Abstract:
Aims:To date, clinical evidence of microvascular dysfunction in patients with heart failure (HF) with preserved ejection fraction (HFpEF) has been limited. We aimed to investigate the prevalence of coronary microvascular dysfunction (CMD) and its association with systemic endothelial dysfunction, HF severity, and myocardial dysfunction in a well defined, multi-centre HFpEF population. Methods and results:This prospective multinational multi-centre observational study enrolled patients fulfilling strict criteria for HFpEF according to current guidelines. Those with known unrevascularized macrovascular coronary artery disease (CAD) were excluded. Coronary flow reserve (CFR) was measured with adenosine stress transthoracic Doppler echocardiography. Systemic endothelial function [reactive hyperaemia index (RHI)] was measured by peripheral arterial tonometry. Among 202 patients with HFpEF, 151 [75% (95% confidence interval 69-81%)] had CMD (defined as CFR <2.5). Patients with CMD had a higher prevalence of current or prior smoking (70% vs. 43%; P = 0.0006) and atrial fibrillation (58% vs. 25%; P = 0.004) compared with those without CMD. Worse CFR was associated with higher urinary albumin-to-creatinine ratio (UACR) and NTproBNP, and lower RHI, tricuspid annular plane systolic excursion, and right ventricular (RV) free wall strain after adjustment for age, sex, body mass index, atrial fibrillation, diabetes, revascularized CAD, smoking, left ventricular mass, and study site (P < 0.05 for all associations). Conclusions:PROMIS-HFpEF is the first prospective multi-centre, multinational study to demonstrate a high prevalence of CMD in HFpEF in the absence of unrevascularized macrovascular CAD, and to show its association with systemic endothelial dysfunction (RHI, UACR) as well as markers of HF severity (NTproBNP and RV dysfunction). Microvascular dysfunction may be a promising therapeutic target in HFpEF.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Shah SJ,Lam CSP,Svedlund S,Saraste A,Hage C,Tan RS,Beussink-Nelson L,Ljung Faxén U,Fermer ML,Broberg MA,Gan LM,Lund LHdoi
10.1093/eurheartj/ehy531subject
Has Abstractpub_date
2018-10-01 00:00:00pages
3439-3450issue
37eissn
0195-668Xissn
1522-9645pii
5077831journal_volume
39pub_type
杂志文章,多中心研究abstract:AIMS:There have been no large observational studies attempting to identify predictors of major bleeding in patients with acute coronary syndromes (ACS), particularly from a multinational perspective. The objective of our study was thus to develop a prediction rule for the identification of patients with ACS at higher r...
journal_title:European heart journal
pub_type: 杂志文章,多中心研究
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abstract:AIMS:The curiosity that leanness is associated with poor survival in patients with chronic heart failure (CHF) needs further insight by investigating the impact of weight loss on prognosis in a large sample of patients across a broad spectrum of both reduced and preserved left ventricular (LV) systolic function. METHO...
journal_title:European heart journal
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更新日期:1983-07-01 00:00:00
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European heart journal
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doi:
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pub_type: 杂志文章,多中心研究
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更新日期:2010-04-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2011-09-01 00:00:00
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pub_type: 杂志文章,多中心研究
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doi:10.1093/oxfordjournals.eurheartj.a060504
更新日期:1994-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-04-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1016/j.ehj.2004.01.016
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pub_type: 临床试验,杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2017-03-21 00:00:00
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更新日期:2014-01-01 00:00:00
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更新日期:2017-03-07 00:00:00
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pub_type: 杂志文章
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