Evaluation of recombinant hirudin (CGP 39,393/TMREVASC) in the prevention of restenosis after percutaneous transluminal coronary angioplasty. Rationale and design of the HELVETICA trial, a multicentre randomized double blind heparin controlled study.

abstract：AIMS:The study aimed to compare the addition of felodipine to metoprolol, and of the replacement of metoprolol by felodipine, with continuation of metoprolol, in patients with angina pectoris despite optimal beta-blockade. METHODS AND RESULTS:The study was double-blind, parallel, randomized and controlled, and compris...

journal_title：European heart journal

authors： Dunselman P,Liem AH,Verdel G,Kragten H,Bosma A,Bernink P

更新日期：1997-11-01 00:00:00

abstract：:Arbutamine (Gensia, Inc., San Diego, CA) is a newly-developed sympathomimetic agent specifically designed for cardiovascular stress testing. It has been successfully used for the detection of coronary artery disease in conjunction with electrocardiography, echocardiographic and radionuclide techniques. Arbutamine incr...

journal_title：European heart journal

authors： Armstrong WF,Bach DS

更新日期：1995-11-01 00:00:00

abstract：:Two patients with myocardial bridging of the left anterior descending coronary artery associated with myocardial infarction are described. One of them died from acute cerebral emboli related to cardiac thrombosis in a left ventricular aneurysm. The other died suddenly while sleeping. Both patients were found to have a...

journal_title：European heart journal

authors： Bestetti RB,Costa RS,Zucolotto S,Oliveira JS

更新日期：1989-06-01 00:00:00

abstract：:Myocardial relaxation is an energy-dependent process. Indeed, adenosine triphosphate (ATP) is required to pump free myoplasmic calcium back into the sarcoplasmic reticulum. It is also necessary to extrude the calcium ions which enter the cell during the plateau phase of the action potential. The calcium-sodium exchang...

journal_title：European heart journal

authors： Pouleur H

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:Patients with univentricular hearts have decreased exercise tolerance and may demonstrate exertional dyspnoea. It is not known if chronic hypoxaemia exacerbates exercise intolerance and contributes to symptomatic limitation. The extent to which surgical correction of a right-to-left shunt by a Fontan-type pr...

journal_title：European heart journal

authors： Iserin L,Chua TP,Chambers J,Coats AJ,Somerville J

更新日期：1997-08-01 00:00:00

abstract：AIMS:The purpose of the Euro Heart Survey Programme of the European Society of Cardiology is to evaluate to which extent clinical practice endorses existing guidelines as well as to identify differences in population profiles, patient management, and outcome across Europe. The current survey focuses on the invasive dia...

journal_title：European heart journal

authors： Lenzen MJ,Boersma E,Bertrand ME,Maier W,Moris C,Piscione F,Sechtem U,Stahle E,Widimsky P,de Jaegere P,Scholte op Reimer WJ,Mercado N,Wijns W,European Society of Cardiology.

更新日期：2005-06-01 00:00:00

abstract：:There is mounting evidence to support the influence of inflammation in the pathogenesis of atrial fibrillation (AF). Indeed, AF is associated with increased levels of known inflammatory markers, even after adjustment for confounding factors. The renin-angiotensin-aldosterone system (RAAS) appears to play a key role in...

journal_title：European heart journal

authors： Boos CJ,Anderson RA,Lip GY

更新日期：2006-01-01 00:00:00

abstract：AIMS:A substantial number of patients with dysfunctional but potentially viable myocardium cannot be accurately evaluated by transthoracic echocardiography due to a poor acoustic window. This study compares the diagnostic value of alternative functional imaging techniques, such as dobutamine-transoesophageal echocardio...

journal_title：European heart journal

authors： Baer FM,Theissen P,Crnac J,Schmidt M,Deutsch HJ,Sechtem U,Schicha H,Erdmann E

更新日期：2000-06-01 00:00:00

abstract：AIMS:Characteristics of sudden cardiac arrest (SCA) during sports offers a novel (and unexplored) setting to assess factors associated with disparities in outcomes across regions. METHODS AND RESULTS:From a prospective 5-year community-based French registry concerning SCA during sports in 10-75 year-olds, we evaluated...

journal_title：European heart journal

authors： Marijon E,Bougouin W,Celermajer DS,Perier MC,Benameur N,Lamhaut L,Karam N,Dumas F,Tafflet M,Prugger C,Mustafic H,Rifler JP,Desnos M,Le Heuzey JY,Spaulding CM,Avillach P,Cariou A,Empana JP,Jouven X

更新日期：2013-12-01 00:00:00

abstract：AIMS:To evaluate efficacy and safety of intrapericardial treatment with the crystalloid corticosteroid triamcinolone in autoreactive pericardial effusion. METHODS AND RESULTS:Two hundred and sixty consecutive patients with pericarditis/myopericarditis underwent pericardiocentesis, pericardioscopy (Storz-AF1101B1), and...

journal_title：European heart journal

authors： Maisch B,Ristić AD,Pankuweit S

更新日期：2002-10-01 00:00:00

abstract：AIMS:Angiographic studies on the natural course of both focal and diffuse coronary atherosclerosis have not been performed before, but can both be assessed by quantitative coronary angiography. The objective of this study was to describe the natural course of focal and diffuse coronary atherosclerosis over time. METHO...

journal_title：European heart journal

authors： Vos J,de Feyter PJ,Kingma JH,Emanuelsson H,Legrand V,Winkelmann B,Dumont JM,Simoons LM

更新日期：1997-07-01 00:00:00

abstract：:To evaluate the efficacy and safety of hirudin, a direct thrombin inhibitor, in patients with acute myocardial infarction, a dose-finding, angiography study was carried out. After a pilot phase in 10 patients treated with a bolus of 0.1 mg.kg-1 and a continuous infusion of 0.06 mg.kg-1.h-1 (dose group I), two doses of...

journal_title：European heart journal

authors： Molhoek GP,Laarman GJ,Lok DJ,Luz CM,Kingma JH,Van den Bos AA,Zijnen P,Bosma AH,Hertzberger DP,Takens LH

更新日期：1995-07-01 00:00:00

abstract：AIMS:The management and outcomes of patients with functional moderate/severe mitral regurgitation and severe left ventricular (LV) systolic dysfunction are not well defined. We sought to determine the characteristics, management strategies, and outcomes of patients with moderate or severe mitral regurgitation (MR) and ...

journal_title：European heart journal

authors： Samad Z,Shaw LK,Phelan M,Ersboll M,Risum N,Al-Khalidi HR,Glower DD,Milano CA,Alexander JH,O'Connor CM,Wang A,Velazquez EJ

更新日期：2015-10-21 00:00:00

abstract：:Out of 84,609 Europeans in the ERICA sample (EHJ 9, Suppl I) 18,931 had adequate 6-year follow-up data so that coronary heart disease (CHD) mortality could be assessed in relation to five risk factors (age, cholesterol, systolic blood pressure, body mass index and cigarette smoking) measured at baseline. In view of kn...

journal_title：European heart journal

authors：

更新日期：1991-03-01 00:00:00

abstract：AIMS:Aortic aneurysm/dissection (AAD) is a life-threatening disorder lacking effective pharmacotherapeutic remedies. Aldehyde dehydrogenase 2 (ALDH2) polymorphism is tied with various risk factors for AAD including hypertension, atherosclerosis, and hypercholesterolaemia although direct correlation between the two rema...

journal_title：European heart journal

authors： Yang K,Ren J,Li X,Wang Z,Xue L,Cui S,Sang W,Xu T,Zhang J,Yu J,Liu Z,Shang H,Pang J,Huang X,Chen Y,Xu F

更新日期：2020-07-07 00:00:00

abstract：:Hereditary factors may have a part to play in the development of bicuspid aortic valve. This report concerns a pair of identical twins, probably monozygotic, who required aortic valve replacement as a result of aortic stenosis occurring in bicuspid aortic valves. This supports the contention that there may be a geneti...

journal_title：European heart journal

authors： Godden DJ,Sandhu PS,Kerr F

更新日期：1987-03-01 00:00:00

abstract：Aims:We have shown that extracellular vesicles (EVs) secreted by embryonic stem cell-derived cardiovascular progenitor cells (Pg) recapitulate the therapeutic effects of their parent cells in a mouse model of chronic heart failure (CHF). Our objectives are to investigate whether EV released by more readily available ce...

journal_title：European heart journal

authors： El Harane N,Kervadec A,Bellamy V,Pidial L,Neametalla HJ,Perier MC,Lima Correa B,Thiébault L,Cagnard N,Duché A,Brunaud C,Lemitre M,Gauthier J,Bourdillon AT,Renault MP,Hovhannisyan Y,Paiva S,Colas AR,Agbulut O,Hagège

更新日期：2018-05-21 00:00:00

abstract：:A 37-year-old man sustained occlusion of the right coronary artery after a bicycle accident with blunt chest trauma over the left scapula. Acute coronary angiography was performed because of chest pain and ST-segment elevation. Despite surgically successful acute revascularization the patient developed a transmural in...

journal_title：European heart journal

authors： Gustavsson CG,Albrechtsson U,Forslind K,Ståhl E,White T

更新日期：1992-01-01 00:00:00

abstract：AIMS:The objectives of this study were to determine the association of waist circumference (WC) and waist-to-hip ratio (WHR) with the risk of incident cardiovascular disease (CVD) events and to determine whether the strength of association of WC and WHR with CVD risk is different. METHODS AND RESULTS:This meta-regress...

journal_title：European heart journal

authors： de Koning L,Merchant AT,Pogue J,Anand SS

更新日期：2007-04-01 00:00:00

abstract：:Cardiac beta-adrenoceptor density and subtype distribution has been determined in different kinds of heart failure. A decrease in cardiac beta-adrenoceptor function appears to be a general phenomenon in all kinds of heart failure. However, cardiac beta 1- and beta 2-adrenoceptors seem to be differentially affected in ...

journal_title：European heart journal

authors： Brodde OE,Zerkowski HR,Borst HG,Maier W,Michel MC

更新日期：1989-06-01 00:00:00

abstract：AIMS:Our aim was to follow changes in myocardial function and physiology in patients awaiting coronary artery bypass surgery (CABG) and relate changes to post-revascularisation functional response. METHODS AND RESULTS:In 21 patients with CAD and LV dysfunction, myocardial glucose utilisation (MGU) and blood flow (MBF)...

journal_title：European heart journal

authors： Pitt M,Dutka D,Pagano D,Camici P,Bonser R

更新日期：2004-03-01 00:00:00

abstract：:The mechanism of coronary spasm is poorly understood. We report a case of coronary artery spasm in a cardiac transplant patient. Pharmacologic testing indicated denervation of the patient's heart. Therefore coronary artery spasm may occur despite cardiac denervation. This case demonstrates that intact autonomic nervou...

journal_title：European heart journal

authors： Cattan S,Drobinski G,Artigou JY,Grogogeat Y,Cabrol C

更新日期：1988-05-01 00:00:00

abstract：:The effects of a single oral dose of nisoldipine, 10 mg, were investigated in two groups of patients. Firstly, the effects of nisoldipine on exercise left ventricular function were assessed in 20 patients with chronic stable angina and coronary disease. Secondly, the effects of nisoldipine on the left ventricular resp...

journal_title：European heart journal

authors： Dymond DS,Caplin JL,O'Keefe JC,Banim S

更新日期：1987-11-01 00:00:00

abstract：AIMS:This study compared plasma levels of established risk markers for atherosclerosis and indices of inflammation in 50 patients with severe periodontitis to those in 46 healthy cases. METHODS AND RESULTS:Full blood counts were performed and levels of high density lipoproteins (HDL), total cholesterol, haptoglobin, e...

journal_title：European heart journal

authors： Buhlin K,Gustafsson A,Pockley AG,Frostegård J,Klinge B

更新日期：2003-12-01 00:00:00

abstract：AIMS:The development of risk associated with diabetes mellitus during long-term follow-up after a myocardial infarction has not been studied in detail. We have studied time-related changes of risk of death during 10 years of follow-up in a cohort of patients not treated with thrombolytic therapy (the Glostrup cohort) a...

journal_title：European heart journal

authors： Melchior T,Kober L,Madsen CR,Seibaek M,Jensen GV,Hildebrandt P,Torp-Pedersen C

更新日期：1999-07-01 00:00:00

abstract：AIMS:To study the implications of European guidelines on the use of antihypertensives and/or lipid-lowering drugs (LLDs) for primary prevention in a Norwegian population. METHODS AND RESULTS:The Tromsø study is a population-based study in the municipality Tromsø, Norway (from 1974 to till now). This analysis includes ...

journal_title：European heart journal

authors： Hartz I,Njølstad I,Eggen AE

更新日期：2005-12-01 00:00:00

abstract：AIMS:Thrombin plays a key role in the clinical syndrome of unstable angina. We investigated the safety and efficacy of five dose levels of efegatran sulphate, a direct thrombin inhibitor, compared to heparin in patients with unstable angina. METHODS:Four hundred and thirty-two patients with unstable angina were enroll...

journal_title：European heart journal

authors： Klootwijk P,Lenderink T,Meij S,Boersma H,Melkert R,Umans VA,Stibbe J,Müller EJ,Poortermans KJ,Deckers JW,Simoons ML

更新日期：1999-08-01 00:00:00

abstract：:The advent of platelet membrane glycoprotein (GP) IIb/IIIa inhibitors has changed the landscape of interventional cardiology. Given the commercial availability of abciximab and expected regulatory approvals for other receptor blockers, defining appropriate use of these agents in the interventional setting is mandated....

journal_title：European heart journal

authors： Chronos N,Vahanian A,Betriu A,Emanuelsson H,Goldberg S,Gulba D,van Hout BA

更新日期：1998-04-01 00:00:00

abstract：AIMS:This study investigated the functional outcome of wall-thinned, akinetic myocardium after revascularization and evaluated the accuracy of dobutamine echocardiography in predicting post-revascularization functional recovery with the assessment of end-diastolic wall thickness in chronic ischaemic patients. METHODS ...

journal_title：European heart journal

authors： Furukawa T,Haque T,Takahashi M,Kinoshita M

更新日期：1997-05-01 00:00:00

abstract：:Tricuspid regurgitation (TR) is the most common lesion of the tricuspid valve (TV). Mild TR is common and usually is benign. However, moderate or severe TR can lead to irreversible myocardial damage and adverse outcomes. Despite these findings, few patients with significant TR undergo surgery. The treatment of functio...

journal_title：European heart journal

authors： Arsalan M,Walther T,Smith RL 2nd,Grayburn PA

更新日期：2017-03-01 00:00:00