Arterial stiffening is a heritable trait associated with arterial dilation but not wall thickening: a longitudinal study in the twins UK cohort.

abstract：Aims:Naturally secreted nanovesicles known as exosomes are required for the regenerative effects of cardiosphere-derived cells (CDCs), and exosomes mimic the benefits of CDCs in rodents. Nevertheless, exosomes have not been studied in a translationally realistic large-animal model. We sought to optimize delivery and as...

journal_title：European heart journal

authors： Gallet R,Dawkins J,Valle J,Simsolo E,de Couto G,Middleton R,Tseliou E,Luthringer D,Kreke M,Smith RR,Marbán L,Ghaleh B,Marbán E

更新日期：2017-01-14 00:00:00

abstract：AIMS:The obesity paradox refers to the epidemiological evidence that obesity compared with normal weight is associated with counter-intuitive improved health in a variety of disease conditions. The aim of this study was to investigate the relationship between body mass index (BMI) and mortality in patients with acute c...

journal_title：European heart journal

authors： Angerås O,Albertsson P,Karason K,Råmunddal T,Matejka G,James S,Lagerqvist B,Rosengren A,Omerovic E

更新日期：2013-02-01 00:00:00

abstract：:Two-dimensional echocardiography (2D echo) and Doppler were performed in a group of patients who had a high probability of having right ventricular (RV) dysplasia (left bundle branch block arrhythmias, no signs of cardiopulmonary diseases) and in a group of age-matched normals. 2D echo showed RV morphofunctional abnor...

journal_title：European heart journal

authors： Iliceto S,Izzi M,De Martino G,Rizzon P

更新日期：1989-09-01 00:00:00

abstract：:The endothelium may play a role as a target and mediator of hypertension. Due to its anatomical position, it is very exposed to mechanical forces; as a source of vasoactive material it may participate in increasing peripheral vascular resistance and in promoting local ischaemia in the heart and brain. Morphological an...

journal_title：European heart journal

authors： Lüscher TF

更新日期：1992-09-01 00:00:00

abstract：:Opiate agonists were administered into the cisterna magna of normotensive urethane-anaesthetized artificially-ventilated rats. Increases in blood pressure and heart rate were produced by fentanyl (0.3-3.0 nmol). [D-ala]2-met-enkephalinamide (17 nmol), and beta-endorphin (2.9 nmol). On the contrary, ethylketocyclazocin...

journal_title：European heart journal

authors： Laurent S,Schmitt H

更新日期：1983-11-01 00:00:00

abstract：:A previously described nitroglycerin-induced heparin resistance could not be verified by in-vitro experiments or in a randomized, double-blind, crossover trial in healthy volunteers. A clinically relevant attenuation of the anticoagulant effect of a heparin bolus (40 U.kg-1) by a concomitant infusion of nitroglycerin ...

journal_title：European heart journal

authors： Schoenenberger RA,Ménat L,Weiss P,Marbet GA,Ritz R

更新日期：1992-03-01 00:00:00

abstract：:Patients who have experienced a myocardial infarction (MI) are at increased risk of sudden cardiac death (SCD). With the advent of implantable cardioverter-defibrillators (ICDs), accurate risk stratification has become very relevant. Numerous investigations have proven that a reduced left ventricular ejection fraction...

journal_title：European heart journal

authors： Dagres N,Hindricks G

更新日期：2013-07-01 00:00:00

abstract：:A 22-year-old man who engaged in intense and regular physical exercise complained of atypical chest pain. The only remarkable abnormality found in the routine clinical work-up was a left posterior hemiblock. The echocardiogram and the magnetic resonance imaging (MRI) study showed a tumour in the posterior and superior...

journal_title：European heart journal

authors： Cola H,Hoffman R,Borrega NG,Lazzari JO

更新日期：1992-04-01 00:00:00

abstract：AIMS:Cardiac biomarkers are routinely elevated after uncomplicated cardiac surgery to levels considered diagnostic of myocardial infarction in ambulatory populations. We investigated the diagnostic power of electrocardiogram (ECG) and cardiac biomarker criteria to predict clinically relevant myocardial injury using ben...

journal_title：European heart journal

authors： Muehlschlegel JD,Perry TE,Liu KY,Nascimben L,Fox AA,Collard CD,Avery EG,Aranki SF,D'Ambra MN,Shernan SK,Body SC,CABG Genomics Investigators.

更新日期：2009-07-01 00:00:00

abstract：:Measurement of the pre-ejection period (PEP) can give valuable information on myocardial function in rats. Depressed cardiac function is accompanied by prolongation of PEP, which shortens when cardiac function improves. Left ventricular ejection time (LVET) may be shortened with ageing in spontaneously hypertensive ra...

journal_title：European heart journal

authors： Schoemaker RG,Smits JF

更新日期：1990-12-01 00:00:00

abstract：:The effects of flosequinan and enalapril on exercise capacity (bicycle exercise duration), quality-of-life symptomatology (visual analogue scales) and New York Heart Association (NYHA) grading, were compared in 61 patients with chronic heart failure (NYHA, grade III). Bicycle exercise duration improved similarly with ...

journal_title：European heart journal

authors： Silke B,Tennet H,Fischer-Hansen J,Keller N,Heikkila J,Salminen K

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:Percutaneous mitral valvuloplasty with the Inoue balloon is conventionally performed with double vascular access: arterial and venous. However, in patients with a good echogenic window it may be performed with venous access only and the procedure monitored by 2D-echocardiography and colour flow mapping. This...

journal_title：European heart journal

authors： Gupta S,Schiele F,Xu C,Meneveau N,Seronde MF,Breton V,Bernard Y,Bassand JP

更新日期：1998-04-01 00:00:00

abstract：:To evaluate the efficacy and safety of hirudin, a direct thrombin inhibitor, in patients with acute myocardial infarction, a dose-finding, angiography study was carried out. After a pilot phase in 10 patients treated with a bolus of 0.1 mg.kg-1 and a continuous infusion of 0.06 mg.kg-1.h-1 (dose group I), two doses of...

journal_title：European heart journal

authors： Molhoek GP,Laarman GJ,Lok DJ,Luz CM,Kingma JH,Van den Bos AA,Zijnen P,Bosma AH,Hertzberger DP,Takens LH

更新日期：1995-07-01 00:00:00

abstract：AIMS:We analysed the contemporary incidence, outcomes, and predictors of heart failure (HF) and/or left ventricular systolic dysfunction (LVSD) before discharge in patients with acute myocardial infarction (MI). The baseline presence of HF or LVSD, or its development during hospitalisation, increases short- and long-te...

journal_title：European heart journal

authors： Velazquez EJ,Francis GS,Armstrong PW,Aylward PE,Diaz R,O'Connor CM,White HD,Henis M,Rittenhouse LM,Kilaru R,van Gilst W,Ertl G,Maggioni AP,Spac J,Weaver WD,Rouleau JL,McMurray JJ,Pfeffer MA,Califf RM,VALIANT registr

更新日期：2004-11-01 00:00:00

abstract：:Over two decades after the introduction of cardiac resynchronization therapy (CRT) into clinical practice, ∼30% of candidates continue to fail to respond to this highly effective treatment of drug-refractory heart failure (HF). Since the causes of this non-response (NR) are multifactorial, it will require multidiscipl...

journal_title：European heart journal

authors： Daubert C,Behar N,Martins RP,Mabo P,Leclercq C

更新日期：2017-05-14 00:00:00

abstract：AIM:Cardiosphere-derived cells (CDCs) produce regenerative effects in the post-infarct setting. However, it is unclear whether CDCs are beneficial in non-ischaemic dilated cardiomyopathy (DCM). We tested the effects of CDC transplantation in mice with cardiac-specific Gαq overexpression, which predictably develop progr...

journal_title：European heart journal

authors： Aminzadeh MA,Tseliou E,Sun B,Cheng K,Malliaras K,Makkar RR,Marbán E

更新日期：2015-03-21 00:00:00

abstract：AIMS:we investigated the relationship between sublingual perfused capillary density (PCD) as a measure of tissue perfusion and outcome (i.e. occurrence of organ failure and mortality) in patients with cardiogenic shock from acute myocardial infarction. METHODS AND RESULTS:we performed a prospective study in 68 patient...

journal_title：European heart journal

authors： den Uil CA,Lagrand WK,van der Ent M,Jewbali LS,Cheng JM,Spronk PE,Simoons ML

更新日期：2010-12-01 00:00:00

abstract：:In 2008, The ESC Working Group on Myocardial and Pericardial Diseases proposed an updated classification of cardiomyopathies based on morphological and functional phenotypes and subcategories of familial/genetic and non-familial/non-genetic disease. In this position statement, we propose a framework for the clinical a...

journal_title：European heart journal

authors： Rapezzi C,Arbustini E,Caforio AL,Charron P,Gimeno-Blanes J,Heliö T,Linhart A,Mogensen J,Pinto Y,Ristic A,Seggewiss H,Sinagra G,Tavazzi L,Elliott PM

更新日期：2013-05-01 00:00:00

abstract：:In the Danish Verapamil Infarction Trial II (DAVIT II) intervention with verapamil significantly decreased the first major event rate (i.e. reinfarction or death) in patients recovering from acute myocardial infarction. As calcium channel antagonists might have a detrimental effect in patients with heart failure, the ...

journal_title：European heart journal

authors： Jespersen CM

更新日期：1993-04-01 00:00:00

abstract：AIMS:To identify changes in multidirectional strain and strain rate (SR) in patients with aortic stenosis (AS). METHODS AND RESULTS:A total of 420 patients (age 66.1 ± 14.5 years, 60.7% men) with aortic sclerosis, mild, moderate, and severe AS with preserved left ventricular (LV) ejection fraction [(EF), ≥50%] were in...

journal_title：European heart journal

authors： Ng AC,Delgado V,Bertini M,Antoni ML,van Bommel RJ,van Rijnsoever EP,van der Kley F,Ewe SH,Witkowski T,Auger D,Nucifora G,Schuijf JD,Poldermans D,Leung DY,Schalij MJ,Bax JJ

更新日期：2011-06-01 00:00:00

abstract：:The implementation of molecular biological approaches has led to the discovery of single genetic variations that contribute to the development of cardiac failure. In the present review, the characteristics that are invariably associated with the development of failure in experimental animals and clinical studies are d...

journal_title：European heart journal

authors： Lips DJ,deWindt LJ,van Kraaij DJ,Doevendans PA

更新日期：2003-05-01 00:00:00

abstract：:Tricuspid regurgitation (TR) is the most common lesion of the tricuspid valve (TV). Mild TR is common and usually is benign. However, moderate or severe TR can lead to irreversible myocardial damage and adverse outcomes. Despite these findings, few patients with significant TR undergo surgery. The treatment of functio...

journal_title：European heart journal

authors： Arsalan M,Walther T,Smith RL 2nd,Grayburn PA

更新日期：2017-03-01 00:00:00

abstract：AIMS:Cigarette smoking is a well-established risk factor for cardiovascular disease yet several studies have shown lower mortality after acute coronary syndromes in smokers compared with non-smokers, the so called 'smoker's paradox'. This study aimed to ascertain the relationship between smoking and clinical outcomes i...

journal_title：European heart journal

authors： Fonarow GC,Abraham WT,Albert NM,Stough WG,Gheorghiade M,Greenberg BH,O'Connor CM,Nunez E,Yancy CW,Young JB

更新日期：2008-08-01 00:00:00

abstract：:We assessed the incremental effect of cardiac catheterization upon the management of 93 adult patients with aortic and/or mitral valve disease, referred for surgical consideration. There were 52 patients with aortic valve disease, 29 with mitral valve disease and 12 with aortic and mitral valve disease. Prior to cardi...

journal_title：European heart journal

authors： Leitch JW,Mitchell AS,Harris PJ,Fletcher PJ,Bailey BP

更新日期：1991-05-01 00:00:00

abstract：:Contraceptive counselling should begin early in females with heart disease, preferably directly after the start of menstruation. In coming to a decision about the method of contraception, the following issues should be considered: (i) the risk of pregnancy for the mother and the consequences of an unplanned pregnancy;...

journal_title：European heart journal

authors： Roos-Hesselink JW,Cornette J,Sliwa K,Pieper PG,Veldtman GR,Johnson MR

更新日期：2015-07-14 00:00:00

abstract：AIMS:To examine the relations between genetic loci, plasma lipoprotein(a) [Lp(a)] levels, and cardiovascular disease (CVD) risk among diabetic patients and compare with the observations in the general population. METHODS AND RESULTS:In two prospective cohorts of patients with type 2 diabetes (n= 2308) from the Nurses'...

journal_title：European heart journal

authors： Qi Q,Workalemahu T,Zhang C,Hu FB,Qi L

更新日期：2012-02-01 00:00:00

abstract：:The aim of our study was to examine if echocardiography can reproducibly be used in a multicentre study to select high risk patients with reduced left ventricular function early after an acute myocardial infarction (MI). In the TRAndolapril Cardiac Evaluation Study (TRACE) patients with reduced left ventricular systol...

journal_title：European heart journal

authors： Køber L,Torp-Pedersen C,Carlsen J,Videbaek R,Egeblad H

更新日期：1994-12-01 00:00:00

abstract：:To investigate the haemodynamic changes after physical training in patients with left ventricular aneurysm, 60 uncomplicated patients, mean age 51 +/- 10 years, underwent a maximal ergometric test in the supine position with haemodynamic monitoring (Swan-Ganz catheter) 37 +/- 10 days from acute myocardial infarction a...

journal_title：European heart journal

authors： Giordano A,Giannuzzi P,Tavazzi L

更新日期：1988-04-01 00:00:00

abstract：:Supraventricular tachycardia is due to altered automaticity, triggered activity or most commonly, reentry. Atrial flutter is most frequently due to reentry with counterclockwise activation in the right atrium with the left atrium acting as a bystander. The small wavefronts demonstrated during atrial fibrillation are l...

journal_title：European heart journal

authors： Shakespeare CF,Anderson M,Camm AJ

更新日期：1993-09-01 00:00:00

abstract：:Randomized clinical trials (RCTs) are the definitive contributors to evidence-based medicine. RCTs assessing serious outcomes in cardiovascular disease have grown, with 'megatrials' becoming more common with the realization that wrong conclusions resulted from random error in inadequately sized trials. Simple design a...

journal_title：European heart journal

authors： Hilbrich L,Sleight P

更新日期：2006-09-01 00:00:00