj.1999.1525
更新日期:1999-11-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehp160
更新日期:2009-07-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1016/s0195-668x(03)00170-2
更新日期:2003-06-01 00:00:00
abstract:AIMS:To evaluate the accuracy of echocardiography in conjunction with quantitative high-dose dipyridamole technetium-99m sestamibi tomography (SPECT) in detecting coronary allograft vasculopathy. METHODS AND RESULTS:Seventy-eight consecutive heart transplant recipients underwent echocardiography while at rest and high...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1053/euhj.2000.2422
更新日期:2001-06-01 00:00:00
abstract:AIM:To investigate fatalities from myocardial infarction at 28 days and one-year among patients aged 35-64 years in the Nordic and Lithuanian centres participating in the World Health Organization MONICA (Monitoring of Trends and Determinants of Cardiovascular Disease) Project. METHODS AND RESULTS:Altogether 9100 myoc...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a015124
更新日期:1997-01-01 00:00:00
abstract::Recent innovations have the potential to improve rhythm control therapy in patients with atrial fibrillation (AF). Controlled trials provide new evidence on the effectiveness and safety of rhythm control therapy, particularly in patients with AF and heart failure. This review summarizes evidence supporting the use of ...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/ehz782
更新日期:2019-12-07 00:00:00
abstract:Aims:Vascular ageing is characterized by arterial stiffening, dilation, and arterial wall thickening. We investigated the extent to which these changes are related and their heritability during 5 year follow-up in the Twins UK cohort. Methods and results:Carotid-femoral pulse wave velocity (PWVcf), carotid diameter, c...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehy165
更新日期:2018-06-21 00:00:00
abstract::All citizens (N = 22066) aged 16 to 65 of a medium-sized Belgian town were personally invited to CPR training sessions held in their neighbourhood. 1152 responded by attending a training session. Those who did not so respond were surveyed (random sample N = 600) for reasons of their not coming. The sample fitted well ...
journal_title:European heart journal
pub_type: 杂志文章
doi:
更新日期:1987-03-01 00:00:00
abstract::Intravenous adenosine proved effective in eight out of ten episodes of acute spontaneous supraventricular tachycardia. AV node blockade induced by adenosine occurred 20 s after injection, and disappeared very quickly. Side-effects were transient and never serious. Therefore, it is thought that adenosine can be propose...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061734
更新日期:1984-09-01 00:00:00
abstract:AIMS:To document the impact of intensive insulin therapy during intensive care on long-term (4 years) outcome of high-risk cardiac surgery patients. METHODS AND RESULTS:In this pre-planned sub-analysis and follow-up study of a large, randomized controlled trial on the effects of intensive insulin therapy during critic...
journal_title:European heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1093/eurheartj/ehi855
更新日期:2006-11-01 00:00:00
abstract:AIMS:Prophylactic administration of N-acetylcysteine (NAC) (600mg orally twice daily), along with hydration, prevents contrast agent-associated nephrotoxicity (CAN) induced by a low dose of non-ionic, low-osmolality contrast dye. We tested whether a double dose of NAC is more effective to prevent CAN. METHODS AND RESU...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.ehj.2003.11.016
更新日期:2004-02-01 00:00:00
abstract::The scientific assessment of diagnostic tests should not be based upon a small series of results published by the best academic institutions, but ought to require large scale, multicentre validation founded on grass roots institutions with real doctors, real patients and real problems. To this purpose, an internationa...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/16.suppl_j.2
更新日期:1995-10-01 00:00:00
abstract:AIMS:We sought to investigate the factors associated with restenosis and its potential association with late clinical deterioration after successful percutaneous mitral valvuloplasty (PMV). METHODS AND RESULTS:We analysed echocardiographic (median 74 months) and clinical (median 109 months) follow-up data of 329 patie...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehp096
更新日期:2009-05-01 00:00:00
abstract::From January 1978 to August 1983, 41 prosthetic valve thromboses in 34 patients were operated upon in our service. They comprised 15 aortic, 25 mitral and one tricuspid valve thromboses. Seven patients had massive thrombus with dysfunction of the prosthesis; others had small and disseminated thrombi on their prosthesi...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/5.suppl_d.39
更新日期:1984-10-01 00:00:00
abstract:Aims:Pulmonary hypertension (PH) and pulmonary vascular disease (PVD) are common and associated with adverse outcomes in heart failure with preserved ejection fraction (HFpEF). Little is known about the impact of PVD on the pathophysiology of exercise intolerance. Methods and results:Heart failure with preserved eject...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehy331
更新日期:2018-08-07 00:00:00
abstract::Thrombolytic therapy is a practical, effective approach to the management of acute myocardial infarction that is widely used in Europe today. Early European trials demonstrated a clear reduction in mortality in patients who received thrombolytic therapy compared with those given conventional treatment. The findings of...
journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/17.suppl_e.21
更新日期:1996-09-01 00:00:00